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Biochemical and Biomolecular Engineering Commons™

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2009

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Articles 1 - 23 of 23

Full-Text Articles in Biochemical and Biomolecular Engineering

Using Artificial Neural Networks And Model Predictive Control To Optimize Acoustically Assisted Doxorubicin Release From Polymeric Micelles, Ghaleb A. Husseini, Farouq S. Mjalli, William G. Pitt, Nabil M. Abdel-Jabbar Dec 2009

Using Artificial Neural Networks And Model Predictive Control To Optimize Acoustically Assisted Doxorubicin Release From Polymeric Micelles, Ghaleb A. Husseini, Farouq S. Mjalli, William G. Pitt, Nabil M. Abdel-Jabbar

Faculty Publications

We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the drug directly to the tumor and in the process minimize the adverse side effects of chemotherapy on non-tumor tissues. Here, we present an artificial neural network (ANN) model that attempts to model the dynamic release of Dox from P105 micelles under different ultrasonic power intensities at two frequencies. The developed ANN model is then utilized to optimize the ultrasound application to achieve a target …

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Quantifying And Resolving Multiple Vector Transformants In S. Cerevisiae Plasmid Libraries, Thomas C. Scanlon, Elizabeth C. Gray, Karl E. Griswold Nov 2009

Quantifying And Resolving Multiple Vector Transformants In S. Cerevisiae Plasmid Libraries, Thomas C. Scanlon, Elizabeth C. Gray, Karl E. Griswold

Dartmouth Scholarship

In addition to providing the molecular machinery for transcription and translation, recombinant microbial expression hosts maintain the critical genotype-phenotype link that is essential for high throughput screening and recovery of proteins encoded by plasmid libraries. It is known that Escherichia coli cells can be simultaneously transformed with multiple unique plasmids and thusly complicate recombinant library screening experiments. As a result of their potential to yield misleading results, bacterial multiple vector transformants have been thoroughly characterized in previous model studies. In contrast to bacterial systems, there is little quantitative information available regarding multiple vector transformants in yeast. Saccharomyces cerevisiae is the …

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Temperature-Induced Restructuring Of Self-Assembled Ptpd Nanoparticle Superlattices, Guoqiang Ren, Yangchuan Xing Nov 2009

Temperature-Induced Restructuring Of Self-Assembled Ptpd Nanoparticle Superlattices, Guoqiang Ren, Yangchuan Xing

Chemical and Biochemical Engineering Faculty Research & Creative Works

PtPd nanoparticle superlattices were prepared at room temperature and investigated for their restructuring at elevated temperatures. the PtPd nanoparticles were spherical with a diameter of 3.5±0.3nm and were capped with surfactants of oleic acids and oleylamine. Images of the nanoparticle superlattices were taken using a transmission electron microscope. Analysis of the images with fast Fourier transform (FFT) revealed whether the superlattices were crystalline or amorphous. It was found that the critical temperature that induced a phase transition of PtPd superlattices from a crystalline state to an amorphous state fall in the range of 100-110 °C. Meanwhile, heat-induced restructuring transformed less-ordered …

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Fabrication Of Spherical Cao-Sro-Zno-Sio2 Particles By Sol-Gel Processing, Ill Yong Kim, Mark R. Towler, Anthony Wren, Chikara Ohtsuki Nov 2009

Fabrication Of Spherical Cao-Sro-Zno-Sio2 Particles By Sol-Gel Processing, Ill Yong Kim, Mark R. Towler, Anthony Wren, Chikara Ohtsuki

Chemical and Biochemical Engineering Faculty Research & Creative Works

This study was concerned with the fabrication of ceramic CaO-SrO-ZnO-SiO2 spherical particles, which are novel candidates for the glass phase in glass polyalkenoate cements (GPCs). GPCs made from these glasses have potential as bone cements because, unlike conventional GPCs, they do not contain aluminum ions, which inhibit the calcification of hydroxyapatite in the body. The glass phase of GPCs require a controllable glass morphology and particle size distribution. Sol-gel processing can potentially be used to fabricate homogenous ceramic particles with controlled morphology. However, a thorough study on preparation conditions of spherical CaO-SrO-ZnO-SiO2 particles by sol-gel processing has, to …

