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2011

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Articles 601 - 630 of 934

Full-Text Articles in Civil and Environmental Engineering

Review Of Assessment, Design, And Mitigation Of Multiple Hazards, Aakash Ahuja Jan 2011

Review Of Assessment, Design, And Mitigation Of Multiple Hazards, Aakash Ahuja

Dissertations, Master's Theses and Master's Reports - Open

Large parts of the world are subjected to one or more natural hazards, such as earthquakes, tsunamis, landslides, tropical storms (hurricanes, cyclones and typhoons), costal inundation and flooding. Virtually the entire world is at risk of man-made hazards. In recent decades, rapid population growth and economic development in hazard-prone areas have greatly increased the potential of multiple hazards to cause damage and destruction of buildings, bridges, power plants, and other infrastructure; thus posing a grave danger to the community and disruption of economic and societal activities. Although an individual hazard is significant in many parts of the United States (U.S.), …


Fracture Energy Method For Determining Stiffness In Polymer Modified Asphalt Binders Using The Single Edge Notched Beam, Alejandro Rosales Jan 2011

Fracture Energy Method For Determining Stiffness In Polymer Modified Asphalt Binders Using The Single Edge Notched Beam, Alejandro Rosales

McNair Scholars Research Journal

Transverse cracking is a prevalent problem that occurs in asphalt pavement binders in cold climates and diminishes the integrity of the road as well as shortens the life span of the road leading to premature failure. Current specification for testing asphalt pavement binders for transverse cracking fails to accurately model the behavior of modified asphalt binders because it does not take into account the effects of physical hardening. Furthermore, current specification, which employs the use of the bending beam rheometer (BBR) and direct tension tests, was developed through the use of unmodified asphalt pavement binders and so it does not …


Effect Of Additive On The Performance Characteristics Of Centrifugal And Progressive Cavity Slurry Pumps With High Concentration Fly Ash Slurries, Sunil Chandel, S.N. Singh, V. Seshadri Jan 2011

Effect Of Additive On The Performance Characteristics Of Centrifugal And Progressive Cavity Slurry Pumps With High Concentration Fly Ash Slurries, Sunil Chandel, S.N. Singh, V. Seshadri

Coal Combustion and Gasification Products Journal Archive

Slurry pumps that are used in the hydraulic transportation of fly ash slurries through pipes in thermal power plants can be broadly classified into two main categories namely positive displacement and centrifugal pumps. The two types of pumps differ considerably in construction as well as in operating principle compared to the conventional pumps. The present study reports the effect of additive on the performance characteristics of centrifugal and progressive cavity screw pumps with fly ash slurries at high concentrations (above Cw < 50% by weight). Mixture of sodium carbonate and Henko detergent (5:1) at a concentration of 0.2% by weight has been used as an additive. For each type of pump, the effect of additive on the performance characteristics has been experimentally evaluated at rated speed with fly ash slurries in the concentration range of 50 to 70% by weight. The pump total head, overall efficiency and pump input power as a function of flow rate have been measured. The results obtained from the centrifugal slurry pump performance show that at rated speed, the performance of the pump improves with the addition of drag reducing additive. In the case of progressive cavity screw pump, pump performance characteristics and behavior were completely different as compared to the centrifugal slurry pump. At rated speed, the performance of screw pump deteriorates with the addition of drag reducing soap solution.


