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Systems and Integrative Engineering Commons™
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Articles 1 - 9 of 9
Full-Text Articles in Systems and Integrative Engineering
Comparative Assessment Of Lower Limb Neuromusculoskeletal Activation And Joint Kinematics In Normal And Impaired Gait, Jack Ryan Schule
Comparative Assessment Of Lower Limb Neuromusculoskeletal Activation And Joint Kinematics In Normal And Impaired Gait, Jack Ryan Schule
Theses and Dissertations
This thesis evaluates whether accessible and affordable technologies can provide clinically significant, quantifiable gait analysis comparable to traditional marker-based motion capture systems. Modern high-end systems offer excellent accuracy but remain financially and logistically inaccessible to many clinicians and researchers. To address this gap, a framework was developed using markerless pose estimation using the model, MediaPipe, inertial measurement units (IMUs) processed through an Extended Kalman Filter (EKF), and surface electromyography (sEMG) to measure joint kinematics and neuromuscular activity during gait. An experiment was performed where data was collected from participants with both normal gait and pathologies including: Osgood–Schlatter disease, Plica Band …
Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb
Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb
Theses and Dissertations
Implantable drug delivery devices have many benefits over traditional drug administration techniques and have attracted a lot of attention in recent years. By delivering the medication directly to the tissue, they enable the use of larger localized concentrations, enhancing the efficacy of the treatment. Passive-release drug delivery systems, one of the various ways to provide medication, are great inventions. However, they cannot dispense the medication on demand since they are nonprogrammable. Therefore, active actuators are more advantageous in delivery applications. Smart material actuators, however, have greatly increased in popularity for manufacturing wearable and implantable micropumps due to their high energy …
Design, Development, And Validation Of A Perfusion-Compression Bioreactor To Study Osteogenesis In Bone Explants, Alexis Victoria Graham
Design, Development, And Validation Of A Perfusion-Compression Bioreactor To Study Osteogenesis In Bone Explants, Alexis Victoria Graham
Theses and Dissertations
The current gold standard treatment for bone defects is autologous cancellous bone graft, which involves increased surgery time and donor site morbidity, and limited supply of bone and cells for regeneration. Bioreactors may aid in the generation of mechanically conditioned bone grafts with more cells compared to traditional grafts. However, the specific parameters of fluid flow and mechanical loading which contribute to osteogenesis and cell viability in bioreactors are not fully characterized. Here, a perfusion-compression bioreactor system was developed to study osteogenesis in porcine trabecular bone explants. Loading accuracy was over 88% across six bioreactors at a 0.1 s-1 strain …
An Epileptic Seizure Detection Method From Eeg Signals Based On A Classifier-Driven Feature Reduction Technique, Raymond N. Kamel
An Epileptic Seizure Detection Method From Eeg Signals Based On A Classifier-Driven Feature Reduction Technique, Raymond N. Kamel
Theses and Dissertations
Epileptic seizure detection can improve the quality of life of epileptic patients, allow for more accurate medication, and minimize the risk of sudden unexpected death in epilepsy (SUDEP). This thesis work aims to develop a robust and stable algorithm for epileptic seizure detection through the classification of EEG signals. To achieve this aim, a methodology is proposed to develop a classifier that can differentiate between the healthy (normal), interictal, and ictal states of EEG signals, while maximizing the classification accuracy and minimizing the computational redundancy. The main pillar upon which this methodology is designed is using a problem-specific classifier-driven feature …
Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence
Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence
Theses and Dissertations
Combining vibrating mesh nebulizers with additional new technologies leads to substantial improvements in pharmaceutical aerosol delivery to the lungs across therapeutic administration methods. In this dissertation, streamlined components, aerosol administration synchronization, and/or Excipient Enhanced Growth (EEG) technologies were utilized to develop and test several novel devices and aerosol delivery systems. The first focus of this work was to improve the poor delivery efficiency, e.g., 3.6% of nominal dose (Dugernier et al. 2017), of aerosolized medication administration to adult human subjects concurrent with high flow nasal cannula (HFNC) therapy, a form of continuous-flow non-invasive ventilation (NIV). The developed Low-Volume Mixer-Heater (LVMH) …
Design And Testing Of An Agonist-Antagonist Position-Impedance Controlled Myoelectric Prosthesis, Christopher Aymonin
Design And Testing Of An Agonist-Antagonist Position-Impedance Controlled Myoelectric Prosthesis, Christopher Aymonin
Theses and Dissertations
Intuitive prosthetic control is limited by the inability to easily convey intention and perceive physical requirements of the task. Rather than providing haptic feedback and allowing users to consciously control every component of manipulation, relegating some aspects of control to the device may simplify operation. This study focuses on the development and testing of a control scheme able to identify object stiffness and regulate impedance. The system includes an algorithm to detect the apparent stiffness of an object, a proportional nonlinear EMG control algorithm for interpreting a user’s desired grasp aperture, and an antagonistically acting impedance controller. Performance of a …
Computer Based Behavioral Biometric Authentication Via Multi-Modal Fusion, Kyle O. Bailey
Computer Based Behavioral Biometric Authentication Via Multi-Modal Fusion, Kyle O. Bailey
Theses and Dissertations
Biometric computer authentication has an advantage over password and access card authentication in that it is based on something you are, which is not easily copied or stolen. One way of performing biometric computer authentication is to use behavioral tendencies associated with how a user interacts with the computer. However, behavioral biometric authentication accuracy rates are much larger then more traditional authentication methods. This thesis presents a behavioral biometric system that fuses user data from keyboard, mouse, and Graphical User Interface (GUI) interactions. Combining the modalities results in a more accurate authentication decision based on a broader view of the …
The Prediction Of Pilot Opinion Ratings Using Optimal And Sub-Optimal Pilot Models, Craig R. Edkins
The Prediction Of Pilot Opinion Ratings Using Optimal And Sub-Optimal Pilot Models, Craig R. Edkins
Theses and Dissertations
This study details the development of a sub-optimal pilot model that blended the classical and optimal pilot model approaches in an attempt to achieve the advantages of each. This model used a numerical solution to the linear quadratic Gaussian problem to find the pilot gain, lead, and lag values that minimized a performance index consisting of task error and control usage. This development was conducted in four phases. First, an optimal pilot model developed by Systems Technology, Incorporated, was analyzed in detail. This analysis included a step-by-step example problem to clarify the model's logic and an in-depth sensitivity analysis of …
Enhancement Of Audio Localization Cue Synthesis By Adding Environmental And Visual Cues, Eric L. Scarborough
Enhancement Of Audio Localization Cue Synthesis By Adding Environmental And Visual Cues, Eric L. Scarborough
Theses and Dissertations
An audio localization cue synthesizer, the DIRectional Audio Display (DIRAD) was used to simulate auditory distance, room reflections, and to provide spatial audio for computer graphics images. The DIRAD processes input audio signals to generate spatially located sounds for headphone listening. The DIRAD can position audio sources around the head and these sounds are stable with respect to the listener's head position. An interactive, real-time simulation of auditory distance and room reflections was accomplished using the DIRAD in combination with a Silicon Graphics audio processor board installed in a Personal Iris 4D/35. Several demonstrations of auditory distance and the effects …