Chemical Engineering Commons^™

Feasibility Of Liquid Carbon Sources For Algae Growth, Brady S. Jones

Chemical Engineering Undergraduate Honors Theses

This thesis explores the use of electrochemically produced aqueous bicarbonate as a novel liquid-phase carbon source for enhancing algal biomass productivity. Targeting the freshwater microalgae Chlorella Saccharophila, the study investigates its growth response to varying bicarbonate concentrations and compares the efficacy of liquid bicarbonate delivery with traditional gaseous CO₂ bubbling methods. Results demonstrate that Chlorella Saccharophila can sustain growth solely on bicarbonate, and that bicarbonate-fed cultures yielded higher biomass than those supplied with gaseous CO₂ or hybrid systems. These findings validate the potential of bicarbonate-based carbon delivery for scalable algae cultivation, offering key advantages such as gas-free operation, improved …

Evaluating Fly-Ash As A Sustainable Solution For Contaminant Removal From Wastewater, Calyn Wisdom

Chemical Engineering Undergraduate Honors Theses

Access to clean and safe water is an escalating global concern due to the persistent presence of toxic contaminants in aquatic environments. Among these, synthetic dyes and per- and polyfluoroalkyl substances (PFAS) represent two distinct yet significant classes of pollutants, both posing serious environmental and public health risks. Dyes in water contribute to intense coloration, elevated chemical and biological oxygen demand (COD and BOD), reduced light penetration, and disruption of aquatic ecosystems, with potential health risks to humans upon exposure. PFAS, often termed "forever chemicals," are synthetic organofluorine compounds associated with a range of adverse health effects, including endocrine disruption, …

The Augmentation Of A Solar Panel Lab For The Chemical Engineering Curriculum To Introduce Sustainability Principles, Lane A. Wilkins

Chemical Engineering Undergraduate Honors Theses

Photovoltaic solar cells are utilized in solar panels to convert sunlight into usable electricity. Since the energy derived from solar panels produces far less greenhouse gas than typical fuels such as coal and natural gas do, it is considered a clean source of energy and is vital to sustainability efforts. Sustainability is often defined by three pillars: environmental, social, and economical. Solar energy incorporates each of these pillars into its process, allowing it to be an effective tool to teach sustainability to students. A previously written lab that employs solar panels focused on the efficiency of converting light into electricity. …

Engaging Future Engineers: Utilizing Ai-Generated Video To Promote The Chemical Engineering Profession, Madeline G. Mondebello

Chemical Engineering Undergraduate Honors Theses

The expected incline of the chemical engineering profession faces a growing need to attract the next generation of prospective students. This research explores the use of artificial intelligence (AI) software to create an innovative form of media fit for secondary school and early college outreach. The pre- and post-video questionnaires were taken by a voluntary population comprised of high school students, college students, and parents. Overall, the feedback received was generally positive but indicated that the AI avatars and the lip-sync discrepancies may disrupt the video more than enhance it. In the future, a larger population will be surveyed to …

Measuring Selectivity Of Ion Exchange Resin For Use In Activated Wafer Electrodeionization, Hope M. Coffman

Chemical Engineering Undergraduate Honors Theses

Ion exchange resins are a type of ion exchange material used throughout industry. Their insolubility allows for the exchange of ions and an easy separation of the resin itself. They are used alone in industry, but they are also found in processes such as electrodialysis and electrodeionization. This research investigates the selectivity of chloride form ion exchange resin in the presence of solutions of lactate and formate ions. The work of this thesis is a part of a larger study investigating the conversion and separation of glucose into lactic acid via coupled electrocatalysis and electrodialysis. The results of this study …

Computationally Guided Liquid Crystal-Based Competitive Binding Sensing Platform For Optical Detection Of Spike Protein, Homa Ghaiedi, Shubham Pandey, Sophia Ezendu, Tibor Szilvasi, Karthik Nayani