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Characterisation And Mechanical Testing Of Hydrothermally Treated Ha/Zro2 Composites, D. J. Curran, T. J. Fleming, G. Kawachi, C. Ohtsuki, Mark R. Towler Nov 2009

Characterisation And Mechanical Testing Of Hydrothermally Treated Ha/Zro2 Composites, D. J. Curran, T. J. Fleming, G. Kawachi, C. Ohtsuki, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Hydrothermal treatment is traditionally employed to improve the sinterability of powder compacts by reducing porosity and increasing apparent density. The effect of hydrothermal treatment on green powder compacts has been assessed in order to better understand how treatment may affect the sinter ability of the bodies. Laboratory synthesized nano sized hydroxyapatite (HA) and a commercial zirconia (ZrO2) powder have been ball milled together to create composite mixtures containing 0-5 wt% ZrO2 loadings. Disc shaped bodies have been formed using uniaxial and subsequent isostatic pressure. The resultant coherent samples were subjected to hydrothermal treatment at either 120 or …

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Analysis Of Γ-Irradiated Synthetic Bone Grafts By ²⁹Si Mas-Nmr Spectroscopy, Calorimetry And Xrd, D. Boyd, S. Murphy, Mark R. Towler, A. W. Wren, S. Hayakawa Nov 2009

Analysis Of Γ-Irradiated Synthetic Bone Grafts By ²⁹Si Mas-Nmr Spectroscopy, Calorimetry And Xrd, D. Boyd, S. Murphy, Mark R. Towler, A. W. Wren, S. Hayakawa

Chemical and Biochemical Engineering Faculty Research & Creative Works

Ca-Sr-Zn-Si glasses have demonstrated excellent biocompatibility both in vitro using the MTT assay with L929 mouse fibroblast cells, and in vivo using healthy and ovariectomized female Wistar rats. However, the biological evaluation of the materials was performed on glass granules that were autoclaved, rather than γ-irradiated; the sterilisation procedure required prior to implantation of these materials in the human body. Given the fact that when a glass is exposed to ionizing radiation changes in its physical properties can take place, it is imperative to determine whether the structure of such glasses will be altered as a result of exposure to …

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Fabrication Of High-Capacity Biomolecular Carriers From Dispersible Single-Walled Carbon Nanotube-Polymer Composites, Pu Zhang, David B. Henthorn Oct 2009

Fabrication Of High-Capacity Biomolecular Carriers From Dispersible Single-Walled Carbon Nanotube-Polymer Composites, Pu Zhang, David B. Henthorn

Chemical and Biochemical Engineering Faculty Research & Creative Works

One of the most interesting applications for carbon nanotubes is as a support material for bioanalytical devices. in this work, we successfully used an ultraviolet light initiated "graft from" polymerization method to fabricate polymer functionalized carbon nanotubes (PFCNTs) with pendant chains of various functionalities, including poly (ethylene glycol) chains to boost dispersibility and pendant epoxy groups for protein conjugate sites. a model enzyme, alkaline phosphatase, was used to study biomolecule loading efficiency as well as the retention of enzyme activity. Samples with various ratios of the two monomers were fabricated to optimize their use in aqueous environments, and an optimal …

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The Effect Of Glass Synthesis Route On Mechanical And Physical Properties Of Resultant Glass Ionomer Cements, A. Wren, O. M. Clarkin, F. R. Laffir, C. Ohtsuki, I. Y. Kim, Mark R. Towler Oct 2009

The Effect Of Glass Synthesis Route On Mechanical And Physical Properties Of Resultant Glass Ionomer Cements, A. Wren, O. M. Clarkin, F. R. Laffir, C. Ohtsuki, I. Y. Kim, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glass ionomer cements (GICs) have potential orthopaedic applications. Solgel processing is reported as having advantages over the traditional melt-quench route for synthesizing the glass phase of GICs, including far lower processing temperatures and higher levels of glass purity and homogeneity. This work investigates a novel glass formulation, BT 101 (0.48 SiO2-0.36 ZnO-0.12 CaO-0.04 SrO) produced by both the melt-quench and the solgel route. The glass phase was characterized by X-ray diffraction (XRD) to determine whether the material was amorphous and differential thermal analysis (DTA) to measure the glass transition temperature (Tg). Particle size analysis (PSA) was …

