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Articles 31 - 39 of 39
Full-Text Articles in Other Biomedical Engineering and Bioengineering
How Imbalanced Excitation And Inhibition May Cause Low Entropy Brain Dynamics, Qusay Redwan Alfaori
How Imbalanced Excitation And Inhibition May Cause Low Entropy Brain Dynamics, Qusay Redwan Alfaori
Biomedical Engineering Undergraduate Honors Theses
To study the effect of the imbalance of excitation and inhibition neurons on brain entropy using a computer model of a brain. The brain model will be composed of a neural network and entropy of the neural network will be measured quantitatively. Entropy in this context quantifies how many different patterns of activated neurons the brain can create. Imbalance between excitation and inhibition neurons causes the brain to malfunction, which can be an underlying cause of autism.
5ht And The 5ht Receptors- Relevance To Cardiac Valve Disease, Christopher Ryan Martindale
5ht And The 5ht Receptors- Relevance To Cardiac Valve Disease, Christopher Ryan Martindale
Biomedical Engineering Undergraduate Honors Theses
Recent studies have revealed that elevated levels of serotonin or 5HT lead to valve dysfunction. A mouse model was successfully established to investigate the effects on the aortic valve in subjects with elevated 5HT levels along with cardiovascular hypertension. For each two-week trial, eight C57BL/6J mice were divided into the following expermental groups: control, 5HT, angiotensin II, and 5HT+angiotensin II. The drug was delivered to the mice via osmotic pumps (Ang II: 0.4ng/g/min, 5HT:0.0025ng/g/min) or direct injections(Ang II: 0.1 mg, 5HT: 2.12 mg, every other day) and the blood pressure of the mice was continually monitored via the CODA tail …
Modeling Of An Oxygenation-Aided 3d Culture For Functional Beta-Cell Expansion, John Lance Mcreynolds
Modeling Of An Oxygenation-Aided 3d Culture For Functional Beta-Cell Expansion, John Lance Mcreynolds
Biomedical Engineering Undergraduate Honors Theses
Introduction: Diabetes affects millions of people and its prevalence is increasing by 2-5% per year. A promising method for the control of diabetes is the transplant of pancreatic β-cell mass. Unfortunately, there is a shortage of the donor tissue that is needed to replace β-cell mass. A potential source of β-cells is the production of β-cells in vitro, but the proliferation rate of β-cells is very slow and elevating the proliferation rate can result in loss of cell function. We observed that β-cells benefit from being cultured in a 3D environment, but in the 3D culture the β-cells often die …
Beginning Of Malignant Tumor Cells, Emily K. Shields
Beginning Of Malignant Tumor Cells, Emily K. Shields
Biomedical Engineering Undergraduate Honors Theses
Despite advances in cancer treatments, cancer is still ranked the second leading cause of death. Cancers are started by cancer stem cells (CSCs). CSCs, also called tumor-initiating cells, are found in tumors and are responsible for the growth of tumors and the spread of cancer to other parts of the body. CSCs are very resistant, and cannot be killed by chemotherapy or radiation treatments. These cells can come from healthy stem cells. The environment surrounding the healthy stem cells and mature cells can cause mutations in the cell’s genetics, resulting in development of CSCs. The environment can also increase tumor …
In Vivo Efficacy Of Chitosan/Interleukin-12 In Controlling Lung Metastasis In 4t1 Breast Cancer Model, Jimmy Vo
Biomedical Engineering Undergraduate Honors Theses
Cancer immunotherapy has emerged as a leading front in cancer treatment. In contrast to other treatment methods such as radiation and surgery, immunotherapy trains the patient's body to recognize and eliminate tumors, thus preventing reoccurrence of secondary tumors. IL-12 has been shown to display a potent anti-tumor immune response in mice; however, when clinical trials were conducted, it was shown to be toxic and in some cases fatal when administered systemically.1,2 Because of this, local delivery of IL-12 is under investigation. Our lab has shown that when paired with the polymer chitosan, local, intratumoral (i.t.) injections of IL-12 are retained …
Highly Sensitive Method For Detecting And Separating Pathogens Using Paramagnetic Particles And A Micro-Fluidic System, William Ryan
Highly Sensitive Method For Detecting And Separating Pathogens Using Paramagnetic Particles And A Micro-Fluidic System, William Ryan
Biomedical Engineering Undergraduate Honors Theses
Water is one of the most important compounds on Earth. If a water supply is contaminated with a pathogen, it can have devastating results to an individual or a community. This research is directed at constructing an easily reproducible procedure that could increase the sensitivity of detecting and separating bacteria from the current limits of about 100 cells to 10-20 cells per sample with a ultimate goal of a single cell detection. Here, we report a micro-fluidic system to magnetically capture pathogenic bacteria in water followed by rapid impedance detection using Escherichia coli K-12 as a model bacterium. Paramagnetic beads …
Comparing Decellularized Muscle Tissue With An Engineered Muscle Biomaterial, Katelin Cherry
Comparing Decellularized Muscle Tissue With An Engineered Muscle Biomaterial, Katelin Cherry
Biomedical Engineering Undergraduate Honors Theses
Decellularized tissues composed of extracellular matrix are commonly used for tissue transplantations but this method has many limitations. An alternative approach is to create an extracellular matrix by seeding degradable foams with cells, culturing these foams to allow extracellular matrix to be secreted from the cells, then washing away the degradable foam to collect the material that is produced. This study was interested in comparing decellularized skeletal muscle tissue to an engineered biomaterial that was seeded with skeletal muscle myoblast cells. Collagen content of decellularized tissue and engineered biomaterial were quantified using a hydroxyproline assay to compare the two samples. …
Rapid Detection And Quantification Of Mycobacterium Tuberculosis Using Single-Based Extension And Capillary Electrophoresis, Anh Vu
Biomedical Engineering Undergraduate Honors Theses
In 1993, the World Health Organization (WHO) has declared tuberculosis (TB) a global emergency. Since then, more than 30 million lives have been claimed by that world-wide epidemic. In 2011, 8.7 million people “felt ill†because of TB and not all TB cases were reported to clinicians. Therefore, it is important to accurately identify TB patients by developing a diagnostic method that is sensitive, fast, and cost-effective. However, conventional methods have not met those criteria because they either require lengthy procedures or may misdiagnose TB cases. Hence, the automated Xpert MTB/RIF, endorsed by WHO in 2010, was developed and so …
Glucose Biosensor Using Electrospun Mn2o3-Ag Nanofibers, Shan Huang
Glucose Biosensor Using Electrospun Mn2o3-Ag Nanofibers, Shan Huang
Master's Theses
The highly porous Mn2O3-Ag nanofibers were fabricated by a facile two-step procedure (electrospinning and calcination) and then employed as the immobilization matrix for glucose oxidase (GOD) to construct an amperometric glucose biosensor. A notable enhancement of direct electron transfer between GOD and the electrode is observed at the Mn2O3-Ag-GOD modified electrode with a fast electron transfer rate constant. The biosensor also shows fast response to glucose, high sensitivity (40.60 μA×mM-1×cm-2), low detection limit (1.73 µM at S/N=3), low Km,app value and excellent selectivity. These results indicate that …