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Biochemical and Biomolecular Engineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Catalysis and Reaction Engineering (3)
- Biomedical Engineering and Bioengineering (2)
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- Amino Acids, Peptides, and Proteins (1)
- Biochemistry, Biophysics, and Structural Biology (1)
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- Biological and Chemical Physics (1)
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- Medicinal and Pharmaceutical Chemistry (1)
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- Ultrasound (4)
- Doxorubicin (3)
- 212 Surface and interfaces (2)
- 504 X-ray / Neutron diffraction and scattering (2)
- 60 New topics / Others (2)
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- Actinides (2)
- Adsorption structure (2)
- Bio-oils (2)
- Biomass up-grading (2)
- Catalysts (2)
- Ceria (2)
- Chemicals (2)
- Crystalline borosilicate (2)
- Heterogeneous catalysis (2)
- Hydrodeoxygenation (2)
- Kinetics (2)
- LEED (2)
- Levulinic acid (2)
- Multiple scattering (2)
- Ni P 2 (2)
- P on Ni(111) (2)
- Rhenium (2)
- SCR operation (2)
- Sugar alcohol (2)
- Supercritical hydrothermal synthesis (2)
- Surface structure (2)
- Three-way catalysts (2)
- Tobacco (2)
- Torrefaction (2)
- Vaccum (2)
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Articles 1 - 24 of 24
Full-Text Articles in Biochemical and Biomolecular Engineering
Molecular Survival Strategies Against Kidney Filtration: Implications For Therapeutic Protein Engineering, William Heaps, Anna Elise Packard, Kristina M. Mccammon, Tyler P. Green, Joseph P. Talley, Bradley C. Bundy, Dennis Della Corte
Molecular Survival Strategies Against Kidney Filtration: Implications For Therapeutic Protein Engineering, William Heaps, Anna Elise Packard, Kristina M. Mccammon, Tyler P. Green, Joseph P. Talley, Bradley C. Bundy, Dennis Della Corte
Faculty Publications
The glomerular filtration barrier poses a significant challenge for circulating proteins, with molecules below ~60–70 kDa facing rapid renal clearance. Endogenous proteins have evolved sophisticated evasion mechanisms including oligomerization, carrier binding, electrostatic repulsion, and FcRn-mediated recycling. Understanding these natural strategies provides blueprints for engineering therapeutic proteins with improved pharmacokinetics. This review examines how endogenous proteins resist filtration, evaluates their application in protein engineering, and discusses clinical translation including established technologies (PEGylation, Fc-fusion) and emerging strategies (albumin-binding domains, glycoengineering). We address critical challenges of balancing half-life extension with tissue penetration, biological activity, and immunogenicity—essential considerations for the rational design of next-generation …
Scaffold-Based 3d Cell Culture Models In Cancer Research, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini
Scaffold-Based 3d Cell Culture Models In Cancer Research, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini
Faculty Publications
Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexity of in vivo tumors. This approach has revolutionized cancer research by providing a more accurate representation of the tumor microenvironment (TME) and enabling the study of tumor behavior and response to therapies in a more physiologically relevant context. One of the key benefits of 3D cell culture in cancer research is the ability to recapitulate the complex interactions …
A Novel Application Of Spinning Disk Technology To Collect Plasma From Whole Blood Prior To Quantifying Plasma Rna, Naomi Rapier-Sharman, Mae-Lynn L. Hutchinson, Carlos M. Moreno, Abraham Quaye, Brian D. Poole, K. Scott Weber, William G. Pitt, Brett E. Pickett
A Novel Application Of Spinning Disk Technology To Collect Plasma From Whole Blood Prior To Quantifying Plasma Rna, Naomi Rapier-Sharman, Mae-Lynn L. Hutchinson, Carlos M. Moreno, Abraham Quaye, Brian D. Poole, K. Scott Weber, William G. Pitt, Brett E. Pickett
