Chemical Engineering Commons^™

Ultrafiltration Membrane Process For Pyrogen Removal In The Preparation Of Water For Injection (Wfi), Thet N. Soe

Inquiry: The University of Arkansas Undergraduate Research Journal

An artificial kidney process based on ultrafiltration (called hemodiafiltration) more effectively removes blood toxins, particularly those of higher molecular weight, than conventional dialysis. In hemodiafiltration, replacement liquid must be added directly to the patient's blood to replace liquid filtered out of the blood in the ultrafiltration cartridge. This replacement liquid is made up of' "water for injection" (WFI) and other components such as salts and glucose. WFI is produced either by distillation or reverse osmosis and has a cost of $1.00 per liter. A patient with kidney problems would require three hemodiafiltration treatments per week, each requiring 70-80 liters of …

Nanoparticles For Enhanced Delivery Of Chemotherapeutics, Emily J. Bahram-Ahi

Opportunities for Undergraduate Research Experience Program (OURE)

Delivery of the anticancer drug paclitaxel (commercially known as Taxol®) is difficult due to its limited solubility in aqueous media. This study proposes a novel bubble bursting technique to generate nanoparticles of the chemotherapeutic in an effort to decrease potential side effects and improve the bioavailability of hydrophobic drugs. The bubble bursting apparatus will be used to produce nanoparticles of a biodegradable polymer, poly(lactide-co-glycolide) (PLGA), as carriers for paclitaxel. The dissolved paclitaxel in this biodegradable polymer matrix will be released at a controlled rate for a more efficient delivery of the drug throughout the body.

Synthesis And Characterization Of Poly(Urethane-Imide)/Poss Nanocomposite, Supanan Patthamasang

Chulalongkorn University Theses and Dissertations (Chula ETD)

A novel type of poly(urethane-imide) (PUI) was prepared by blending the isocyanate terminated polyurethane containing dihydroxy-POSS prepolymer (PU/POSS) and anhydride-terminated polyimide (PI) with various chain lengths of PU/POSS prepolymer and various molecular weights of PI. The effect of chain length of PU prepolymer and molecular weight of PI on the properties of PUI/POSS films was examined. From the results, we found the best condition for synthesis of the PUI/POSS hybrid films is to use the PI prepared via 1 step method with MW of 80,000 and that can prepared the transparent films, follwed by casting films and heat treatment at …

Intracellular Signaling Networks In The Immune Response: Pathways Activated By Interleukin-2 And-4 Receptors And Their Roles In T Cell Proliferation, Kristen K. Comfort

Chemical and Materials Engineering Faculty Publications

Cells sense and respond to chemical and physical stimuli through signal transduction pathways, which mediate cell proliferation, differentiation, migration, and survival. The cytokines interleukin-2 (IL-2) and interleukin-4 (IL-4) are key regulators of the adaptive immune system, particularly influencing the clonal expansion and differentiation of T cells. At least in culture, both synergistic and antagonistic effects of IL-2 and -4 co-stimulation have been reported; the antagonism, when observed, is thought to arise from the utilization of a common subunit shared by IL-2 and IL-4 receptors. We have sought to characterize IL-2 and IL-4 signaling at the level of intracellular pathways activated …

Control Of Plasma Flux Composition Incident On Tin Films During Reactive Magnetron Sputtering And The Effect On Film Microstructure, Christopher Muratore, Scott G. Walton, Darrin Leonhardt, Richard F. Fernsler

Chemical and Materials Engineering Faculty Publications

A hybrid plasma enhanced physical vapor deposition (PEPVD) system consisting of an unbalanced dc magnetron and a pulsed electron beam-produced plasma was used to deposit reactively sputtered titanium nitride thin films. The system allowed for control of the magnitudes of the ion and neutral flux, in addition to the type of nitrogen ions (atomic or molecular) that comprised the flux. For all deposition experiments, the magnitude of the ion flux incident on the substrate was held constant, but the composition of the total flux was varied. X-ray diffraction and atomic force microscopy showed that crystallographic texture and surface morphology of …

Development Of An Electroless Method To Deposit Corrosion-Resistant Silicate Layers On Metallic Substrates, Swaminatha P. Kumaraguru, Basker Veeraraghavan, Branko N. Popov