Personas As A User-Centred Design Tool For The Built Environment., Emma Siddall, Corelia Baibarac, Aimee Byrne, Niall Byrne, Ashling Deasy, Nuala Flood, Camille Goulding, Shane O'Driscoll, Niamh Rabbitt, Angharad Sweeney, Yue Wang, Mark Dyer Jan 2011

Personas As A User-Centred Design Tool For The Built Environment., Emma Siddall, Corelia Baibarac, Aimee Byrne, Niall Byrne, Ashling Deasy, Nuala Flood, Camille Goulding, Shane O'Driscoll, Niamh Rabbitt, Angharad Sweeney, Yue Wang, Mark Dyer

Articles

The physical structure of a city frequently defines how people interact with each other and their environment. This paper examines the use of personas as a user-centred design tool for the re-engineering of a city to promote sustainable behaviour and social inclusion of its citizens (the Eight Eyes of Dublin Project). The research was carried out through the adoption of personas and collaboration with design partners to identify barriers to sustainability, and resulted in recommendations for the future development of Dublin city, Ireland. These recommendations are then compared with the draft Dublin development plan 2011–17 to determine the effectiveness of …


A Parametric Study Of Pedestrian Vertical Force Models For Dynamic Analysis Of Footbridges, Paul Archbold, Joe Keogh, Colin C. Caprani, Paul Fanning Jan 2011

A Parametric Study Of Pedestrian Vertical Force Models For Dynamic Analysis Of Footbridges, Paul Archbold, Joe Keogh, Colin C. Caprani, Paul Fanning

Conference papers

Footbridge vibration has received much attention in recent years. However, stochastic models for crowd loading are not common, and estimation of crowd-induced vibration is typically done through enhancement factors applied to single pedestrian loading models. This work compares two such models, a moving force model and a spring-mass-damper model (SMD). Typical ranges for various pedestrian parameters are examined, and it is found that the pacing frequency has by far the greatest influence on bridge vibration response. It is also found that the magnitude of the response for pacing frequencies near the bridge natural frequency is lower for the SMD model, …


Special Section On Advanced Modeling And Numerical Simulations In Geomechanics, Louis Ge, Dar Hao Chen, Rafiqul Alam Tarefder Jan 2011

Special Section On Advanced Modeling And Numerical Simulations In Geomechanics, Louis Ge, Dar Hao Chen, Rafiqul Alam Tarefder

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

No abstract provided.


Cottonwood Management Plan/Programmatic Environmental Assessment Proposed Implementation Of A Cottonwood Management Plan Along Six Priority Segments Of The Missouri River Jan 2011

Cottonwood Management Plan/Programmatic Environmental Assessment Proposed Implementation Of A Cottonwood Management Plan Along Six Priority Segments Of The Missouri River

United States Army Corps of Engineers, Omaha District

The U.S. Army Corps of Engineers (Corps) proposes to preserve existing stands and reestablish new stands of plains cottonwood (Populus deltoides) at selected public/government lands along the Missouri River in accordance with the Cottonwood Management Plan (CMP). The Proposed Action is the implementation of the CMP. The goal of the plan is to be a living document that preserves, creates, or restores cottonwood habitats along the Missouri River and meets the requirements of the USFWS 2003 Amended Biological Opinion (BiOp) concerning the bald eagle (Haliaeetus leucocephalus). The principal immediate focus of the CMP includes measures in …


Missouri River Recovery Program: 2009 Spring Pulse And Rises Drainage Monitoring And Evaluation Jan 2011

Missouri River Recovery Program: 2009 Spring Pulse And Rises Drainage Monitoring And Evaluation

United States Army Corps of Engineers, Omaha District

Spring pulse releases for the benefit of the endangered pallid sturgeon were planned for March and May 2009 to mimic historic natural spring rises that occurred on the Missouri River before the closure of the main stem dams. The March spring pulse from Gavins Point Dam was not released in 2009 due to high downstream flows and the possibility of flow-limit violations. A 6.1 -kcfs May spring pulse was released in 2009.

