Biomechanics and Biotransport Commons^™

Effects Of A Passive Assistive Hamstring Device On Overground Running Kinematics And Hamstring Activation., Quinn Castner

All Theses

Hamstring strain injuries are among the most common and recurring injuries in sports, occurring most often during the terminal swing phase of gait. Despite progress in rehabilitation, the incidence of injury has only increased, suggesting a need for a novel intervention. We designed a passive, assistive, wearable device with two specific criteria in mind: to offload the hamstrings during running, and do so without hindering normal kinematic patterns. The device consists of an adjustable elastic band anchored proximally at the waist and distally just above the ankle joint center. It stretches and shortens with the hamstrings, providing passive hip extension …

Investigation Into The Effects Of Moderate-Dose Radiation On Ligament Biomechanics, Andrew Landefeld

All Theses

Recent advances in arthritis treatment pin ionizing X-ray radiation as a useful tool in reducing joint pain and immune response. However, due to a lack of fundamental research in the effects of low-dose ionizing radiation on tendon and ligament biomechanics, the safety of these studies is rather unknown. While most related studies investigated cellular response to low dose treatment, surrounding tissue physiology is left out of the picture. Additionally, moderate range doses of irradiation are rarely studied, as most uses of radiation on tendons and ligaments are for sterilization of cadaver tendons for allografts. This study provides a preliminary investigation …

Exercise-Induced Muscle Damage As A Model For Exploring The Effects Of Pain On Gait, Sydney Savage

All Theses

Persistent gait asymmetry following anterior cruciate ligament reconstruction (ACLR) is a recognized contributor to post-traumatic knee osteoarthritis, yet the independent role of pain in driving altered movement patterns remains poorly understood due to confounding factors inherent to clinical populations. This study used exercise-induced muscle damage (EIMD) as a controlled experimental model to isolate the effects of musculoskeletal pain on gait, independent of kinesiophobia, structural damage, and proprioceptive disruption. Eighteen healthy adults underwent unilateral eccentric calf-raise protocols to induce delayed onset muscle soreness (DOMS), with gait assessed at baseline, 48 hours, and 168 hours post-exercise using bilateral inertial measurement units. Outcomes …

Effect Of Cigarette Smoke Extract And Nutrient Deficiency On Energy Metabolism And Biosynthesis: An In Vitro Intervertebral Disc Explant Culture Study, Avery E. Madden

All Theses

Low back pain consistently ranks among the leading causes of disability worldwide, with degenerative changes in spinal intervertebral discs (IVDs) recognized as a key contributor. Degeneration arises from the disruption of mechanical and biological cues within the disc’s cartilaginous tissue, often exacerbated by aging or injury. In recent decades, cigarette smoking has also been identified as a significant risk factor, as IVD degeneration is more prevalent among individuals with a history of smoking. Smoke inhalation is thought to promote degeneration both directly, by exposing cells to water-soluble toxic chemicals in smoke; and indirectly, through nutrient deficiency resulting from vasoconstriction and …

The Effect Of Pressure Gradients On Perceived Discomfort, Zachary Bush

All Theses

Introduction:

A pressure gradient is where high and low pressure meet. It is responsible for displacement and irritation of the skin commonly caused by tight bandages, bracelets, or socks. The irritation is at the edge where the skin is displaced by the high and low pressure. An analysis of the effect pressure gradients have on discomfort would have significant medical relevance for any device, fixture, or clothing pressed against the skin at high pressure. This primarily includes prosthetic and orthotic devices.

The bottom surface of the heel provides a naturally circular, uniform pressure profile. This makes it the optimal testing …

The Effect Of Central Screw And Post Vault Containment On Reverse Total Shoulder Arthroplasty (Rsta) Baseplate Stability, Mickaela J. Gunnison

All Theses

Reverse total shoulder arthroplasty (RTSA) is a procedure that aims to fix irreversible rotator cuff damage and degenerative glenohumeral joint diseases that hinder arm abduction. One major complication of RTSA is glenoid baseplate failure resulting from increased movement at the bone-baseplate interface. This study examined 36, 12 PCF composite Sawbones® scapulae. The specimens were split equally into 6 study groups, each having different implant configurations with varying baseplate lateralization and central screws or posts. Each specimen was subjected to cyclic shear loading and failure testing on an Instron to determine implant micromotion and load values.

