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Missouri University of Science and Technology

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Articles 211 - 240 of 691

Full-Text Articles in Biochemical and Biomolecular Engineering

Impact Of Rheology Models On Horizontal Well Polymer Flooding In A Heavy Oil Reservoir On Alaska North Slope: A Simulation Study, Jianqiao Leng, Mingzhen Wei, Baojun Bai, Randall S. Seright, Yin Zhang, David Cercone, Samson Ning Jan 2021

Impact Of Rheology Models On Horizontal Well Polymer Flooding In A Heavy Oil Reservoir On Alaska North Slope: A Simulation Study, Jianqiao Leng, Mingzhen Wei, Baojun Bai, Randall S. Seright, Yin Zhang, David Cercone, Samson Ning

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Polymer rheology can have either a positive or a negative effect on polymer flooding performance under varied circumstances. Many researchers have studied the effect of polymer rheology in a vertical well, but no field scale studies have been conducted to investigate whether polymer rheology is beneficial to polymer flooding in heavy oil reservoirs developed by horizontal wells. In this paper, we conducted a numerical simulation study to examine the effect of HPAM polymer rheology on a polymer flooding pilot, which is the first-ever project conducted on a heavy oil reservoir from Alaska North Slope (ANS) developed by horizontal wells. Three …

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Aldosterone Up-Regulates Voltage-Gated Potassium Currents And Nkcc1 Protein Membrane Fractions, Parveen Bazard, Bo Ding, Harish K. Chittam, Xiaoxia Zhu, Thomas A. Parks, Thomas E. Taylor-Clark, Venkat R. Bhethanabotla, Robert D. Frisina, Joseph P. Walton Dec 2020

Aldosterone Up-Regulates Voltage-Gated Potassium Currents And Nkcc1 Protein Membrane Fractions, Parveen Bazard, Bo Ding, Harish K. Chittam, Xiaoxia Zhu, Thomas A. Parks, Thomas E. Taylor-Clark, Venkat R. Bhethanabotla, Robert D. Frisina, Joseph P. Walton

Chemical and Biochemical Engineering Faculty Research & Creative Works

Na+–K+–2Cl− Cotransporter (NKCC1) is a protein that aids in the active transport of sodium, potassium, and chloride ions across cell membranes. It has been shown that long-term systemic treatment with aldosterone (ALD) can enhance NKCC1 protein expression and activity in the aging cochlea resulting in improved hearing. In the present work, we used a cell line with confirmed NKCC1 expression to demonstrate that in vitro application of ALD increased outward voltage-gated potassium currents significantly, and simultaneously upregulated whole lysate and membrane portion NKCC1 protein expression. These ALD-induced changes were blocked by applying the mineralocorticoid receptor antagonist eplerenone. However, application of …

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Calcium Sulfate-Containing Glass Polyalkenoate Cement For Revision Total Knee Arthroplasty Fixation, Leyla Hasandoost, Adel Alhalawani, Omar Rodriguez, Alireza Rahimnejad Yazdi, Paul Zalzal, Emil H. Schemitsch, Stephen D. Waldman, Marcello Papini, Mark R. Towler Nov 2020

Calcium Sulfate-Containing Glass Polyalkenoate Cement For Revision Total Knee Arthroplasty Fixation, Leyla Hasandoost, Adel Alhalawani, Omar Rodriguez, Alireza Rahimnejad Yazdi, Paul Zalzal, Emil H. Schemitsch, Stephen D. Waldman, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Poly (methyl methacrylate) (PMMA) bone cement is used as a minor void filler in revision total knee arthroplasty (rTKA). The application of PMMA is indicated only for peripheral bone defects with less than 5 mm depth and that cover less than 50% of the bone surface. Treating bone defects with PMMA results in complications as a result of volumetric shrinkage, bone necrosis, and aseptic loosening. These concerns have driven the development of alternative bone cements. We report here on novel modified glass polyalkenoate cements (mGPCs) containing 1, 5 and 15 wt% calcium sulfate (CaSO4) and how the modified …

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Hybrid Electro-Plasmonic Neural Stimulation With Visible-Light-Sensitive Gold Nanoparticles, Ratka Damnjanovic, Parveen Bazard, Robert D. Frisina, Venkat R. Bhethanabotla Sep 2020

