Chemical Engineering Commons^™

Biomarkers For Vincristine-Induced Neuropathy, Danni Li, Jayachandran Devaraj, Doraiswami Ramkrishna

The Summer Undergraduate Research Fellowship (SURF) Symposium

Vincristine is a vinca alkaloid, a commonly used chemotherapy drug for treating leukemia, lymphoma, multiple myeloma and some pediatric cancers. Its major dose-limiting side effect is peripheral neuropathy. The current dosing of “standard-dose-for-all” ignores the genetic and phenotypic variations among different patients, and causes severe neuropathy in some patients while ineffectively treats the others. In the present study, we aim to discover novel biomarkers involved in vincristine-induced neuropathy and identify patients with varied metabolic characteristics. Thus treatment can be tailored accordingly to improve outcomes of vincristine treatment. Pre-dose and post-dose serum samples were collected from two groups of patients (low …

Adhesive Elastomeric Proteins, Haefa Mansour, Julie Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Sutures and staples commonly used to close surgical wounds tend to be much stiffer than the surrounding tissue, often resulting in external tissue damage. Surgical adhesives provide a promising alternative to these sutures and staples. Ideal surgical adhesives are biocompatible, able to set well and remain sticky in moist conditions, possess strong adhesive and cohesive properties, and exhibit mechanical properties that mimic those of the surrounding tissue. Unfortunately, the adhesives available today are unable to satisfactorily meet all of these criteria. We are utilizing protein engineering techniques to design, create, and test a new surgical adhesive that combines the adhesive …

Photolithography In Fabrication Of Thin-Film Solar Cells, Yusheng Zhu, Rakesh Agrawal

The Summer Undergraduate Research Fellowship (SURF) Symposium

Solar energy has steadily increased its efficiency and cost-effectiveness throughout the past three decades and seems poised to compete with current primary energy (natural gas, oil, coal) as the need for alternative energy sources rises. One type of solar cell, thin-film cells, often relies on use of permanent photomasks in order to imprint a pattern onto the front metal contact. However, these machined metal masks are rigid and do not allow for different designs to be explored as current masks encounter difficulties in machining grids thin enough for optimization. Photolithography, traditionally used in the microfabrication field, provides a method in …

Solvent Selection For Liquid-Liquid Extraction Of Acetic Acid From Biomass Hydrolysate, Emma A. Barber, Mahdieh Aghazadeh, Abigail Engelberth

The Summer Undergraduate Research Fellowship (SURF) Symposium

Biofuels are one of the most hopeful alternative energy sources to fossil fuels. However, the processing and production of biofuels needs improvement to be economically competitive in the current market. One drawback is the presence of naturally occurring compounds that decrease the bioethanol production rate and yield; these are called inhibitors. A resolution to this problem is to remove the inhibitors from biomass fermentation broth prior to fermentation. This project examined liquid-liquid extraction (LLE) for removal of acetic acid, a major inhibitor. Initially, a stock solution of glucose, xylose, acetic acid, and water was combined with an additional organic solvent …

Characterization Of The Saturation Level Of Nucleosome Arrays And Plasmids By Mnase Digestion, Wenjie Liu, Nathan Nurse, Chongli Yuan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Studying processes involving DNA such as DNA replication and transcription is best done in the context of chromatin because the structure of DNA influences the efficiency of such processes. Chromatin structure is derived from DNA wrapping around histone octamers with the histone octamer density termed saturation level. For in vitro studies on DNA replication and transcription, it is important to maintain a constant saturation level so that saturation level can be removed as a variable. Our goal is to characterize the saturation level of plasmids using the rate of MNase digestion. MNase digestions were first performed on reconstituted nucleosome arrays …

In Situ Study Of The Role Of Substrate Temperature During Atomic Layer Deposition Of Hfo2 On Inp, H. Dong, Santosh Kc, X. Qin, B. Brennan, S. Mcdonnell, D. Zhernokletov, C. Hinkle, J. Kim, K. Cho, R. Wallace

Faculty Publications

The dependence of the “self cleaning” effect of the substrate oxides on substrate temperature during atomic layer deposition (ALD) of HfO2 on various chemically treated and native oxide InP (100) substrates is investigated using in situ X-ray photoelectron spectroscopy. The removal of In-oxide is found to be more efficient at higher ALD temperatures. The P oxidation states on native oxide and acid etched samples are seen to change, with the total P-oxide concentration remaining constant, after 10 cycles of ALD HfO2 at different temperatures. An (NH4)2 S treatment is seen to effectively remove native oxides and passivate the InP surfaces …

