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Biochemical and Biomolecular Engineering Commons™
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Articles 61 - 63 of 63
Full-Text Articles in Biochemical and Biomolecular Engineering
Metabolic Engineering Of Serratia Marcescens, Qiang Yan
Metabolic Engineering Of Serratia Marcescens, Qiang Yan
Theses and Dissertations
The potential value of the chitin biomass (e.g. food waste) is recently considered being ignored by landfill. Chitin can be a potential cheap carbon source for converting into value-added chemicals by microorganisms. Serratia marcescens is a chitinolytic bacterium that harbors endogenous chitinase systems. With goals of characterzing S. marcescens chitinolytic capabilities and applying S. marcescens to chemical production from chitin, my dissertation main content includes five chapters: 1) Chapter 1 highlights background information of chitin source, S. marcescens and potential metabolic engineering targets using chitin as a substrate; 2) Chapter 2 demonstrates that ChiR is a key regulator in regulating …
Inhibition Of Blood Coagulation Factor Xii: Evaluation Of Flavonoids As A Drug Candidate, Betsy Crosswhite
Inhibition Of Blood Coagulation Factor Xii: Evaluation Of Flavonoids As A Drug Candidate, Betsy Crosswhite
Honors Theses
This study investigated natural product inhibitors of blood coagulation Factor XII (FXII). FXII initiates the Kallikrein Kinin-System (KKS) within the intrinsic coagulation pathway. Increased expression of this system leads to proinflammatory and procoagulant activities. Inflammation occurs through downstream activation in the KKS. Following the activation of FXII-dependent pathway, bradykinin (BK) binds to the BK receptor 2 (B2) and produces inflammatory signaling. Abnormally increased BK can result in life threatening Hereditary Angioedema (HAE), characterized by severe reoccurring swelling. FXII is critical for pathogenic thrombosis, but is dispensable for hemostasis. This unique property of FXII makes it an attractive drug target. We …
Molecular Biogeochemistry Of A Poor Fen, Zhimin Song
Molecular Biogeochemistry Of A Poor Fen, Zhimin Song
Dissertations, Master's Theses and Master's Reports
Variations in climate may rapidly change the carbon balance of peatlands and increase greenhouse gas emissions through accelerated decomposition of peat and dissolved organic matter (DOM). In this study, porewater samples were collected monthly from May to October in 2017 to study the effects of plant functional groups (PFGs) on DOM, dissolved inorganic and organic nitrogen through the season in a poor fen with replicate plots dominated by different PFGs in Nestoria, Michigan, USA (46.34˚N 88.16˚W). The composition of the peat porewater showed strong statistical significance with plot type and season.The observed PFG and season impact on the composition of …