Faculty Publications

A novel electroless method for depositing corrosion-resistant silicate layers on metallic substrates from aqueous solutions has been developed. The silicate layer was deposited from an aqueous solution of sodium silicate (3.22 weight ratio sodium silicate, 37.5% solution in water from PQ Corporation) and sodium borohydride. The technique is demonstrated by forming a passive film on galvanized steel. Deposition parameters such as concentration of the bath, temperature, and pH have been optimized based on the corrosion characteristics of the final coating. Studies on the coating reveal the formation of a very thin (5 nm) zinc disilicate layer followed by a much …

Distribution Dynamics Of Complex Systems, Young-Pyo Jeon

LSU Doctoral Dissertations

A complex system is defined as a system with many interdependent parts having emergent self-organization; analyzing and designing such complex systems is a new challenge. A common observable structure of many complex systems is the network, which is connections among nodes, and thus inherently difficult to describe. The goal of this research is to introduce an effective methodology to describe complex systems, and thus we will construct a population balance (distribution kinetics) model based on the association-dissociation process to describe the evolution of complex systems. Networks are commonly observed structures in complex systems with interdependent parts that self-organize. How networks …

Electrodeposition Of Cocu Nanostructures, Yutong Li

LSU Doctoral Dissertations

Electrodeposition is a key component in the microelectronic industry because it has the following advantages: low cost, easy operation and the capability to deposit into irregular geometries such as recessed and curved areas. In this dissertation, CoCu alloys were investigated to fabricate multilayers, microdevices and microposts. All of these multilayer structures were composed of nanometric copper and cobalt-rich layers in order to obtain magnetoresistance, a phenomenon where the resistance of multilayer structures decreases with increases of external magnetic field. An investigation was carried out in order to evaluate appropriate plating conditions during multilayered thin film deposition, with the aim to …

A Distribution Kinetics Approach For Polymer Crystallization And Phase Separation, Jiao Yang

LSU Doctoral Dissertations

The mechanism of polymer crystallization is extensively studied and still far away from consensus. This research adopted cluster size distribution kinetics approach to explore the kinetics of polymer crystallization and phase separation within spinodal region. The kinetics of polymer crystallization is studied by integrating nucleation, crystal growth and ripening. Population balance equations based on crystal size distribution and concentration of amorphous polymer segments are solved numerically and the related differential moment equations are also solved. The model accounts for nucleation and crystal growth. Different mass dependences of growth and dissociation rate coefficients are proposed to investigate the fundamental features of …

Accelerating Whole-Cell Biocatalysis By Enhancing Outer Membrane Permeability, Ye Ni

Theses and Dissertations

Whole-cell biocatalysts are preferred in many biocatalysis applications. However, cell envelope often represents a formidable permeability barrier. As a result, reactions catalyzed by whole-cells are reportedly orders of magnitude slower than those of by their free enzyme counterparts. The present research addresses this critical issue by using membrane engineering approaches. Two E. coli strains with genetically altered outer membrane structures were used in the study, a lipopolysaccarides (LPS) mutant SM101 and a Braun's lipoprotein mutant E609L. The effects of outer membrane mutation on the permeability of substrates differing substantially in size and hydrophobicity were investigated by combining the mutant cells …

Quantification Of Doxorubicin Concentration In Rat Tissues Using Polymeric Micelles In Ultrasonic-Drug Delivery, William G. Pitt, Beverly Roeder, Bryant J. Staples

Faculty Publications

The triblock copolymer, Pluronic P105, has been found to be an ideal ultrasonically activated drug delivery vehicle because it forms micelles with hydrophobic polypropylene oxide cores that sequester hydrophobic drugs (Fig. 1). These micelles release their contents upon the application of low frequency ultrasound [1]such that drugs can be released specifically at the ultrasonicated region (Fig. 2). Such ultrasonically controlled release has been effective against cancer cells in vitro [2] and in vivo [3]. The purpose of this research is to assess the use of these novel polymeric micelles in ultrasonically-activated Doxorubicin® (DOX) delivery to tumors. This cancer therapy involves …

Design And Development Of Oligonucleotide Microarrays And Their Application In Diagnostic And Prognostic Estimation Of Human Gliomas, G. Scott Taylor

Theses and Dissertations

DNA microarrays represent an ultra-high throughput gene expression assay employed to study the transcriptomic profiles of biological tissues. These devices are increasingly being used to study many aspects of gene regulation, and there is growing interest in the biotechnology and pharmaceutical industries for developing such devices in efforts toward rational product/drug design. The DNA microarray also provides a unique and objective means for diagnosis and prognosis of human diseases based on patterns of gene expression. This is especially important in cancer research and the thrust toward personalized medicine. This dissertation details the design and development of oligonucleotide microarrays and the …

