Chemical Engineering Commons^™

Oil Recovery By Surfactant Flooding; Sensitivity Analysis To Technical Parameters And Economic Analysis, Hadel Mohsen Moustafa

Theses

Various enhanced oil recovery methods including miscible gas injection, chemical, thermal and other methods are applied at the third phase of production after the primary and secondary recovery have been exhausted. Surfactant flooding is one of the chemical methods that is capable of recovering more oil by decreasing the IFT and/or wettability alteration.This piece of work aims to asses and select the development options using surfactant process that maximize oil recovery for a synthetic reservoir model by optimizing technical and economic analysis.

Reservoir simulation study using ECLIPSE 100 was used to study the different development options of surfactant flooding applied …

Novel Experimental Method For The Determination Of The Minimum Agitation Speed For Solids Suspension In Flat-Bottomed Stirred Tank Reactors, Shriarjun Shastry

Theses

Knowledge of the minimum agitation speed, Njs, required to suspend finely divided solids in vessels stirred by an impeller is a critical parameter to properly operate industrial tanks in a large number of industrial operations. The most common experimental approach to measure N_js is that of Zwietering’s (Chem. Eng. Sci., 1958, 8, 244-253), consisting of visually inspecting the tank bottom and visually determining the impeller agitation speed at which the solids are observed to rest on the tank bottom for no more than 1-2 seconds before being swept away. This method is quite reliable, but a method …

Real Time, Integrated, Paper Based Temperature Sensor For Lab On A Chip Device, Vignesh Shekhar

Theses

Temperature measurement and manipulation is a critical factor in a wide range of applications like Point Of Care Diagnostics (POC's), Polymerase Chain Reaction (PCR), Temperature Gradient Focusing (TGF) to cite few prominent examples. In the past decade, researchers have used various techniques to sense and control the temperature in microfluidic systems. The primary challenge has been the twin problem of integration and accuracy using minimal equipment while keeping it simple. In this study, an equipment free fabrication of the temperature sensor using filter paper impregnated with p-type colloidal PbS quantum dots is demonstrated. This sensor is later integrated into line …

Eis Analysis Of Shear Enhanced Microfluidic Lab-On-A-Chip Device, Mehnaz Mursalat

Theses

Electrochemical sensors and biosensors have received much attention owing to the feasibility demonstrated regarding instrumental simplicity, decent cost, and portability during the detection of a wide range of biological and pharmaceutical macromolecules. Carbon-based nanomaterials, including carbon nanotubes, have garnered tremendous interest for their unique thermal, mechanical, electronic and catalytic properties while designing these sensors. Whenever the macromolecules interact with a bio-recognition element on the electrode transducer surface, a measurable change in the electrical current or potential takes place. To achieve lower limits of detection, the use of sensor surfaces modified with nanostructured materials such as nanotubes, or nanoparticles is becoming …

Dissolution Kinetics Of Model Api In Molten Polymer Excipients During Batch Processing, Shen Ji

Theses

In the pharmaceutical industrial application field, hot-melt extrusion (HME) has been recently introduced to develop new solid dosage forms and products. By dissolving the poorly–soluble active pharmaceutical ingredients (API) into water-soluble polymers, the bioavailability of the Class II (with low solubility and high permeability in water) API in Biopharmaceutical Classification System (BCS) could be significantly improved in the body. For readily water-soluble API, HME provides a new approach to produce a controlled release drug system. Hence, pharmaceutical HME is a promising processing method in the pharmaceutical industry.

However, HME has not been widely applied into the pharmaceutical industry. The thermal …

Preparation, Ignition And Combustion Of Reactive Metal-Sulfur Nanocomposites, Ziyue Zhong

Theses

Mechanical milling is applied to synthesize reactive metal-sulfur nanocomposites. Specifically, magnesium-sulfur, aluminum-sulfur and zirconium-sulfur nanocomposite powders are prepared. Each powder particle contained homogeneously mixed sulfur and respective metal. These materials are expected to be stable in room air. They are also expected to release sulfur upon ignition; the released sulfur may serve as a biocidal agent. The ignition temperatures of the three prepared sulfur-bearing materials fall in a range of 750 - 1000 K. All prepared materials are successfully ignited in electrostatic discharge experiment as well as in a constant volume explosion experiment. The most sensitive material to spark ignition …

