Open Access. Powered by Scholars. Published by Universities.®
Biochemical and Biomolecular Engineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biomedical Engineering and Bioengineering (5)
- Biomedical Devices and Instrumentation (4)
- Heat Transfer, Combustion (2)
- Mechanical Engineering (2)
- Thermodynamics (2)
-
- Bacteriology (1)
- Business (1)
- Chemistry (1)
- Civil and Environmental Engineering (1)
- Electrical and Computer Engineering (1)
- Environmental Chemistry (1)
- Environmental Engineering (1)
- Environmental Sciences (1)
- Geological Engineering (1)
- Health Information Technology (1)
- Life Sciences (1)
- Medicine and Health Sciences (1)
- Microbiology (1)
- Petroleum Engineering (1)
- Physical Sciences and Mathematics (1)
- Technology and Innovation (1)
- Institution
- Keyword
-
- Active transport (2)
- Bioenergetics (2)
- Coupling (2)
- Non-equilibrium thermodynamics (2)
- Thermodynamic regulations (2)
-
- Adsorption (1)
- Bacteria (1)
- Biotechnology (1)
- Blood flow (1)
- Capillary electrochromatography (1)
- Cellulase (1)
- Cellulose (1)
- Charged porous adsorbent particles (1)
- Dodecyl-agarose (1)
- Electrochromatography (1)
- Electroosmotic flow (1)
- Enzyme (1)
- Ethylene oxide (1)
- Gene (1)
- Glycosidases (1)
- Height equivalent to a theoretical plate (1)
- Hydrolases (1)
- Hydrolysis (1)
- Interfaces (1)
- Intraparticle convection (1)
- Intraparticle diffusion (1)
- Intraparticle electroosmotic fluid flow (1)
- Intraparticle isoconcentration contours (1)
- Intraparticle pore diffusion (1)
- Ion exchange (1)
Articles 1 - 19 of 19
Full-Text Articles in Biochemical and Biomolecular Engineering
Computer Simulations And Neutron Reflectivity Of Proteins At Interfaces, Amol A. Mungikar, Daniel Forciniti
Computer Simulations And Neutron Reflectivity Of Proteins At Interfaces, Amol A. Mungikar, Daniel Forciniti
Chemical and Biochemical Engineering Faculty Research & Creative Works
Computer simulations in conjunction with neutron reflectivity is an excellent combination for the study of biological materials at solid-liquid interfaces: Both techniques have excellent resolution levels (Ångströms) and they are mature. A stronger interaction between physicists and biologists will allow the use of these two approaches in topics of biological-biomedical interest.
Novel General Expressions That Describe The Behavior Of The Height Equivalent Of A Theoretical Plate In Chromatographic Systems Involving Electrically-Driven And Pressure-Driven Flows, B. A. Grimes, S. Lüdtke, K. K. Unger, Athanasios I. Liapis
Novel General Expressions That Describe The Behavior Of The Height Equivalent Of A Theoretical Plate In Chromatographic Systems Involving Electrically-Driven And Pressure-Driven Flows, B. A. Grimes, S. Lüdtke, K. K. Unger, Athanasios I. Liapis
Chemical and Biochemical Engineering Faculty Research & Creative Works
Novel general expressions are constructed and presented that describe the behavior of the height equivalent of a theoretical plate (plate height), H, as a function of the linear velocity, Vx, along the axis, x, of the column and the kinetic parameters that characterize the mass transfer and adsorption mechanisms in chromatographic columns. Open tube capillaries as well as columns packed with either non-porous or porous particles are studied. The porous particles could have unimodal or bimodal pore-size distributions and intraparticle convective fluid flow and pore diffusion are considered. The expressions for the plate height, H, presented in this work could …
The Evolution And Implications Of The Concentration Profiles Of An Analyte In Porous Adsorbent Particles Packed In A Capillary Electrochromatography Column Operated In The Analytical Mode, B. A. Grimes, Athanasios I. Liapis
The Evolution And Implications Of The Concentration Profiles Of An Analyte In Porous Adsorbent Particles Packed In A Capillary Electrochromatography Column Operated In The Analytical Mode, B. A. Grimes, Athanasios I. Liapis
Chemical and Biochemical Engineering Faculty Research & Creative Works
In this work, a mathematical model is constructed and solved to describe the propagation and dispersion of the mass wave of an analyte in a capillary electrochromatography (CEC) column packed with porous adsorbent particles and operated in the analytical mode. The evolution and dynamic behavior of the isoconcentration contours of the concentration of the analyte in the pores of the particles are presented in order to demonstrate the significant impact that the velocity of the intraparticle electroosmotic flow (EOF) encountered in CEC systems could have in reducing the overall intraparticle mass transfer resistance. It is shown that under both unretained …