Enzyme Engineering Of Aminotransferases For Improved Activity And Thermostability, Abraham Rogelio Mártin García

Dissertations, Master's Theses and Master's Reports - Open

The production by biosynthesis of optically active amino acids and amines satisfies the pharmaceutical industry in its demand for chiral building blocks for the synthesis of various pharmaceuticals. Among several enzymatic methods that allow the synthesis of optically active aminoacids and amines, the use of minotransferase is a promising one due to its broad substrate specificity and no requirement for external cofactor regeneration. The synthesis of chiral compounds by aminotransferases can be done either by asymmetric synthesis starting from keto acids or ketones, and by kinetic resolution starting from racemic aminoacids or amines.

The asymmetric synthesis of substituted (S)-aminotetralin, an …

Electrodeposited Metal Matrix Nanocomposites As Thin Films And High Aspect Ratio Microstructures For Mems, Alonso Lozano Morales

LSU Doctoral Dissertations

The electrodeposition of metal-matrix nanocomposites as thin film and high aspect ratio microstructures (HARM’s) for MicroElectroMechanical Systems (MEMS) components is examined. The effect of -Al2O3 nanopowder on copper reduction from acidic and basic electrolytes is examined with rotating disk electrodes (RDE’s). At pH 0.2, regions of copper inhibition and enhancement are identified in the kinetic regime. Low particle loading (12.5 g/L) results in an inhibited copper rate, while, high particle concentration (60 g/L) does both, inhibits the rate at low overpotentials and accelerates it at higher overpotentials, depending on the electrode rotation rate. At pH 8 the presence of particles …

Experimental And Computational Analysis Of Random Cylinder Packings With Applications, Wenli Zhang

LSU Doctoral Dissertations

Random cylinder packings are prevalent in chemical engineering applications and they can serve as prototype models of fibrous materials and/or other particulate materials. In this research, comprehensive studies on cylinder packings were carried out by computer simulations and by experiments. The computational studies made use of a collective rearrangement algorithm (based on a Monte Carlo technique) to generate different packing structures. 3D random packing limits were explored, and the packing structures were quantified by their positional ordering, orientational ordering, and the particle-particle contacts. Furthermore, the void space in the packings was expressed as a pore network, which retains topological and …

Surface Modification Of Su-8 By Photografting Of Functional Polymers For Lab-On-A-Chip Applications, Zhan Gao, David Henthorn, Chang-Soo Kim

Chemical and Biochemical Engineering Faculty Research & Creative Works

Due to the high flexibility and versatility in the process development of microfluidic devices, an epoxybased, high-aspect ratio photoresist SU-8 is now attracting attention as the main structuring material of the fluidic channels. Manipulation of the surface properties of SU-8 channel wall is critical to attach functional films such as enzyme-immobilized layers or biocompatible layers. We describe a new in situ patterning method to form a hydrogel film on SU-8 by a photografted polymerization procedure. The hydrophobic surface of SU-8 is modified using a surface bound initiator HCPK (1-hydroxycyclohexyl phenyl ketone). A p-HEMA (poly-2-hydroxyethylmethacrylate) hydrogel film is grafted by photopolymerization …

Enhanced Degradation Of Phenanthrene And Benzo(A)Pyrene In A Field-Contaminated Sediment Inhabited By Ilyodrilus Templetoni: A Microcosm Study, Marilou Montevirgen Nabatilan

LSU Master's Theses

The influence of the oligochaete Ilyodrilus templetoni on the degradation of phenanthrene and benzo(a)pyrene present in a field-contaminated sediment was studied in microcosm experiments. Results indicate an enhanced degradation of phenanthrene and benzo(a)pyrene in microcosms inhabited by I. templetoni. Total phenanthrene reduction was observed at an average of 9.78 % in worm microcosms, while no reduction was observed in the control microcosms. Benzo(a)pyrene reduction, on the other hand, was determined at 78.60 % and 30.04 % in worm and control microcosms, respectively. The lowest concentrations of these PAHs at the end of 97-day study were observed well below the surface …