Design And Preparation Of A Ni Steam Reforming Catalyst, Phillip R. Smith, Dr. Calvin H. Bartholomew

Journal of Undergraduate Research

Steam reforming catalysts play an essential role in the production of hydrogen, which is an essential fuel, feedstock, and reactant in the worldwide chemical industry. These steam reforming catalysts use a finely dispersed metal, supported on a porous ceramic material, to produce hydrogen from hydrocarbon sources. This is shown in reaction 1, where HC denotes hydrocarbon, H2O denotes water, H2 denotes dihydrogen, CO denotes carbon monoxide, CO2 denotes carbon dioxide, and CH4 denotes methane.

Black Liquor Pyrolysis, Jarom D. Webster, Dr. Thomas H. Fletcher

Journal of Undergraduate Research

The black liquor recovery boiler is the largest and most expensive piece of equipment in a modern pulp mill. Inside this boiler, black liquor is burned to produce electricity for the mill and also to recover spent chemicals. Black liquor combustion occurs in three stages: drying, pyrolysis, and char combustion. Understanding black liquor pyrolysis is an important step to controlling and improving the efficiency of the recovery boiler.

Determining Biomass Particle Properties Via Digital Imaging, Justin Scott, Dr. Larry Baxter

Journal of Undergraduate Research

Understanding the devolatilization and combustion of biomass (sawdust, agricultural waste, etc.) will lead to better use of this renewable fuel source. The overall goal of the project is to write a computer model that can accurately predict what will occur during biomass combustion. The research conducted over the past year has focused on developing an apparatus capable of determining the needed data for model development. The apparatus, once completed, will consist of an entrained flow reactor, an optical measurement system, and a computer algorithm to process the needed data from the images.

Catalyst Regeneration/Wax Solubility, Steven Gale Smith, Dr. Calvin Bartholomew

Journal of Undergraduate Research

Catalysts are widely used throughout many industries to decrease reaction time and make processes economically favorable. In the synthetic fuels industry a catalyst is used to convert carbon monoxide gases (CO) to hydrocarbon liquids (CnH2n+2). In this process, the catalyst becomes coated with the heavier hydrocarbon products. This coating is a wax and deactivates the catalyst (inhibits the catalyst from reacting). The catalyst is currently one of the largest expenses for this process and prevents the process from being competitive with natural fuels. Hence, a method to remove the waxes from the catalysts was studied. The process of removing the …

Polymers Functioning As Artificial Muscles, Nicholas Stanonis, William Pitt

Journal of Undergraduate Research

Current research in the field of polymers has led to the development of synthetic muscles that function similar to biological muscles. Scientists have engineered polymers to contract up to one thousand times their original volume when exposed to changes in light, temperature, voltage, or pH. The ability to contract and relax makes these polymers ideal artificial muscles. Currently, artificial muscles are being applied in the field of robotics. NASA is in the process of developing a dust wiper for their planetary rovers that operates with an artificial muscle. A common goal that many scientists are working towards is the implementation …

Is Dna A Good Model Polymer?, Douglas R. Tree, Abhiram Muralidhar, Patrick S. Doyle, Kevin D. Dorfman

Faculty Publications

The details surrounding the crossover from wormlike-specific to universal polymeric behavior has been the subject of debate and confusion even for the simple case of a dilute, unconfined wormlike chain. We have directly computed the polymer size, form factor, free energy, and Kirkwood diffusivity for unconfined wormlike chains as a function of molecular weight, focusing on persistence lengths and effective widths that represent single-stranded and double-stranded DNA in a high ionic strength buffer. To do so, we use a chain-growth Monte Carlo algorithm, the pruned-enriched Rosenbluth method (PERM), which allows us to estimate equilibrium and near-equilibrium dynamic properties of wormlike …

Analysis Of Electrical Current As An Agent For Bacterial Killing, Taylor Turner, Dr. William Pitt