Method, Apparatus And Article For Microfluidic Control Via Electrowetting, For Chemical, Biochemical And Biological Assays And The Like, James D. Sterling
Method, Apparatus And Article For Microfluidic Control Via Electrowetting, For Chemical, Biochemical And Biological Assays And The Like, James D. Sterling
Business and Information Technology Faculty Research & Creative Works
An active-matrix microfluidic platform employs thin film transistor active ("TFT") matrix liquid crystal display ~ technology to manipulate small samples of fluid for chemical, biochemical, or biological assays without moving parts, for example, using a two-dimensional matrix array of drive electrodes. The active-matrix microfluidic platform may employ existing active matrix 0 addressing schemes and/or commercial "off-the-shelf" animation software to program assay protocols. A feedback subsystem may > determine an actual location of a fluid in the microfluidic structure, and provides location information to for display, for example, on an active-matrix display, and/or to control movement of one or more fluid bodies …
An Approach To Sequence Dna Without Tagging, Sanjun Niu, Ravi F. Saraf
An Approach To Sequence Dna Without Tagging, Sanjun Niu, Ravi F. Saraf
Papers in Biotechnology
Microarray technology is playing an increasingly important role in biology and medicine and its application to genomics for gene expression analysis has already reached the market with a variety of commercially available instruments. In these combinatorial analysis methods, known probe single-strand DNA (ssDNA) ‘primers’ are attached in clusters of typically 100 μm × 100 μm pixels. Each pixel of the array has a slightly different sequence. On exposure to ‘unknown’ target ssDNA, the pixels with the right complementary probe ssDNA sequence convert to double-stranded DNA (dsDNA) by a hybridization reaction. To transduct the conversion of the pixel to dsDNA, the …
Microbial Cellulose Utilization: Fundamentals And Biotechnology, Lee R. Lynd, Paul J. Weimer, Willem H. Van Zyl, Isak S. Pretorius
Microbial Cellulose Utilization: Fundamentals And Biotechnology, Lee R. Lynd, Paul J. Weimer, Willem H. Van Zyl, Isak S. Pretorius
Dartmouth Scholarship
Fundamental features of microbial cellulose utilization are examined at successively higher levels of aggregation encompassing the structure and composition of cellulosic biomass, taxonomic diversity, cellulase enzyme systems, molecular biology of cellulase enzymes, physiology of cellulolytic microorganisms, ecological aspects of cellulase-degrading communities, and rate-limiting factors in nature. The methodological basis for studying microbial cellulose utilization is considered relative to quantification of cells and enzymes in the presence of solid substrates as well as apparatus and analysis for cellulose-grown continuous cultures. Quantitative description of cellulose hydrolysis is addressed with respect to adsorption of cellulase enzymes, rates of enzymatic hydrolysis, bioenergetics of microbial …
Fluoride Release From Model Glass Ionomer Cements, A. Guida, R. G. Hill, Mark R. Towler, S. Eramo
Fluoride Release From Model Glass Ionomer Cements, A. Guida, R. G. Hill, Mark R. Towler, S. Eramo
Chemical and Biochemical Engineering Faculty Research & Creative Works
Glass ionomer cements (GICs) are an important class of biomedical material used extensively for color matched mercury free, dental restorations. GICs can release clinically beneficial amounts of fluoride and have acceptable handling properties which make them suitable as dental restoratives. The fluoride release of model GICs produced from specially synthesized fluoro-alumino-silicate glasses was studied. Nine glasses of varying fluoride content based on 4.5SiO2-3Al2O3-1.5P2O5-(5-Z)CaO-ZCaF2 were synthesized, and cement disks were prepared from them. The glass transition temperature reduced with increasing fluorine content of the glass. Fluoride ion release was measured …
A Preliminary Study Of An Aluminum-Free Glass Polyalkenoate Cement, Mark R. Towler, C. M. Crowley, D. Murphy, A. M.C. O'Callaghan
A Preliminary Study Of An Aluminum-Free Glass Polyalkenoate Cement, Mark R. Towler, C. M. Crowley, D. Murphy, A. M.C. O'Callaghan
Chemical and Biochemical Engineering Faculty Research & Creative Works
No abstract provided.