The Bioturbation Transport Of Chemicals In Surface Soils, Maria D. Rodriguez

LSU Master's Theses

Large quantities of chemicals, such as pesticides, fertilizers, and industrial wastes, have been found throughout the environment raising concerns due to their ecological impacts and implications to human health. Soil is the most important repository of many organic chemicals in the environment. The objective of the present study was to determine the importance of the soil solid phase in the transport of chemicals in soils, and yield quantitative information to better describe bioturbation and its role in the movement of soil particles. Vertical movement of chemicals in the soil solid phase occurs by mixing mechanisms, such as bioturbation, cryoturbation, and …

Polycyclic Aromatic Compounds In Wood Soot Extracts From Henan, China, Robyn Joy Cabrido Alcanzare

LSU Master's Theses

Polycyclic aromatic compounds (PAC) are organic compounds composed of two or more fused benzene rings. These compounds are ubiquitous in the environment and some are found to be mutagenic and carcinogenic. High rates of esophageal cancer in the Henan Province of China had led to the suspicion that PAC from domestic coal and wood combustion are the main cause. Extraction of PAC from wood soot was done with a Soxhlet apparatus using dichloromethane as the solvent and concentration of the solution using a Kuderna Danish apparatus. Analysis of the different PAC was performed by high performance liquid chromatography (HPLC) with …

Physical Model Study Of The Effects Of Wettability And Fractures On Gas Assisted Gravity Drainage (Gagd) Performance, Wagirin Ruiz Paidin

LSU Master's Theses

The Gas-Assisted Gravity Drainage (GAGD) process was developed to take advantage of the natural segregation of injected gas from crude oil in the reservoir. It consists of placing a horizontal producer near the bottom of the reservoir and injecting gas using existing vertical wells. As the injected gas rises to the top to form a gas cap, oil and water drain down to the horizontal producer. Earlier experimental work using a physical model by Sharma had demonstrated the effectiveness of the GAGD process in improving the oil recovery when applied in water-wet porous media. The current research is an extension …

Demonstration And Performance Characterization Of The Gas Assisted Gravity Drainage (Gagd) Process Using A Visual Method, Thaer N.N. Mahmoud

LSU Master's Theses

The Gas Assisted Gravity Drainage (GAGD) process, currently being developed at LSU, is designed to take advantage of gravity to allow vertical segregation between the injected gas and reservoir crud oil due to their density differences. GAGD is recommended for use with CO2 gas. CO2 dissolves in oil and causes both swelling and viscosity reduction of oil. The GAGD process uses the existing vertical wells for CO2 gas injection, and a horizontal well near the bottom of the payzone for oil production. GAGD, as an EOR process, is not restricted to tertiary oil recovery only. In this research study, a …

Compositional Effects On Gas-Oil Interfacial Tension And Miscibility At Reservoir Conditions, Daryl Sean Sequeira

LSU Master's Theses

Minimum miscibility pressure (MMP) is an important optimization parameter for an enhanced oil recovery process involving Carbon Dioxide or hydrocarbon gas injection. Therefore an accurate experimental measurement is required to determine the MMP. The MMP for a gas-oil system is directly related to the interfacial tension between the injected gas and the reservoir crude oil. When CO2 gas contacts the reservoir oil at reservoir temperature, the interfacial tension between the fluid-fluid phases reduces as the miscibility is approached and the interface between the fluid-fluid phases eventually disappears at miscibility i.e. the interfacial tension becomes zero. Hence, a pressure condition of …

Overview Of Cogeneration At Lsu, Robert,Jr. Buckley

LSU Master's Theses

Cogeneration (or Combined Heat and Power) continues to gain importance in power production because of its high efficiency, environmental friendliness, and flexibility. Louisiana State University (LSU) recently began operation of a new 20 MW cogeneration system. This new facility can serve as a useful learning tool for chemical and mechanical engineering students throughout their education at LSU. The goal of this project is to develop educational modules utilizing the cogeneration system which have industrial significance. Educational modules will include: a comparison of ideal gas versus real gas thermodynamics for a cogeneration optimization problem, a cogeneration data reconciliation problem, and a …

Feasibility Of Supercritical Carbon Dioxide As A Drilling Fluid For Deep Underbalanced Drilling Operations, Anamika Gupta

LSU Master's Theses

Feasibility of drilling with supercritical carbon dioxide to serve the needs of deep underbalanced drilling operations has been analyzed. A case study involving underbalanced drilling to access a depleted gas reservoir is used to illustrate the need for such a research. For this well, nitrogen was initially considered as the drilling fluid. Dry nitrogen, due to its low density, was unable to generate sufficient torque in the downhole motor. The mixture of nitrogen and water, stabilized as foam generated sufficient torque but made it difficult to maintain underbalanced conditions. This diminished the intended benefit of using nitrogen as the drilling …

