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Articles 1 - 13 of 13
Full-Text Articles in Biomaterials
Quaternary Ammonium Silane-Functionalized, Methacrylate Resin Composition With Antimicrobial Activities And Self-Repair Potential, Shi-Qiang Gong, Li-Na Niu, Lisa K. Kemp, Cynthia K.Y. Yiu, Heonjune Ryou, Yi-Pin Qi, John D. Blizzard, Sergey Nikonov, Martha G. Brackett, Regina L.W. Messer, Christine D. Wu, Jing Mao, L. Bryan Brister, Frederick A. Rueggeberg, Dwayne D. Arola, David H. Pashley, Franklin R. Tay
Quaternary Ammonium Silane-Functionalized, Methacrylate Resin Composition With Antimicrobial Activities And Self-Repair Potential, Shi-Qiang Gong, Li-Na Niu, Lisa K. Kemp, Cynthia K.Y. Yiu, Heonjune Ryou, Yi-Pin Qi, John D. Blizzard, Sergey Nikonov, Martha G. Brackett, Regina L.W. Messer, Christine D. Wu, Jing Mao, L. Bryan Brister, Frederick A. Rueggeberg, Dwayne D. Arola, David H. Pashley, Franklin R. Tay
Faculty Publications
The design of antimicrobial polymers to address healthcare issues and minimize environmental problems is an important endeavor with both fundamental and practical implications. Quaternary ammonium silane-functionalized methacrylate (QAMS) represents an example of antimicrobial macromonomers synthesized by a sol–gel chemical route; these compounds possess flexible Si–O–Si bonds. In present work, a partially hydrolyzed QAMS co-polymerized with 2,2-[4(2-hydroxy 3-methacryloxypropoxy)-phenyl]propane is introduced. This methacrylate resin was shown to possess desirable mechanical properties with both a high degree of conversion and minimal polymerization shrinkage. The kill-on-contact microbiocidal activities of this resin were demonstrated using single-species biofilms of Streptococcus mutans (ATCC 36558), Actinomyces naeslundii (ATCC …
Characterization Of Printed Skin Equivalents, Mayela R, Aldaz Cervantes, Maria Yanez, Thomas Boland
Characterization Of Printed Skin Equivalents, Mayela R, Aldaz Cervantes, Maria Yanez, Thomas Boland
COURI Symposium Abstracts, Summer 2012
Severe burns, ulcerations, and cuts are some of the reasons people need bioengineered skin as a treatment for full-thickness wounds. When patients run out of donor sites in their own body, using the patient’s skin as a graft is no longer an option, and tissue-engineered constructs are the only possible replacement for damaged skin. The goal of this research is to develop a hydrogel-based skin graft that will be able to function as a skin replacement in full-thickness wounds while minimizing the possibility of rejection, being cost-effective, and possessing a longer shelf-life than the grafts currently in the market. Endothelial …
Propagation Of Ultrasound Through Freshly Excised Human Calvarium, Armando Garcia Noguera
Propagation Of Ultrasound Through Freshly Excised Human Calvarium, Armando Garcia Noguera
Department of Engineering Mechanics: Dissertations, Theses, and Student Research
The propagation of ultrasound through complex biological media, such as the human calvarium, poses a great challenge for modern medicine. Several ultrasonic techniques commonly used for treatment and diagnosis in most of the human body are still difficult to apply to the human brain, in part, because of the properties of the skull. Moreover, an understanding of the biomechanics of transcranial ultrasound may provide needed insight into the problem of blast wave induced traumatic brain injury (TBI). In the present study, the spatial variability of ultrasonic properties was evaluated for relevant frequencies of 0.5, 1, and 2.25 MHz. A total …
Development Of In Vitro Tissue Engineered Blood Vessel Mimics In Complex Geometries For Coronary Stent Testing, Robert Dalton Chavez
Development Of In Vitro Tissue Engineered Blood Vessel Mimics In Complex Geometries For Coronary Stent Testing, Robert Dalton Chavez
Master's Theses
Coronary heart disease is the leading cause of death in the United States and occurs when plaque occludes coronary arteries. Coronary stents, which may be used to treat coronary occlusions, are small metal tubes that are implanted in coronary arteries to restore blood flow. After stent implantation, endothelial cells grow over the stent so that blood contacts the endothelial cells instead of the stent surface; this event is known as re-endothelialization. Re-endothelialization prevents blood from clotting on the stent surface and is a good predictor of stent success. Blood vessel mimics (BVMs) are in vitro tissue engineered models of human …
Design Of Experimentation To Systematically Determine The Interaction Between Electrospinning Variables And To Optimize The Fiber Diameter Of Electrospun Poly (D, L-Lactide-Co-Glycolide) Scaffolds For Tissue Engineered Constructs, Yvette S. Castillo