Cfd Of Multiphase Flow In Packed-Bed Reactors: Ii. Results And Applications, Y. Jiang, M. R. Khadilkar, M. (Muthanna) H. Al-Dahhan, M. P. Dudukovic
Cfd Of Multiphase Flow In Packed-Bed Reactors: Ii. Results And Applications, Y. Jiang, M. R. Khadilkar, M. (Muthanna) H. Al-Dahhan, M. P. Dudukovic
Chemical and Biochemical Engineering Faculty Research & Creative Works
Numerical Simulations of Multiphase Flow using the K-Fluid CFD Model Described in Part I of This Issue Are Presented for Packed Beds at Various Operating Conditions. Both Steady-State and Unsteady-State (E.g., Periodic Operation) Feed Conditions Were Studied Numerically. Predictions of the K-Fluid CFD Model Are Comparable with the Experimental Data in the Literature for Liquid Upflow in a Cylindrical Packed Bed. in Addition to the Mean Porosity and the Longitudinally Averaged Radial Porosity Profile, the Variance of the Porosity Distribution is Needed for Predicting the Probability Density Function of the Sectional Flow Velocity. in the Trickling Flow Regime, the K-Fluid …
Cfd Of Multiphase Flow In Packed-Bed Reactors: I. K-Fluid Modeling Issues, Y. Jiang, M. R. Khadilkar, M. (Muthanna) H. Al-Dahhan, M. P. Dudukovic
Cfd Of Multiphase Flow In Packed-Bed Reactors: I. K-Fluid Modeling Issues, Y. Jiang, M. R. Khadilkar, M. (Muthanna) H. Al-Dahhan, M. P. Dudukovic
Chemical and Biochemical Engineering Faculty Research & Creative Works
The Eulerian K-Fluid CFD Model Was Used to Simulate the Macroscale Multiphase Flow in Packed Beds. the Geometric Complexity of the Bed Structure is Resolved by Statistically Describing the Porosity Distribution. the Complicated Multiphase Interactions Are Computed using the Ergun Type of Formula Developed based on Bench-Scale Hydrodynamic Experiments. the Work is Presented in Two Sequential Articles. Part I Discusses Implementation Issues of the K-Fluid CFD Model for Packed Beds. the Drag Exchange Coefficients Are Obtained from the Model of Holub Et Al. for the Particle-Fluid Interfaces Xks and from the Model of Attou Et Al. (1999) for the Gas …
Ethylene Oxide And Propylene Oxide Random Copolymer/Sodium Chloride Aqueous Two-Phase Systems: Wetting And Adsorption On Dodecyl-Agarose And Polystyrene, Yingqing Huang, Daniel Forciniti
Ethylene Oxide And Propylene Oxide Random Copolymer/Sodium Chloride Aqueous Two-Phase Systems: Wetting And Adsorption On Dodecyl-Agarose And Polystyrene, Yingqing Huang, Daniel Forciniti
Chemical and Biochemical Engineering Faculty Research & Creative Works
Liquid/liquid partition chromatography is a mild yet powerful separation method for a variety of biological materials. This work demonstrates that it should be feasible to immobilize an ethylene oxide-propylene oxide (EO/PO) random copolymer solution and to use a solution of NaCl equilibrated against the polymer solution as the mobile-phase (poly (EO-PO) [P(EO-PO)] and NaCl form two aqueous phases known as aqueous two-phase systems). Three random copolymers with different molecular weights and EO/PO ratios were used. Dodecyl-agarose and polystyrene were tested as possible supports. The wetting energies of the aqueous two-phase systems on these two kinds of surfaces were calculated as …
Thermal Analysis Of Fly Ashes Sourced From European Non-Blended Coals, Kenneth T. Stanton, Mark R. Towler, Patrick Mooney, Robert G. Hill, Xavier Querol
Thermal Analysis Of Fly Ashes Sourced From European Non-Blended Coals, Kenneth T. Stanton, Mark R. Towler, Patrick Mooney, Robert G. Hill, Xavier Querol
Chemical and Biochemical Engineering Faculty Research & Creative Works
