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Biochemical and Biomolecular Engineering Commons

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2008

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Articles 1 - 26 of 26

Full-Text Articles in Biochemical and Biomolecular Engineering

Antibacterial Coatings For Medical Devices Based On Glass Polyalkenoate Cement Chemistry, A. Coughlan, D. Boyd, C. W.I. Douglas, Mark R. Towler Dec 2008

Antibacterial Coatings For Medical Devices Based On Glass Polyalkenoate Cement Chemistry, A. Coughlan, D. Boyd, C. W.I. Douglas, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

A biofilm is an accumulation of micro-organisms and their extracellular products forming a structured community on a surface. Biofilm formation on medical devices has severe health consequences as bacteria growing in this lifestyle are tolerant to both host defense mechanisms and antibiotic therapies. However, silver and zinc ions inhibit the attachment and proliferation of immature biofilms. The objective of this study is to evaluate whether it is possible to produce silver and zinc-containing glass polyalkenoate cement (GPC) coatings for medical devices that have antibacterial activity and which may therefore inhibit biofilm formation on a material surface. Two silver and zinc-containing …


Effect Of Operating Pressure On The Extent Of Hysteresis In A Trickle Bed Reactor, Zeljko V. Kuzeljevic, Werner Van Der Merwe, Muthanna H. Al-Dahhan, Milorad P. Dudukovic, Willie Nicol Oct 2008

Effect Of Operating Pressure On The Extent Of Hysteresis In A Trickle Bed Reactor, Zeljko V. Kuzeljevic, Werner Van Der Merwe, Muthanna H. Al-Dahhan, Milorad P. Dudukovic, Willie Nicol

Chemical and Biochemical Engineering Faculty Research & Creative Works

The Dependence of Hydrodynamic Parameters, Such as Pressure Drop, on the Flow History of the Bed is Called Hysteresis. This Phenomenon is Most Commonly Associated with Changes of Flow Distribution and Flow Patterns with the Flow History. Many Studies Have Shown that Increased Operating Pressure Will Affect Flow Distribution and Wetting Efficiency; However, There Seems to Be No Study of the Effect of the Elevated Operating Pressure on the Extent of Hysteresis. in This Study, an Experimental Investigation of the Hysteresis in a High-Pressure Trickle Bed Has Been Performed. a Hysteresis Factor Has Been Introduced to Quantify the Extent of …


Enhancing Water Removal From Whole Stillage By Enzyme Addition During Fermentation, Ana Beatriz Henriques, David B. Johnston, Muthanna H. Al-Dahhan Sep 2008

Enhancing Water Removal From Whole Stillage By Enzyme Addition During Fermentation, Ana Beatriz Henriques, David B. Johnston, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

The Removal of Water from Coproducts in the Fuel Ethanol Process Requires a Significant Energy Input. in This Study, the Addition of Commercially Available Cell-Wall-Degrading Enzymes Was Investigated to Determine Whether or Not the Enzymes Could Reduce the Amount of Water Bound within the Wet Grains. This Would Have the Effect of Allowing More Water to Be Removed during Centrifugation, Reducing the Time and Energy Needed during the Drying Process. the Experiment Screened 15 Cell-Wall-Degrading Enzyme Preparations. a Significant Reduction in Water-Binding Capacity Was Found for a Number of Enzymes Tested in the Initial Screening. the Experiment Was Repeated and …


Modeling Of Fermentation Processes Using Online Kernel Learning Algorithm, Yi Liu Jul 2008

Modeling Of Fermentation Processes Using Online Kernel Learning Algorithm, Yi Liu

Dr. Yi Liu

No abstract provided.


Adaptive Control Of A Class Of Nonlinear Discrete-Time Systems With Online Kernel Learning, Yi Liu Jul 2008

Adaptive Control Of A Class Of Nonlinear Discrete-Time Systems With Online Kernel Learning, Yi Liu

Dr. Yi Liu

No abstract provided.