Faculty Publications
The spinning disk technology has previously been utilized to isolate bacterial components from blood in hours instead of days. We hypothesized that this platform could be applied as an alternative approach to isolating plasma RNA from a whole blood sample. We consequently tested the efficacy of the spinning disk technology to extract plasma from whole blood upstream of RNA isolation and analysis. To do so, we collected plasma using either the spinning disk or the typical two-spin centrifuge method. We found that the spinning disk method results in significantly more hemolysis during collection than the conventional two-spin centrifuge method. However, …
Photo-Induced Drug Release From Polymeric Micelles And Liposomes: Phototriggering Mechanisms In Drug Delivery Systems, Najla M. Salkho, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Photo-Induced Drug Release From Polymeric Micelles And Liposomes: Phototriggering Mechanisms In Drug Delivery Systems, Najla M. Salkho, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Faculty Publications
Chemotherapeutic drugs are highly effective in treating cancer. However, the side effects associated with this treatment lower the quality of life of cancer patients. Smart nanocarriers are able to encapsulate these drugs to deliver them to tumors while reducing their contact with the healthy cells and the subsequent side effects. Upon reaching their target, the release of the encapsulated drugs should be carefully controlled to achieve therapeutic levels at the required time. Light is one of the promising triggering mechanisms used as external stimuli to trigger drug release from the light-responsive nanocarriers. Photo-induced drug release can be achieved at a …
The Effects Of Ceria Loading On Three-Way Catalysts For Passive Scr Operation, Calvin R. Thomas, Josh A. Pihl, Vitaly Y. Prikhodko, Michelle K. Kidder, Jochen A. Lauterbach, Todd J. Toops
The Effects Of Ceria Loading On Three-Way Catalysts For Passive Scr Operation, Calvin R. Thomas, Josh A. Pihl, Vitaly Y. Prikhodko, Michelle K. Kidder, Jochen A. Lauterbach, Todd J. Toops
Faculty Publications
Passive SCR systems, which employ both a three-way catalyst and SCR catalyst, are effective for the reduction of nitrogen oxide (NOx) emissions from lean burn gasoline engines. However, questions remain regarding the effect of three-way catalyst formulations on their performance in these systems. Here, Pd/CeOx/Al2O3 catalysts with variable CeOx loading were synthesized, characterized, and evaluated to determine the effects of CeOx on catalyst performance. While a small amount of ceria was beneficial for promoting essential reactions, excess ceria was detrimental due to the increase in oxygen storage capacity. Additionally, insights into potential reaction pathways for NH3 production were determined.
The Effects Of Ceria Loading On Three-Way Catalysts For Passive Scr Operation, Calvin R. Thomas, Josh A. Pihl, Vitaly Y. Prikhodko, Michelle K. Kidder, Jochen A. Lauterbach, Todd J. Toops
The Effects Of Ceria Loading On Three-Way Catalysts For Passive Scr Operation, Calvin R. Thomas, Josh A. Pihl, Vitaly Y. Prikhodko, Michelle K. Kidder, Jochen A. Lauterbach, Todd J. Toops
Faculty Publications
Passive SCR systems, which employ both a three-way catalyst and SCR catalyst, are effective for the reduction of nitrogen oxide (NOx) emissions from lean burn gasoline engines. However, questions remain regarding the effect of three-way catalyst formulations on their performance in these systems. Here, Pd/CeOx/Al2O3 catalysts with variable CeOx loading were synthesized, characterized, and evaluated to determine the effects of CeOx on catalyst performance. While a small amount of ceria was beneficial for promoting essential reactions, excess ceria was detrimental due to the increase in oxygen storage capacity. Additionally, insights into potential reaction pathways for NH3 production were determined.