Fly ashes exist as a mixture of major amorphous phases and minor crystalline phases. For commercial applications, such as in concretes and for the production of zeolites, it would be desirable to be able to predict the reactivity of fly ashes. The amorphous phase dominates degradation behaviour, because glasses have a higher potential energy than the equivalent crystal structure and the variation of bond angles and distances in a glass make the bond breakage easier. Despite the large quantities of fly ash produced annually by coal-burning power plants, there have been very few studies investigating the microstructure and composition of …
Thermodynamics And Bioenergetics, Yaşar Demirel, Stanley I. Sandler
Thermodynamics And Bioenergetics, Yaşar Demirel, Stanley I. Sandler
Papers in Thermal Mechanics
Bioenergetics is concerned with the energy conservation and conversion processes in a living cell, particularly in the inner membrane of the mitochondrion. This review summarizes the role of thermodynamics in understanding the coupling between the chemical reactions and the transport of substances in bioenergetics. Thermodynamics has the advantages of identifying possible pathways, providing a measure of the efficiency of energy conversion, and of the coupling between various processes without requiring a detailed knowledge of the underlying mechanisms. In the last five decades, various new approaches in thermodynamics, non-equilibrium thermodynamics and network thermodynamics have been developed to understand the transport and …
Thermodynamics And Bioenergetics, Yaşar Demirel, Stanley I. Sandler
Thermodynamics And Bioenergetics, Yaşar Demirel, Stanley I. Sandler
Papers in Thermal Mechanics
Bioenergetics is concerned with the energy conservation and conversion processes in a living cell, particularly in the inner membrane of the mitochondrion. This review summarizes the role of thermodynamics in understanding the coupling between the chemical reactions and the transport of substances in bioenergetics. Thermodynamics has the advantages of identifying possible pathways, providing a measure of the efficiency of energy conversion, and of the coupling between various processes without requiring a detailed knowledge of the underlying mechanisms. In the last five decades, various new approaches in thermodynamics, non-equilibrium thermodynamics and network thermodynamics have been developed to understand the transport and …
Expression Of Active Human Factor Ix In Mammary Tissue And Of Milk Non Human Transgenic Mammals , William H. Velander, William N. Drohan
Expression Of Active Human Factor Ix In Mammary Tissue And Of Milk Non Human Transgenic Mammals , William H. Velander, William N. Drohan
Papers in Biotechnology
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes Factor IX, such that the foreign DNA is stably incorporated in the DNA of germ line cells of the mature animal. Particularly efficient expression was accomplished using a chimeric construct comprising a mammary gland specific promoter, Factor IX cDNA that lacked the complete or any portion of the 5'-untranslated and 3'-untranslated region, which is …
Modelling Of The Glass Phase In Fly Ashes Using Network Connectivity Theory, Mark R. Towler, Kenneth T. Stanton, Patrick Mooney, Robert G. Hill, Natalia Moreno, Xavier Querol
Modelling Of The Glass Phase In Fly Ashes Using Network Connectivity Theory, Mark R. Towler, Kenneth T. Stanton, Patrick Mooney, Robert G. Hill, Natalia Moreno, Xavier Querol
Chemical and Biochemical Engineering Faculty Research & Creative Works
