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Articles 451 - 480 of 823
Full-Text Articles in Chemical Engineering
Mineralization Potential Of Electrospun Pdo-Hydroxyapatite-Fibrinogen Blended Scaffolds, Isaac A. Rodriguez, Parthasarathy A. Madurantakam, Jennifer M. Mccool, Scott A. Sell, Hu Yang, Peter C. Moon, Gary L. Bowlin
Mineralization Potential Of Electrospun Pdo-Hydroxyapatite-Fibrinogen Blended Scaffolds, Isaac A. Rodriguez, Parthasarathy A. Madurantakam, Jennifer M. Mccool, Scott A. Sell, Hu Yang, Peter C. Moon, Gary L. Bowlin
Chemical and Biochemical Engineering Faculty Research & Creative Works
The current bone autograft procedure for cleft palate repair presents several disadvantages such as limited availability, additional invasive surgery, and donor site morbidity. The present preliminary study evaluates the mineralization potential of electrospun polydioxanone:nano-hydroxyapatite: fibrinogen (PDO: nHA: Fg) blended scaffolds in different simulated body fluids (SBF). Scaffolds were fabricated by blending PDO: nHA: Fg in the following percent by weight ratios: 100: 0: 0, 50: 25: 25, 50: 50: 0, 50: 0: 50, 0: 0: 100, and 0: 50: 50. Samples were immersed in (conventional (c), revised (r), ionic (i), and modified (m)) SBF for 5 and 14 days to …
Polymers For Delivering A Substance Into A Cell, Kaushal Rege, Ravindra S. Kane, Steven M. Cramer, Sutapa Barua
Polymers For Delivering A Substance Into A Cell, Kaushal Rege, Ravindra S. Kane, Steven M. Cramer, Sutapa Barua
Chemical and Biochemical Engineering Faculty Research & Creative Works
Disclosed herein are polymers that can be made cationic and used to deliver a substance into a cell. Also disclosed are pharmaceutical compositions comprising the polymers and methods of using the polymers.
Experimental Composite Guidance Conduits For Peripheral Nerve Repair: An Evaluation Of Ion Release, X. F. Zhang, A. Coughlan, H. O'Shea, Mark R. Towler, S. Kehoe, D. Boyd
Experimental Composite Guidance Conduits For Peripheral Nerve Repair: An Evaluation Of Ion Release, X. F. Zhang, A. Coughlan, H. O'Shea, Mark R. Towler, S. Kehoe, D. Boyd
Chemical and Biochemical Engineering Faculty Research & Creative Works
Poly (lactide-co-glycolide) (PLGA) - Pluronic F127 - glass composites have demonstrated excellent potential, from the perspective of controlled mechanical properties and cytocompatibility, for peripheral nerve regeneration. In addition to controlling the mechanical properties and cytotoxicity for such composite devices, the glass component may mediate specific responses upon implantation via degradation in the physiological environment and release of constituent elements. However, research focused on quantifying the release levels of such therapeutic ions from these experimental medical devices has been limited. To redress the balance, this paper explores the ion release profiles for Si4+, Ca2+, Na+, …
Gallium Containing Glass Polyalkenoate Anti-Cancerous Bone Cements: Glass Characterization And Physical Properties, A. W. Wren, A. Coughlan, L. Placek, Mark R. Towler
Gallium Containing Glass Polyalkenoate Anti-Cancerous Bone Cements: Glass Characterization And Physical Properties, A. W. Wren, A. Coughlan, L. Placek, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
A gallium (Ga) glass series (0.48SiO2-0.40ZnO-0.12CaO, with 0.08 mol% substitution for ZnO) was developed to formulate a Ga-containing Glass Polyalkenoate Cement (GPC) series. Network connectivity (NC) and X-ray Photoelectron Spectroscopy (XPS) was employed to investigate the role of Ga3+ in the glass, where it is assumed to act as a network modifier. Ga-GPC series was formulated with E9 and E11 polyacrylic acid (PAA) at 50, 55 and 60 wt% additions. E11 working times (Tw) ranged from 68 to 96 s (Lcon.) and 106 s for the Ga-GPCs (LGa-1 and LGa-2). Setting times (Ts) …
Adsorption Kinetics Of Pb(Ii) And Zn(Ii) Ions Unto Carbonized Groundnut Shells And Maize Cobs, Leke Luter, Aboi Julius, Henry T. Dekaa, B. A. Ikyenge, Ande Sesugh, Monday Uchenna Okoronkwo
Adsorption Kinetics Of Pb(Ii) And Zn(Ii) Ions Unto Carbonized Groundnut Shells And Maize Cobs, Leke Luter, Aboi Julius, Henry T. Dekaa, B. A. Ikyenge, Ande Sesugh, Monday Uchenna Okoronkwo
Chemical and Biochemical Engineering Faculty Research & Creative Works
Maize cobs and groundnut shell adsorbents from agricultural by-products were carbonized and investigated for adsorption of two selected metals, Lead (Pb II) and Zinc (Zn II) from aqueous solutions of these metals. Kinetic studies of the adsorption processes were investigated employing Elovich and the intraparticle diffussion models. The results showed that, the adsorption capacities of these comparatively cheaper adsorbents and their efficiency for the removal of Pb(II) and Zn(II) ions from aqueous solution present them suitable for use in place of the costly commercial activated carbons.