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Methanol Electro-Oxidation On Pt-Ru Alloy Nanoparticles Supported On Carbon Nanotubes, Ang Li, Yangchuan Xing Sep 2009

Methanol Electro-Oxidation On Pt-Ru Alloy Nanoparticles Supported On Carbon Nanotubes, Ang Li, Yangchuan Xing

Chemical and Biochemical Engineering Faculty Research & Creative Works

Carbon nanotubes (CNTs) have been investigated in recent years as a catalyst support for proton exchange membrane fuel cells. Improved catalyst activities were observed and attributed to metal-support interactions. We report a study on the kinetics of methanol electro-oxidation on CNT supported Pt-Ru alloy nanoparticles. Alloy catalysts with different compositions, Pt 53Ru 47/CNT, Pt 69Ru 31/CNT and Pt 77Ru 23/CNT, were prepared and investigated in detail. Experiments were conducted at various temperatures, electrode potentials, and methanol concentrations. It was found that the reaction order of methanol electro-oxidation on the PtRu/CNT catalysts was consistent with what has been reported for PtRu …

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Comparison Of Failure Mechanisms For Cements Used In Skeletal Luting Applications, O. Clarkin, D. Boyd, Mark R. Towler Aug 2009

Comparison Of Failure Mechanisms For Cements Used In Skeletal Luting Applications, O. Clarkin, D. Boyd, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glass Polyalkenoate Cements (GPCs) based on strontium calcium zinc silicate (Sr-Ca-Zn-SiO2) glasses and low molecular weight poly (acrylic acid) (PAA) have been shown to exhibit suitable compressive strength (65 MPa) and flexural strength (14 MPa) for orthopaedic luting applications. In this study, two such GPC formulations, alongside two commercial cements (Simplex ® P and Hydroset™) were examined. Fracture toughness and tensile bond strength to sintered hydroxyapatite and a biomedical titanium alloy were examined. Fracture toughness of the commercial Poly(methyl methacrylate) cement, Simplex® P, (3.02 MPa m1/2) was superior to that of the novel GPC (0.36 MPa …

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Comparison Of An Experimental Bone Cement With A Commercial Control, Hydroset™, O. M. Clarkin, D. Boyd, S. Madigan, Mark R. Towler Jul 2009

Comparison Of An Experimental Bone Cement With A Commercial Control, Hydroset™, O. M. Clarkin, D. Boyd, S. Madigan, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glass polyalkenoate cements based on strontium calcium zinc silicate glasses (Zn-GPCs) and high molecular weight polyacrylic acids (PAA) (MW; 52,000-210,000) have been shown to exhibit mechanical properties and in vitro bioactivity suitable for arthroplasty applications. Unfortunately, these formulations exhibit working times and setting times which are too short for invasive surgical applications such as bone void filling and fracture fixation. In this study, Zn-GPCs were formulated using a low molecular weight PAA (MW; 12,700) and a modifying agent, trisodium citrate dihydrate (TSC), with the aim of improving the rheological properties of Zn-GPCs. These novel formulations were then compared with commercial …

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Ptau Bimetallic Heteronanostructures Made By Post-Synthesis Modification Of Pt-On-Au Nanoparticles, Zhenmeng Peng Apr 2009

Ptau Bimetallic Heteronanostructures Made By Post-Synthesis Modification Of Pt-On-Au Nanoparticles, Zhenmeng Peng

Chemical, Biomolecular, and Corrosion Engineering Faculty Research

imetallic PtAu heteronanostructures have been synthesized from Pt-on-Au nanoparticles, which were made from platinum acetylacetonate and gold nanoparticles. Using the Pt-on-Au nanoparticles as precursors, Ptsurface rich PtAu bimetallic heteronanostructures can be produced through controlled thermal treatments, as confirmed by field emission high-resolution transmission electron microscopy (HR-TEM) and elemental mapping using a high-angle annular dark-field scanning transmission electron microscope (HAADF-STEM). Oxidation of formic acid was used as a model reaction to demonstrate the effects of varying composition and surface structure on the catalytic performance of PtAu bimetallic nanostructures. Cyclic voltammetry (CV) showed that these carbon-supported PtAu heteronanostructures were much more active …