Master's Theses
Cardiac disease causes approximately a third of the deaths in the United States. Furthermore, most of these deaths are due to a condition termed atherosclerosis, which is a buildup of plaque in the coronary arteries, leading to occlusion of normal blood flow to the cardiac muscle. Among the methods to treat the condition, stents are devices that are used to restore normal blood flow in the atherosclerotic arteries. Before advancement can be made to these devices and changes can be tested in live models, a reliable testing method that mimics the environment of the native blood vessel is needed. Dr. …
Corrosion Of Stainless Steel 316l And Astm F75 Cobalt Chromium Alloy During Immersion Testing In Silver Salt Solutions, Meagan Higgins
Corrosion Of Stainless Steel 316l And Astm F75 Cobalt Chromium Alloy During Immersion Testing In Silver Salt Solutions, Meagan Higgins
Materials Engineering
This study evaluates the potential effects of silver salts on biocompatible metals used for prostheses during the chemical reduction process to produce a silver antimicrobial layer on the metal’s surface. Samples of two biocompatible metals were obtained: Stainless Steel 316L and ASTM F75 Cobalt Chromium Alloy. Three different silver salts were also acquired: silver nitrate, silver sulfadiazine, and silver chloride. Specimens of each metal were cut to size using a 4-1/2 inch aluminum oxide, 40 grit, cut off wheel for metal, attached to a Dewalt Angle Grinder. The biocompatible metal samples were then subject to either Solution 1, water with …
The Characterization Of Biofilm Attachment To Metal Interfaces: Effects Of Substratum Properties, Marcel D. Mendes
The Characterization Of Biofilm Attachment To Metal Interfaces: Effects Of Substratum Properties, Marcel D. Mendes
Master's Theses
Bacteria are among the most abundant microorganisms on earth, and can be found in essentially every environment. When a clean surface is exposed to media containing planktonic bacteria, the bacterial cells will attach to the surface and aggregate to form what is known as a biofilm. Biofilms have been shown to negatively affect many industries including medical, industrial, and food science applications. While biofilms have been well characterized from a microbiology perspective, there has been much less research from a materials science standpoint. It is hypothesized that the material properties of the substratum (such as the micro-structure) have a significant …
Growth And Expression Of Halorhodopsin For Application In A Protein-Based Artificial Retina, Megan Ryan Gillespie
Growth And Expression Of Halorhodopsin For Application In A Protein-Based Artificial Retina, Megan Ryan Gillespie
Honors Scholar Theses
Halorhodopsin (HR), a light-activated chloride ion pump, demonstrates potential for use as the scaffolding in an artificial retina. Retinal implants are needed to restore vision to people afflicted with ophthalmic diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). A protein-based chloride ion-patch would be utilized by the eye to create an influx of chloride ions, similar to ion concentrations in healthy retinas during the conversion of light stimuli to electrochemical signals. This protein-based retinal prosthesis will directly stimulate the bipolar cells of the retina, replacing the function of damaged photoreceptor cells. Other alternative treatments for AMD and …
Evaluation Of Decellularization Procedures For Porcine Arteries, Charles Clapp
Evaluation Of Decellularization Procedures For Porcine Arteries, Charles Clapp
Biomedical Engineering
Coronary artery disease has become the leading cause of death in the United States, with over 425,000 deaths in 2006. Stenting has evolved into the preferred preventative technique for myocardial infarction by opening up an occluded artery, due to its low invasiveness compared to the alternative of coronary artery bypass grafting. Bare metal stents have been improved by coating with anti-proliferative drugs to advance their effects, but even drug eluting stents still have a risk of restenosis, thrombus formation, and necessary revascularization. Continual advancement in stent design necessitates faster, effective pre-clinical evaluation techniques. Kristen Cardinal, Ph.D., developed the blood vessel …
Investigation Of A New Material For Heart Valve Tissue Engineering, Claire Brougham, Nian Shen, Allison Cudsworth, Thomas Flanagan, Stefan Jockenhoevel, Fergal O'Brien
Investigation Of A New Material For Heart Valve Tissue Engineering, Claire Brougham, Nian Shen, Allison Cudsworth, Thomas Flanagan, Stefan Jockenhoevel, Fergal O'Brien
Conference Papers
No abstract provided.