Processes For The Production Of Buprenorphine With Reduced Impurity Formation, Brenda E. Allen, Esa T. Jarvi, Dennis J. Kaluta, James R. Meyer, Keith Tomazi, Anthony Mannino, Brian Orr
Processes For The Production Of Buprenorphine With Reduced Impurity Formation, Brenda E. Allen, Esa T. Jarvi, Dennis J. Kaluta, James R. Meyer, Keith Tomazi, Anthony Mannino, Brian Orr
Chemical and Biochemical Engineering Faculty Research & Creative Works
The present invention provides process for the production of opiate alkaloids. In particular, the present invention provides processes for the production of buprenorphine or a derivative of buprenorphine that minimizes the formation of impurities.
Examination Of The Migratory Potential Of Patterned Cortical Neurons Using Laser Direct-Write, T. B. Phamduy, C. J. Rivet, D. Kingsley, R. J. Gilbert, D. B. Chrisey
Examination Of The Migratory Potential Of Patterned Cortical Neurons Using Laser Direct-Write, T. B. Phamduy, C. J. Rivet, D. Kingsley, R. J. Gilbert, D. B. Chrisey
Chemical and Biochemical Engineering Faculty Research & Creative Works
We describe the patterning of neuronal cultures by a laser-based printing system. Embryonic chick cortical neurons were transferred into predetermined array positions with micron accuracy, enabling detailed study of neuronal migration, aggregation, and neurite outgrowth regulated by cell-cell interactions on a homogeneous surface. Images of cells were analyzed up to 14 days. Results demonstrated that increasing the spacing between neighboring groups of cells causes intra-group cells to preferentially migrate towards each other and aggregate towards the center of the printed 'spot'. In addition, increasing the printed 'spot' size encouraged migration towards neighboring groups of cells. © 2012 IEEE.
The Structural Characterization Of Ga 2o 3-Na 2o-Cao-Zno-Sio 2 Bioactive Glasses, T. J. Keenan, A. W. Wren, A. Coughlan, M. M. Hall, Mark R. Towler
The Structural Characterization Of Ga 2o 3-Na 2o-Cao-Zno-Sio 2 Bioactive Glasses, T. J. Keenan, A. W. Wren, A. Coughlan, M. M. Hall, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
The characterization of bioactive glasses in which zinc (Zn) has been incrementally replaced by gallium (Ga). © 2012 IEEE.