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Effects Of Growth Media Ph And Reaction Water Activity On The Conversion Of Acetophenone To (S)-1-Phenylethanol By Saccharomyces Cerevisiae Immobilized On Celite 635 And In Calcium Alginate, Nicholas P. Coleman, Czarena Crofcheck, Sue E. Nokes, Barbara L. Knutson Mar 2009

Effects Of Growth Media Ph And Reaction Water Activity On The Conversion Of Acetophenone To (S)-1-Phenylethanol By Saccharomyces Cerevisiae Immobilized On Celite 635 And In Calcium Alginate, Nicholas P. Coleman, Czarena Crofcheck, Sue E. Nokes, Barbara L. Knutson

Biosystems and Agricultural Engineering Faculty Publications

Biologically catalyzed reactions often produce enantiomers of the product; however, only one configuration is desired. Reaction conditions are known to affect enantiomer ratios and reaction kinetics, but little is known regarding the effect of processing conditions on whole-cell biocatalysis. Saccharomyces cerevisiae cells were grown in batch on glucose at pH = 4, 5, and 7, and then immobilized on Celite beads or in calcium alginate beads and used as the biocatalyst for the conversion of acetophenone in hexane to (S)-1-phenylethanol at water activities of 0.37, 0.61, and 0.80. S. cerevisiae was used as a model microorganism for the whole-cell catalyzed …

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Biofilm Inhibitory Coatings Formulated From Glass Polyalkenoate Cement Chemistry: An Evaluation Of Their Adhesive Nature, A. Coughlan, D. Boyd, Mark R. Towler Mar 2009

Biofilm Inhibitory Coatings Formulated From Glass Polyalkenoate Cement Chemistry: An Evaluation Of Their Adhesive Nature, A. Coughlan, D. Boyd, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Researchers evaluated the adhesive nature of the biofilm inhibitory coatings formulated from glass polyalkenoate cement (GPC) chemistry with the aim to establish the novel testing modality by modifying the conventional T-peel tests. Special consideration was given to determine the resistance of a bonded assembly of two adherents having at least one adherent flexible to quantify the bond between tape and a surgical metal substrate bonded by a luting GPC. The delaminated tape surface was examined by scanning electron microscopy (SEM) with an accelerating voltage of 20 K V to determine whether failure of the bond was adhesive of cohesive in …

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Extraction Of Alkaloids From Opium, Keith Tomazi Feb 2009

Extraction Of Alkaloids From Opium, Keith Tomazi

Chemical and Biochemical Engineering Faculty Research & Creative Works

A method for extracting at least one alkaloid from opium that includes dissolving opium in a solvent, heating the dissolved opium solution, cooling the dissolved opium solution, adjusting the pH of the dissolved opium solution with at least one first weak acid, filtering the dissolved opium solution to recover a filtrate; and then separating and purifying at least one alkaloid in the filtrate. Preferably, this includes an additional step of chilling the opium solution after adjusting the pH of the dissolved opium solution with at least one first acid. The preferred method for separating and purifying at least one alkaloid …

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Temperature Influence And Heat Management Requirements Of Microalgae Cultivation In Photobioreactors, Thomas Hagen Mehlitz Feb 2009

Temperature Influence And Heat Management Requirements Of Microalgae Cultivation In Photobioreactors, Thomas Hagen Mehlitz

Master's Theses

Microalgae are considered one of the most promising feedstocks for biofuel production for the future. The most efficient way to produce vast amounts of algal biomass is the use of closed tubular photobioreactors (PBR). The heat requirement for a given system is a major concern since the best algae growth rates are obtained between 25-30 °C, depending on the specific strain. A procedure to determine temperature influence on algal growth rates was developed for a lab-scale PBR system using the species Chlorella. A maximum growth rate of 1.44 doublings per day at 29 °C (optimal temperature) was determined. In addition, …

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Computed Tomographic Investigation Of The Influence Of Gas Sparger Design On Gas Holdup Distribution In A Bubble Column, B. C. Ong, P. Gupta, A. Youssef, M. (Muthanna) H. Al-Dahhan, M. P. Duduković Jan 2009

Computed Tomographic Investigation Of The Influence Of Gas Sparger Design On Gas Holdup Distribution In A Bubble Column, B. C. Ong, P. Gupta, A. Youssef, M. (Muthanna) H. Al-Dahhan, M. P. Duduković