Development And Analysis Of Aluminum-Ptfe Reactive Composite Material, Siva Kumar Valluri

Theses

The shortcomings of micron sized aluminum due to the oxide barrier and two phase loses pose a hindrance for its efficient use as a fuel. In this study a fluoropolymer; Teflon’s inclusion in micron sized -325 mesh aluminum is suggested as a replacement to aluminum. Aluminum Teflon based energetic material see great potential for use in pyrotechnics, propellants and even explosives. A composite with composition Al-PTFE (90-10 wt. %) is prepared through Cryomilling and is shown to be a better method of preparation as compared to room temperature milling. The prepared materials are studied to identify best conditions. The analysis …

Carbon Dioxide Capture By Steel-Making Residues In A Fluidized Bed Reacto, Suhaib Mohammad Hameedi

Theses

Global warming is one of the most challenging problems facing societies these days, and it is known to be caused by the increasing emissions of Green House Gases (GHG's), mainly CO₂, from various human activities. To solve such a problem, or at least minimize its effects, several actions have been considered. One of these actions is carbon capture, which has many different options and techniques. This research focuses on the capture of CO₂ through reactions with steel-making residues, an alkaline solid by-product of the steel-making process. The aim is to sequester CO₂ and form carbonates, which …

Contact Angle And Ift Measurements Of Smart Water At Elevated Temperatures And Pressures For Evaluating Wettability In A Selected Carbonate Reservoir In The Uae, Jassim Abubacker Ponnambathayil

Theses

Water flooding has been regarded as a well-known secondary oil recovery method. In the recent years, extensive research on crude oil, brine, and rock systems has acknowledged that the composition of the injected water can change wetting properties of the reservoir during a water flood in a promising way to improve oil recovery. Hence, injection of “smart water” with correct salinity and composition is considered as a tertiary recovery method. The mechanism behind wettability alteration that is promoted by smart water injection has been a topic of discussion in carbonate and sandstone formations. In this work, some key properties of …

Oil Recovery By Flooding; Sensitivity Analysis To Technical Parameters, Rana Osama Fahmi Saqer

Theses

Numerous enhanced oil recovery techniques including miscible gas injection, chemical, thermal and other methods are applied at the third phase of production after both primary and secondary recovery have been exhausted. Polymer flooding is one of the chemical methods that recover more oil by decreasing the mobility of the system; by increasing the viscosity of the injected water that results in an improvement in the volumetric sweep efficiency.

The objective of this work is to asses and select the development options using polymer process that maximize oil recovery for a synthetic reservoir model where technical parameters are optimized thoroughly.

Reservoir …

Oil Recovery By Polymer Flooding; Sensitivity Analysis To Technical Parameters, Rana Osama Fahmi Saqer

Theses

Numerous enhanced oil recovery techniques including miscible gas injection, chemical, thermal and other methods are applied at the third phase of production after both primary and secondary recovery have been exhausted. Polymer flooding is one of the chemical methods that recover more oil by decreasing the mobility of the system; by increasing the viscosity of the injected water that results in an improvement in the volumetric sweep efficiency.

The objective of this work is to asses and select the development options using polymer process that maximize oil recovery for a synthetic reservoir model where technical parameters are optimized thoroughly.

Reservoir …

Synthesis Of A Renewable Sourced Thermotropic Polyester With 2,5-Furandicarboxylic Acid, Alicia Marie Marguerite Hurst

Theses

With the rapid depletion of non-renewable sourced materials, unpredictable fluctuations in the prices of fossil fuels, and increased environmental awareness the need to develop biobased materials grows ever more desperate. Furan derivatives sourced from hexoses provide a promising solution for replacing petrochemical based materials. One furan derivative in particular, 2,5-furandicarboxylic acid (FDCA), is especially promising due to its structural similarity to terephthalic acid and potential for use in the production of polyesters similar to PET, PPT, and PBT. This study investigated the synthesis, thermal and liquid crystalline properties of a totally renewable sourced thermotropic polyester based on FDCA. Fructose was …

Computational And Experimental Determination Of The Hydrodynamics In A Stirred Unbaffled Vessel Provided With Angle-Mounted Axial Impellers, Ji Ma