Modeling Of Fermentation Processes Using Online Kernel Learning Algorithm, Yi Liu, Haiqing Wang, Ping Li Jul 2008

Modeling Of Fermentation Processes Using Online Kernel Learning Algorithm, Yi Liu, Haiqing Wang, Ping Li

Dr. Yi Liu

A novel online identification method is developed for nonlinear multi-input multi-output process modeling issue, which is based on kernel learning framework and named as online kernel learning (OKL) algorithm in this paper. This proposed approach can adaptively control its complexity and thus acquire controlled generalization ability. The OKL algorithm performs first a forward increasing for incorporating a “new” online sample and then a backward decreasing for pruning an “old” one, both in a recursive manner. Furthermore, the prior knowledge about process can be easily integrated into the OKL scheme to improve its performance. Numerical simulations on a fed-batch penicillin fermentation …


Local Characteristics Of Hydrodynamics In Draft Tube Airlift Bioreactor, Hu Ping Luo, Muthanna H. Al-Dahhan Jun 2008

Local Characteristics Of Hydrodynamics In Draft Tube Airlift Bioreactor, Hu Ping Luo, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Airlift Column Reactors Have Been Widely Used in Bioprocesses. the Design, Scale-Up, and Performance Evaluation of Such Reactors All Require Extensive and Accurate Information About the Gas-Liquid Flow Dynamics, Particularly as Computational Fluid Dynamics (CFD) Has Become More Popular in the Last Decade. However, Due to the Limitation of Most Conventional Techniques for Gas-Liquid Flow Dynamics Measurement, Only Global Hydrodynamic Parameters (E.g., Cross-Sectionally Averaged Liquid Circulation Velocity, overall Gas Holdup, and overall Mass Transfer Rate) Have Been Extensively Studied. the Local Flow Characteristics (E.g., the Macro-Mixing and the Turbulence Intensity) Remain Unclear. in This Study, We Use the Computer Automated …


Promoting Neuron Adhesion And Growth, Laura M. Y. Yu, Nic Leipzig, Molly S. Schoichet May 2008

Promoting Neuron Adhesion And Growth, Laura M. Y. Yu, Nic Leipzig, Molly S. Schoichet

Chemical, Biomolecular, and Corrosion Engineering Faculty Research

During nervous system development, the extracellular matrix (ECM) plays a pivotal role offering anchorage points to maturing neurons and neurites, as well as a permissive environment for tissue formation. Thus enhancement of cell adhesion is often an important criterion when designing biomaterials for neural tissue engineering. In addition to functionalizing biomaterials with ECM-derived cell adhesive molecules, there is emerging evidence that indicates the surface topography, stiffness, and electrical properties play an important role in neuron adhesion and neurite outgrowth. We describe recent developments in biomaterials modification for simulating the microenvironment in order to promote neuron adhesion and growth, as well …


Bubble Dynamics Investigation In A Slurry Bubble Column, Chengtian Wu, Kelsey Suddard, Muthanna H. Al-Dahhan May 2008

Bubble Dynamics Investigation In A Slurry Bubble Column, Chengtian Wu, Kelsey Suddard, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

The Application of Four-Point Optical Probe Has Been for the First Time Extended to a Slurry System in a 10.2-Cm ID Column. Bubble Dynamics (Local Gas Holdup, Bubble Chord Length, Bubble Velocity, Bubble Frequency, and Specific Interfacial Area) Were Investigated using an Air-Water-Catalyst System under Atmospheric Pressure. with an Increase in Solids Loading, the Local Gas Holdup, Specific Interfacial Area, and Bubble Frequency Decreased, While the Bubble Velocity Changed Slightly. Bubble Chord Length Increased Noticeably, and the Bubble Chord Length Distribution Spread More Widely at High Solids Loading. It Has Also Been Found that the Probe Orientation is Important for …


Effect Of Shear On Performance And Microbial Ecology Of Continuously Stirred Anaerobic Digesters Treating Animal Manure, Rebecca A. Hoffmann, Marcelo L. Garcia, Mehul Veskivar, Khursheed Karim, Muthanna H. Al-Dahhan, Largus T. Angenent May 2008

Effect Of Shear On Performance And Microbial Ecology Of Continuously Stirred Anaerobic Digesters Treating Animal Manure, Rebecca A. Hoffmann, Marcelo L. Garcia, Mehul Veskivar, Khursheed Karim, Muthanna H. Al-Dahhan, Largus T. Angenent

