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Full-Text Articles in Biomedical
A Novel Model To Study Adipose-Derived Stem Cell Differentiation, Austin N. Worden
A Novel Model To Study Adipose-Derived Stem Cell Differentiation, Austin N. Worden
Theses and Dissertations
The use of three-dimensional (3D) culture systems (hydrogels) and adipose-derived stem cells (ADSCs) in regenerative medicine to advance early-stage investigation and modeling of the mechanisms of diseases, treatments, targets, etc. has recently increased. ADSCs, specifically, are utilized due to their innate programming during embryogenesis and in adult tissues in addition to their ability to differentiate into mesodermal, endodermal, and ectodermal cell-specific lineages. Of importance is that these advancements do not involve a model specimen (i.e. mice or rats) and simulate the numerous conflicting signals a migrating cell is exposed to in vivo such as chemokines, extracellular matrix (ECM), growth factors, …
Optimization Of Collagen Microneedle Using Taguchi Method, Abhilash Aditya
Optimization Of Collagen Microneedle Using Taguchi Method, Abhilash Aditya
Open Access Theses & Dissertations
Research is conducted to create dissolving collagen microneedles and to optimize the parameters for close to perfect dimension microneedles. A collagen microneedle patch has been developed with a micro-manufacturing process (micro-molding process). The collagen microneedles, varying in length from 300 to 600-μm may reach different targeted layers of the skin depending on the application. As the microneedles penetrate the skin they dissolve, delivering collagen through the epidermis. Such addition of collagen directly to the dermis layers allows it to be absorbed, increasing skin's strength and resilience, since it is one of the natural components of the younger looking skin. This …
Oriented Collagen And Applications Of Waveguide Evanescent Field Scattering (Wefs) Microscopy, Qamrun Nahar
Oriented Collagen And Applications Of Waveguide Evanescent Field Scattering (Wefs) Microscopy, Qamrun Nahar
Electronic Thesis and Dissertation Repository
In this thesis, Waveguide Evanescent Field Scattering (WEFS) microscopy is developed as a non-invasive, label-free live cell imaging technique. This new high-contrast imaging can be employed to study the first hundred nanometers from the surface as it utilizes the evanescent field of a waveguide as the illumination source. Previously, waveguide evanescent field fluorescence (WEFF) microscopy was developed as a fluorescence imaging technique comparable to the total internal reflection fluorescent (TIRF) microscopy. Both the WEFF and WEFS technique utilizes the same fundamental concepts except in WEFS microscopy imaging is accomplished without the application of any fluorescent labeling. In this work, bacterial …