Hydrothermal Synthesis And Structural Investigation Of A Crystalline Uranyl Borosilicate, Kristen A. Pace, Vladislav V. Klepov, Mark D. Smith, Travis Williams, Gregory Morrison, Jochen A. Lauterbach, Scott T. Misture, Hans Conrad Zur Loye
Hydrothermal Synthesis And Structural Investigation Of A Crystalline Uranyl Borosilicate, Kristen A. Pace, Vladislav V. Klepov, Mark D. Smith, Travis Williams, Gregory Morrison, Jochen A. Lauterbach, Scott T. Misture, Hans Conrad Zur Loye
Faculty Publications
The relevance of multidimensional and porous crystalline materials to nuclear waste reme-diation and storage applications has motivated exploratory research focused on materials discovery of compounds, such as actinide mixed-oxoanion phases, which exhibit rich structural chemistry. The novel phase K1.8 Na1.2 [(UO2)BSi4 O12 ] has been synthesized using hydrothermal methods, rep-resenting the first example of a uranyl borosilicate. The three-dimensional structure crystallizes in the orthorhombic space group Cmce with lattice parameters a = 15.5471(19) Å, b = 14.3403(17) Å, c = 11.7315(15) Å, and V = 2615.5(6) Å3, and is composed of UO6 octahedra linked by [BSi4 O12 ]5− chains to …
Hydrothermal Synthesis And Structural Investigation Of A Crystalline Uranyl Borosilicate, Kristen A. Pace, Vladislav V. Klepov, Mark D. Smith, Travis Williams, Gregory Morrison, Jochen A. Lauterbach, Scott T. Misture, Hans Conrad Zur Loye
Hydrothermal Synthesis And Structural Investigation Of A Crystalline Uranyl Borosilicate, Kristen A. Pace, Vladislav V. Klepov, Mark D. Smith, Travis Williams, Gregory Morrison, Jochen A. Lauterbach, Scott T. Misture, Hans Conrad Zur Loye
Faculty Publications
The relevance of multidimensional and porous crystalline materials to nuclear waste reme-diation and storage applications has motivated exploratory research focused on materials discovery of compounds, such as actinide mixed-oxoanion phases, which exhibit rich structural chemistry. The novel phase K1.8 Na1.2 [(UO2)BSi4 O12 ] has been synthesized using hydrothermal methods, rep-resenting the first example of a uranyl borosilicate. The three-dimensional structure crystallizes in the orthorhombic space group Cmce with lattice parameters a = 15.5471(19) Å, b = 14.3403(17) Å, c = 11.7315(15) Å, and V = 2615.5(6) Å3, and is composed of UO6 octahedra linked by [BSi4 O12 ]5− chains to …
Kinetics Study Of The Hydrodeoxygenation Of Xylitol Over A ReoX-Pd/Ceo2 Catalyst, Blake Macqueen, Michael Royko, Bradie S. Crandall, Andreas Heyden, Yomaira J. Pagán-Torres, Jochen A. Lauterbach
Kinetics Study Of The Hydrodeoxygenation Of Xylitol Over A ReoX-Pd/Ceo2 Catalyst, Blake Macqueen, Michael Royko, Bradie S. Crandall, Andreas Heyden, Yomaira J. Pagán-Torres, Jochen A. Lauterbach
Faculty Publications
In this study, we elucidate the reaction kinetics for the simultaneous hydrodeoxygenation of xylitol to 1,2-dideoxypentitol and 1,2,5-pentanetriol over a ReOx-Pd/CeO2 (2.0 weight% Re, 0.30 weight% Pd) catalyst. The reaction was determined to be a zero-order reaction with respect to xylitol. The activation energy was elucidated through an Arrhenius relationship as well as non-Arrhenius kinetics. The Arrhenius relationship was investigated at 150–170◦ C and a constant H2 pressure of 10 bar resulting in an activation energy of 48.7 ± 10.5 kJ/mol. The investigation of non-Arrhenius kinetics was conducted at 120–170◦ C and a sub-Arrhenius relation was elucidated with activation energy …
Kinetics Study Of The Hydrodeoxygenation Of Xylitol Over A ReoX-Pd/Ceo2 Catalyst, Blake Macqueen, Michael Royko, Bradie S. Crandall, Andreas Heyden, Yomaira J. Pagán-Torres, Jochen A. Lauterbach
Kinetics Study Of The Hydrodeoxygenation Of Xylitol Over A ReoX-Pd/Ceo2 Catalyst, Blake Macqueen, Michael Royko, Bradie S. Crandall, Andreas Heyden, Yomaira J. Pagán-Torres, Jochen A. Lauterbach
Faculty Publications