The May spring pulse was monitored at 44 sites along the Missouri River. Nineteen of these were interior-drainage sites that were monitored for possible socioeconomic impacts to landowners. …


Accidental Releases Of Hazardous Materials And Relevance To Terrorist Threats At Industrial Facilities, Laura J. Steinberg, Nicholas Santella Jan 2011

Accidental Releases Of Hazardous Materials And Relevance To Terrorist Threats At Industrial Facilities, Laura J. Steinberg, Nicholas Santella

Civil and Environmental Engineering - All Scholarship

Hazardous material releases, some with serious consequences, are a common occurrence in the U.S. Of late, the hazards posed by releases caused by terrorist attacks or natural disasters have been of particular concern. Although terrorism directed at hazardous material handling industries within the U.S. has not yet resulted in a significant incident, there is much recent experience with serious accidental releases resulting from natural disasters. Case studies are developed from a number of recent natural disasters and severe weather events that resulted in large releases of hazardous materials. These case studies are used to illustrate parallels between the risks posed …


Spatial And Temporal Patterns Of Mercury Accumulation In Lacustrine Sediments Across The Laurentian Great Lakes Region, Paul E. Drevnick, Daniel R. Engstrom, Charles T. Driscoll, Edward B. Swain, Steven J. Balogh Jan 2011

Spatial And Temporal Patterns Of Mercury Accumulation In Lacustrine Sediments Across The Laurentian Great Lakes Region, Paul E. Drevnick, Daniel R. Engstrom, Charles T. Driscoll, Edward B. Swain, Steven J. Balogh

Civil and Environmental Engineering - All Scholarship

Data from 104 sediment cores from the Great Lakes and “inland lakes” in the region were compiled to assess historical and recent changes in mercury (Hg) deposition. The lower Great Lakes showed sharp increases in Hg loading c. 1850-1950 from point-source water dischargers, with marked decreases during the past half century associated with effluent controls and decreases in the industrial use of Hg. In contrast, Lake Superior and inland lakes exhibited a pattern of Hg loading consistent with an atmospheric source - gradual increases followed by recent (post-1980) decreases. Variation in sedimentary Hg flux among inland lakes was primarily attributed …


Modelling Of Highway Bridge Traffic Loading: Some Recent Advances, Bernard Enright, Colin C. Caprani, Eugene J. Obrien Jan 2011

Modelling Of Highway Bridge Traffic Loading: Some Recent Advances, Bernard Enright, Colin C. Caprani, Eugene J. Obrien

Conference papers

The accurate estimation of site-specific lifetime extreme traffic load effects is an important element in the cost-effective assessment of bridges. In recent years, the improved quality and increasing use of weigh-in-motion technology has meant that better quality and larger databases of vehicle weights are now available. This has enabled measurements of the regular occurrence of extremely heavy vehicles, with weights in excess of 100 t. The collected measurements have been used as the basis for building and calibrating a Monte Carlo simulation model for bridge loading. The computer programs written to implement this model generate simulated traffic in two lanes …


Radar-Rainfall Estimation Algorithms Of Hydro-Nexrad, Bong Chul Seo, Witold F. Krajewski, Anton Kruger, Piotr Domaszczynski, James A. Smith, Matthias Steiner Jan 2011

Radar-Rainfall Estimation Algorithms Of Hydro-Nexrad, Bong Chul Seo, Witold F. Krajewski, Anton Kruger, Piotr Domaszczynski, James A. Smith, Matthias Steiner

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Hydro-NEXRAD is a prototype software system that provides hydrology and water resource communities with ready access to the vast data archives of the U.S. weather radar network known as NEXRAD (Next Generation Weather Radar). This paper describes radar-rainfall estimation algorithms and their modular components used in the Hydro-NEXRAD system to generate rainfall products to be delivered to users. A variety of customized modules implemented in Hydro-NEXRAD perform radar-reflectivity data processing, produce radar-rainfall maps with user-requested space and time resolution, and combine multiple radar data for basins covered by multiple radars. System users can select rainfall estimation algorithms that range from …


Structural Health Monitoring For Damage Detection Using Wired And Wireless Sensor Clusters, Thomas Terrell Jan 2011

Structural Health Monitoring For Damage Detection Using Wired And Wireless Sensor Clusters, Thomas Terrell