Chemical and Biochemical Engineering Faculty Research & Creative Works

We Determined the Effect of Different Mixing Intensities on the Performance, Methanogenic Population Dynamics, and Juxtaposition of Syntrophic Microbes in Anaerobic Digesters Treating Cow Manure from a Dairy Farm. Computer Automated Radioactive Particle Tracking in Conjunction with Computational Fluid Dynamics Was Performed to Quantify the Shear Levels Locally. Four Continuously Stirred Anaerobic Digesters Were Operated at Different Mixing Intensities of 1,500, 500, 250, and 50 Revolutions Per Min (RPM) over a 260-Day Period at a Temperature of 34 ± 1°C. Animal Manure at a Volatile Solids (VS) Concentration of 50 G/L Was Fed into the Digesters Daily at Five Different …


Mathematical Modeling Of Oral Cavity Mucositis, Jason White May 2008

Mathematical Modeling Of Oral Cavity Mucositis, Jason White

Honors Scholar Theses

Oral Mucositis is a condition seen in post-treatment mouth cancer patients and is a condition of which the pathobiology is not entirely known. It is a condition that shares many common pathways with other alimentary tract injuries such as inflammatory bowel disease. Mathematical modeling of the system can help to identify gaps in the current knowledge base as well as assist in generating new hypotheses and predicting clinical outcomes of conditions. A detailed mathematical model would assist researchers in determining which drug targets are worthwhile investigating. Deterministic modeling and Virtual Cell&#; software were used to assign rate constants to each …


The Processing, Mechanical Properties And Bioactivity Of Strontium Based Glass Polyalkenoate Cements, Anthony Wren, Daniel Boyd, Mark R. Towler Apr 2008

The Processing, Mechanical Properties And Bioactivity Of Strontium Based Glass Polyalkenoate Cements, Anthony Wren, Daniel Boyd, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

The suitability of zinc-based glass polyalkenoate cements (GPCs) for use in orthopaedics can be improved by the substitution of strontium into the glass phase which should impart improved radiopacity and bone forming properties to the cements without retarding strength. The purpose of this research was to produce novel GPCs based on calcium-strontium-zinc-silicate glasses and to evaluate their mechanical properties and biocompatibility with the ultimate objective of developing a new range of cements for skeletal applications. Three glass compositions, based on incremental substitutions of strontium for calcium, were synthesized; BT100 (0.16CaO, 0.36ZnO, 0.48SiO2), BT101 (0.04SrO, 0.12CaO, 0.36ZnO, 0.48SiO2 …


Comparison Of An Experimental Bone Cement With Surgical Simplex® P, Spineplex® And Cortoss®, D. Boyd, Mark R. Towler, A. Wren, O. M. Clarkin Apr 2008

Comparison Of An Experimental Bone Cement With Surgical Simplex® P, Spineplex® And Cortoss®, D. Boyd, Mark R. Towler, A. Wren, O. M. Clarkin

Chemical and Biochemical Engineering Faculty Research & Creative Works

Conventional polymethylmethacrylate (PMMA) cements and more recently Bisphenol-a-glycidyl dimethacrylate (BIS-GMA) composite cements are employed in procedures such as vertebroplasty. Unfortunately, such materials have inherent drawbacks including, a high curing exotherm, the incorporation of toxic components in their formulations, and critically, exhibit a modulus mismatch between cement and bone. The literature suggests that aluminum free, zinc-based glass polyalkenoate cements (Zn-GPC) may be suitable alternative materials for consideration in such applications as vertebroplasty. This paper examines one formulation of Zn-GPC and compares its strengths, modulus, and biocompatibility with three commercially available bone cements, Spineplex®, Simplex® P and Cortoss®. The setting times indicate …


Proceedings From Scientific Conference On Green Energy And It, Dr. Erik Dahlquist Mar 2008

Proceedings From Scientific Conference On Green Energy And It, Dr. Erik Dahlquist

Dr. Erik Dahlquist

This conference is part of the annual Energitinget, a national arena for energy in Sweden, with some 2500 participants. The focus with this session is to give a forum for researchers to present scientific results, and also to discuss these with other researchers. It contains papers in the area of Energy and IT as well as Green energy generally


Macro-Mixing In A Draft-Tube Airlift Bioreactor, Hu Ping Luo, Muthanna H. Al-Dahhan Mar 2008