Theses

In most industrial applications, stirred tanks and reactors are typically provided with baffles to improve their mixing characteristics. However, in a number of pharmaceutical production facilities unbaffled vessels are commonly used. The absence of baffles is preferred in such cases because it reduces the potential for contamination and makes cleaning the vessel between batches easier. However, the lack of baffles also has a negative impact on the system’s hydrodynamics since it often results in poor mixing of the batch, especially if the impeller is centrally placed, since the liquid in such a system is subject to a strong tangential flow, …

A Preliminary Investigation Of The Sterile-Filterability Of Bcs Class Ii Drug Nanosuspensions Prepared Via Wet Stirred Media Milling, Parul Ohri

Theses

Drug nanoparticles can achieve targeting capabilities, enhanced dissolution rates and improved bioavailability when injected intravenously. Sterile filtration of drug nanoparticle suspensions (nanosuspensions) is critically needed for administration by intravenous delivery route. Avoiding gamma irradiation and high temperatures, sterile filtration could be an effective process to sterilize drug nanosuspensions. On the other hand, two major challenges must be tackled: drug particles must at least be smaller than the filter pore size and minimum amount of non-toxic stabilizers must be used to prevent side effects like pain on the injection site. The aim of this study is to prepare naproxen (NPX) nanosuspensions …

Principles And Applications Of Mechanical Dry Coating - Review And State-Of-The-Art, Sayani Bhaumik

Theses

Dry Coating of powders to form composite particulates has been firmly established and has garnered interest both in academia and industry due to its myriad applications. This thesis work is an attempt to map the progress of the dry coating technology from its incipient years in the '80s to the thriving practice in the present day. Dry coating is a relatively simple approach to coat powders with specific guest particles via mechanical means to produce composites with desired tailor-made properties, without the constraints of harmful emissions or huge capital investment. Composite particulates with enhanced flowability, high-temperature resistant properties, and modified …

Experimental Determination Of The Agitation Requirements For Solids Suspension In Dissolution Systems Using A Mini Paddle Apparatus, Yang Song

Theses

Dissolution testing is a critical step in quality control of manufactured final products in the pharmaceutical industry. The United State Pharmacopeia (USP) Dissolution Testing Apparatus 2 (paddle) is the most widely used dissolution test devices in the pharmaceutical industry to formulate solid drug dosage forms and to develop quality control specifications for its manufacturing process.

Mini vessels and mini paddle dissolution testing systems are smaller versions of the USP 2 Apparatus. The concept of the mini paddle apparatus is similar to that of the USP 2 setup but it is scaled down about to 1/5 of the volume and 40% …

Effect Of Impeller Submergence On Power Dissipation And Solids Suspension In Mixing Systems Equipped With Pitch-Blade Turbines, Yufeng Song

Theses

Mixing and dispersion of solids in a liquid is a process frequently encountered in the pharmaceutical industry and often conducted in cylindrical baffled tanks stirred by mechanical impellers. In operations where the liquid level is decreased (as often which emptying the tank) the process must be stopped when the solids are no longer suspended. In this work, the minimum agitation to suspend solids (Njs) when the liquid level was lowered, and the impeller submergence S_b changed as a result were determined for the case of a six-blade, pitch-blade turbine (6-PBT) impeller. The power consumed by the impeller …

Experimental Determination Of Solids Suspension With Angled Impeller In A Pharmaceutical Mixing Vessel, Yingxi Tang

Theses

Angled-mounted impellers are commonly used in a number of pharmaceutical industry applications, from laboratory reactors to full-scale tanks. In these systems, the impeller is not centrally and vertically mounted, as in most stirred vessels, but it enters the vessel, and is therefore immersed in the fluid, at an angle from the vertical. This arrangement provides some baffling effects that would not otherwise exist if the impeller was centrally mounted.