Chemical Engineering Faculty Publications and Presentations

A liquid crystal (LC)-based sensing platform for the rapid optical detection of SARS-CoV-2 ' s spike protein's receptor binding domain (RBD) domain is introduced. This platform utilizes a thermotropic LC, hosted on metal-cation decorated substrates, onto which the spike protein can competitively bind. Density functional theory (DFT) calculations guide the experiments that reveal a homeotropic-to-planar transition in the LCs upon exposure to SARS-CoV-2 spike-decorated yeast, providing a basis for sensitive virus detection. The sensor's reversibility/specificity is confirmed through antibody-induced orientation recovery of the LCs initial orientation. Strikingly, the sensor can detect approximate to 2000 copies of the spike protein per …

Reweighting Configurations Generated By Transferable, Machine Learned Models For Protein Sidechain Backmapping, Jacob Monroe

Chemical Engineering Faculty Publications and Presentations

Multiscale modeling requires the linking of models at different levels of detail, with the goal of gaining accelerations from lower fidelity models while recovering fine details from higher resolution models. Communication across resolutions is particularly important in modeling soft matter, where tight couplings exist between molecular-level details and mesoscale structures. While multiscale modeling of biomolecules has become a critical component in exploring their structure and self-assembly, backmapping from coarse-grained to fine-grained, or atomistic, representations presents a challenge, despite recent advances through machine learning. A major hurdle, especially for strategies utilizing machine learning, is that backmappings can only approximately recover the …

Integrating Sustainability And Food Safety Through Quantitative Microbial Risk Assessment And Life Cycle Assessment Of Low-Moisture Foods, Jessica Bain

Graduate Theses and Dissertations

Food safety and sustainability are critical concerns in the food industry. However, these areas are often evaluated separately, leading to an incomplete understanding of the overall impact of food production on human health. This dissertation aims to integrate food safety with sustainability to provide a comprehensive assessment of the impact of low-moisture foods on human health, using the almond processing supply chain as a case study.

In addition to conducting life cycle assessments (LCA) of almond processing, wheat flour production, and dried apple processing, this dissertation aims to create a framework to bridge the gap between sustainability and food safety. …

Wind Tunnel Investigation Of The Along-Wind Dispersion In Finite-Duration Neutrally Buoyant Gas Releases, Daniel Williams

Graduate Theses and Dissertations

This thesis investigates the along-wind dispersion of hazardous gas releases within a turbulent boundary layer using controlled experiments in an ultra-low-speed wind tunnel, recognizing the limitations of numerical modeling and field tests. This study utilizes a neutrally buoyant gas mixture and dual Flame Ionization Detectors (FIDs) to capture representative, repeatable data on gas cloud behavior over finite durations. Ensemble averaging of 65 trials across varying release durations and downwind distances provided detailed insights into gas dispersion and the distinct time phases within finite-duration releases. Analysis revealed that along-wind dispersion coefficients depend on turbulence and vertical wind shear, with normalized coefficients …

Liquid Crystalline Collagen Assemblies As Substrates For Directed Alignment Of Human Schwann Cells, Homa Ghaiedi, Luis Carlos Pinzon-Herrera, Saja Alshafeay, Leonard Harris, Jorge Almodovar, Karthik Nayani

Chemical Engineering Faculty Publications and Presentations

Collagen is a key component of the extracellular matrix (ECM) and well-oriented domains of collagen are important for mimicking the local cell environment in vitro. While there has been significant attention directed towards the alignment of collagen, formation of large-scale oriented domains remains a key challenge. Type I collagen self-assembles to form liquid crystalline (LC) mesophases in acidic conditions at concentrations above 100 mg mL−1. The LC mesophase provides an efficient platform for large-scale alignment and patterning of collagen coated substrates. However, there still exist challenges related to solubilizing and processing of collagen at such high concentrations in order …

Investigating The Detection And Transport Of Low Molecular Weight Species To Better Understand Their Impact On Disease Pathology And Treatment, Haley Michelle Duncan