Electronic Theses and Dissertations

Sensing and analysis of a structure for the purpose of detecting, tracking, and evaluating damage and deterioration, during both regular operation and extreme events, is referred to as Structural Health Monitoring (SHM). SHM is a multi-disciplinary field, with a complete system incorporating sensing technology, hardware, signal processing, networking, data analysis, and management for interpretation and decision making. However, many of these processes and subsequent integration into a practical SHM framework are in need of development. In this study, various components of an SHM system will be investigated. A particular focus is paid to the investigation of a previously developed damage …


Assessment Of Global And Regional Reanalyses Data For Hydro- Climatic Impact Studies In The Upper Thames River Basin, Tarana A. Solaiman, Slobodan P. Simonovic Jan 2011

Assessment Of Global And Regional Reanalyses Data For Hydro- Climatic Impact Studies In The Upper Thames River Basin, Tarana A. Solaiman, Slobodan P. Simonovic

Water Resources Research Report

This study evaluates NCEP-NCAR reanalyses hydro-climatic data as an initial check for assessment of climate change studies and hydrologic modeling on the basin scale. Reanalysis data set for daily precipitation, and temperature from the National Centers for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR) (a) global (NNGR) and (b) regional (NARR) reanalysis project are used as input into the semi-distributed hydrologic model (HEC-HMS) during the period of 1980-2005. First, the precipitation and temperature data are interpolated to selected stations to check for their trends and similarity in means and variances. Although NARR shows some over-estimated values, mainly in estimating temperature …


Pressure-Equalized Rainscreen Wall System: A Full-Scale Experiment, Samar D. Dernayka Jan 2011

Pressure-Equalized Rainscreen Wall System: A Full-Scale Experiment, Samar D. Dernayka

Digitized Theses

The pressure equalized rainscreen wall, considered as the most effective building envelope against wind induced rain penetration, requires continuous investigations to reach better performance. This research seeks the optimum pressure equalization process under external pressure conditions and wall parameters that have not previously been studied in detail. For this purpose, a single compartment full-scale wall model was built in a controlled facility at the University of Western Ontario. The cavity pressure response to external fluctuations was experimentally examined with respect to the rainscreen venting area ratio, under two types of real wind pressure distributions generated mechanically at zero degree incidence: …


Dietary Supplement Wastewater Treatment By Biological Methods, Xiangting Hou Jan 2011

Dietary Supplement Wastewater Treatment By Biological Methods, Xiangting Hou

ETD Archive

Dietary supplements, pre-mixed meal like Slim Fast, are part of most people's lives. Since dietary supplements have a high order of complex sugars, low-fat milk, and all kinds of nutrients, they bring hazards to the environment if discharged to water bodies without any proper treatment. Therefore, wastewater from dietary supplement gains much more attention at the present time. Dietary supplement wastewater contains amounts of organic compounds which may be bio- friendly and non-toxic. Biological treatment shows its strong advantages in dealing with this kind of wastewater.In this research, four kinds of Live Liquid Micro-organisms (LLMO) were used as the sources …


Electrocoagulation/Flotation Treatment Of Synthetic Surface Water, Sampath Gunukula Jan 2011

Electrocoagulation/Flotation Treatment Of Synthetic Surface Water, Sampath Gunukula

ETD Archive

Rainfall generated surface runoff water could contaminate groundwater through transportation of suspended solids and organic matter in to the aquifer. Surface runoff water composition mainly depends on soil amendment. Surface runoff mainly contains clay, minerals, organic and inorganic matter, total dissolved lead, zinc. ECF technology presents an alternative for the removal of total suspended solids, turbidity, and organic matter from generated surface runoff water. This research presents development of bench scale ECF unit for the treatment of synthetic surface water. Experiments were conducted in a 10 liter Plexiglas unit provided with two aluminum electrodes, one serving as cathode, and other …


Measuring The Environmental Impact Of Embedded/Bankfull Culverts, Joseph A. Pavlick Jan 2011