The amorphous phase of fly ash dominates degradation behaviour because glass has a higher potential energy than the equivalent crystal structure and the variation of bond angles and distances in a glass make the bond breakage easier. It would be advantageous to predict the presence and subsequent degradability of glass on the basis of the solid-state chemistry of the fly ash. To this end, and inorganic polymer model was applied to a selection of European fly ashes to determine the value known as cross-link density (CLD). A cross-link density value of less than two implies that the material is amorphous …
Ultrafast Flow Quantification With Segmented K-Space Magnetic Resonance Phase Velocity Mapping, Haosen Zhang, Sandra S. Halliburton, James R. Moore, Orlando P. Simonetti, Paulo R. Schvartzman, Richard D. White, George P. Chatzimavroudis
Ultrafast Flow Quantification With Segmented K-Space Magnetic Resonance Phase Velocity Mapping, Haosen Zhang, Sandra S. Halliburton, James R. Moore, Orlando P. Simonetti, Paulo R. Schvartzman, Richard D. White, George P. Chatzimavroudis
Chemical & Biomedical Engineering Faculty Publications
Magnetic resonance (MR) phase-velocity mapping (PVM) is routinely being used clinically to measure blood flow velocity. Conventional nonsegmented PVM is accurate but relatively slow (3–5 min per measurement). Ultrafast k-space segmented PVM offers much shorter acquisitions (on the order of seconds instead of minutes). The aim of this study was to evaluate the accuracy of segmented PVM in quantifying flow from through-plane velocity measurements. Experiments were performed using four straight tubes (inner diameter of 5.6–26.2 mm), under a variety of steady (1.7–200 ml/s) and pulsatile (6–90 ml/cycle) flow conditions. Two different segmented PVM schemes were …
Biological Reduction Of Perchlorate In Ion Exchange Regenerant Solutions Containing High Salinity And Ammonium Levels, Tina M. Gingras, Jacimaria R. Batista
Biological Reduction Of Perchlorate In Ion Exchange Regenerant Solutions Containing High Salinity And Ammonium Levels, Tina M. Gingras, Jacimaria R. Batista
Civil and Environmental Engineering and Construction Faculty Research
The most promising technologies to remove perchlorate from water are ion exchange and biological reduction. Although successful, ion exchange only separates perchlorate from water; it does not eliminate it from the environment. The waste streams from these systems contain the caustic or saline regenerant solutions used in the process as well as high levels of perchlorate. Biological reduction could be used to treat the regenerant waste solutions from the ion exchange process. A treatment scheme, combining ion exchange and biodegradation, is proposed to completely remove perchlorate from the environment. Perchlorate-laden resins generate brines containing salt concentrations up to 6% or …
Incorporation Of Cerium And Neodymium In A Uranyl Hydroxide Solid, Chang-Soo Kim, David J. Wronkiewicz, R. J. Finch, E. C. Buck
Incorporation Of Cerium And Neodymium In A Uranyl Hydroxide Solid, Chang-Soo Kim, David J. Wronkiewicz, R. J. Finch, E. C. Buck
Electrical and Computer Engineering Faculty Research & Creative Works
The migration behavior of radionuclides in a nuclear-waste repository will be influenced, in part, by their equilibrium solubilities in the presence of radionuclide-bearing solids and/or adsorption affinities as trace components onto the surfaces of solid host phases. Uranium phases that precipitate on the surface of altered spent nuclear fuel may thus influence the mobility of radionuclides released in the near-field environment, since by proximity, these will be the first phases that the radionuclides encounter following their release from the spent fuel matrix. We have evaluated the potential for incorporating radionuclides into crystalline compounds by precipitating uranyl phases from aqueous solutions …