Graduate Theses and Dissertations

Due to the drastic differences in the projects involved, this dissertation will be split into two sections: Alzheimer’s disease and chronic kidney disease. Each chapter will contain an introduction, materials and methods section, results and discussion, conclusions, and works cited section. The Alzheimer’s disease chapter will also have a supplemental figures section containing the polyacrylamide gels that were silver stained and quantified via ImageJ. The presence of elevated levels of amyloid beta oligomeric species in the brain has been related to the pathology of Alzheimer’s disease. As these oligomeric species are transient in nature, their kinetics pose a challenge to …

Impact Of Non-Thermal Plasma Generated Using Air And Nitrogen On Functional Properties Of Milk Protein Dispersions, Nikitha Modupalli, Md Mahfuzur Rahman

Food Science Faculty Publications and Presentations

This study focuses on improving the functionalities of milk protein concentrate (MPC) using a nonthermal plasma jet and plasma-activated water (PAW) with atmospheric air and nitrogen as source gases. The 5% and 10% MPC dispersions were directly treated with a plasma jet, and PAW was used to make the MPC dispersions. The dispersions were analyzed for changes in protein structure and functional properties. The treatment altered the secondary structure of MPC protein structure by increasing β-components and changing the order of random coils. The solubility of the PAW-treated 5% protein dispersions doubled due to plasma-induced modification of hydrophilic and covalent …

Carbon-Based Nanocomposite Membranes For Membrane Distillation: Progress, Problems And Future Prospects, Chhabilal Regmi, Yuwaraj K. Kshetri, S. Ranil Wickramasinghe

Chemical Engineering Faculty Publications and Presentations

The development of an ideal membrane for membrane distillation (MD) is of the utmost importance. Enhancing the efficiency of MD by adding nanoparticles to or onto a membrane’s surface has drawn considerable attention from the scientific community. It is crucial to thoroughly examine state-of-the-art nanomaterials-enabled MD membranes with desirable properties, as they greatly enhance the efficiency and reliability of the MD process. This, in turn, opens up opportunities for achieving a sustainable water–energy–environment nexus. By introducing carbon-based nanomaterials into the membrane’s structure, the membrane gains excellent separation abilities, resistance to various feed waters, and a longer lifespan. Additionally, the use …

Computational Predictions Of Heart Failure Drug Effects On Cardiac Fibrosis, Aaron Gardner

Chemical Engineering Undergraduate Honors Theses

The extracellular matrix is a complex system surrounding cells that is crucial to all of the cardiovascular system’s functions. Fibrosis is an excessive accumulation (scarring) of the extracellular matrix. Fibrosis is typically a negative event, and the scarring must be reduced in the heart in order to maintain its functionality. Due to this, simulations are run using the software “Netflux” in order to determine the effects of different heart failure drugs on cardiac fibrosis. The drugs that were simulated were an ACE Inhibitor, BAR Beta Blocker, ARB Blocker, and Entresto. These drugs were simulated over 50 hours at three different …

Optimization Of Collagen And Cell Concentrations For Engineered Tissues, Avery Fiser

Chemical Engineering Undergraduate Honors Theses

Improvements regarding the drug discovery process are necessary due to less than 1% of drugs making it from the initial discovery phase to patient treatment in clinics. One method of enhancing this process involves improving the relevance and dependability of in vitro testbeds utilized during pre-clinical testing. Improvement along these factors can provide a more relevant view for eventual drug behavior in patients. This additional relevance can allow for a reduced timeline in drug development for improving patient care. A consistent and morphologically sound baseline engineered tissue is vital to the creation of successful experimental models. Parameters such as cell …

Integrating Galectin-3 Into A Computational Model Of Cardiac Fibrosis Progression, Adam Pieratt

Chemical Engineering Undergraduate Honors Theses

Cardiac fibrosis, a large contributor to heart failure, is the excessive accumulation of extracellular matrix in response to stress or injury. There are no approved treatments for cardiac fibrosis, and targeting specific species involved creates complex problems for drug development, so a computational model of the cardiac fibroblast signaling network can be used to observe the interactions involved in the progression of cardiac fibrosis. In this paper, a new protein called galectin-3 is integrated into this existing model, and connections are established to expand the coverage of the network. The additions are described, simulated using Netflux biological system simulation software, …