In this study, we elucidate the reaction kinetics for the simultaneous hydrodeoxygenation of xylitol to 1,2-dideoxypentitol and 1,2,5-pentanetriol over a ReOx-Pd/CeO2 (2.0 weight% Re, 0.30 weight% Pd) catalyst. The reaction was determined to be a zero-order reaction with respect to xylitol. The activation energy was elucidated through an Arrhenius relationship as well as non-Arrhenius kinetics. The Arrhenius relationship was investigated at 150–170◦ C and a constant H2 pressure of 10 bar resulting in an activation energy of 48.7 ± 10.5 kJ/mol. The investigation of non-Arrhenius kinetics was conducted at 120–170◦ C and a sub-Arrhenius relation was elucidated with activation energy …
Bio-Oils From Vacuum Ablative Pyrolysis Of Torrefied Tobacco Residues, Nattawut Khuenkaeo, Blake Macqueen, Thossaporn Onsree, Sangu Daiya, Nakorn Tippayawong, Jochen A. Lauterbach
Bio-Oils From Vacuum Ablative Pyrolysis Of Torrefied Tobacco Residues, Nattawut Khuenkaeo, Blake Macqueen, Thossaporn Onsree, Sangu Daiya, Nakorn Tippayawong, Jochen A. Lauterbach
Faculty Publications
Fast pyrolysis, in combination with torrefaction pretreatment, was used to convert tobacco residues to value-added bio-fuels and chemicals. Tobacco plant residues were torrefied at 220, 260, and 300 °C, before being pyrolyzed at 450, 500, 550, and 600 °C in a rotating blade ablative reactor under vacuum conditions to test the effects on product yields. With torrefaction, tobacco residues thermally decomposed 20-25% w/w at low temperatures. Torrefaction and pyrolysis temperatures were found to markedly affect pyrolytic product yields of bio-chars and bio-oils, while having no effect on gas-phase products. Bio-oil yields exhibited a direct relation with pyrolysis temperature and an …
Bio-Oils From Vacuum Ablative Pyrolysis Of Torrefied Tobacco Residues, Nattawut Khuenkaeo, Blake Macqueen, Thossaporn Onsree, Sangu Daiya, Nakorn Tippayawong, Jochen A. Lauterbach
Bio-Oils From Vacuum Ablative Pyrolysis Of Torrefied Tobacco Residues, Nattawut Khuenkaeo, Blake Macqueen, Thossaporn Onsree, Sangu Daiya, Nakorn Tippayawong, Jochen A. Lauterbach
Faculty Publications
Fast pyrolysis, in combination with torrefaction pretreatment, was used to convert tobacco residues to value-added bio-fuels and chemicals. Tobacco plant residues were torrefied at 220, 260, and 300 °C, before being pyrolyzed at 450, 500, 550, and 600 °C in a rotating blade ablative reactor under vacuum conditions to test the effects on product yields. With torrefaction, tobacco residues thermally decomposed 20-25% w/w at low temperatures. Torrefaction and pyrolysis temperatures were found to markedly affect pyrolytic product yields of bio-chars and bio-oils, while having no effect on gas-phase products. Bio-oil yields exhibited a direct relation with pyrolysis temperature and an …
Challenges To Levulinic Acid And Humins Valuation In The Sugarcane Bagasse Biorefinery Concept, Emília Savioli Lopes, Jean Felipe Leal Silva, Elmer Ccopa Rivera, Alana Petrina Gomes, Melina Savioli Lopes, Rubens Maciel Filho, Laura Plazas Tovar
Challenges To Levulinic Acid And Humins Valuation In The Sugarcane Bagasse Biorefinery Concept, Emília Savioli Lopes, Jean Felipe Leal Silva, Elmer Ccopa Rivera, Alana Petrina Gomes, Melina Savioli Lopes, Rubens Maciel Filho, Laura Plazas Tovar
Faculty Publications
© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Levulinic acid (LA) is currently one of the most promising chemicals derived from biomass. However, its large-scale production is hampered by the challenges in biomass hydrolysis and the poor selectivity due to the formation of humins (HUs). This study addresses these challenges using the biorefinery concept of biomass fractionation. A three-step process (pretreatment, delignification, and acid-catalyzed conversion) was optimized to produce LA from SCB considering the yield (YLA), efficiency (ELA), and concentration of LA (CLA) as functions of temperature, reaction time, acid concentration, and solids loading. By means of a …
Kinetic Insights Into The Lignocellulosic Biomass-Based Levulinic Acid Production By A Mechanistic Model, Emília Savioli Lopes, Elmer Ccopa Rivera, Julio César De Jesus Gariboti, Luis Henrique Zimmermann Feistel, João Vitor Dutra, Rubens Maciel Filho, Laura Plazas Tovar
