Biomedical Commons^™

Scaffold Based In-Vitro Osteodistraction For Bone Tissue Engineering, Cesar Adrian Terrazas

Open Access Theses & Dissertations

Engineering of hard tissues such as bone is a challenge because of the limited ability of the body to heal large defects. Current treatment options, such as employing bone sections from the patient or a deceased donor have been utilized for some time now with various degrees of success. However, these methods still exhibit many limitations such as limited supply and the possibility of transmission of disease.

To address the many limitations of bone grafts, synthetic engineered substitutes have been developed and widely researched for nearly three decades. Generally termed scaffolds, these are matrices that serve the purpose of temporary …

Application Of Sensor Fusion To Human Locomotor System, John Kweku Avor

Open Access Theses & Dissertations

This research study proposes a multi-sensor data fusion technique to determine the complex interactions between the sensory, muscular and mechanical components of the human locomotor systems (neuromechanics). The object in this work is to demonstrate the viability in using inertial sensors for accurate gait phase determination and to present the acceleration effect specific body segment contributes in order to establish a functional gait. The current method used in determining gait phases consist of combining ground reaction force and angular data, this method is time consuming and cannot be totally reliable. We found out that gait phases can be determined distinctively …

Identification Of Human Gait Using Genetic Algorithm Tuned Fuzzy Logic, Abdallah Abdel-Rahman Hassan Mahmoud

Open Access Theses & Dissertations

Data mining is concerned with the discovery of useful hidden information in large databases. Classification is a data mining task producing rules in which a set of attributes in data predict the value of a class attribute. Classifiers usually produce a large number of rules, most of which are not interesting to the user. Rule interestingness is a decisive factor. However, evaluating rule interestingness is challenging as it involves both objective (data-driven) and subjective (user-driven) aspects.

In this research, a fuzzy genetic algorithm is proposed to discover classification rules that are both accurate and interesting. Continuous attributes are fuzzified so …

Exploring Poly(Ethylene Glycol) As A Suitable Material For Peripheral Nerve Regeneration Scaffolds Manufactured By Stereolithography, Nubia Zuverza

Open Access Theses & Dissertations

One of the challenges in tissue engineering is to have spatial and temporal control over the biological elements within a scaffold used to guide regeneration for example of transected nerves. Some of the physical and chemical characteristics to regulate include incorporation of bioactive domains and release of chemical signals. This study presents the use of stereolithography (SL) to incorporate localized domains for cell adhesion in addition to include releasable nerve growth factor (NGF) in the process of building poly(ethylene glycol)diacrylate (PEGda) hydrogel scaffolds. Besides providing sites for cell attachment, an ideal nerve guidance conduit (NGC) should be able to release …

Stereolithography Of Poly(Ethylene Glycol) Hydrogels With Application In Tissue Engineering As Peripheral Nerve Regeneration Scaffolds, Karina Arcaute

Open Access Theses & Dissertations

In recent years, rapid prototyping (RP) technologies initially developed to create prototypes prior to production for the automotive, aerospace, and other industries, have found applications in tissue engineering (TE). Several different RP technologies are being used to fabricate biocompatible 3D structures with controlled micro- and macro-scale characteristics. The focus of this research was to explore the capabilities of the RP technology, stereolithography (SL), for creating complex, 3D scaffolds with applications in TE using a photocrosslinkable biopolymer, poly(ethylene glycol) (PEG). The primary objective was to create an implantable multi-lumen nerve guidance conduit (NGC) for the regeneration of peripheral nerves.

Studies of …

Assessment Of Human Muscle Fatigue From Surface Emg Signals Recorded During Isometric Voluntary Contractions By Using A Cosine Modulated Filter Bank, Cristhian Mauricio Potes

Open Access Theses & Dissertations

Human muscle fatigue involves both a decrease in the frequency and increase in the amplitude of a surface electromyographic (EMG) signal. Muscle fatigue is also related to a decrease of the force impeding to reach the same initial level of the maximum voluntary contraction (MVC). To determine muscle fatigue indices, a method is proposed by decomposing a surface EMG signal into 32-subbands. This decomposition was attained by using a cosine modulated filter bank. The

surface EMG signals analyzed during this research were recorded during isometric voluntary contractions. Both the instantaneous mean frequency (IMF) and the instantaneous amplitude (IA) are estimated …