Biomechanics and Biotransport Commons^™

Personal Navigation Via High-Resolution Gait-Corrected Inertial Measurement Units, Özkan Bebek, Michael A. Suster, Srihari Rajgopal, Michael J. Fu, Xuemei Huang, M. Cenk Çavu¸So˘Glu,, Darrin J. Young, Mehran Mehregany, Antonie J. Van Den Bogert, Carlos H. Mastrangelo

Mechanical Engineering Faculty Publications

In this paper, a personal micronavigation system that uses high-resolution gait-corrected inertial measurement units is presented. The goal of this paper is to develop a navigation system that uses secondary inertial variables, such as velocity, to enable long-term precise navigation in the absence of Global Positioning System (GPS) and beacon signals. In this scheme, measured zerovelocity duration from the ground reaction sensors is used to reset the accumulated integration errors from accelerometers and gyroscopes in position calculation. With the described system, an average position error of 4 m is achieved at the end of half-hour walks.

Rapid Cell Extraction In Aqueous Two-Phase Microdroplet Systems, Kalpana Vijayakumar, Shelly Gulati, Andrew J. De Mello, Joshua B. Edel

All Faculty Articles - School of Engineering and Computer Science

Distinguishing specific cells is an essential technique in cell research and clinical diagnostics. We report a novel method to passively isolate and extract cells in a microfluidic device. We utilise a droplet-based microfluidic system to generate an aqueous two phase system in which aqueous droplets consist of two phases in the form of a double emulsion. Specifically, we generate PEG droplets that completely encapsulate DEX droplets within a microfluidic channel. Target cells can be introduced directly into the droplets and driven to partition to the more favourable phase, whilst still being contained within the aqueous droplet. Human T lymphoma cells, …

3d Micro-Mr And Micro-Ct Models For Determining In-Vivo Function In The Guinea Pig Knee Model Of Osteoarthritis (Oa), Kristoffer W. Dean

Undergraduate Research Opportunities Program (UROP)

Osteoarthritis (OA) is a debilitating disease that affects an estimated 27 million adults in the United States. OA causes damage to cartilage in the joints resulting in bones that rub together. This creates pain, swelling, loss of motion of the joint, and bone spurs. As the number of adults above 65 grows (an estimated 72 million people by 2030) even more people will be at high risk for OA. It is the most common type of arthritis by far yet very little is known about it including relationships between joint structure and function. In 2004, the NIH created the Osteoarthritis …

Integration Of Microfluidics With Surface Plasmon Resonance, Scott B. Fratzke

Master's Theses

This thesis successfully integrates laminate microfluidic devices with an analytic Surface Plasmon Resonance (SPR) instrument. Integration was accomplished at low-cost using materials such as polydimethylsiloxane (PDMS), Poly(methyl methacrylate) (PMMA), Tygon tubing, and a 3-way stopcock. The main components of this thesis are the design and fabrication of the low-cost, in-house fluidics that can integrate with upstream microfluidics and the validation of the in-house fluidics using the Biosensing Instruments BI-2000 SPR instrument. The low-cost fluidics was designed and fabricated “in-house” using a novel investment casting technique that required the use of laser cutting technology to make a master cast, and candle …

Using The Continuous Wavelet Transform To Characterize Differences Between Impact Signals From Non-Cleated And Cleated Turf Shoes, Wayne Robert Fischer

Boise State University Theses and Dissertations

The continuous wavelet transform was used to characterize the time-frequency differences between impact forces from non-cleated and cleated turf shoes among male football athletes who perform cut and run activities. This research is significant because it elucidates how athletes experience different impact force and torque frequency content based on the type of shoe they are wearing. The complex Morlet mother wavelet was used to analyze all ground reaction force and vertical ground reaction moment signals to create time-frequency power spectrum plots. For each signal, a statistical confidence interval was calculated and displayed along with the cone of influence caused by …

Effects Of Static Stretching On Foot Velocity During The Instep Soccer Kick, Craig D. Workman