One common requirement for such systems is that they are capable of suspending small solids dispersed in the liquid. Therefore, it is critical to know the value of the minimum agitation …

The Kinetics Of Drug Dissolution In Polymers During Hot-Melt Extrusion, Huayang Fang

Theses

Extrusion has been a most important and widely used continuous process in polymer processing for over one hundred and fifty years. However, it has only been recently applied and adopted by the pharmaceutical industry to prepare solid oral dosage formulations with increased bioavailability for the poorly-water soluble drugs and controlled release characteristics for the water-soluble drugs. In pharmaceutical Hot-melt extrusion poorly water soluble drug particulates are mixed with water soluble polymer excipient particulates and fed in the extruder, where the polymer is melted, after which the drug particulates begin to dissolve into the polymer melt. Extrusion-generated mixing accelerates dissolution process. …

Optimization Of A Combined Approach For The Treatment Of Desalination Reject Brine And Capture Of Co₂, Ameera Fares Mohammad

Theses

Carbon dioxide (CO₂) is the most widespread greenhouse gas that traps heat and raises the global temperature, contributing to climate change. Existing techniques to sequester carbon dioxide have numerous environmental concerns and usually require an extensive amount of energy. New technologies and methods, such as reactions with desalination reject brine according to the Solvay process, offer new hope for the reduction of carbon dioxide concentration in the atmosphere. Brine management is another environmental concern, as many desalination plants need to find suitable approaches for the treatment or disposal of the large amounts of concentrated brine, resulting from the desalination processes. …

Combustion Dynamics Of Metal Powders In Mixed Gas Flows, Amy Lee Corcoran

Theses

Predictive mechanisms for particle ignition and combustion rates are required in order to develop optimized propellant and energetic formulations using micron-sized metal powders, such as aluminum and magnesium. Most current descriptions are based on laboratory experiments performed in stationary or laminar combustion configurations using pure metals burned in single oxidizers. However, practical configurations take into account different metals, including alloys, that burn in various oxidizing environments and various flow conditions. Validity of the present descriptions for such environments has not been established. This experimental study is aimed to measure burn times for aluminum, magnesium, and mechanically alloyed Al-Mg particles burning …

Preparation And Characterization Of Fast Dissolving Pullulan Films Containing Griseofulvin Nanoparticles For Bioavailability Enhancement, Zhelun Ma

Theses

The aim of this study is to enhance the bioavailability of griseofulvin, a model poorly water-soluble drug, via increasing drug dissolution rate through preparation of drug nanoparticle-laden, pullulan-based strip films. The work entails (i) wet-milling griseofulvin in a stirred media mill using pullulan (polymer) along with sodium dodecyl sulfate (surfactant) as stabilizers, (i i) preparing strip films by casting-drying a precursor suspension consisting of the mixture of the milled drug suspension and a film-forming pul l ul an–xanthan gum-glycerin solution, (iii) characterizing the suspensions and the films, and (iv) exploring the effects of film thickness, drug and xanthan gum loadings, …

The Photophysics Properties Of Lanthanide Luminescent Probes, Ke Li

Theses

A detailed study of the luminescence quantum yield, lifetimes and the number of water molecules coordinated to lanthanide luminescent probes based on biphenylyl-7-amino-4- methyl-2(1H)-quinolinon (Bi-cs124) derivatives have been carried out using a time- resolved fluorescence assay (TRFA). Bi-cs124 was conbined with different chelating agents, specifically diethylene triamine pentaacetic acid (DTPA), ethylene diamine tetraacetic acid (EDTA), ethylene glycol tetraacetic acid (EGTA), and 3,6,9,12-Tetrakis carboxymethyl)-3,6,9,12-tetraazatetradecane-1,14-dioic acid (TTHA). The results indicate that Bi-cs 124-TTHA has a longest lifetime and smallest number of coordinated water molecules because TTHA has larger number of chelating groups. The dependence of the luminescence lifetimes on the probes concentrations …

Combustion Of Fine Magnesium Particles, Song Wang

Theses

Recent interest in developing Al-Mg alloys as reactive materials prompted studies of combustion mechanisms for particles of such alloys with different Al/Mg ratios. Reference experiments with pure Al and Mg powders are also desired to better understand and model combustion of the respective alloys. While combustion of pure Al powders has been addressed in many recent studies, combustion of magnesium explored mostly coarse, 50 μm, and larger particles. This effort is focused to characterize and understand combustion dynamics for fine Mg powders. Spherical, micron-sized magnesium particles were introduced in an air-acetylene flame using a custom-made screw feeder. Particles were observed …

Hydrodynamic Cfd Modeling Of A Pharmaceutical Reactor Vessel Provided With A Retreat-Blade Impeller Under Different Baffling Conditions, Christopher G. Foehner

Theses

In the pharmaceutical industry, glass-lined reactors and vessels are often utilized to carry out a variety of different unit operations. Within these systems, both the vessel and impellers are typically glass-lined in order to provide superior corrosion resistance, prevent product contamination, and enhance cleanability. This approach, in turn, often requires the use of different, and sometimes sub-optimal, baffling conditions, which affect the hydrodynamics of the vessels and the reactor performance.