Kinetic Insights Into The Lignocellulosic Biomass-Based Levulinic Acid Production By A Mechanistic Model, Emília Savioli Lopes, Elmer Ccopa Rivera, Julio César De Jesus Gariboti, Luis Henrique Zimmermann Feistel, João Vitor Dutra, Rubens Maciel Filho, Laura Plazas Tovar
Faculty Publications
© 2020, Springer Nature B.V. Abstract: In this work, a mechanistic model was developed to simulate the kinetics of the production of levulinic acid (LA) from sugarcane bagasse (SCB), rice husk (RH) and soybean straw (SS). The production of LA from those agro-industrial wastes followed the methodology of biorefining in three stages. Experimental data from the third stage (catalytic depolymerization of cellulose) obtained under a wide range of operating conditions were used to estimate the parameters of the model. An optimization procedure based on a genetic algorithm was used to determine the optimal parameter values. The prediction of the concentrations …
A New Interpretation Of The √7×√7 R19.1° Structure For P Adsorbed On A Ni(111) Surface, Elizabeth Barrow, Grant S. Seuser, Hiroko Ariga-Miwa, Donna A. Chen, Jochen A. Lauterbach, Kiyotaka Asakura
A New Interpretation Of The √7×√7 R19.1° Structure For P Adsorbed On A Ni(111) Surface, Elizabeth Barrow, Grant S. Seuser, Hiroko Ariga-Miwa, Donna A. Chen, Jochen A. Lauterbach, Kiyotaka Asakura
Faculty Publications
We have studied P adsorption on Ni(111), a system which shows complex adsorbate structures. We determined the phase diagram of the surface P adsorbed on Ni(111). At low coverage, amorphous P was observed. At temperatures between 373 and 673 K and coverages above 0.1 monolayer, we found a √7×√7 R19.1° structure, but above 673 K, other complex structures were created. These structures seemed to correlate with each other and we reinterpret a √7×√7 R19.1° structure of P adsorbed on Ni(111) based on the similarities of these surface structures. The new rectangular structure for the √7×√7 19.1° is discussed in relation …
A New Interpretation Of The √7×√7 R19.1° Structure For P Adsorbed On A Ni(111) Surface, Elizabeth Barrow, Grant S. Seuser, Hiroko Ariga-Miwa, Donna A. Chen, Jochen A. Lauterbach, Kiyotaka Asakura
A New Interpretation Of The √7×√7 R19.1° Structure For P Adsorbed On A Ni(111) Surface, Elizabeth Barrow, Grant S. Seuser, Hiroko Ariga-Miwa, Donna A. Chen, Jochen A. Lauterbach, Kiyotaka Asakura
Faculty Publications
We have studied P adsorption on Ni(111), a system which shows complex adsorbate structures. We determined the phase diagram of the surface P adsorbed on Ni(111). At low coverage, amorphous P was observed. At temperatures between 373 and 673 K and coverages above 0.1 monolayer, we found a √7×√7 R19.1° structure, but above 673 K, other complex structures were created. These structures seemed to correlate with each other and we reinterpret a √7×√7 R19.1° structure of P adsorbed on Ni(111) based on the similarities of these surface structures. The new rectangular structure for the √7×√7 19.1° is discussed in relation …
Investigating The Stability Of Eliposomes At Elevated Temperatures, Ghaleb A. Husseini, William G. Pitt, Marjan Javadi
Investigating The Stability Of Eliposomes At Elevated Temperatures, Ghaleb A. Husseini, William G. Pitt, Marjan Javadi
Faculty Publications
eLiposomes encapsulate a perfluorocarbon nanoemulsion droplet inside a liposome. Ultrasound is then used as a trigger mechanism to vaporize the perfluorocarbon, break the liposome, and release the desired drug to the tumor tissue. The purpose of this research is to show that eLiposomes synthesized using perfluoropentane are stable above the normal boiling point of the perfluoropentane and at body temperature and thus has potential for use in vivo. Experiments involving the release of fluorescent calcein molecules were performed on eLiposomes to measure the release of calcein at various temperatures in the absence of ultrasound. Results showed that eLiposomes are stable …