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to assess the acute effects of static stretching on foot velocity at impact with a soccer ball. Eighteen Division I female soccer athletes underwent two test conditions separated by 48 hr. Each condition was randomly assigned and began by placing four retro-reflective markers on bony landmarks of the ankle (total of eight markers, four on each ankle). One condition was the no-stretch condition, in which each participant performed a self-paced jog for 5 min as a warm-up, and then sat quietly for 6 min before performing three maximal instep kicks into a net. The …

Modeling The Long Term Effects Of Alendronate On Bone Mass Preservation Of The Femur With Articular Surface And Total Hip Replacements, Trevor J. Hryce

Master's Theses

Calculating femoral bone density changes after hip arthroplasty is of interest to researchers and clinicians for predicting the longevity of the prosthetic implant and the surrounding bone. Recently clinicians have been administering bisphosphonate drugs in an attempt to reduce the bone resorption due to stress shielding caused by these implants. Current strain-adaptive computational models with bisphosphonate treatment don’t predict the long term effects or look at treatment with hip resurfacing implants. The main goal of this study was to create and validate a computer model of the human femur incorporating a bone remodeling algorithm based on biological remodeling processes and …

An Investigation Of Humeral Stress Fractures In Racing Thoroughbreds Using A 3d Finite Element Model In Conjunction With A Bone Remodeling Algorithm, Ryan James Moore

Master's Theses

The humerus of a racing horse Thoroughbred is highly susceptible to stress fractures at a characteristic location as a result of cyclic loading. The propensity of a Thoroughbred to exhibit humeral fracture has made equines useful models in the epidemiology of stress fractures. In this study, a racing Thoroughbred humerus was simulated during training using a 3D finite element model in conjunction with a bone remodeling algorithm. Nine muscle forces and two contact forces were applied to the 3-dimensional finite element model, which contains four separate load cases representing fore-stance, mid-stance, aft-stance, and standing. Four different training programs were incorporated …

Reflections Of College Students Promoting Engineering Through Biomechanical Outreach Activities Indicate Dual Benefits, Kimberly Edginton Bigelow

Mechanical and Aerospace Engineering Faculty Publications

Recent work by the National Academy of Engineering revealed that the public has a poor understanding of what engineers actually do on a day-to-day basis. This issue is compounded for non-traditional fields in engineering, such as biomechanical engineering. This is particularly problematic as such fields could draw interest from students not interested in traditional engineering careers, resulting in increased diversity.

To address this, mechanical engineering students taking an elective course, Biomechanical Engineering, were given an outreach assignment to teach at least one individual under the age of 18 about the field of biomechanical engineering through a hands-on activity. Students worked …

Nonequilibrium Thermodynamics Modeling Of Coupled Biochemical Cycles In Living Cells, Yaşar Demirel

Yaşar Demirel Publications

Living cells represent open, nonequilibrium, self organizing, and dissipative systems maintained with the continuous supply of outside and inside material, energy, and information flows. The energy in the form of adenosine triphosphate is utilized in biochemical cycles, transport processes, protein synthesis, reproduction, and performing other biological work. The processes in molecular and cellular biological systems are stochastic in nature with varying spatial and time scales, and bounded with conservation laws, kinetic laws, and thermodynamic constraints, which should be taken into account by any approach for modeling biological systems. In component biology, this review focuses on the modeling of enzyme kinetics …

Motion Of The Multisegmental Foot In Hallux Valgus, Karl Canseco, Leah Rankine, Jason T. Long, Thomas Smedberg, Richard Marks, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Hallux valgus is a common condition characterized by lateral deviation of the large toe and medial deviation of the first metatarsal. While some gait analyses of patients with hallux valgus have been performed using plantar pressures, very little is known about the kinematics of gait in this population. The purpose of this study was to evaluate triplanar kinematics in patients with hallux valgus using a multisegmental foot model. Materials and Methods: A 15-camera Vicon Motion Analysis System was used to evaluate the gait of 38 feet in 33 patients with mild to severe hallux valgus. The Milwaukee foot model was …