Hydrate Dissociation During Drilling Through In-Situ Hydrate Formations, Erdem Catak

LSU Master's Theses

Natural gas hydrates are thought to be the future hydrocarbon source of the energy hungry world. Tremendous amount of research has been done to investigate the feasibility of gas production from the hydrate formations. In this direction, three basic production methods, thermal stimulation, depressurization and thermodynamic inhibitor injection have been proposed to produce hydrocarbons off the hydrates. On the other hand, they present high potential risk of drilling hazards, such as severe gasification of drilling fluid, casing collapse due to increase in pressure after dissociation of hydrate zone, and instability of ocean floor, which may cause a platform failure. Scientists …

Purification And Scale-Up Of A Recombinant Heavy Chain Fragment C Of Botulinum Neurotoxin Serotype E In Pichia Pastoris Gs115, Michael P. Dux, Rick Barent, Jayanta Sinha, Mark Gouthro, Todd Swanson, Ardis Barthuli, Mehmet Inan, John T. Ross, Leonard A. Smith, Theresa J. Smith, Robert Webb, Bonnie Loveless, Ian Henderson, Michael M. Meagher

Michael Meagher Publications

A recombinant C-terminus heavy chain fragment from botulinum neurotoxin serotype E (BoNT/E) is proposed as a vaccine against the serotype E neurotoxin. This fragment, rBoNTE(H_c), was produced intracellular in Pichia pastoris GS115 by a three-step fermentation process, i.e., glycerol batch phase and a glycerol fed-batch phase to achieve high cell densities, followed by a methanol fed-batch induction phase. The rBoNTE(H_c) protein was purified from the soluble fraction of cell lysates using three ion-exchange chromatography steps (SP Sepharose Fast Flow, Q Sepharose Fast Flow, Sp Sepharose High Performance) and polished with a hydrophobic charge induction chromatography step …

Modeling Volume Changes In Porous Electrodes, Parthasarathy M. Gomadam, John W. Weidner

Faculty Publications

A three-dimensional mathematical model is presented to describe volume changes in porous electrodes occurring during operation. Material conservation equations are used to derive governing relationships between electrode dimensions and porosity for deposition/precipitation, intercalation, and ionomer-based electrodes. By introducing a parameter, called the swelling coefficient, the relative magnitudes of the change in electrode dimensions and the change in porosity are determined. The swelling coefficient is design-dependent and measured experimentally for a given cell design. The model is general and forms a critical addition required to extend the existing porous electrode models to include volume change effects. For the special case of …

Combinatorial Study Of Ni-Ti-Pt Ternary Metal Gate Electrodes On Hfo2 For The Advanced Gate Stack, K.-S. Chang, M. L. Green, J. Suehle, E. M. Vogel, H. Xiong, Jason R. Hattrick-Simpers, I. Takeuchi, O. Famodu, K. Ohmori, P. Ahmet, T. Chikyow, P. Majhi, B.-H. Lee, M. Gardner

Faculty Publications

The authors have fabricated combinatorial Ni–Ti–Pt ternary metal gate thin film libraries on HfO₂ using magnetron co-sputtering to investigate flatband voltage shift (ΔV_fb) , work function (Φ_m) , and leakage current density (J_L) variations. A more negative ΔV_fb is observed close to the Ti-rich corner than at the Ni- and Pt-rich corners, implying smaller Φ_m near the Ti-rich corners and higher Φ_m near the Ni- and Pt-rich corners. In addition, measured J_L values can be explained consistently with the observed Φ_m variations. Combinatorial methodologies prove to be useful …

Development And Modeling Of Thermally Conductive Resins For Fuel Cell Bipolar Plate Applications, Michael G. Miller

Dissertations, Master's Theses and Master's Reports - Open

Thermally conductive resins are a class of material that show promise in many different applications. One growing field for their use is in the area of bipolar plate technology for fuel cell applications. In this work, a LCP was mixed with different types of carbon fillers to determine the effects of the individual carbon fillers on the thermal conductivity of the composite resin. In addition, mathematical modeling was performed on the thermal conductivity data with the goal of developing predictive models for the thermal conductivity of highly filled composite resins.