Measuring The Environmental Impact Of Embedded/Bankfull Culverts, Joseph A. Pavlick

ETD Archive

Streams are dynamic systems constantly changing over time. The health of a stream system is tied to the amount of sedimentation occurring in a stream. The addition of roadway culverts into a stream has been shown to cause erosion and sedimentation problems if the culvert does not meet stream characteristics of slope, bankfull/width, and channel orientation. This has led to the design of embedded/bankfull culverts. In the State of Ohio, the Ohio Environmental Protection Agency and the United States Army Corps of Engineers now require the Ohio Transportation to install embedded/bankfull culverts at all stream locations during new roadway construction. …


Quality Control Using Inferential Statistics In Weibull Analyses For Components Fabricated From Monolithic Ceramics, Ankurben H. Parikh Jan 2011

Quality Control Using Inferential Statistics In Weibull Analyses For Components Fabricated From Monolithic Ceramics, Ankurben H. Parikh

ETD Archive

No abstract provided.


Restoration Of Emergent Sandbar Habitat Complexes In The Missouri River, North Dakota Jan 2011

Restoration Of Emergent Sandbar Habitat Complexes In The Missouri River, North Dakota

United States Army Corps of Engineers, Omaha District

In 2003, the United States Fish and Wildlife Service (USFWS) issued an Amendment to the 2000 Biological Opinion (BiOp) with recommendations for the US Army Corps of Engineers’ (Corps) operations on the Missouri River Mainstem System (MRMS). The BiOp Amendment was the result of continuing consultation between the Corps and the USFWS under the Endangered Species Act (ESA) and supplemented the recommendations given in the previous BiOp (USFWS, 2000). The 2000 BiOp and amendments made in 2003 will be collectively referred to as “BiOp” hereafter. The document found that Corps operations on the Missouri River were not likely to jeopardize …


A Multi-Temporal Analysis Of Amsr-E Data For Flood And Discharge Monitoring During The 2008 Flood In Iowa, Marouane Temimi, Teodosio Lacava, Tarendra Lakhankar, Valerio Tramutoli, Hosni Ghedira, Riadh Ata, Reza Khanbilvardi Jan 2011

A Multi-Temporal Analysis Of Amsr-E Data For Flood And Discharge Monitoring During The 2008 Flood In Iowa, Marouane Temimi, Teodosio Lacava, Tarendra Lakhankar, Valerio Tramutoli, Hosni Ghedira, Riadh Ata, Reza Khanbilvardi

Publications and Research

The objective of this work is to demonstrate the potential of using passive microwave data to monitor flood and discharge conditions and to infer watershed hydraulic and hydrologic parameters. The case study is the major flood in Iowa in summer 2008. A new Polarisation Ratio Variation Index (PRVI) was developed based on a multi-temporal analysis of 37 GHz satellite imagery from the Advanced Microwave Scanning Radiometer (AMSR-E) to calculate and detect anomalies in soil moisture and/or inundated areas. The Robust Satellite Technique (RST) which is a change detection approach based on the analysis of historical satellite records was adopted. A …


Evaluating The Use Of Steady Burn Warning Lights On Drums For Workzone Safety, Prasad Nannapaneni Jan 2011

Evaluating The Use Of Steady Burn Warning Lights On Drums For Workzone Safety, Prasad Nannapaneni

Wayne State University Dissertations

Abstract

EVALUATING THE USE OF

STEADY BURN WARNING LIGHTS ON DRUMS

FOR WORK ZONE SAFETY

by

PRASAD LAKSHMI VARA NANNAPANENI

May 2011

Advisor: Dr. Timothy Gates

Major: Civil Engineering

Degree: Doctor of Philosophy

Roadway maintenance and repair has become increasingly commonplace in the United States over the past several decades as our roadway infrastructure has continued to age and deteriorate. Maintenance and repair work on an existing roadway often presents the challenge of maintaining traffic on the existing roadway while work is being performed, thereby necessitating the use of what is commonly referred to as a roadway "work zone". One …


Characteristics And Causal Factors Of Claims In Michigan Highway Construction Projects, Abel K. Sahlool Jan 2011

Characteristics And Causal Factors Of Claims In Michigan Highway Construction Projects, Abel K. Sahlool

Wayne State University Dissertations

The US highway system is the largest road network system in the world. MDOT administers about 9,722 route-miles, (28,000 lane-miles) of roadway networks in Michigan. Every year, hundreds of projects worth millions of dollars are let by the State Transportation Agency (STA).