Silver Coated Bioactive Glass Particles For Wound Healing Applications, P. Hassanzadeh, A. W. Wren, Mark R. Towler
Silver Coated Bioactive Glass Particles For Wound Healing Applications, P. Hassanzadeh, A. W. Wren, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Hench and colleagues discovered that bone could bond chemically to certain glass compositions in 1969 [1]. This group of glasses is known as bioactive glasses [1]. Some special compositions of bioactive glasses will bond to soft tissues as well as bone [1]. One of the important characteristics of bioactive glasses is their ability to release beneficial ions such as Ca2+, Na+, Zn2+, Sr2+, and PO 43- in the body, which promote self-healing [2]. Bioactive glasses generally contain much less glass former (e.g., SiO2, B2O3 etc.) than conventional …
Increasing The Quantity Of Silver In Zinc-Based Glass Polyalkenoate Cement: Is There An Improvement In Antibacterial Efficacy?, A. Coughlan, S. M. Breed, C. Ashraf, J. A. Cardinale, M. M. Hall, Mark R. Towler
Increasing The Quantity Of Silver In Zinc-Based Glass Polyalkenoate Cement: Is There An Improvement In Antibacterial Efficacy?, A. Coughlan, S. M. Breed, C. Ashraf, J. A. Cardinale, M. M. Hall, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Bone cements should have the ability to chemically bond to both bone and surgical metals, exhibit no chemical or thermal necrosis, and have no significant shrinkage or exotherm upon setting. Taking these properties into consideration, glass polyalkenoate cements (GPCs) have potential as bone cements. GPCs are formed by the reaction between an ion-leachable glass and an aqueous solution of polyacrylic acid (PAA) [1] and have proven antibacterial and cariostatic properties [2], which are related to their ability to release beneficial amounts of ions over time [3, 4]. The GPCs can be formulated to release ions that can have a therapeutic …
Gallium Containing Glass Polyalkenoate Bone Cements: Glass Characterization And Physical Properties, L. Placek, A. W. Wren, A. Coughlan, Mark R. Towler
Gallium Containing Glass Polyalkenoate Bone Cements: Glass Characterization And Physical Properties, L. Placek, A. W. Wren, A. Coughlan, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Gallium (Ga) glasses were developed to formulate a Glass Polyalkenoate Cement (GPC) series with both E9 and E11 polyacrylic acid (PAA) at 50, 55 and 60wt% additions. Working times (T w), setting times (T s), compression (σ c), and biaxial flexural (σ f) strength testing were evaluated to determine the GPCs potential use in orthopedics. © 2012 IEEE.
Using Student Ambassadors To Relay Themes From Changing The Conversation In Engineering First Year Seminars, Sarah Rzasa Zappe, Melissa Marshall, Enrique D. Gomez, Esther W. Gomez, Angela D. Lueking
Using Student Ambassadors To Relay Themes From Changing The Conversation In Engineering First Year Seminars, Sarah Rzasa Zappe, Melissa Marshall, Enrique D. Gomez, Esther W. Gomez, Angela D. Lueking
Chemical and Biochemical Engineering Faculty Research & Creative Works
This paper describes the efforts at a large mid-Atlantic university to integrate themes from Changing the Conversation into First Year Seminars. Changing the Conversation, a 2008 book by the National Academy of Engineering, found that both male and female students were more attracted to messages describing engineering in terms relating to societal impact, such as the phrases, "Engineering makes a world of difference" and "Engineering is essential to our health, happiness, and safety." Although the research was conducted with younger students, the potential for using these themes in the undergraduate curricula could have the potential to impact persistence in engineering, …
Scalable Synthesis Of Palladium Nanoparticle Catalysts By Atomic Layer Deposition, Xinhua Liang, Lauren B. Lyon, Ying Bing Jiang, Alan W. Weimer
Scalable Synthesis Of Palladium Nanoparticle Catalysts By Atomic Layer Deposition, Xinhua Liang, Lauren B. Lyon, Ying Bing Jiang, Alan W. Weimer
Chemical and Biochemical Engineering Faculty Research & Creative Works