Computational Fluid Dynamics (CFD) is a computational tool that employs numerical methods and algorithms to discretize and numerically solve partial differential equations (PDEs) representing mass, energy, and momentum conservation equations …

Assessment Of A Marine Polysaccharide For Use As Excipient In Pharmaceutical Hot-Melt Extrusion, Qing Ye

Theses

Pharmaceutical Hot Melt Extrusion (HME) is currently investigated by both industry and academia as a method for manufacturing solid oral dosages with improved bioavailability of poorly-water soluble active pharmaceutical ingredients (APIs) and control drug release of water-soluble APIs. Although HME is traditionally utilizing synthetic polymers to produce such dosages, biopolymers constantly gain ground by virtue of renewability, biocompatibility and in some cases biodegradability. In this work, the possibility of using Keltone, a marine polysaccharide derived from brown seaweed, as a polymeric excipient for pharmaceutical HME is explored. Keltone is insoluble in acidic pH and soluble in basic pH, therefore making …

Dispersion And Dissolution Kinetics Of Api Particles In Pharmaceutical Hot Melt Extrusion, Wang Zhan

Theses

Pharmaceutical Hot Melt Extrusion (HME) is essentially a special case of polymer compounding. The elementary steps involved in traditional plastics melt processing are handling of particulates, melting, dispersive and distributive mixing, devolatilization and stripping, and finally pressurization and pumping. However, for pharmaceutical HME, the dissolution of the API (Active Pharmaceutical Ingredient) is an additional and very important elementary step, along with the melting of the polymeric excipient that precedes it, and mixing which accelerates the dissolution process. A major concern in pharmaceutical HME is the thermal degradation of the API. To avoid overexposure of API to heat while ensuring complete …

Experimental Determination Of The Mixing Requirements For Solid Suspension In Pharmaceutical Stirred Tank Reactors, Anqi Zhou

Theses

Glass and glass-lined, stirred-tank reactors are of significant importance in the pharmaceutical and related industries. Because of fabrication issues, a retreat blade impeller (RBI) with a low impeller clearance off the tank bottom is commonly used in glass-lined reactors, typically combined with a single baffle (providing only partial baffling conditions) mounted from the top of the reactor. In addition, these reactors are often provided with a torispherical bottom. Other configurations are also used, including full baffling or no baffles at all, hemispherical bottoms, and different impeller types. Despite their common use, some of the most important mixing characteristics of this …

Evaluation Of Electrocoagulation For The Removal Of Chromium (Vi) From Brackish Groundwater, Shaima S Hamdan

Theses

Electrocoagulation (EC) has been evaluated for the removal of Cr (VI) from brackish groundwater using three different bench-scale EC reactors, namely batch stirred tank reactor (BSTR), continuous stirred tank reactor (CSTR) and a continuous electrocoagulation column (ECC). Batch EC process was experimentally examined at room temperature and the results indicated that Fe-Fe electrode pair was the most efficient arrangement and was able to achieve 100 % Cr removal at an electrocoagulation time of 5 minutes, a current density of 7.94 mA/cm², and pH of 8. A kinetic study of batch EC was then performed using both pseudo-first-order and …

Biodegradation Of Cresols Using Pseudomonas Putida Immobilized In Poly Vinyl Alcohol (Pva) Gel, Riham Mohamed Sorkatti Abu Bakr

Theses

The characteristics and viability of polyvinyl alcohol (PVA) as a support material for biomass immobilization and utilization for the biodegradation of cresols have been evaluated. PVA gel pellets were prepared by repeated freezing-thawing method using different PVA compositions. The porous structures of the PVA pellets were examined using a Compound Microscope and SEM and revealed that the matrix structure and pore size distribution were affected by PVA composition. Mechanical properties of the PVA gel were also characterized to evaluate the PVA integrity as a matrix for immobilizing microbial cells and found to be dependent on the PVA mass composition. The …