After testing, ANOVA tests were …

Evaluation And Development Of Tourniquet Test Methods, Catherine Pitts

All Theses

Since the beginning of the 21^st century the general perspective on tourniquets has changed to a more positive outlook on their life saving abilities. The US has seen a greater number of mass casualty events, and conflicts across the globe have led to an increased use of tourniquets. The increased demand has also led to faulty counterfeit tourniquets and improvised tourniquets that don not properly occlude blood flow or cause significant nerve damage to the injured limb.

ASTM started designing a tourniquet testing standard with experts in the tourniquet community to cut down on the dangers of tourniquet use. …

Hand Movement Analysis For Surgical Suturing Skill Assessment, Amir Mehdi Shayan

All Theses

To enhance patient safety, surgical education is increasingly incorporating simulation for formative skills assessment and training. However, many standardized assessment tools rely on human raters for performance assessment, which is resource-intensive and subjective. Simulators that provide automated and objective metrics from sensor data can address this limitation. This thesis presents an instrumented bench suturing simulator, patterned after the Clock Face (CF) radial suturing model from the Fundamentals of Vascular Surgery (FVS), for automated and objective assessment of open suturing skills by particularly focusing on biomechanical analysis of hand movements. For this research, 97 participants (35 attending surgeons and fellows, 32 …

Characterization Of Thermal Gelation Properties In Bioresorbable Thermally Activated Hydrogel Polymers For Hernia Surgery Applications, Alexander Mayfield

All Theses

Hydrogel adhesives are a new class of materials with excellent biocompatibility, which makes them very attractive for biomaterial applications. It has been previously shown that Tetronic T1107, a four-arm poly (propylene oxide)-poly (ethylene oxide) (PPO-PEO) block copolymer, is useful as a chemical crosslinking thermo-responsive hydrogel for bioadhesive applications. The end groups of this polymer are modified with acrylate and N-hydroxysuccinimide (NHS) functional groups. The acrylate end group gives the polymer cohesive properties with long-range chemical crosslinking using dithiothreitol (DTT), while the NHS end group gives the polymer adhesive properties through bonding with amines found in organic tissue. It was found …

Variations In Surgeon-Applied Loads During Passive Range Of Motion Following Total Knee Replacement With Relevance To Computational Modeling, Cj Bakle Ii

All Theses

Total knee replacement (TKR) is generally considered a successful treatment for musculoskeletal disorders of the knee. However, as many as 20% of patients report some dissatisfaction in their physical function after TKR. And approximately 50% of early revisions needed to address conditions related to component alignment and soft tissue tension to stabilize the knee. During TKR, surgeons manually perform passive range of motion (ROM) assessments to gain feedback perceived as tension in ligaments and other soft tissues. Such assessments are highly subjective and rely on the surgeon's perception of soft tissue tension rather than quantitative objective means. The variability in …

Design Of A Four Channel Pulsatile Perfusion Bioreactor For Ex-Vivo Study Of Vascular Grafts, Thomas M. Fair

All Theses

Cardiovascular diseases are the leading cause of death in the United States. Atherosclerosis in peripheral arteries is a major contributing factor. Autologous saphenous vein grafts are the most common bypass grafts for treating peripheral artery diseases. A quarter of these grafts fail within a year, and around half have failed within 10 years of the initial surgery. Graft failure is attributed to the development of intimal hyperplasia indicated by the migration and proliferation of vascular smooth muscle cells, fibroblasts, and the deposition of extracellular proteins.

Increases in flow, pressure, the pulse frequency, and the differential of pressure that model an …