Hybrid Electro-Plasmonic Neural Stimulation With Visible-Light-Sensitive Gold Nanoparticles, Ratka Damnjanovic, Parveen Bazard, Robert D. Frisina, Venkat R. Bhethanabotla

Chemical and Biochemical Engineering Faculty Research & Creative Works

Biomedical prosthetics utilizing electrical stimulation have limited, effective spatial resolution due to spread of electrical currents to surrounding tissue, causing nonselective stimulation. So, precise spatial resolution is not possible for traditional neural prosthetic devices, such as cochlear implants. More recently, alternative methods utilize optical stimulation, mainly infrared, sometimes paired with nanotechnology for stimulating action potentials. Infrared stimulation has its own drawbacks, as it may cause collateral heating of surrounding tissue. In previous work, we employed a plasmonic method for stimulation of an electrically excitable neuroblastoma cell line, which had limited success. Here, we report the development of a hybrid electro-plasmonic …

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A Review Of The Latest Insights Into The Mechanism Of Action Of Strontium In Bone, Daniella Marx, Alireza Rahimnejad Yazdi, Marcello Papini, Mark R. Towler Jun 2020

A Review Of The Latest Insights Into The Mechanism Of Action Of Strontium In Bone, Daniella Marx, Alireza Rahimnejad Yazdi, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Interest in strontium (Sr) has persisted over the last three decades due to its unique mechanism of action: it simultaneously promotes osteoblast function and inhibits osteoclast function. While this mechanism of action is strongly supported by in vitro studies and small animal trials, recent large-scale clinical trials have demonstrated that orally administered strontium ranelate (SrRan) may have no anabolic effect on bone formation in humans. Yet, there is a strong correlation between Sr accumulation in bone and reduced fracture risk in post-menopausal women, suggesting Sr acts via a purely physiochemical mechanism to enhance bone strength. Conversely, the local administration of …

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The Role Of Poly(Methyl Methacrylate) In Management Of Bone Loss And Infection In Revision Total Knee Arthroplasty: A Review, Leyla Hasandoost, Omar Rodriguez, Adel Alhalawani, Paul Zalzal, Emil H. Schemitsch, Stephen D. Waldman, Marcello Papini, Mark R. Towler Jun 2020

The Role Of Poly(Methyl Methacrylate) In Management Of Bone Loss And Infection In Revision Total Knee Arthroplasty: A Review, Leyla Hasandoost, Omar Rodriguez, Adel Alhalawani, Paul Zalzal, Emil H. Schemitsch, Stephen D. Waldman, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Poly (methyl methacrylate) (PMMA) is widely used in joint arthroplasty to secure an implant to the host bone. Complications including fracture, bone loss and infection might cause failure of total knee arthroplasty (TKA), resulting in the need for revision total knee arthroplasty (rTKA). The goals of this paper are: (1) to identify the most common complications, outside of sepsis, arising from the application of PMMA following rTKA, (2) to discuss the current applications and drawbacks of employing PMMA in managing bone loss, (3) to review the role of PMMA in addressing bone infection following complications in rTKA. Papers published between …

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Evaluation Of Diode Laser Application On Chemical Analysis And Surface Microhardness Of White Spots Enamel Lesions With Two Remineralizing Agents, Lamiaa Mahmoud Moharam, Doaa Mohamed Sadony, Shaymaa Mohamed Nagi Mar 2020

Evaluation Of Diode Laser Application On Chemical Analysis And Surface Microhardness Of White Spots Enamel Lesions With Two Remineralizing Agents, Lamiaa Mahmoud Moharam, Doaa Mohamed Sadony, Shaymaa Mohamed Nagi

Chemical and Biochemical Engineering Faculty Research & Creative Works

Background: To investigate the effect of diode laser application and two commercial remineralizing agents on the remineralization and surface microhardness of white spot enamel lesions. Material and Methods: Sixty specimens were prepared then equally divided into six groups (n=10/group), according to the diode laser and the two commercial remineralizing agents applied to demineralized enamel surfaces (APF gel and sodium fluoride NaF mousse) with or without diode Laser application as follows; Group A; control, Group B; diode Laser application, Group C; APF gel application, Group D; NaF mousse application, Group E; APF gel application + diode Laser, Group F; NaF mousse …