Majority of these projects are successfully completed within the original scope of work, budget, schedule, and without litigation. However; some projects end up in litigation and disputes costing tax payers a great amount of money and the STA a great amount of resources. The number and cost of these construction claims has been substantially increasing in recent years. …


Michigan Cone Test : A Reliability Study, Karl M. Krueger Jan 2011

Michigan Cone Test : A Reliability Study, Karl M. Krueger

Dissertations, Master's Theses and Master's Reports - Open

No abstract provided.


Development Of A Physically-Based Method For Delineation Of Hydrologically Homogeneous Regions And Flood Quantile Estimation In Ungauged Basins Via The Index Flood Method, Fredline Ilorme Jan 2011

Development Of A Physically-Based Method For Delineation Of Hydrologically Homogeneous Regions And Flood Quantile Estimation In Ungauged Basins Via The Index Flood Method, Fredline Ilorme

Dissertations, Master's Theses and Master's Reports - Open

Regional flood frequency techniques are commonly used to estimate flood quantiles when flood data is unavailable or the record length at an individual gauging station is insufficient for reliable analyses. These methods compensate for limited or unavailable data by pooling data from nearby gauged sites. This requires the delineation of hydrologically homogeneous regions in which the flood regime is sufficiently similar to allow the spatial transfer of information. It is generally accepted that hydrologic similarity results from similar physiographic characteristics, and thus these characteristics can be used to delineate regions and classify ungauged sites. However, as currently practiced, the delineation …


Creep And Shrinkage Behavior Of Ultra High-Performance Concrete Under Compressive Loading With Varying Curing Regimes , Jason C. Flietstra Jan 2011

Creep And Shrinkage Behavior Of Ultra High-Performance Concrete Under Compressive Loading With Varying Curing Regimes , Jason C. Flietstra

Dissertations, Master's Theses and Master's Reports - Open

This Ultra High Performance Concrete research involves observing early-age creep and shrinkage under a compressive load throughout multiple thermal curing regimes. The goal was to mimic the conditions that would be expected of a precast/prestressing plant in the United States, where UHPC beams would be produced quickly to maximize a manufacturing plant’s output. The practice of steam curing green concrete to accelerate compressive strengths for early release of the prestressing tendons was utilized (140°F [60°C], 95% RH, 14 hrs), in addition to the full thermal treatment (195°F [90°C], 95% RH, 48 hrs) while the specimens were under compressive loading. Past …


Ecosystem Services Altered By Human Changes In The Nitrogen Cycle: A New Perspective For Us Decision Making, Jana E. Compton, John A. Harrison, Robin L. Dennis, Tara L. Greaver, Brian H. Hill, Stephen J. Jordan, Henry Walker, Holly V. Campbell Jan 2011

Ecosystem Services Altered By Human Changes In The Nitrogen Cycle: A New Perspective For Us Decision Making, Jana E. Compton, John A. Harrison, Robin L. Dennis, Tara L. Greaver, Brian H. Hill, Stephen J. Jordan, Henry Walker, Holly V. Campbell

United States Environmental Protection Agency: Publications

Human alteration of the nitrogen (N) cycle has produced benefits for health and well-being, but excess N has altered many ecosystems and degraded air and water quality. US regulations mandate protection of the environment in terms that directly connect to ecosystem services. Here, we review the science quantifying effects of N on key ecosystem services, and compare the costs of N-related impacts or mitigation using the metric of cost per unit of N. Damage costs to the provision of clean air, reflected by impaired human respiratory health, are well characterized and fairly high (e.g. costs of ozone and particulate damages …