Modeling Sex-Specific Changes In Myocardial Fibrosis, Grace Martin

Chemical Engineering Undergraduate Honors Theses

Heart disease the leading cause of death for both men and women in the United States. Cardiac fibrosis, or accumulation of extracellular matrix proteins in the heart, can occur after a heart attack and increase the risk for further complications. Current treatments for heart disease do not include extracellular matrix regulators, partly due to the complicated signaling network responsible for the production of these proteins. By using a computational model of the signaling network in cardia fibroblasts, the relationship between particular molecules and downstream extracellular matrix production can be examined.

Biological sex is an important factor for cardiac health and …

Biomass Derived Lignin Polymer Modification For Sustainable Chemical Engineering Applications, Samantha Glidewell, Keisha Walters

Chemical Engineering Undergraduate Honors Theses

Lignin is an abundant naturally occurring plant-based polymer that is branched, highly unsaturated, and rich in aliphatic and aromatic hydroxyl groups. Lignin is a significant byproduct of the wood pulp and paper industries; however, it has yet to be widely utilized in commercial applications due to its non-linear structure, broad range of molecular weights, hydrophobicity, high rigidity, and brittleness. Recent investigations into modifying lignin to broaden its potential uses have shown promising results. This thesis explores different modification techniques of the naturally occurring hardwood lignin polymer for specific applications in areas of water treatment and polyurethane (PU) production. The first …

Yeast Surface Display Of Multiple Heterologous Proteins Via Molecular And Biochemical Processing Techniques, Shadrach Ibinola

Graduate Theses and Dissertations

The arming of yeast cell wall, also known as yeast surface display, is an effective technology for expressing target proteins extracellularly. It has been shown to provide bioengineered yeast with qualities that are not known to native yeast such as the ability to survive harsh conditions including high pH and temperature, for example. Furthermore, this technique has been implemented for various applications which include, protein engineering, bioethanol production, bioremediation, vaccine construction, and antibody development. The major mechanisms of yeast surface display exploit agglutination, flocculation, or proteins with internal repeats as the means by which a target (protein) is covalently attached …

Developing Anisotropic Soft Matter As Functional Materials To Interface With Biological Systems, Homa Ghaiedi

Graduate Theses and Dissertations

Liquid crystals (LCs) constitute a subset of soft matter possessing hybrid characteristics from both liquid and crystalline phases. In this state, the center of masses remains uncorrelated similar to an isotropic phase, while the long axis of molecules aligns in parallel, resulting in molecules exhibiting orientational and positional order, either individually or concurrently. The directional alignment inherent in LCs arises from the asymmetrical shape and structure of the constituent molecules, causing a spontaneous self-assembly into ordered phases. This cooperative molecular behavior manifests distinctive optical features when subjected to cross polarizers. The remarkable sensitivity of LCs to external stimuli, including temperature, …

Ltspice Modeling For Gan-Git Hemt Including Cryogenic Temperature, Md Maksudul Hossain, Yuqi Wei, H. Alan Mantooth

Electrical Engineering Faculty Publications and Presentations

Highly efficient electrically driven avionics have led to a renewed interest in cryogenic propulsion systems with the goal of reducing carbon emission footprint. Although cryogenic converters promise better efficiency and improved power density, the successful design is incumbent upon the appropriate switching device selection and simulation-based analyses prior to initial prototyping. In this work, a datasheet-driven compact model for a gallium nitride (GaN) Gate Injection Transistor (GIT) has been proposed and implemented in LTspice, a versatile, high performance, and free circuit simulator in order to investigate the merit of the chosen device in a power electronic system.

