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Full-Text Articles in Membrane Science
How Many Passes Does It Take? An Investigation To Determine The Optimal Number Of Liposome Extrusion Cycles, Kasey Piper
How Many Passes Does It Take? An Investigation To Determine The Optimal Number Of Liposome Extrusion Cycles, Kasey Piper
Honors Theses
Liposomes are lipid-based nanoparticles with significant applications in drug delivery and membrane research. One of the most common methods for fabricating liposomes of specific sizes is membrane extrusion, where liposomes are passed through porous membranes to reduce their size. The precise number of passes needed and the factors influencing this process remain unclear. This thesis investigates the relationship between the number of passes through a track-etched polycarbonate membrane and size and lamellarity of extruded liposomes with a focus on lipid type (DOPC, DMPC, Soy PC), membrane pore size (50, 100, 200, 400 nm), and the effect of freeze-thaw cycling. To …
Assessing The Impact Of Block-Selective Homopolymers On The Diffusion Of Payload Through Polymeric Organogels, Ian Coates
Honors Theses
Styrenic polymer gels have received recent attention for their application in transdermal patches due to their unique properties. Previous research in the pharmaceutical industry has identified that polymeric gels, specifically styrenic gels, have the potential to encompass multiple functions of the transdermal delivery patch including controlling mechanical and delivery properties. To tailor styrenic gels either the gel nanostructure or the drug complex can be controlled. Specifically, this thesis investigated the effect of gel nanostructure in an attempt to control the gel diffusivity and mechanical properties. To control gel nanostructure a phase selective styrene homopolymer was used at varying concentrations. It …