Macro-Mixing In A Draft-Tube Airlift Bioreactor, Hu Ping Luo, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Airlift Reactors Are Pneumatically Agitated Reactors that Have Been Widely Used in Industries, Particularly in Bioprocesses. Extensive Studies About the Flow Dynamics in Airlift Column Reactors Exist; However, Most of These Studies Have Focused on Global Hydrodynamic Parameters using Conventional Techniques. the Local Flow Characteristics, such as the Macro-Mixing and the Turbulence Intensity, Are Crucial for Reliable Design and Scale-Up, and They Remain Unclear. This Work Focuses on Studying the Macro-Mixing in a Draft-Tube Airlift Bioreactor Utilizing an Advanced Flow Dynamic Measurement Technique, Computer Automated Radioactive Particle Tracking (CARPT). True Residence Time Distribution Analyses for the overall Column as Well …


Digestion Of Sand-Laden Manure Slurry In An Upflow Anaerobic Solids Removal (Uasr) Digester, Khursheed Karim, Rebecca Hoffmann, M. (Muthanna) H. Al-Dahhan Feb 2008

Digestion Of Sand-Laden Manure Slurry In An Upflow Anaerobic Solids Removal (Uasr) Digester, Khursheed Karim, Rebecca Hoffmann, M. (Muthanna) H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Studies on the Performance of a Laboratory Scale Up flow Anaerobic Solids Removal (UASR) Digester Were Carried Out using Sand-Laden Cow Manure Slurries Having Total Solids (TS) Concentration as 50 and 100 G/l. Hydraulic Retention Time (HRT) Was Maintained as 32.4 Days, Which Resulted in the Volatile Solids (VS) Loading Rates of 1 and 1.64 G/l D. the UASR System Was Designed to Remove Sand from the Manure Slurry, While Anaerobically Digesting Biodegradable Solids Inside a Single Reactor. to Enhance the Contact of Microorganisms and Substrate, the Liquor from the Top of the Digester Was Recirculated through the Bed of …


Bubble Velocity, Size, And Interfacial Area Measurements In A Bubble Column By Four-Point Optical Probe, Junli Xue, Muthanna H. Al-Dahhan, M. P. Dudukovic, R. F. Mudde Feb 2008

Bubble Velocity, Size, And Interfacial Area Measurements In A Bubble Column By Four-Point Optical Probe, Junli Xue, Muthanna H. Al-Dahhan, M. P. Dudukovic, R. F. Mudde

Chemical and Biochemical Engineering Faculty Research & Creative Works

The Four-Point Optical Probe is Applied in a Bubble Column with an Air-Water System to Investigate the Bubble Properties (Local Gas Holdup, Velocity, Chord Length, Specific Interfacial Area, and Frequency) over a Range of Gas Superficial Velocities. Both Bubbles Moving Upward and Downward Are Recorded and Measured as Opposed to Only Upward Bubbles Measured and Reported in Other Studies Involving Probes. the Probe Worked Efficiently in Both Bubbly Flow and Highly Churn-Turbulent Flow at Very High Superficial Gas Velocities. Bubble Properties at the Conditions of Churn-Turbulent Flow Are Obtained and Investigated for the First Time. the Changes in the Bubble …


The Role Of Sr²⁺ On The Structure And Reactivity Of Sro-Cao-Zno-Sio2 Ionomer Glasses, Daniel Boyd, Mark R. Towler, Sally Watts, Robert G. Hill, Anthony W. Wren, Owen M. Clarkin Feb 2008

The Role Of Sr²⁺ On The Structure And Reactivity Of Sro-Cao-Zno-Sio2 Ionomer Glasses, Daniel Boyd, Mark R. Towler, Sally Watts, Robert G. Hill, Anthony W. Wren, Owen M. Clarkin

Chemical and Biochemical Engineering Faculty Research & Creative Works

The suitability of Glass Polyalkenoate Cements (GPCs) for use in orthopaedics is retarded by the presence in the glass phase of aluminum, a neurotoxin. Unfortunately, the aluminum ion plays an integral role in the setting process of GPCs and its absence is likely to hinder cement formation. However, the authors have previously shown that aluminum free GPCs may be formulated based on calcium zinc silicate glasses and these novel materials exhibit significant potential as hard tissue biomaterials. To further improve their potential and given that Strontium (Sr) based drugs have had success in the treatment of osteoporosis, the authors have …