Gan Hemt And Air Core Magnetics Based Power Converters Evaluations At Cryogenic Temperature, Yuqi Wei, Md Maksudul Hossain, H. Alan Mantooth

Electrical Engineering Faculty Publications and Presentations

Cryogenic power electronics is both advantageous and indispensable in many applications, like deep space probe, military electric vehicle, magnetic resonance imaging etc. Among different semiconductors, the gallium nitride (GaN) high electron mobility transistor (HEMT) is the most promising candidate for cryogenic applications with significant conduction loss and switching loss reductions. Moreover, there is no carrier freeze out effect for the GaN HEMTs, which is applicable in extreme low temperature operating conditions. In this work, the efficiency of GaN HEMTs based power converters with different power levels (from several Watts to several kiloWatts) are evaluated at cryogenic temperature. Three different commercial …

Recovery Of Ionic Liquid From The Model Solution Mixture Mimicking The Catalytically Hydrolyzed Cellulose Product Utilizing Amberlyst Ion-Exchange Resin, Chhabilal Regmi, Chidambaram Thamariselvan, Zhexi Zhu, Xianghong Qian, S. Ranil Wickramasinghe

Chemical Engineering Faculty Publications and Presentations

The hydrolysis of cellulose using ionic liquid (IL) has been extensively studied but there is limited understanding of the removal of IL from the biomass hydrolysate. Finding a suitable method for the recovery and reuse of IL is one of the biggest challenges before its large-scale application. Selecting an appropriate combined recovery process is very important. This study proposed a facile ion-exchange combined method for the recovery of IL from the modeled cellulose hydrolysate mixture containing sugars as well as γ-valerolactone (GVL) via an adsorption–desorption mechanism using sulfonic acid cation-exchange (Amberlyst 15 (H)) resin. The results showed that the resin …

Enhancing Rubber (Hevea Brasiliensis) Seed Shell Biochar Through Acid-Base Modification For Effective Phenol Removal From Aqueous Environments, Oyinlola R. Obanla, Jamie A. Hestekin, Modupe E. Ojewumi, Imen Bousrih, Modupeoluwa C. Fawole

Chemical Engineering Faculty Publications and Presentations

This work encompasses using acid-base modified rubber seed shell biochar (RSSB) as an adsorption approach to eradicate phenol from aqueous mediums. Potassium hydroxide (KOH) was used pre-pyrolysis to modify the RSS, and hydrochloric acid (HCl) was used post-pyrolysis to modify the RSSB. The methodology was divided into three stages: RSS pretreatment, RSS base-modification and pyrolysis, and RSSB acid-modification and processing. Temperature, pH and several other factors were investigated for their impacts on the adsorbent, and optimal conditions were established at pH 6, 1.0 g of rubber seed shell biochar (RSSB), 50 mg/L initial concentration, 120 min contact time, and 30°C …

Development Of Lignin-Based Copolymers And Polymer Blends, David Chem

Graduate Theses and Dissertations

Increasing industrial interest in reducing fossil fuels in virgin polymer production and incorporating bio-based polymeric materials has led researchers to explore the potential of utilizing plant-based polymers such as lignin. Chapter 1 of this thesis presents a comprehensive overview of copolymerization and blending techniques for lignin and synthetic polymers, emphasizing different types of modifications and copolymerization techniques as well as key parameters such as temperature, reaction time, pH level, and solution compositions. These valorization methods are directed towards the development of high-value lignin-based materials with properties well-suited for various commercial applications. Chapter 2 offers a fundamental exploration into the amination …

Innovative Approaches To Poultry Processing Wastewater Treatment: The Stainless Steel Ultrafiltration Membrane As A Viable Option, Saubana Olorunrola Dada, Chidambaram Thamariselvan, Mahmood Jebur, Sumith Ranil Wickramasinghe

Chemical Engineering Faculty Publications and Presentations

In pursuit of sustainability, we explored replacing conventional dissolved air floatation (DAF) in poultry processing wastewater (PPW) treatment with a precisely tuned 0.02 µm stainless-steel ultrafiltration (SSUF) membrane. SSUF is a robust, homogenously porous membrane with strong chemical resistance, ease of cleaning, and exceptional resistance to organic fouling. Unlike polymeric membranes, it can be regenerated multiple times, making it a cost-effective choice due to its compatibility with harsh chemical cleaning. The PPW used for the study was untreated wastewater from all processing units and post-initial screening. Our study revealed the SSUF membrane’s exceptional efficiency at eliminating contaminants. It achieved an …