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Effect Of Tio2 Doping On Degradation Rate, Microstructure And Strength Of Borate Bioactive Glass Scaffolds, Romina Shafaghi, Omar Rodriguez, Sunjeev Phull, Emil H. Schemitsch, Paul Zalzal, Stephen D. Waldman, Marcello Papini, Mark R. Towler Feb 2020

Effect Of Tio2 Doping On Degradation Rate, Microstructure And Strength Of Borate Bioactive Glass Scaffolds, Romina Shafaghi, Omar Rodriguez, Sunjeev Phull, Emil H. Schemitsch, Paul Zalzal, Stephen D. Waldman, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

A titanium-containing borate glass series based on the system (52-X) B2O3–12CaO–6P2O5–14Na2O–16ZnO-XTiO2 with X varying from 0, 5 and 15 mol% of TiO2 incorporated, identified as BRT0, BRT1 and BRT3, respectively, were used in this study. Scaffolds (pore sizes, 165–230 μm and porosity, 53.51–69.51%) were prepared using a polymer foam replication technique. BRT3 scaffolds exhibited higher compressive strength (7.16 ± 0.22 MPa) when compared to BRT0 (6.02 ± 0.47 MPa) and BRT1 (5.65 ± 0.28 MPa) scaffolds with lower, or no, TiO2 content. The solubility of the scaffolds decreased …

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Emulsion Stability Of Heavy Oil With Surfactants And Nanoparticles, Zainab Abdulmohsein, Baojun Bai, Parthasakha Neogi Jan 2020

Emulsion Stability Of Heavy Oil With Surfactants And Nanoparticles, Zainab Abdulmohsein, Baojun Bai, Parthasakha Neogi

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The recovered crude oil is often in form of an emulsion and the recovery is cut off when water to oil ratio exceeds a certain amount. The emulsions vary from water-in-oil to oil-in-water and the step that follows is to coalesce droplets to get two continuous liquids. Difficulties arise when the oil contains emulsifiers. There are naturally occurring surfactants, or the oil recovered is by enhanced oil recovery techniques which have additives that stabilize the droplets. We have considered below a heavy oil (viscosity 650-750 mPa.s) containing one of the three surfactants: a nonionic surfactant or a cationic surfactant or …

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A Review Of Materials For Managing Bone Loss In Revision Total Knee Arthroplasty, Romina Shafaghi, Omar Rodriguez, Emil H. Schemitsch, Paul Zalzal, Stephen D. Waldman, Marcello Papini, Mark R. Towler Nov 2019

A Review Of Materials For Managing Bone Loss In Revision Total Knee Arthroplasty, Romina Shafaghi, Omar Rodriguez, Emil H. Schemitsch, Paul Zalzal, Stephen D. Waldman, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

In 2014–2015, 61,421 total knee arthroplasties (TKAs) were performed in Canada; an increase of about 20% over 2000–2001. Revision total knee arthroplasties (rTKAs) accounted for 6.8% of TKAs performed between 2014 and 2015, and this is estimated to grow another 12% by 2025. rTKAs are typically more complicated than primary TKAs due to the significant loss of femoral and tibial bone stock. The escalating demand and limitations associated with total knee arthroplasty and their revision drives the development of novel treatments. A variety of materials have been utilized to facilitate regeneration of healthy bone around the site of a knee …

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Systems, Apparatus And Method For Material Preparations And / Or Handling, Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine Oct 2019

Systems, Apparatus And Method For Material Preparations And / Or Handling, Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine

Business and Information Technology Faculty Research & Creative Works

Oscillating angularly rotating a container containing a mate rial may cause the material to be separate. Denser or heavier material may unexpectedly tend to be collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow - through stop or semi-batch mode, or flow - through continuous mode. Lysing particulate material may exceed material to be lysed …

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The Effect Of Tantalum Incorporation On The Physical And Chemical Properties Of Ternary Silicon–Calcium–Phosphorous Mesoporous Bioactive Glasses, Andrew Mendonca, Md Saidur Rahman, Adel Alhalawani, Omar Rodriguez, Reid C. Gallant, Heyu Ni, Owen M. Clarkin, Mark R. Towler Oct 2019