Modeling Of Trickle-Bed Reactors With Exothermic Reactions Using Cell Network Approach, Jing Guo, Yi Jiang, Muthanna H. Al-Dahhan Feb 2008

Modeling Of Trickle-Bed Reactors With Exothermic Reactions Using Cell Network Approach, Jing Guo, Yi Jiang, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

One-Dimensional (1D) and Two-Dimensional (2D) Cell Network Models Were Developed to Simulate the Steady-State Behavior of Trickle-Bed Reactors Employed for the Highly Exothermic Hydrotreating of Benzene. the Multiphase Mass Transfer-Reaction Model and Novel Solution Method Are Discussed in This Report. the 1D Model Was Shown to Satisfactorily Simulate the Axial Temperature Field Observed Experimentally for Multiphase Flow with Exothermic Reactions. the 2D Reactor Modeling Provided Valuable Information About Local Hot Spot Behavior within the Multiphase Reactor, Identifying Situations in Which Hot Spots May Form. the Model Took into Consideration the Heterogeneous Nature of Liquid Distribution, Including Radial Liquid Maldistribution and …


Tem Analysis Of Apatite Surface Layers Observed On Zinc Based Glass Polyalkenoate Cements, D. Boyd, Mark R. Towler, A. W. Wren, O. M. Clarkin, D. A. Tanner Feb 2008

Tem Analysis Of Apatite Surface Layers Observed On Zinc Based Glass Polyalkenoate Cements, D. Boyd, Mark R. Towler, A. W. Wren, O. M. Clarkin, D. A. Tanner

Chemical and Biochemical Engineering Faculty Research & Creative Works

The amorphous nature and composition of the surface apatite layers observed on glass polyalkenoate cements based on zinc silicate glasses (Zn-GPCs) after immersion in simulated body fluid (SBF) have been analyzed by the transmission electron microscopy (TEM). TEM was conducted using a JEOL JEM-2011 electron microscope operated at an accelerating voltage of 200 kV. The composition elements of the surface layer indicated the presence of calcium, phosphorous, zinc, and strontium within the amorphous structure. This composition, in particular the inclusion of Zn in the structure, indicates the lack of crystallinity associated with the formation of the apatite layers observed on …


A Comparison Of Alternating Minimization And Expectation Maximization Algorithms For Single Source Gamma Ray Tomography, R. Varma, S. Bhusarapu, J. A. O'Sullivan, M. (Muthanna) H. Al-Dahhan Jan 2008

A Comparison Of Alternating Minimization And Expectation Maximization Algorithms For Single Source Gamma Ray Tomography, R. Varma, S. Bhusarapu, J. A. O'Sullivan, M. (Muthanna) H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Lange and Carson (1984 J. Comput. Assist. Tomogr. 8 306-16) Defined Image Reconstruction for Transmission Tomography as a Maximum Likelihood Estimation Problem and Derived an Expectation Maximization (EM) Algorithm to Obtain the Maximum Likelihood Image Estimate. However, in the Maximization Step or M-Step of the EM Algorithm, an Approximation is Made in the Solution Which Can Affect the Image Quality, particularly in the Case of Domains with High Attenuating Material. O'Sullivan and Benac (2007 IEEE Trans. Med. Imaging 26 283-97) Reformulated the Maximum Likelihood Problem as a Double Minimization of an I-Divergence to Obtain a Family of Image Reconstruction Algorithms, …


Use Of Modeling And Simulation In Pulp And, Dr. Erik Dahlquist Jan 2008

Use Of Modeling And Simulation In Pulp And, Dr. Erik Dahlquist

Dr. Erik Dahlquist

The book is a handbook for operators and process engineers in primarily pulp and paper industry, but also other process industries about how to utilise simulation as a tool for enhanced process operations. The book has been written as part of a EU COST action on Process Simulation, with 14 countries and 50 researchers and process industry representatives involved.