Phase Transitions Of Perfluorocarbon Nanoemulsion Induced With Ultrasound: A Mathematical Model, William G. Pitt, Ram N. Singh, Krystian X. Perez, Ghaleb A. Husseini, Daniel R. Jack
Phase Transitions Of Perfluorocarbon Nanoemulsion Induced With Ultrasound: A Mathematical Model, William G. Pitt, Ram N. Singh, Krystian X. Perez, Ghaleb A. Husseini, Daniel R. Jack
Faculty Publications
While ultrasound has been used in many medical and industrial applications, only recently has research been done on phase transformations induced by ultrasound. This paper presents a numerical model and the predicted results of the phase transformation of a spherical nanosized droplet of perfluorocarbon in water. Such a model has applications in acoustic droplet vaporization, the generation of gas bubbles for medical imaging, therapeutic delivery and other biomedical applications. The formation of a gas phase and the subsequent bubble dynamics were studied as a function of acoustic parameters, such as frequency and amplitude, and of the physical aspects of the …
One-Step Production Of Long-Chain Hydrocarbons From Waste-Biomass-Derived Chemicals Using Bi-Functional Heterogeneous Catalysts, Cun Wen, Elizabeth A. Barrow, Jason R. Hattrick-Simpers, Jochen A. Lauterbach
One-Step Production Of Long-Chain Hydrocarbons From Waste-Biomass-Derived Chemicals Using Bi-Functional Heterogeneous Catalysts, Cun Wen, Elizabeth A. Barrow, Jason R. Hattrick-Simpers, Jochen A. Lauterbach
Faculty Publications
n this study, we demonstrate the production of long-chain hydrocarbons (C8+) from 2-methylfuran (2MF) and butanal in a single step reactive process by utilizing a bi-functional catalyst with both acid and metallic sites. Our approach utilizes a solid acid for the hydroalkylation function and as a support as well as a transition metal as hydrodeoxygenation catalyst. A series of solid acids was screened, among which MCM-41 demonstrated the best combination of activity and stability. Platinum nanoparticles were then incorporated into the MCM-41. The Pt/MCM-41 catalyst showed 96% yield for C8+ hydrocarbons and the catalytic performance was stable …
Phase Transitions Of Nanoemulsions Using Ultrasound: Experimental Observations, Ram Singh, Ghaleb A. Husseini, William G. Pitt
Phase Transitions Of Nanoemulsions Using Ultrasound: Experimental Observations, Ram Singh, Ghaleb A. Husseini, William G. Pitt
Faculty Publications
The ultrasound-induced transformation of perfluorocarbon liquids to gases is of interest in the area of drug and gene delivery. In this study, three independent parameters (temperature, size, and perfluorocarbon species) were selected to investigate the effects of 476-kHz and 20-kHz ultrasound on nanoemulsion phase transition. Two levels of each factor (low and high) were considered at each frequency. The acoustic intensities at gas bubble formation and at the onset of inertial cavitation were recorded and subsequently correlated with the acoustic parameters. Experimental data showed that low frequencies are more effective in forming and collapsing a bubble. Additionally, as the size …
Optimizing The Use Of Ultrasound To Deliver Chemotherapeutic Agents To Cancer Cells From Polymeric Micelles, Ghaleb A. Husseini, Nabil M. Abdel-Jabbar, Farouq S. Mjalli, William G. Pitt, Ala'a Al-Mousa
Optimizing The Use Of Ultrasound To Deliver Chemotherapeutic Agents To Cancer Cells From Polymeric Micelles, Ghaleb A. Husseini, Nabil M. Abdel-Jabbar, Farouq S. Mjalli, William G. Pitt, Ala'a Al-Mousa
Faculty Publications
In this study, we present an artificial neural network (ANN) model that attempts to predict the dynamic release of doxorubicin (Dox) from P105 micelles under different ultrasonic power densities at 20 kHz. The goal is to utilize the developed ANN model in optimizing the ultrasound application to achieve a target drug release at the tumor site by controlling power density and ultrasound duration via an ANN-based model predictive control. The parameters of the controller are then tuned to achieve good reference signal tracking.