Chemical and Biochemical Engineering Faculty Research & Creative Works

The Effect of Gas Sparger Design on the Gas Holdup Radial Profile in a Bubble Column (With a Diameter of 0.162 M) Has Been Studied using Γ-Ray Computed Tomography (CT). Six Different Configurations of Gas Spargers Were Examined, using an Air-Water System for Selected Superficial Gas Velocities from 2 Cm/s to 30 Cm/s, Covering the Homogeneous and Heterogeneous (Churn-Turbulent) Flow Regimes. Two Operating Pressures Were Used: 1 and 4 Atm. Differences Were Found between the Gas Holdup Distributions Produced by Different Spargers at Dimensionless Radii of R/R < 0.8 in the Central Region of the Column. the Cross and Single Nozzle Spargers Produced Closely Similar Gas Holdup Distributions, While the Perforated Plate Sparger Produced a Higher Gas Holdup When Compared to Other Spargers with the Same Percentage Open Area (POA). at 4 Atm, the Sparger Design Did Not Have a Significant Effect on the Gas Holdup Profiles, Compared to Atmospheric Pressure, Except for the Case of the Single-Hole Sparger, Which Was Found to Yield a Higher Gas Holdup. © 2009 American Chemical Society.

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The Effect Of Sodium On The Catalytic Activity Of Zno-Al2o3/Zsm-5 And Sno-Al2o3/Zsm-5 For The Transesterification Of Vegetable Oil With Methanol, Manhoe Kim, Shuli Yan, Steven O. Salley, K.Y. Simon Ng Jan 2009

The Effect Of Sodium On The Catalytic Activity Of Zno-Al2o3/Zsm-5 And Sno-Al2o3/Zsm-5 For The Transesterification Of Vegetable Oil With Methanol, Manhoe Kim, Shuli Yan, Steven O. Salley, K.Y. Simon Ng

National Biofuels Energy Laboratory

In order to elucidate the effect of sodium on the activity of ZSM-5 supported metal oxides catalysts (ZnO-Al2O3/ZSM-5 and SnO-Al2O3/ZSM-5) for the transesterification of soybean oil with methanol, ZSM-5 supported metal oxides were prepared with and without sodium hydroxide by impregnation. The metal compositions of the ZSM-5 supported metal oxide catalysts and the metal concentrations dissolved from the catalysts to the methylester phase were measured by SEM-EDS and inductive coupled plasma spectroscopy, respectively. The catalytic activity of ZnO-Al2O3/ZSM-5 and SnO-Al2O3/ZSM-5 containing sodium did not originate from surface metal oxides sites, but from surface sodium sites or dissolved sodium leached from …

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Simulation Of Corn Stover And Distillers Grains Gasification With Aspen Plus, Ajay Kumar, Hossein Noureddini, Yaşar Demirel, David Jones, Milford Hanna Jan 2009

Simulation Of Corn Stover And Distillers Grains Gasification With Aspen Plus, Ajay Kumar, Hossein Noureddini, Yaşar Demirel, David Jones, Milford Hanna

Yaşar Demirel Publications

A model was developed to simulate the performance of a lab‐scale gasifier and predict the flowrate and composition of product from given biomass composition and gasifier operating conditions using Aspen Plus software. Mass balance, energy balance, and minimization of Gibbs free energy during the gasification were applied to determine the product gas composition. Carbon conversion efficiency and tar content were provided to the model as inputs as these could not be predicted by the model based on minimization of Gibbs free energy. Experiments for validation of the model were performed on a lab‐scale fluidized bed gasifier using corn stover and …

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Antibacterial Properties Of A Tri-Sodium Citrate Modified Glass Polyalkenoate Cement, A. W. Wren, D. Boyd, R. Thornton, J. C. Cooney, Mark R. Towler Jan 2009

Antibacterial Properties Of A Tri-Sodium Citrate Modified Glass Polyalkenoate Cement, A. W. Wren, D. Boyd, R. Thornton, J. C. Cooney, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Primary deep infection following joint replacement surgery accounts for 7% of all revisions. Glass polyalkenoate cements (GPCs) have previously been shown to exhibit antibacterial properties. The present study had two objectives. The first was to determine if addition of tri-sodium citrate (TSC) to the powder phase of an Al-free GPC (0.04 SrO-0.12 CaO-0.36 ZnO-0.48 SiO2, by mole fraction) enhanced the resultant cement's antibacterial properties against three strains of bacteria that are commonly found in periprosthetic sites following total joint replacements (TJRs); namely, E. coli, B. fragilis, and S. epidermidis. Four cement sets were prepared, which contained 0 wt% TSC (control), …