Atomic layer deposition (ALD) was used to produce Pd/Al2O 3 catalysts using sequential exposures of Pd (II) hexafluoro acetylacetonate and formalin at 200 °C in a fluidized bed reactor. the ALD-prepared Pd/alumina catalysts were characterized by various methods including hydrogen chemisorption, XPS, and TEM, and compared with a commercially available 1 wt.% Pd/alumina catalyst, which was also characterized. the content of Pd on alumina support and the size of Pd nanoparticles can be controlled by the number of ALD-coating cycles and the dose time of the Pd precursor. One layer of organic component from the Pd precursor remained on the …
Silver Coated Bioactive Glass Particles For Wound Healing Applications, A. W. Wren, A. Coughlan, P. Hassanzadeh, Mark R. Towler
Silver Coated Bioactive Glass Particles For Wound Healing Applications, A. W. Wren, A. Coughlan, P. Hassanzadeh, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Bioactive glass particles (0.42SiO2-0.15CaO-0.23Na 2O-0.20ZnO) of varying size (<90 >μm and 425-850 μm) were synthesized and coated with silver (Ag) to produce Ag coated particles (PAg). These were compared against the uncoated analogous particles (Pcon.). Surface area analysis determined that Ag coating of the glass particles resulted in increased the surface area from 2.90 to 9.12 m2/g (90 μm) and 1.09-7.71 m2/g (425-850 μm). Scanning electron microscopy determined that the Ag coating remained at the surface and there was little diffusion through the bulk. Antibacterial (Escherichia coli - 13 mm and Staphylococcus epidermidis …
On The Measurement Of Gas Holdup Distribution Near The Region Of Impeller In A Gas-Liquid Stirred Rushton Tank By Means Of Γ-Ct, Li Na Kong, Wei Li, Lu Chang Han, Yue Jin Liu, He An Luo, Muthanna H. Al Dahhan, Milorad P. Dudukovic
On The Measurement Of Gas Holdup Distribution Near The Region Of Impeller In A Gas-Liquid Stirred Rushton Tank By Means Of Γ-Ct, Li Na Kong, Wei Li, Lu Chang Han, Yue Jin Liu, He An Luo, Muthanna H. Al Dahhan, Milorad P. Dudukovic
Chemical and Biochemical Engineering Faculty Research & Creative Works
Three Flow Patterns of Flooding, Loading and Complete Recirculation in a Gas-Liquid Stirred Rushton Tank Were Identified based on Experimental Observation. the Gas-Liquid System Was Composed of Air and Water. under Different Operating Conditions of Gas Flow Rate and Impeller Rotating Speed, the Distribution of Gas Holdup Near the Region of Impeller Was Measured using a Γ-CT Scan Method. Both Quantitative Digital Distribution Curves of Gas Holdup and their Qualitative Color CT Images Were Obtained. at the Region of Impeller, There Was a Convex Characteristic Peak of Gas Holdup Distribution Both in Radial and in Axial Directions, and with the …
Airlift Column Photobioreactors For Porphyridium Sp. Culturing: Part I. Effects Of Hydrodynamics And Reactor Geometry, Hu Ping Luo, Muthanna H. Al-Dahhan
Airlift Column Photobioreactors For Porphyridium Sp. Culturing: Part I. Effects Of Hydrodynamics And Reactor Geometry, Hu Ping Luo, Muthanna H. Al-Dahhan
Chemical and Biochemical Engineering Faculty Research & Creative Works
Photosynthetic Microorganisms Have Been Attracting World Attention for their Great Potential as Renewable Energy Sources in Recent Years. Cost Effective Production in Large Scale, However, remains a Major Challenge to overcome. It is Known to the Field that Turbulence Could Help Improving the Performance of Photobioreactors Due to the So-Called Flashing Light Effects. Better Understanding of the Multiphase Fluid Dynamics and the Irradiance Distribution Inside the Reactor that Cause the Flashing Light Effects, as Well as Quantifying their Impacts on the Reactor Performance, Thus, Are Crucial for Successful Design and Scale-Up of Photobioreactors. in This Study, a Species of Red …
Impact Of Internals On The Heat-Transfer Coefficient In A Bubble Column, Rahman S. Abdulmohsin, Muthanna H. Al-Dahhan
Impact Of Internals On The Heat-Transfer Coefficient In A Bubble Column, Rahman S. Abdulmohsin, Muthanna H. Al-Dahhan
Chemical and Biochemical Engineering Faculty Research & Creative Works
The Effect of Heat Exchanging Internals on the Heat-Transfer Coefficient Has Been Investigated in a 0.19 M Diameter Bubble Column. an Air-Water System Was Used with Superficial Gas Velocities Varying from 3 to 20 Cm/s, Which Cover Both the Bubbly and Churn-Turbulent Flow Regimes. Internals Occluding 0% (Empty Column), 5% (Simulating Methanol Synthesis), and 22% (Simulating Fischer-Tropsch Synthesis) of the Column Cross-Sectional Area Were Implemented. a Fast Response Heat-Transfer Probe Was Utilized to Measure the Radial Profile of the Heat-Transfer Coefficient in the Fully Developed Flow Region. the Results Indicate that the Presence of a High Percentage of Internals Causes …