Using Artificial Neural Networks And Model Predictive Control To Optimize Acoustically Assisted Doxorubicin Release From Polymeric Micelles, Ghaleb A. Husseini, Farouq S. Mjalli, William G. Pitt, Nabil M. Abdel-Jabbar
Using Artificial Neural Networks And Model Predictive Control To Optimize Acoustically Assisted Doxorubicin Release From Polymeric Micelles, Ghaleb A. Husseini, Farouq S. Mjalli, William G. Pitt, Nabil M. Abdel-Jabbar
Faculty Publications
We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the drug directly to the tumor and in the process minimize the adverse side effects of chemotherapy on non-tumor tissues. Here, we present an artificial neural network (ANN) model that attempts to model the dynamic release of Dox from P105 micelles under different ultrasonic power intensities at two frequencies. The developed ANN model is then utilized to optimize the ultrasound application to achieve a target …
The Comet Assay To Determine The Mode Of Cell Death For The Ultrasonic Delivery Of Doxorubicin To Human Leukemia (Hl-60 Cells) From Pluronic P105 Micelles, Ghaleb A. Husseini, Kim L. O'Neill, William G. Pitt
The Comet Assay To Determine The Mode Of Cell Death For The Ultrasonic Delivery Of Doxorubicin To Human Leukemia (Hl-60 Cells) From Pluronic P105 Micelles, Ghaleb A. Husseini, Kim L. O'Neill, William G. Pitt
Faculty Publications
This notes examines the mode of cell death of HL-60 cells exposed to 70 kHz and 1.3 W/cm2 in the presence of 1% Pluronic P105 and 1.67 μg/ml doxorubicin (Dox). The cells were ultrasonicated for 30, 60 and 120 minutes. They were then lysed, electrophorised, stained using propidium iodide, and their DNA profile captured using a fluorescent microscope. The gradual DNA damage observed and the comet tails captured after 1 and 2 hours of insonation suggest that the mode of cell killing is apoptosis.
Growth And Transport Properties Of Complementary Germanium Nanowire Field Effect Transistors, Andrew B. Greytak, Lincoln J. Lauhon, Mark S. Gudiksen, Charles M. Lieber
Growth And Transport Properties Of Complementary Germanium Nanowire Field Effect Transistors, Andrew B. Greytak, Lincoln J. Lauhon, Mark S. Gudiksen, Charles M. Lieber
Faculty Publications
n- and p-type Ge nanowires were synthesized by a multistep process in which axial elongation, via vapor–liquid–solid (VLS) growth, and doping were accomplished in separate chemical vapor deposition steps. Intrinsic, single-crystal, Ge nanowires prepared by Au nanocluster-mediated VLS growth were surface-doped in situ using diborane or phosphine, and then radial growth of an epitaxial Ge shell was used to cap the dopant layer. Field-effect transistors prepared from these Ge nanowires exhibited on currents and transconductances up to 850 µA/µm and 4.9 µA/V, respectively, with device yields of >85%.