Toxicity And Recovery In The Pregnant Mouse After Gestational Exposure To The Cyanobacterial Toxin, Cylindrospermopsin, N. Chernoff, E. H. Rogers, R. D. Zehr, M. I. Gage, D. E. Malarkey, C. A. Bradfield, Y. Liu, J. E. Schmid, R. H. Jaskot, J. H. Richards, C. R. Wood, M. B. Rosen Jan 2011

Toxicity And Recovery In The Pregnant Mouse After Gestational Exposure To The Cyanobacterial Toxin, Cylindrospermopsin, N. Chernoff, E. H. Rogers, R. D. Zehr, M. I. Gage, D. E. Malarkey, C. A. Bradfield, Y. Liu, J. E. Schmid, R. H. Jaskot, J. H. Richards, C. R. Wood, M. B. Rosen

United States Environmental Protection Agency: Publications

Cylindrospermopsin (CYN) is a tricyclic alkaloid toxin produced by fresh water cyanobacterial species worldwide. CYN has been responsible for both livestock and human poisoning after oral exposure. This study investigated the toxicity of CYN to pregnant mice exposed during different segments of gestation. The course of recovery and individual responses to the toxin were evaluated. Adverse effects of CYN were monitored up to 7 weeks post-dosing by clinical examination, histopathology, biochemistry and gene expression. Exposure on gestational days (GD) 8–12 induced significantly more lethality than GD13–17 exposure. Periorbital, gastrointestinal and distal tail hemorrhages were seen in both groups. Serum markers …


Maternal Influences On Epigenetic Programming Of The Developing Hypothalamic-Pituitary-Adrenal Axis, Curtis E. Grace, Sung-Je Kim, John M. Rogers Jan 2011

Maternal Influences On Epigenetic Programming Of The Developing Hypothalamic-Pituitary-Adrenal Axis, Curtis E. Grace, Sung-Je Kim, John M. Rogers

United States Environmental Protection Agency: Publications

Parental and environmental factors during the prenatal and postnatal periods permanently affect the physiology and metabolism of offspring, potentially increasing disease risk later in life. Underlying mechanisms are being elucidated, and effects on a number of organs and metabolic pathways are likely involved. In this review, we consider effects on the developing hypothalamic-pituitary-adrenal (HPA) axis, which may represent a common pathway for developmental programming. The focus is on prenatal and early postnatal development, during which the HPA axis may be programmed in a manner that affects health for a lifetime. Programming of the HPA axis involves, at least in part, …


Current And Future Needs For Developmental Toxicity Testing, Susan L. Makris, James H. Kim, Amy Ellis, Willem Faber, Wafa Harrouk, Joseph M. Lewis, Merle G. Paule, Jennifer Seed, Melissa Tassinari, Rochelle Tyl Jan 2011

Current And Future Needs For Developmental Toxicity Testing, Susan L. Makris, James H. Kim, Amy Ellis, Willem Faber, Wafa Harrouk, Joseph M. Lewis, Merle G. Paule, Jennifer Seed, Melissa Tassinari, Rochelle Tyl

United States Environmental Protection Agency: Publications

A review is presented of the use of developmental toxicity testing in the United States and international regulatory assessment of human health risks associated with exposures to pharmaceuticals (human and veterinary), chemicals (agricultural, industrial, and environmental), food additives, cosmetics, and consumer products. Developmental toxicology data are used for prioritization and screening of pharmaceuticals and chemicals, for evaluating and labeling of pharmaceuticals, and for characterizing hazards and risk of exposures to industrial and environmental chemicals. The in vivo study designs utilized in hazard characterization and dose-response assessment for developmental outcomes have not changed substantially over the past 30 years and have …