The Effect Of Tantalum Incorporation On The Physical And Chemical Properties Of Ternary Silicon–Calcium–Phosphorous Mesoporous Bioactive Glasses, Andrew Mendonca, Md Saidur Rahman, Adel Alhalawani, Omar Rodriguez, Reid C. Gallant, Heyu Ni, Owen M. Clarkin, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Synthesis and characterization of the first mesoporous bioactive glasses (MBGs) containing tantalum are reported here, along with their potential application as hemostats. Silica MBGs were synthesized using with the molar composition of (80-x)% Si, 15% Ca, 5% P, and x% Ta. It was found that incorporation of >1 mol % Ta into the MBGs changes their physical and chemical properties. Increasing Ta content from 0 to 10 mol % causes a decrease in the surface area and pore volume of ~20 and ~35%, respectively. This is due to the increase in nonbridging oxygens and mismatch of thermal expansion coefficient which …

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Sequencing Heparan Sulfate Using Hilic Lc-Netd-Ms/Ms, Jiandong Wu, Juan Wei, Pradeep Chopra, Geert Jan Boons, Cheng Lin, Joseph Zaia Sep 2019

Sequencing Heparan Sulfate Using Hilic Lc-Netd-Ms/Ms, Jiandong Wu, Juan Wei, Pradeep Chopra, Geert Jan Boons, Cheng Lin, Joseph Zaia

Chemical and Biochemical Engineering Faculty Research & Creative Works

Heparan Sulfate (HS) Mediates a Wide Range of Protein Binding Interactions Key to Normal and Pathological Physiology. Though Liquid Chromatography Coupled with Mass Spectrometry (LC-MS) based Disaccharide Composition Analysis is Able to Profile Changes in HS Composition, the Heterogeneity of Modifications and the Labile Sulfate Group Present Major Challenges for Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Sequencing of the HS Oligosaccharides that Represent Protein Binding Determinants. Here, We Report Online LC-MS/MS Sequencing of HS Oligosaccharides using Hydrophilic Interaction Liquid Chromatography (HILIC) and Negative Electron Transfer Dissociation (NETD). a Series of Synthetic HS Oligosaccharides Varying in Chain Length (Tetramers and Hexamers), …

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Measurement Of Adhesion Of Sternal Wires To A Novel Bioactive Glass-Based Adhesive, Varinder Pal Singh Sidhu, Mark R. Towler, Marcello Papini Sep 2019

Measurement Of Adhesion Of Sternal Wires To A Novel Bioactive Glass-Based Adhesive, Varinder Pal Singh Sidhu, Mark R. Towler, Marcello Papini

Chemical and Biochemical Engineering Faculty Research & Creative Works

Stainless steel wires are the standard method for sternal closure because of their strength and rigidity, the simplicity of the process, and the short healing time that results from their application. Despite this, problems still exist with sternal stability due to micromotion between the two halves of the dissected and wired sternum. Recently, a novel glass-based adhesive was developed which, in cadaveric trials and in conjunction with wiring, was shown to restrict this micromotion. However, in order to avoid complications during resternotomy, the adhesive should adhere only to the bone and not the sternal wire. In this study, sternal wires …

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Bioactive Glass Fiber Fabrication Via A Combination Of Sol-Gel Process With Electro-Spinning Technique, Malvika Nagrath, Adel Alhalawani, Alireza Rahimnejad Yazdi, Mark R. Towler Aug 2019

Bioactive Glass Fiber Fabrication Via A Combination Of Sol-Gel Process With Electro-Spinning Technique, Malvika Nagrath, Adel Alhalawani, Alireza Rahimnejad Yazdi, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

No abstract provided.

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Characterization And Quantification Of Highly Sulfated Glycosaminoglycan Isomers By Gated-Trapped Ion Mobility Spectrometry Negative Electron Transfer Dissociation Ms/Ms, Juan Wei, Jiandong Wu, Yang Tang, Mark E. Ridgeway, Melvin A. Park, Catherine E. Costello, Joseph Zaia, Cheng Lin Feb 2019

Characterization And Quantification Of Highly Sulfated Glycosaminoglycan Isomers By Gated-Trapped Ion Mobility Spectrometry Negative Electron Transfer Dissociation Ms/Ms, Juan Wei, Jiandong Wu, Yang Tang, Mark E. Ridgeway, Melvin A. Park, Catherine E. Costello, Joseph Zaia, Cheng Lin