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The Design By Molecular Dynamics Modeling And Simulations Of Porous Polymer Adsorbent Media Immobilized On The Throughpore Surfaces Of Polymeric Monoliths, E. Riccardi, J. C. Wang, A. I. Liapis Jan 2009

The Design By Molecular Dynamics Modeling And Simulations Of Porous Polymer Adsorbent Media Immobilized On The Throughpore Surfaces Of Polymeric Monoliths, E. Riccardi, J. C. Wang, A. I. Liapis

Chemical and Biochemical Engineering Faculty Research & Creative Works

Ion-exchange porous adsorbent media having intermediate and low surface densities of dextran polymer grafted on the surface of the through pores of polymeric monoliths are constructed and characterized by a molecular dynamic modeling and simulation approach that has also been shown to be effective in the construction and characterization of porous ion-exchange adsorbent media whose number of immobilized dextran polymer chains per unit surface area is high. the activation step that prepares the surface of the pores of the dextran polymer layer for the immobilization of the charged ligands insignificantly affected the pore structure of the dextran polymer layer, while …

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Continuous-Flow, Rapid Lysis Devices For Biodefense Nucleic Acid Diagnostic Systems, Robert W. Doebler, Barbara Erwin, Anna Hickerson, Bruce Irvine, Denice Woyski, Ali Nadim, James D. Sterling Jan 2009

Continuous-Flow, Rapid Lysis Devices For Biodefense Nucleic Acid Diagnostic Systems, Robert W. Doebler, Barbara Erwin, Anna Hickerson, Bruce Irvine, Denice Woyski, Ali Nadim, James D. Sterling

Business and Information Technology Faculty Research & Creative Works

Two mechanical lysis devices have been developed as compact, robust components to provide rapid sample preparation for nucleic acid diagnostic systems. One such component, known as the Micro Bead-Beater™ (μBB™, BBTM, Claremont BioSolutions, Upland, CA), is a compact device that is capable of ultrarapid lysis (>90% lysis in 30 s) of micro volumes (< 80 μL) of Bacillus spores in a continuous-flow format or in a disposable single-tube format. The μBB is also capable of processing much larger volumes of solutions containing spores or vegetative cells using a continuous-flow mode. A second mechanical lysis device designed as a disposable component is the microfluidic bead blender, which uses a small electric motor to spin vanes within the bead-laden solution. DNA quantification results using dsDNA-binding fluorescence dyes and real-time PCR are presented, comparing the lysis of Bacillus subtilis spores using the μBB™ with other well-known lysis techniques. Nanoscale imaging results obtained using scanning electron microscopy and transmission electron microscopy on B. subtilis spores lyzed using the μBB™ are also presented. © 2009, Society for Laboratory Automation and Screening. All rights reserved.

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Preliminary Investigation Of Novel Bone Graft Substitutes Based On Strontium-Calcium-Zinc-Silicate Glasses, D. Boyd, G. Carroll, Mark R. Towler, C. Freeman, P. Farthing, I. M. Brook Jan 2009

Preliminary Investigation Of Novel Bone Graft Substitutes Based On Strontium-Calcium-Zinc-Silicate Glasses, D. Boyd, G. Carroll, Mark R. Towler, C. Freeman, P. Farthing, I. M. Brook

Chemical and Biochemical Engineering Faculty Research & Creative Works

Bone graft procedures typically require surgeons to harvest bone from a second site on a given patient (Autograft) before repairing a bone defect. However, this results in increased surgical time, excessive blood loss and a significant increase in pain. In this context a synthetic bone graft with excellent histocompatibility, built in antibacterial efficacy and the ability to regenerate healthy tissue in place of diseased tissue would be a significant step forward relative to current state of the art philosophies. We developed a range of calcium-strontium-zinc-silicate glass-based bone grafts and characterized their structure and physical properties, then evaluated their in vitro …

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