Journal of Undergraduate Research

Previously it has been shown that antibiotic killing of bacteria, especially biofilms, can be enhanced by various non-invasive treatments. Low-level electric current has been shown to increase killing of Streptococcus gordonii biofilms when applied during treatment with gentamicin.1 Others have partially tested the feasibility of electrically killing bacteria on prosthetic joints.2 Ultrasonic exposure has also been shown to increase killing of bacterial biofilms.3 Our group previously observed that ultrasound increased the transport of gentamicin through biofilms.4 Electrical treatment of S. gordonii in the absence of gentamicin also generates a 1.9 log reduction in biofilm cell counts.1 Our previous findings showed …

Computer Simulated Multi-Component Aerosol Thermodynamics And Chemistry, Eric Halpenny, Dr. Larry Baxter

Journal of Undergraduate Research

Aerosols are small (sub-micron) particles formed mainly in combustion processes by the vaporization and subsequent re-condensation of volatile, inorganic compounds. Cloud formation is an example of an aerosol process. However, unlike clouds, most aerosol-generating processes produce negative effects on both the process that forms them and the environment. Aerosols represent major process and emissions issues for essentially all systems employing low-grade fuel (coal, biomass, and black liquor). An accurate, predictive understanding of aerosol formation and chemistry would substantially improve the efficiency and environmental performance of many processes.

An Experimental Study Of The Mechanisms Of Fine Particle Deposition In Kraft Recovery Boilers, Larry Baxter

Journal of Undergraduate Research

Experiments on the deposition of fume (submicron) and particles produced during black liquor combustion indicate that deposit mass accumulation increases linearly with time and is independent of temperature gradient – results that are inconsistent with the classical explanation of thermophoresis as a driving force. Temperature-controlled, cylindrical probes in cross flow collected particles for periods up to ten hours and at Reynolds and Stokes numbers comparable to those in commercial boilers. Fume deposits appear dense and smooth to the unaided eye but under microscopic examination prove to have filamentary structures, with individual filaments radiating from the probe center and consisting of …

Streamline-Based Novel Dynamic Grid Reservoir Simulation, Bradley C. Bundy, Dr. Larry Lin Baxter, Dr. Hugh Bradley Hales

Journal of Undergraduate Research

Oil is one of the most important commodities we have. It provides energy, transportation, and chemicals to provide a better life for mankind. However, it is a depleting recourse that is getting harder and harder to find and recover. Simulation techniques have been used for many years to determine the best place to drill wells and when it is the best time economically to stop pumping slurry. Unfortunately, current simulators often take weeks to months to complete and are only an estimate of what may occur. The industry is currently limited by slow, inaccurate simulation techniques. Faster simulators with increased …

Three-Dimensional Cfd Model Of A Reacting Char Bed, Michael M. Choi, Dr. Larry Baxter

Journal of Undergraduate Research

Black liquor is a recycled byproduct formed during the pulping of wood in the papermaking industry. In this process, cellulose is used to form paper fibers while lignin is combined with water and chemical used for the extraction to form black liquor. Black liquor is burned in a recovery boiler to produce steam and electricity and is the second largest renewable energy next to hydro energy.

Bacteriorhodopsin-Based Sensors, Craig Friedrich, Donald Lueking, Mark Griep

Michigan Tech Patents

A sensor comprising a membrane containing bacteriorhodopsin. In one embodiment, the sensor comprises a layer of purple membrane between a first and a second electrode, wherein the electrodes are connected to a circuit such that a signal is produced when a charge is transferred across the membrane. In another embodiment, the sensor comprises a field effect transistor with a layer of purple membrane deposited on the gate. The layer of purple membrane may be further functionalized by adding fluorophores to the layer of purple membrane. The fluorophores may be deposited adjacent to the layer of purple membrane, or the fluorophores …

Cell-Free Unnatural Amino Acid Incorporation With Alternative Energy Systems And Linear Expression Templates, Prashanta Shrestha, Mark Thomas Smith, Bradley Charles Bundy

Faculty Publications

Site-specific incorporation of unnatural amino acids (uAAs) during protein synthesis expands the proteomic code through the addition of unique residue chemistry. This field provides a unique tool to improve pharmacokinetics, cancer treatments, vaccine development, proteomics and protein engineering. The limited ability to predict the characteristics of proteins with uAA-incorporation creates a need for a low-cost system with the potential for rapid screening. Escherichia coli-based cell-free protein synthesis is a compelling platform for uAA incorporation due to the open and accessible nature of the reaction environment. However, typical cell-free systems can be expensive due to the high cost of energizing …