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glycosaminoglycans (GAGs) Play Vital Roles in Many Biological Processes and Are Naturally Present as Complex Mixtures of Polysaccharides with Tremendous Structural Heterogeneity, Including Many Structural Isomers. Mass Spectrometric Analysis of GAG Isomers, in Particular Highly Sulfated Heparin (Hep) and Heparan Sulfate (HS), is Challenging Because of their Structural Similarity and Facile Sulfo Losses during Analysis. Herein, We Show that Highly Sulfated Hep/HS Isomers May Be Resolved by Gated-Trapped Ion Mobility Spectrometry (Gated-TIMS) with Negligible Sulfo Losses. Subsequent Negative Electron Transfer Dissociation (NETD) Tandem Mass Spectrometry (MS/MS) Analysis of TIMS-Separated Hep/HS Isomers Generated Extensive Glycosidic and Cross-Ring Fragments for Confident Isomer …

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The Effect Of Calcination Rate On The Structure Of Mesoporous Bioactive Glasses, Saidur Rahman, Andrew Mendonca, Adel Alhalawani, Deanna Polintan, Owen M. Clarkin, Mark R. Towler Feb 2019

The Effect Of Calcination Rate On The Structure Of Mesoporous Bioactive Glasses, Saidur Rahman, Andrew Mendonca, Adel Alhalawani, Deanna Polintan, Owen M. Clarkin, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Mesoporous bioactive glasses (MBGs) are designed to have high specific surface area. They are formulated by a sol–gel process to formulate the glass followed by calcination. This study evaluates how calcination heating rate influences the porous architecture, and thereby the specific surface area, of MBGs. MBGs of molar ratio 80:15:5 for SiO2 :CaO:P2 O 5 were calcined using both low (1 °C/min) and high (20 °C/min) heating rates, termed as L-MBG and H-MBG, respectively. The results obtained from small-angle X-ray diffraction (SAXRD) confirm that the MBGs possess 2D hexagonal (P6mm) spacing groups and wide-angle XRD confirms the amorphicity …

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Raman Spectroscopy As A Predictive Tool For Monitoring Osteoporosis Therapy In A Rat Model Of Postmenopausal Osteoporosis, J. Renwick Beattie, Antonia Sophocleous, M. Clare Caraher, Olive O'Driscoll, Niamh M. Cummins, Steven E.J. Bell, Mark R. Towler, Alireza Rahimnejad Yazdi, Stuart H. Ralston, Aymen I. Idris Feb 2019

Raman Spectroscopy As A Predictive Tool For Monitoring Osteoporosis Therapy In A Rat Model Of Postmenopausal Osteoporosis, J. Renwick Beattie, Antonia Sophocleous, M. Clare Caraher, Olive O'Driscoll, Niamh M. Cummins, Steven E.J. Bell, Mark R. Towler, Alireza Rahimnejad Yazdi, Stuart H. Ralston, Aymen I. Idris

Chemical and Biochemical Engineering Faculty Research & Creative Works

Pharmacological therapy of osteoporosis reduces bone loss and risk of fracture in patients. Modulation of bone mineral density cannot explain all effects. Other aspects of bone quality affecting fragility and ways to monitor them need to be better understood. Keratinous tissue acts as surrogate marker for bone protein deterioration caused by oestrogen deficiency in rats. Ovariectomised rats were treated with alendronate (ALN), parathyroid hormone (PTH) or estrogen (E2). MicroCT assessed macro structural changes. Raman spectroscopy assessed biochemical changes. Micro CT confirmed that all treatments prevented ovariectomy-induced macro structural bone loss in rats. PTH induced macro structural changes unrelated to ovariectomy. …

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Well-Ordered Mesoporous Silica And Bioactive Glasses: Promise For Improved Hemostasis, Sara Pourshahrestani, Nahrizul Adib Kadri, Ehsan Zeimaran, Mark R. Towler Jan 2019

Well-Ordered Mesoporous Silica And Bioactive Glasses: Promise For Improved Hemostasis, Sara Pourshahrestani, Nahrizul Adib Kadri, Ehsan Zeimaran, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Immediate control of uncontrolled bleeding and infection are essential for saving lives in both combat and civilian arenas. Inorganic well-ordered mesoporous silica and bioactive glasses have recently shown great promise for accelerating hemostasis and infection control. However, to date, there has been no comprehensive report assessing their specific mechanism of action in accelerating the hemostasis process and exerting an antibacterial effect. After providing a brief overview of the hemostasis process, this review presents a critical overview of the recently developed inorganic mesoporous silica and bioactive glass-based materials proposed for hemostatic clinical applications and specifically investigates their unique characteristics that render …