Microstructure Evolution And Monomer Partitioning In Reversible Addition - Fragmentation Chain Transfer Microemulsion Polymerization, Jennifer M. O'Donnell, Eric W. Kaler Jan 2008

Microstructure Evolution And Monomer Partitioning In Reversible Addition - Fragmentation Chain Transfer Microemulsion Polymerization, Jennifer M. O'Donnell, Eric W. Kaler

Jennifer M. Heinen

Small-angle neutron scattering (SANS) studies of reversible addition - fragmentation chain transfer (RAFT) microemulsion polymerizations of butyl acrylate and 2-ethylhexyl acrylate with the RAFT agent methyl-2-(O-ethylxanthyl) propionate (MOEP) allow the observed rate retardation to be attributed to slow fragmentation of the macro-RAFT radical. Microemulsion polymerization allows the RAFT mechanism to be investigated in the absence of termination reactions so that the cause of the rate retardation frequently observed in both homogeneous and heterogeneous polymerizations may be isolated. However, the concentration of monomer at the locus of polymerization (Cmon(part)) must be known as a function of conversion before a mechanistic study …


Determination Of The Escherichia Coli S-Nitrosoglutathione Response Network Using Integrated Biochemical And Systems Analysis, Laura R. Jarboe, Daniel R. Hyduke, Linh M. Tran, Katherine J.Y. Chou, James C. Liao Jan 2008

Determination Of The Escherichia Coli S-Nitrosoglutathione Response Network Using Integrated Biochemical And Systems Analysis, Laura R. Jarboe, Daniel R. Hyduke, Linh M. Tran, Katherine J.Y. Chou, James C. Liao

Laura R. Jarboe

During infection or denitrification, bacteria encounter reactive nitrogen species. Although the molecular targets of and defensive response against nitric oxide (NO) in Escherichia coli are well studied, the response elements specific to S-nitrosothiols are less clear. Previously, we employed an integrated systems biology approach to unravel the E. coli NO-response network. Here we use a similar approach to confirm that S-nitrosoglutathione (GSNO) primarily impacts the metabolic and regulatory programs of E. coli in minimal medium by reaction with homocysteine and cysteine and subsequent disruption of the methionine biosynthesis pathway. Targeting of homocysteine and cysteine results in altered regulatory activity of …


A Reactive Oxide Overlayer On Rhodium Nanoparticles During Co Oxidation And Its Size Dependence Studied By In Situ Ambient-Pressure X-Ray Photoelectron Spectroscopy, Michael E. Grass, Hendrik Bluhm, Yawen Zhang, Derek Butcher, Jeong Y. Park, Yimin Li, Kaitlin M. Bratlie, Tianfu Zhang, Gabor A. Somorjai Jan 2008

A Reactive Oxide Overlayer On Rhodium Nanoparticles During Co Oxidation And Its Size Dependence Studied By In Situ Ambient-Pressure X-Ray Photoelectron Spectroscopy, Michael E. Grass, Hendrik Bluhm, Yawen Zhang, Derek Butcher, Jeong Y. Park, Yimin Li, Kaitlin M. Bratlie, Tianfu Zhang, Gabor A. Somorjai

Kaitlin M. Bratlie

The smaller, the better: In situ synchrotron ambient pressure X-ray photoelectron spectroscopy allows examination of the oxidation state of the surface of the rhodium nanoparticles (NPs) during CO oxidation in an O2 atmosphere. 2 nm NPs oxidize to a larger extent than 7 nm NPs during reaction at 150-200°C, which correlates with a fivefold increase in turnover frequency for the smaller nanoparticles.


Effect Of Hydrodynamic Multiplicity On Trickle Bed Reactor Performance, Werner Van Der Merwe, Willie Nicol, Muthanna H. Al-Dahhan Jan 2008

Effect Of Hydrodynamic Multiplicity On Trickle Bed Reactor Performance, Werner Van Der Merwe, Willie Nicol, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Multiple Hydrodynamic States in Trickle Bed Reactors Have Been the Subject of Numerous Hydrodynamic Investigations. the Extent of Variation in the Hydrodynamic Parameters (Like Holdup and Pressure Drop) is Large and This Variation Can Be Expected to Have a Significant Impact on the Conversion in a Reaction System. This Study Presents Reaction Data for Α-Methyl Styrene Hydrogenation in a Trickle Bed Reactor over a Range of Conditions that Include Gas and Liquid Limitations. It is Seen that Liquid Flow Rate Variation Induced Hysteresis Has a Large Impact on the Conversion. for Gas-Limited Reactions, the Upper Branch of the Pressure Drop …