Encapsulation Of Supported Metal Nanoparticles With An Ultra-Thin Porous Shell For Size-Selective Reactions, Zeyu Shang, Rajankumar L. Patel, Brian W. Evanko, Xinhua Liang

Chemical and Biochemical Engineering Faculty Research & Creative Works

A novel nanostructured catalyst with an ultra-thin, porous shell obtained from the thermal decomposition of an aluminum alkoxide film deposited by molecular layer deposition for size-selective reactions was developed. The molecular sieving capability of the porous metal oxide films was verified by examining the liquid-phase hydrogenation of n-hexene versus cis-cyclooctene. © 2013 The Royal Society of Chemistry.

A Tensile Deformation Model For In-Situ Dendrite/Metallic Glass Matrix Composites, J. W. Qiao, T. Zhang, Fuqian Yang, P. K. Liaw, S. Pauly, B. S. Xu

Chemical and Materials Engineering Faculty Publications

In-situ dendrite/metallic glass matrix composites (MGMCs) with a composition of Ti₄₆Zr₂₀V₁₂Cu₅Be₁₇ exhibit ultimate tensile strength of 1510 MPa and fracture strain of about 7.6%. A tensile deformation model is established, based on the five-stage classification: (1) elastic-elastic, (2) elastic-plastic, (3) plastic-plastic (yield platform), (4) plastic-plastic (work hardening), and (5) plastic-plastic (softening) stages, analogous to the tensile behavior of common carbon steels. The constitutive relations strongly elucidate the tensile deformation mechanism. In parallel, the simulation results by a finite-element method (FEM) are in good agreement with the experimental findings and theoretical calculations. The present study gives a mathematical model to clarify …

Spectroscopic And Kinetic Characterization Of Catalytic Materials For The Conversion Of Biomass-Derived Compounds, Paul James Dietrich

Open Access Dissertations

As economies look to transition away from petroleum for social, economic, and political reasons, biomass will continue to attract attention as a renewable feedstock for the fuels and chemicals industry. In order to turn biomass into end use fuels and chemicals, the oxygen content must be lowered significantly, requiring large hydrogen inputs. For these processes to be completely renewable, the hydrogen must come from biomass or biomass-derived compounds. In this work, catalysts for the aqueous phase reforming (APR) of biomass-derived sugars were characterized by a combination of reaction kinetics, X-ray spectroscopy, electron microscopy, and theoretical computation to determine the active …

An Analysis Of The Impact Of Storage Temperature, Moisture Content & Duration Upon The Chemical Components & Bioprocessing Of Lignocellulosic Biomass, Arun Athmanathan

Open Access Dissertations

The successful utilization of lignocellulosic biomass as a feedstock for fuels and chemicals necessitates storage for 2-6 months. It is correspondingly important to understand the impact of storage parameters - moisture concentration, temperature and duration - on biomass quality.

As aerobic storage is the most viable large-scale solution, aerobic storage experiments were carried out with three projected bioenergy feedstocks - sweet sorghum (Sorghum bicolor) bagasse, corn (Zea mays) stover and switchgrass (Panicum virgatum). Stored samples of each were examined for dry matter loss and composition change to develop a material balance around carbohydrates and lignin.

A mean dry matter loss …

The Biological Impact Of Concurrent Exposure To Metallic Nanoparticles And A Static Magnetic Field, Kristen K. Comfort, Elizabeth I. Maurer, Saber M. Hussain

Chemical and Materials Engineering Faculty Publications

The rapid advancement of technology has led to an exponential increase of both nanomaterial and magnetic field utilization in applications spanning a variety of sectors. While extensive work has focused on the impact of these two variables on biological systems independently, the existence of any synergistic effects following concurrent exposure has yet to be investigated. This study sought to ascertain the induced alterations to the stress and proliferation responses of the human adult low calcium, high temperature keratinocyte (HaCaT) cell line by the application of a static magnetic field (approximately 0.5 or 30 mT) in conjunction with either gold or …

Gas Barrier And Mechanical Properties Of Crosslinked Ethylene Vinyl Acetate Nanocomposites, S. A. Ahmad Ramazani, M. Shafiee, Hossein Abedsoltan, A. Shafiee