Influence Of Solid-Phase Wall Boundary Condition On Cfd Simulation Of Spouted Beds, Xingying Lan, Chunming Xu, Jinsen Gao, Muthanna H. Al-Dahhan
Influence Of Solid-Phase Wall Boundary Condition On Cfd Simulation Of Spouted Beds, Xingying Lan, Chunming Xu, Jinsen Gao, Muthanna H. Al-Dahhan
Chemical and Biochemical Engineering Faculty Research & Creative Works
The Influence of Solid-Phase Wall Boundary Condition in Terms of Specularity Coefficient and Particle-Wall Restitution Coefficient on the Flow Behavior of Spouted Beds Was Investigated using Two-Fluid Model Approach in the Computational Fluid Dynamics Software FLUENT 6.3. Parametric Studies of Specularity Coefficient and Particle-Wall Restitution Coefficient Were Performed to Evaluate their Effects on the Flow Hydrodynamics in Terms of Fountain Height, Spout Diameter, Pressure Drop, Local Voidage and Particles Velocity. the Numerical Predictions Were Compared with Available Experimental Data in the Literatures to Obtain the Suitable Values of Specularity Coefficient and Particle-Wall Restitution Coefficient for Spouted Beds. the Simulated Results …
Heat Transfer Coefficients In Mimicked Fischer-Tropsch Slurry Bubble Columns, Chengtian Wu, Muthanna H. Al-Dahhan
Heat Transfer Coefficients In Mimicked Fischer-Tropsch Slurry Bubble Columns, Chengtian Wu, Muthanna H. Al-Dahhan
Chemical and Biochemical Engineering Faculty Research & Creative Works
To Provide More Support for Fischer-Tropsch (FT) Slurry Bubble Column Reactor Design, Scale-Up, and Performance, the Effects of Operating Conditions on the Heat Transfer Coefficients Were Investigated in a Mimicked FT Cold Flow System (Compressed Air:C 9-C 11:FT Catalyst Carrier). the Studied Operating Conditions Varied in Superficial Gas Velocity (Up to 0.3 M/s), Pressure (Up to 10 Bar), and Solids Concentration (Up to 25 Vol %). the Effects of These Variables on Heat Transfer Coefficients Are Discussed and Analyzed. the Increase in Pressure Tended to Reduce the Heat Transfer Coefficient, While the Increase in Solids Loading Enhanced the Heat Transfer …
Altering Iron Oxide Nanoparticle Surface Properties Induce Cortical Neuron Cytotoxicity, Christopher J. Rivet, Yuan Yuan, Diana Andra Borca-Tasciuc, Ryan J. Gilbert
Altering Iron Oxide Nanoparticle Surface Properties Induce Cortical Neuron Cytotoxicity, Christopher J. Rivet, Yuan Yuan, Diana Andra Borca-Tasciuc, Ryan J. Gilbert
Chemical and Biochemical Engineering Faculty Research & Creative Works
Superparamagnetic iron oxide nanoparticles, with diameters in the range of a few tens of nanometers, display the ability to cross the blood-brain barrier and are envisioned as diagnostic and therapeutic tools in neuro-medicine. However, despite the numerous applications being explored, insufficient information is available on their potential toxic effect on neurons. While iron oxide has been shown to pose a decreased risk of toxicity, surface functionalization, often employed for targeted delivery, can significantly alter the biological response. This aspect is addressed in the present study, which investigates the response of primary cortical neurons to iron oxide nanoparticles with coatings frequently …
Airlift Column Photobioreactors For Porphyridium Sp. Culturing: Part Ii. Verification Of Dynamic Growth Rate Model For Reactor Performance Evaluation, Hu Ping Luo, Muthanna H. Al-Dahhan
Airlift Column Photobioreactors For Porphyridium Sp. Culturing: Part Ii. Verification Of Dynamic Growth Rate Model For Reactor Performance Evaluation, Hu Ping Luo, Muthanna H. Al-Dahhan
Chemical and Biochemical Engineering Faculty Research & Creative Works
Dynamic Growth Rate Model Has Been Developed to Quantify the Impact of Hydrodynamics on the Growth of Photosynthetic Microorganisms and to Predict the Photobioreactor Performance. Rigorous Verification of Such Reactor Models, However, is Rare in the Literature. in This Part of Work, Verification of a Dynamic Growth Rate Model Developed in Luo and Al-Dahhan (2004) [Biotech Bioeng 85(4): 382-393.] Was Attempted using the Experimental Results Reported in Part I of This Work and Results from Literature. the Irradiance Distribution Inside the Studied Reactor Was Also Measured at Different Optical Densities and Successfully Correlated by the Lambert-Beer Law. When Reliable Hydrodynamic …