Mineralization Potential Of Electrospun Pdo-Hydroxyapatite-Fibrinogen Blended Scaffolds, Isaac Rodriguez, Parthasarathy A. Madurantakam, Jennifer M. Mccool, Scott A. Sell, Hu Yang, Peter C. Moon, Gary L. Bowlin
Mineralization Potential Of Electrospun Pdo-Hydroxyapatite-Fibrinogen Blended Scaffolds, Isaac Rodriguez, Parthasarathy A. Madurantakam, Jennifer M. Mccool, Scott A. Sell, Hu Yang, Peter C. Moon, Gary L. Bowlin
Biomedical Engineering Publications
The current bone autograft procedure for cleft palate repair presents several disadvantages such as limited availability, additional invasive surgery, and donor site morbidity. The present preliminary study evaluates the mineralization potential of electrospun polydioxanone:nano-hydroxyapatite : fibrinogen (PDO : nHA : Fg) blended scaffolds in different simulated body fluids (SBF). Scaffolds were fabricated by blending PDO : nHA : Fg in the following percent by weight ratios: 100 : 0 : 0, 50 : 25 : 25, 50 : 50 : 0, 50 : 0 : 50, 0 : 0 : 100, and 0 : 50 : 50. Samples were immersed …
The Use Of An In Vitro 3d Melanoma Model To Predict In Vivo Plasmid Transfection Using Electroporation, Benadette Marrero, Richard Heller
The Use Of An In Vitro 3d Melanoma Model To Predict In Vivo Plasmid Transfection Using Electroporation, Benadette Marrero, Richard Heller
Bioelectrics Publications
A large-scale in vitro 3D tumor model was generated to evaluate gene delivery procedures in vivo. This 3D tumor model consists of a "tissue-like" spheroid that provides a micro-environment supportive of melanoma proliferation, allowing cells to behave similarly to cells in vivo. This functional spheroid measures approximately 1 cm in diameter and can be used to effectively evaluate plasmid transfection when testing various electroporation (EP) electrode applicators. In this study, we identified EP conditions that efficiently transfect green fluorescent protein (GFP) and interleukin 15 (IL-15) plasmids into tumor cells residing in the 3D construct. We found that plasmids …
A Preliminary Study On The Potential Of Manuka Honey And Platelet-Rich Plasma In Wound Healing, Scott A. Sell, Patricia S. Wolfe, Andrew J. Spence, Isaac A. Rodriguez, Jennifer M. Mccoll, Rebecca L. Petrella, Koyal Garg, Jeffery J. Ericksen, Gary L. Bowlin
A Preliminary Study On The Potential Of Manuka Honey And Platelet-Rich Plasma In Wound Healing, Scott A. Sell, Patricia S. Wolfe, Andrew J. Spence, Isaac A. Rodriguez, Jennifer M. Mccoll, Rebecca L. Petrella, Koyal Garg, Jeffery J. Ericksen, Gary L. Bowlin
Ellmer School of Nursing Faculty Publications
Aim. The purpose of this study was to determine the in vitro response of cells critical to the wound healing process in culture media supplemented with a lyophilized preparation rich in growth factors (PRGF) and Manuka honey. Materials and Methods. This study utilized cell culture media supplemented with PRGF, as well as whole Manuka honey and the medical-grade Medihoney (MH), a Manuka honey product. The response of human fibroblasts (hDF), macrophages, and endothelial cells (hPMEC) was evaluated, with respect to cell proliferation, chemotaxis, collagen matrix production, and angiogenic potential, when subjected to culture with media containing PRGF, MH, Manuka honey, …