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Slightly Fluorination Of Al2o3 Ald Coating On Li1.2mn0.54co0.13ni0.13o2 Electrodes: Interface Reaction To Create Stable Solid Permeable Interphase Layer, Han Yu, Yan Gao, Xinhua Liang Jan 2019

Slightly Fluorination Of Al2o3 Ald Coating On Li1.2mn0.54co0.13ni0.13o2 Electrodes: Interface Reaction To Create Stable Solid Permeable Interphase Layer, Han Yu, Yan Gao, Xinhua Liang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Improving the performance of cathodes by using surface coatings has proven to be an effective method for improving the stability of Li-ion batteries (LIBs), while a high-quality film satisfying all requirements of electrochemical inertia, chemical stability, and lithium-ion conductivity has not been found. In this study, a composite film composed of Al2O3 and AlF3 layers was coated on the surface of Li1.2Mn0.54Co0.13Ni0.13O2 (Li-rich NMC) based electrodes by atomic layer deposition (ALD). By varying the ratio of Al2O3 and AlF3, an optimal coating …

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Exploring Structure-Property Relationships Of Gags To Tailor Ecm-Mimicking Hydrogels, Ralf Zimmermann, Carsten Werner, James Sterling Dec 2018

Exploring Structure-Property Relationships Of Gags To Tailor Ecm-Mimicking Hydrogels, Ralf Zimmermann, Carsten Werner, James Sterling

Business and Information Technology Faculty Research & Creative Works

Glycosaminoglycans (GAGs) are a class of linear polysaccharides that are ubiquitous in the extracellular matrix (ECM) and on cell surfaces. Due to their key role in development, homeostasis, pathogenesis, and regeneration, GAGs are increasingly used in the design of ECM-mimicking hydrogels to stimulate tissue formation and regenerative processes via specifically orchestrated cell-instructive signals. These applications first and foremost build on the ability of GAGs to effectively bind, protect, and release morphogens. The specificity and strength of morphogen-GAG interactions are largely governed by the number and spatial distribution of negatively charged sulfate groups carried by GAGs. Herein, we summarize a mean-field …

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Co2-Eor Mechanisms In Huff-N-Puff Operations In Shale Oil Reservoirs Based On History Matching Results, Dheiaa Alfarge, Mingzhen Wei, Baojun Bai Aug 2018

Co2-Eor Mechanisms In Huff-N-Puff Operations In Shale Oil Reservoirs Based On History Matching Results, Dheiaa Alfarge, Mingzhen Wei, Baojun Bai

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Improved Oil Recovery (IOR) techniques in Unconventional Liquids Rich Reservoirs (ULR) are still a new concept because there is no commercial project for any IOR technique so far. Carbon dioxide (CO2) based EOR technique has been effectively applied to improve oil recovery in the tight formations of conventional reservoirs. Extending this approach to unconventional formations has been extensively investigated over the last decade because CO2 has unique properties which make it the first option of EOR methods to be tried. However, the applications and mechanisms for CO2-EOR in unconventional reservoirs would not necessarily be the same as …

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Arrayed Lyser And Homogenizer Systems With Multiple Agitator Devices, Robert W. Doebler, Mark Brown, Tanya Ferguson, Bruce Irvine, James D. Sterling Aug 2018

Arrayed Lyser And Homogenizer Systems With Multiple Agitator Devices, Robert W. Doebler, Mark Brown, Tanya Ferguson, Bruce Irvine, James D. Sterling

Business and Information Technology Faculty Research & Creative Works

Systems and methods for the efficient agitation of tissue samples. A device may include a plurality of chambers that each receives samples therein. The plurality of chambers may be uniformly spaced with respect to a least one dimension, to form a one dimensional or two-dimensional array. Each of the chambers may include an opening and an agitator device in fluid contact with the sample disposed within the chamber. The agitator devices may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision …

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Incorporating Germanium Oxide Into The Glass Phase Of Novel Zinc/Magnesium-Based Gpcs Designed For Bone Void Filling: Evaluating Their Physical And Mechanical Properties, Basel A. Khader, Omar Rodriguez, Mark R. Towler Jul 2018

Incorporating Germanium Oxide Into The Glass Phase Of Novel Zinc/Magnesium-Based Gpcs Designed For Bone Void Filling: Evaluating Their Physical And Mechanical Properties, Basel A. Khader, Omar Rodriguez, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