Comparison Of Microwave And Conventionally Sintered Yttria-Doped Zirconia Ceramics, Colin J. Reidy, Thomas J. Fleming, Stuart Hampshire, Mark R. Towler
Comparison Of Microwave And Conventionally Sintered Yttria-Doped Zirconia Ceramics, Colin J. Reidy, Thomas J. Fleming, Stuart Hampshire, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
This paper reports on improvement of the physical and mechanical properties of Y2O3-ZrO2 ceramics through compositional optimization, the use of nanograined powders and utilization of microwave sintering. ZrO2 with 2-5 mol% Y2O3, prepared from nanopowders, was sintered in both conventional and microwave furnaces under exactly the same heating schedule. It was found that microwave sintering improves physical and mechanical properties of Y2O3-ZrO2 ceramics compared with conventional sintering. Compositions containing 2 mol% Y2O3 exhibit the greatest improvement due to retention of tetragonal ZrO …
Γ-Ct Measurement And Cfd Simulation Of Cross Section Gas Holdup Distribution In A Gas-Liquid Stirred Standard Rushton Tank, Yue Jin Liu, Wei Li, Lu Chang Han, Yang Cao, He An Luo, Muthanna H. Al-Dahhan, M. P. Dudukovic
Γ-Ct Measurement And Cfd Simulation Of Cross Section Gas Holdup Distribution In A Gas-Liquid Stirred Standard Rushton Tank, Yue Jin Liu, Wei Li, Lu Chang Han, Yang Cao, He An Luo, Muthanna H. Al-Dahhan, M. P. Dudukovic
Chemical and Biochemical Engineering Faculty Research & Creative Works
Cross Section Gas Holdup Distributions at 3/4 Dimensionless Static Liquid Height in a Gas-Liquid Stirred Standard Rushton Tank Were Measured using 137Cs Γ-CT Scan Measuring Technology at Larger Gas Flow Rates and Higher Impeller Rotating Speeds. the Obtained CT Scan Images and Digital Distribution Curves of Gas Holdup with Dimensionless Radius based on the CT Images Could Explain the Fluctuation Changes of Gas Holdup Distribution. the Dense Area of Gas Holdup Distribution Appeared in the Upper Space of Impeller Blades. Gas Holdup Increased Both with Gas Flow Rate and Impeller Rotating Speed, But Gas Flow Rate Had More Influence on …
Robust Cns Regeneration After Complete Spinal Cord Transection Using Aligned Poly-L-Lactic Acid Microfibers, Andres Hurtado, Jared M. Cregg, Han B. Wang, Dane F. Wendell, Martin Oudega, Ryan J. Gilbert, John W. Mcdonald
Robust Cns Regeneration After Complete Spinal Cord Transection Using Aligned Poly-L-Lactic Acid Microfibers, Andres Hurtado, Jared M. Cregg, Han B. Wang, Dane F. Wendell, Martin Oudega, Ryan J. Gilbert, John W. Mcdonald
Chemical and Biochemical Engineering Faculty Research & Creative Works
Following spinal cord injury, axons fail to regenerate without exogenous intervention. In this study we report that aligned microfiber-based grafts foster robust regeneration of vascularized CNS tissue. Film, random, and aligned microfiber-based conduits were grafted into a 3 mm thoracic rat spinal cord gap created by complete transection. Over the course of 4 weeks, microtopography presented by aligned or random poly- l-lactic acid microfibers facilitated infiltration of host tissue, and the initial 3 mm gap was closed by endogenous cell populations. This bulk tissue response was composed of regenerating axons accompanied by morphologically aligned astrocytes. Aligned fibers promoted long distance …
Sol-Gel Derived Silver-Incorporated Titania Thin Films On Glass: Bactericidal And Photocatalytic Activity, Betul Akkopru Akgun, Anthony W. Wren, Caner Durucan, Mark R. Towler, Nathan P. Mellott
Sol-Gel Derived Silver-Incorporated Titania Thin Films On Glass: Bactericidal And Photocatalytic Activity, Betul Akkopru Akgun, Anthony W. Wren, Caner Durucan, Mark R. Towler, Nathan P. Mellott
Chemical and Biochemical Engineering Faculty Research & Creative Works
Titanium dioxide (TiO2) and silver-containing TiO2 (Ag-TiO2) thin films were prepared on silica pre-coated float glass substrates by a sol-gel spin coating method. The bactericidal activity of the films was determined against Staphylococcus epidermidis under natural and ultraviolet (UV) illumination by four complementary methods; (1) the disk diffusion assay, (2) UV-induced bactericidal test, (3) qualitative Ag ion release in bacteria inoculated agar media and (4) surface topographical examination by laserscan profilometry. Photocatalytic activity of the films was measured through the degradation of stearic acid under UV, solar and visible light conditions. The chemical state and …