Chemical and Biochemical Engineering Faculty Research & Creative Works

In this research, the effects of crosslinking agent and clay content on the morphology, barrier and mechanical properties of ethylene vinyl acetate-organoclay nanocomposites prepared by solution method were studied. Dicumyl peroxide has been used as crosslinking agent. The morphology of the prepared nanocomposites was investigated using wide-angle X-ray diffraction and transmission electron microscopy. Wide-angle X-ray diffraction and transmission electron microscopy indicated that the prepared nanocomposites had predominantly intercalated morphologies. The obtained results of permeability tests showed that the permeability of ethylene vinyl acetate films dramatically decreases with addition of organoclay and dicumyl peroxide. Mechanical tests showed that tensile modulus and …

Preparation Of Mesoporous Silica Supported Ruthenium Oxides And The Application And Kinetic Study In The Catalysis Of Water Oxidation, Yang Zhang

Open Access Dissertations

Photo-induced water splitting of water into H2 and O2 has been a major focus in the development of clean and renewable energy. The development of viable and efficient catalysts that facilitates O2 production remains the major challenge in the study of the corresponding half-reaction of water oxidation. There are plenty of metal oxides reported active in the catalysis of water oxidation. However, several important performance bench marks of those materials, such as the non-stoichiometric production of O2, slow reaction rate and/or low quantum efficiency, remain to be improved.

Ruthenium oxide (RuO2) has long been known as one of the most …

High-Pressure Vapor-Phase Catalytic Hydrodeoxygenation Of Lignin-Derived Compounds To Hydrocarbons On Bimetallic Catalysts In The Range Of 0.2-2.4 Mpa., Sara Lynn Yohe

Open Access Dissertations

Biomass, as the only renewable source of carbon, presents a sustainable alternative to liquid fossil fuels for the production of renewable transportation fuels and chemicals. The lignin portion of biomass poses a significant challenge in the upgrading and conversion of lignocellulosic biomass to fuels and chemicals, and in many current biorefineries is not utilized. However, the lignin fraction is a valuable feedstock due to its aromatic structure, lower O:C ratio than cellulose and hemicellulose, and high energy content (up to 40%) and weight fraction (average 25 wt%) of biomass. Several processes (including fast-pyrolysis, fast-hydropyrolysis, and liquid phase processing) are able …

Design And Assembly Of Nanostructured Complex Metal Oxide Materials For The Construction Of Batteries And Thermoelectric Devices, Gautam Ganapati Yadav

Open Access Dissertations

Thermoelectric devices and lithium-ion batteries are among the fastest growing energy technologies. Thermoelectric devices generate energy from waste heat, whereas lithium-ion batteries store energy for use in commercial applications. Two different topics are bound with a common thread in this thesis - nanotechnology! In fact, nanostructuring is a more preferred term for the approach I have taken herein. Another commonality between these two topics is the material system I have used to prove my hypotheses - complex metal oxides.

Complex metal oxides can be used for both energy generation and storage as they are stable at high temperatures, are benign …

Comprehensive Computational Modeling Of Hypergolic Propellant Ignition, Swanand Vijay Sardeshmukh

Open Access Dissertations

Ignition and combustion of hypergolic propellants mono-methyl hydrazine (MMH) and red fuming nitric acid (RFNA) is investigated computationally. A hierarchical approach is chosen to study parametric behavior of isolated processes and complex interactions thereof, in this transient phenomenon. Starting with a homogeneous reactor, performance of three reduced kinetic mechanisms is assessed first, followed by the study of auto-ignition delay as a function of initial composition and thermal state of the mixture. Macroscopic features as well as the structure of opposed diffusion flame are studied next, followed by the study of opposed liquid jets and the gas layer at the interface. …

Development Of Quantitative Ft- Ir Methods For Analyzing The Cure Kinetics Of Epoxy Resins, Sang Ha Son

Open Access Dissertations

Epoxy thermosets are important engineering materials with applications in coating, adhesives, packaging and as structural components in a variety of advanced engineering products. The ultimate performance of polymer critically depends upon the details of the cure chemistry used to produce the thermoset. In order to better understand and monitor the cure chemistry, quantitative analysis of the FT-IR response has been developed for describing the epoxy-amine curing reaction as well as monitoring the hydrogen bonding that occurs in these systems The FT-IR analysis includes (i) quantitative deconvolution of complex peaks into individual spectral contributions, (ii) peak identification via DFT analysis and …