The structural role of Germanium (Ge), when substituting for Zinc (Zn) up to 8 mol % in the 0.48SiO2-0.12CaO-0.36ZnO-0.04MgO glass series, was investigated with respect to both the glass chemistry and also the properties of glass polyalkenoate cements (GPCs) manufactured from them. The Network connectivity (NC) of the glass was calculated to increase from 1.83 to 2.42 with the addition of GeO2 (0-8 mol %). Differential thermal analysis (DTA) results confirmed an increase in the glass transition temperature (Tg) of the glass series with GeO2 content. X-ray photoelectron spectroscopy (XPS) showed an increase in …

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Software For Peak Finding And Elemental Composition Assignment For Glycosaminoglycan Tandem Mass Spectra, John D. Hogan, Joshua A. Klein, Jiandong Wu, Pradeep Chopra, Geert Jan Boons, Luis Carvalho, Cheng Lin, Joseph Zaia Jul 2018

Software For Peak Finding And Elemental Composition Assignment For Glycosaminoglycan Tandem Mass Spectra, John D. Hogan, Joshua A. Klein, Jiandong Wu, Pradeep Chopra, Geert Jan Boons, Luis Carvalho, Cheng Lin, Joseph Zaia

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glycosaminoglycans (GAGs) Covalently Linked to Proteoglycans (PGs) Are Characterized by Repeating Disaccharide Units and Variable Sulfation Patterns Along the Chain. GAG Length and Sulfation Patterns Impact Disease Etiology, Cellular Signaling, and Structural Support for Cells. We and Others Have Demonstrated the Usefulness of Tandem Mass Spectrometry (MS 2 ) for Assigning the Structures of GAG Saccharides; However, Manual Interpretation of Tandem Mass Spectra is Time-Consuming, So Computational Methods Must Be Employed. in the Proteomics Domain, the Identification of Monoisotopic Peaks and Charge States Relies on Algorithms that Use Averagine, or the Average Building Block of the Compound Class Being Analyzed. …

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Synthesis Of Cr, Cu, Ni, And Y-Doped 3d-Printed Zsm-5 Monoliths And Their Catalytic Performance For N-Hexane Cracking, Xin Li, Abdo Alslam Alwakwak, Fateme Rezaei, Ali A. Rownaghi Jun 2018

Synthesis Of Cr, Cu, Ni, And Y-Doped 3d-Printed Zsm-5 Monoliths And Their Catalytic Performance For N-Hexane Cracking, Xin Li, Abdo Alslam Alwakwak, Fateme Rezaei, Ali A. Rownaghi

Chemical and Biochemical Engineering Faculty Research & Creative Works

In this work, chromium, copper, nickel, and yttrium-doped 3D-printed ZSM-5 monoliths were synthesized by doping the ZSM-5 zeolite paste with corresponding metal precursors. The physical and acid properties of the metal-doped 3D-printed ZSM-5 monoliths were systematically characterized by X-ray diffraction (XRD), X-ray fluorescence (XRF), scanning electron microscopy (SEM), Fourier transform-infrared (FT-IR), N2 adsorption, temperature programmed reduction of H2(H2-TPR), and temperature-programmed desorption of ammonia (NH3-TPD) techniques. The characterization of bare and metal-doped monoliths confirmed the presence of metal promoters within the zeolite matrix while their MFI frameworks were retained after doping and printing. It …

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Negative Electron Transfer Dissociation Sequencing Of 3-O-Sulfation-Containing Heparan Sulfate Oligosaccharides, Jiandong Wu, Juan Wei, John D. Hogan, Pradeep Chopra, Apoorva Joshi, Weigang Lu, Joshua Klein, Geert Jan Boons, Cheng Lin, Joseph Zaia Jun 2018

Negative Electron Transfer Dissociation Sequencing Of 3-O-Sulfation-Containing Heparan Sulfate Oligosaccharides, Jiandong Wu, Juan Wei, John D. Hogan, Pradeep Chopra, Apoorva Joshi, Weigang Lu, Joshua Klein, Geert Jan Boons, Cheng Lin, Joseph Zaia