Clinical Risk Factors For Osteoporosis In Ireland And The Uk: A Comparison Of Frax And Qfracturescores, N. M. Cummins, E. K. Poku, Mark R. Towler, O. M. O'Driscoll, S. H. Ralston
Clinical Risk Factors For Osteoporosis In Ireland And The Uk: A Comparison Of Frax And Qfracturescores, N. M. Cummins, E. K. Poku, Mark R. Towler, O. M. O'Driscoll, S. H. Ralston
Chemical and Biochemical Engineering Faculty Research & Creative Works
Recently two algorithms have become available to estimate the 10-year probability of fracture in patients suspected to have osteoporosis on the basis of clinical risk factors: the FRAX algorithm and QFractureScores algorithm (QFracture). The aim of this study was to compare the performance of these algorithms in a study of fracture patients and controls recruited from six centers in the United Kingdom and Ireland. A total of 246 postmenopausal women aged 50-85 years who had recently suffered a low-trauma fracture were enrolled and their characteristics were compared with 338 female controls who had never suffered a fracture. Femoral bone mineral …
Controlled Release Of 6-Aminonicotinamide From Aligned, Electrospun Fibers Alters Astrocyte Metabolism And Dorsal Root Ganglia Neurite Outgrowth, Nicholas J. Schaub, Ryan J. Gilbert
Controlled Release Of 6-Aminonicotinamide From Aligned, Electrospun Fibers Alters Astrocyte Metabolism And Dorsal Root Ganglia Neurite Outgrowth, Nicholas J. Schaub, Ryan J. Gilbert
Chemical and Biochemical Engineering Faculty Research & Creative Works
Following central nervous system (CNS) injury, activated astrocytes form a glial scar that inhibits the migration of axons ultimately leading to regeneration failure. Biomaterials developed for CNS repair can provide local delivery of therapeutics and/or guidance mechanisms to encourage cell migration into damaged regions of the brain or spinal cord. Electro spun fibers are a promising type of biomaterial for CNS injury since these fibers can direct cellular and axonal migration while slowly delivering therapy to the injury site. In this study, it was hypothesized that inclusion of an anti-metabolite, 6-aminonicotinamide (6AN), within poly-l-lactic acid electro spun fibers could attenuate …
An Argument For The Importance Of Material Property Characterization Of Hydrogels, J. M. Zuidema, R. J. Gilbert
An Argument For The Importance Of Material Property Characterization Of Hydrogels, J. M. Zuidema, R. J. Gilbert
Chemical and Biochemical Engineering Faculty Research & Creative Works
Hydrogels are being fabricated for use in many tissue engineering applications. In order to advance the field, material properties must be characterized to determine the most desirable attributes. The data presented shows the importance of both surface charge and mechanical properties on dorsal root ganglia neurite extension. © 2011 IEEE.
Aluminium-Free Glass Polyalkenoate Spinal Cements, A. W. Wren, N. M. Cummins, Mark R. Towler
Aluminium-Free Glass Polyalkenoate Spinal Cements, A. W. Wren, N. M. Cummins, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Addition of Yitanium increased the Wt & St and the sf strength of these cements compared to the control (BT 101). © 2011 IEEE.
Fabrication And Characterization Of A Hydrogel Containing Electrospun Fibers, C. J. Rivet, R. J. Gilbert
Fabrication And Characterization Of A Hydrogel Containing Electrospun Fibers, C. J. Rivet, R. J. Gilbert
Chemical and Biochemical Engineering Faculty Research & Creative Works
Electro spun an fibers hydrogels are two focal points of research within the biomaterial's community. The electrospinning process allows for fabrication of nanoscale, aligned topography and has been shown to direct cellular migration and outgrowth. Hydrogels exhibit benefits over traditional, rigid scaffolds in that they are injectable and can be tailored to mimic the mechanical properties of the surrounding tissue. Although both electro spun fibers and hydrogels display favorable characteristics for biomedical applications in vitro, there in vivo benefits are limited due to inherent deficiencies Therefore, to advance the field of biomaterials research, a composite material containing electro spun fibers …