Influence Of Metal-Coordinating Comonomers On The Coordination Structure And Binding In Magnetic Poly(Ionic Liquid)S, Kayla Foley, Lucas Condes, Keisha B. Walters

Chemical Engineering Faculty Publications and Presentations

A poly(ionic liquid) (PIL), poly(acrylamide-co-diallyl dimethylammonium chloride), was systematically complexed with Co²⁺, Fe³⁺, and Co²⁺/Fe³⁺ (mixed) at different molar equivalencies to form a series of magnetic PILs (MPILs). These novel MPILs were utilized to examine molecular structure and binding between the polymer and metal species using comprehensive spectroscopic studies in both dry and liquid states. FTIR, X-ray photoelectron, UV-vis, and Raman spectroscopies showed evidence of metal coordination of both the iron and cobalt chloride species with the acrylamide comonomer. Using AC susceptibility measurements, the MPILs were found to have magnetic properties …

Solution And Film Self-Assembly Behavior Of A Block Copolymer Composed Of A Poly(Ionic Liquid) And A Stimuli-Responsive Weak Polyelectrolyte, Kayla Foley, Keisha B. Walters

Chemical Engineering Faculty Publications and Presentations

Cu(0)-mediated atom transfer radical polymerization was used to synthesize a poly(ionic liquid), poly[4-vinylbenzyl-3-butylimidazolium bis(trifluoromethylsulfonyl)imide] (PVBBImTf₂N), a stimuli-responsive polyelectrolyte, poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA), and a novel block copolymer formed from these two polymers. The synthesis of the block copolymer, poly[2-(dimethylamino) ethyl methacrylate]-block-[poly(4-vinylbenzyl-3-butylimidazolium bis(trifluoromethylsulfonyl)imide] (PDMAEMA-b-PVBBImTf₂N), was examined to evaluate the control of “livingness” polymerization, as indicated by molecular weight, characterizations of degree of polymerization, and ¹HNMR spectroscopy. 2D DOSY NMR measurements revealed the successful formation of block copolymer and the connection between the two polymer blocks. PDMAEMA-b-PVBBImTf₂N was further characterized …

Wind Tunnel Modeling Of The Jack Rabbit Ii Mock Urban Environment Chlorine Releases Based On Comparison With Field Scale Video Record, Samuel Gallimore

Graduate Theses and Dissertations

Unintentional releases of hazardous gases have led to significant injuries and fatalities in severe cases. Field tests can be used to release hazardous gases to document and evaluate the behavior of the gases. Chlorine is an especially hazardous gas due to its toxicity. The Jack Rabbit II Phase I field tests released chlorine within a mock urban environment (MUE) consisting of Conex containers arranged in rows to simulate buildings and streets. The number of field tests is limited by both expense and time. Simulation of a field test using a wind tunnel model can provide additional data and opportunity for …

Investigation Of The Flow Field In The Jack Rabbit Ii Mock Urban Environment Field Tests Using A 1:50 Scale Wind Tunnel Model, Paulo Victor De Freitas Lopes

Graduate Theses and Dissertations

Accidental release of toxic chemicals can put workers and nearby populations at significant risk. Consequence assessment of accidents in urban environments is of particular interest. Urban geometries create wind channels between buildings, along with particularly dangerous areas downwind of buildings, where near-stagnant flow is present. Furthermore, recirculation zones can be formed between buildings, trapping high concentrations of toxic gases at ground level, particularly for denser-than-air gases. In 2015, the Department of Homeland Security conducted the Jack Rabbit II Field Test (JR-II) at Dugway Proving Ground, UT. During JR-II, chlorine was released at the center of a Mock Urban Environment (MUE) …