Chemical and Biochemical Engineering Faculty Research & Creative Works

Among Dissociation Methods, Negative Electron Transfer Dissociation (NETD) Has Been Proven the Most Useful for Glycosaminoglycan (GAG) Sequencing Because It Produces Informative Fragmentation, a Low Degree of Sulfate Losses, High Sensitivity, and Translatability to Multiple Instrument Types. the Challenge, However, is to Distinguish Positional Sulfation. in Particular, NETD Has Been Reported to Fail to Differentiate 4-O- Versus 6-O-Sulfation in Chondroitin Sulfate Decasaccharide. This Raised the Concern of Whether NETD is Able to Differentiate the Rare 3-O-Sulfation from Predominant 6-O-Sulfation in Heparan Sulfate (HS) Oligosaccharides. Here, We Report that NETD Generates Highly Informative Spectra that Differentiate Sites of O-Sulfation on Glucosamine …

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Development Of A Novel Bioactive Glass Suitable For Osteosarcoma-Related Bone Grafts, Alireza Rahimnejad Yazdi, Lawrence Torkan, Stephen D. Waldman, Mark R. Towler Apr 2018

Development Of A Novel Bioactive Glass Suitable For Osteosarcoma-Related Bone Grafts, Alireza Rahimnejad Yazdi, Lawrence Torkan, Stephen D. Waldman, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

In this study, zinc borate-based glasses with increasing gallium content (0, 2.5, 5, 10, and 15 wt % Ga) were synthesized and their effect on the viability and proliferation of preosteoblasts and osteosarcoma cancer cells were investigated. Methyl thiazolyl tetrazolium (MTT) cell viability assays using glass degradation extracts revealed that the extracts from glasses with lower Ga contents could enhance the viability of preosteoblasts, while extracts from the glass composition with 15 wt % Ga caused statistically significant reduction of their viability. MTT cell viability assays using the extracts and osteosarcoma cells showed that only extracts from the glass composition …

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The Effect Of Incorporating Different Concentrations Of Chlorhexidine Digluconate On The Degree Of Conversion Of An Experimental Adhesive Resin, Lamiaa Mahmoud Moharam, Haidy Nabil Salem, Hanaa Mahmoud Elgamily Apr 2018

The Effect Of Incorporating Different Concentrations Of Chlorhexidine Digluconate On The Degree Of Conversion Of An Experimental Adhesive Resin, Lamiaa Mahmoud Moharam, Haidy Nabil Salem, Hanaa Mahmoud Elgamily

Chemical and Biochemical Engineering Faculty Research & Creative Works

Background: The aim of this study was to evaluate the effect of chlorhexidine digluconate incorporation on the degree of conversion of an experimental adhesive resin. Material and methods: The experimental resin was prepared from 70 wt.% bisphenol A glycerolate dimethacrylate, 30 wt.% hydroxyethyl methacrylate, silanized SiO2 nanofillers, 0.5% of camphorquinone and ethyl 4-dimethylaminebenzoate (binary photo-initiator system). Five chlorhexidine digluconate concentrations (0, 0.5, 1, 2 and 4 wt%) were then incorporated into the experimental resin. Thirty Potassium Bromide pellets were prepared then divided into six groups (n=5/group), representing the tested adhesive resins (Single Bond 2, 0, 0.5, 1, 2 and …

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Injectable Glass Polyalkenoate Cements: Evaluation Of Their Rheological And Mechanical Properties With And Without The Incorporation Of Lidocaine Hydrochloride, P. Niranjan, A. Alhalawani, S. Phull, I. Beniluz, B. Krishnan, P. Zalzal, Mark R. Towler Mar 2018

Injectable Glass Polyalkenoate Cements: Evaluation Of Their Rheological And Mechanical Properties With And Without The Incorporation Of Lidocaine Hydrochloride, P. Niranjan, A. Alhalawani, S. Phull, I. Beniluz, B. Krishnan, P. Zalzal, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Lidocaine hydrochloride is used as an anesthetic in many clinical applications. This short communication investigates the effect of complete substitution of lidocaine hydrochloride for deionized (DI) water on the physico-chemical properties of two novel glass polyalkenoate cements. Substituting DI water with lidocaine hydrochloride resulted in cements with shorter working times but comparable setting times and mechanical properties. Fourier transform infrared spectroscopy confirmed that the setting reaction in cements containing DI water and lidocaine hydrochloride was completed within 24 h, post cement preparation and maturation. Further, it was explained that lidocaine hydrochloride binds to poly(acrylic) acid (PAA) due to electrostatic forces …

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