Biomedical Engineering and Bioengineering Commons^™

Making Meaning: Shifts In Meaningfulness Across Three Modeling Units, Jeannette Manger

Browse all Theses and Dissertations

Recent reform calls for a more comprehensive approach to science education that positions learners as constructors of knowledge via scientific practices (NRC, 2012; Osborne, 2014). This 'practice turn' shifts from passive science learning to incorporating science actions with epistemic thinking (Duschl & Grandy, 2013; Ford & Forman, 2006; Osborne, 2014; Shouse, Schweingruber, & Duschl, 2007). Teachers are often underprepared in understanding the nuances of scientific practices, and frequently struggle with supporting students in meaningful practice engagement (Abd-El-Khalick & Akerson, 2004; Crawford, 1999; Davis, Petish, & Smithey, 2006; Duschl & Gitomer, 1997). Here, I draw upon the Berland et al. Epistemologies …

New Design Of Nasogastric Decompression Tube That Incorporates A Self-Cleaning Brushing Mechanism, Nichole Abla, Lindsay Rucker, Paige Schroder

Senior Theses

Many hospitalized patients require the removal of secretions that accumulate in the stomach and must be removed by a nasogastric tube, which unfortunately clogs often. This project outlines the redesign of the nasogastric tube that will ideally prevent nasogastric tube clogging by incorporating a brush mechanism and a contracting tip mechanism, to act as preventative measures against clogging.

Solute Partitioning In Elastin-Like Polypeptides: A Foundation For Drug Delivery Applications, Eric Helm

ETD Archive

No abstract provided.

Measuring The Acute Physiological Effects Of Leptin In The Carotid Body, Richard Laurence Pye

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Obesity is the healthcare crisis of our generation. Circulating levels of the adipokine leptin are proportional to adiposity and in addition to its role as a satiety factor leptin has been shown to have a host of pleiotropic effects. Among these effects is its role as a respiratory stimulant where it has been shown to have both whole body and central stimulatory effects on breathing. Porzionato et al. (2011) showed that leptin and leptin receptors are selectively expressed in the chemosensing type I cells of the carotid body. Carotid bodies are small chemosensitive organs that act as the primary peripheral …

The Guinea Pig Model For Organophosphate Toxicology And Therapeutic Development, Christopher Daniel Ruark

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Organophosphates (OPs) are highly toxic insecticides and nerve agents that have been designed to inhibit the hydrolysis of acetylcholine by binding to the serine active site of acetylcholinesterase (AChE). They are one of the most common causes of human poisoning worldwide and are frequently intentionally used in suicides in agricultural areas. For this reason, there is a need for therapeutics to rescue those from intoxication. Obvious ethical concerns prevent humans from being subjected to OP exposure for therapeutic efficacy and safety testing. Therefore, animal surrogates for humans must be appropriately selected. A new paradigm, described herein, incorporating both in silico …

Foley Catheter Priming Device, Melissa A. Boswell, Landon Davis, Renee Horn, Tyler Grubb, Jason Green

Williams Honors College, Honors Research Projects

A lack of a pressure gradient throughout the catheter prevents urine flow from the bladder and through catheter system in a condition referred to as “air-lock.” The purpose of this project was to design a device that could be utilized by person with a catheter faced with the problem of air-lock to restore urine flow and normal functioning of the catheter system. After a prototype was created, the device was put through a series of tests to insure proper functioning, absence of leakage, and durability. The device created can be added in-line with the catheter system, inconspicuously under the user’s …

Power Soccer Footguard Attachment System, Allison Hubbell, Vivian Kontoveros, Andrew Mcclain, Lauren Monsanty

Williams Honors College, Honors Research Projects

The purpose of this research project was to develop a new method of attaching a footguard to the front of a power wheelchair to be used in the adaptive sport, power soccer. Completion of this project was requested by Adaptive Sports Program of Ohio (A.S.P.O.). It was requested that Limitless Sports Solutions, a team of Biomedical Engineering students, create a new design which would be more efficient, have less moving parts, and be easier to attach overall than the system currently being used by A.S.P.O. During the scope of this project, research was conducted on other existing systems and several …

Modification And Evaluation Of A Brain Computer Interface System To Detect Motor Intention, Christopher V. Hagerty-Hoff

Theses and Dissertations

It is widely understood that neurons within the brain produce electrical activity, and electroencephalography—a technique used to measure biopotentials with electrodes placed upon the scalp—has been used to observe it. Today, scientists and engineers work to interface these electrical neural signals with computers and machines through the field of Brain-Computer Interfacing (BCI). BCI systems have the potential to greatly improve the quality of life of physically handicapped individuals by replacing or assisting missing or debilitated motor functions. This research thus aims to further improve the efficacy of the BCI based assistive technologies used to aid physically disabled individuals. This study …

Chemosensitive Neurons Of The Locus Coeruleus And The Nucleus Tractus Solitarius: Three Dimensional Morphology And Association With The Vasculature, Cathy D. Graham

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We studied the 3 dimensional structure of LC and cNTS neurons from neonatal rats. Neurons were identified as either chemosensitive or nonchemosensitive based on their firing rate response to hypercapnia, using whole-cell patch clamping and were passively loaded with Lucifer Yellow. The identified, loaded neurons were reconstructed and analyzed using Neurolucida Neuron Tracing Software. Chemosensitive LC neurons have less rounded soma than nonchemosensitive neurons, and they have dendrites arising from two poles to produce a fusiform appearance. The dendritic branches extend a greater distance from the soma of chemosensitive than nonchemosensitive neurons. Conversely, chemosensitive cNTS neurons were found to have …

Guanine Nucleotide Exchange Activity Of Phospholipase D2 And Its Regulation, Madhupriya Mahankali

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Phospholipase D2 (PLD2) is a cell membrane lipase that catalyzes the break down of phosphatidyl choline (PC) to phosphatidic acid (PA) and choline. PA is one of the major lipid second messengers that modulate a wide variety of signaling pathways, which are crucial for various cellular functions. In addition to this, PLD2 via binding to a large number of proteins and thereby regulates them independent of its lipase activity. Whereas PLD2 is involved in plethora of cellular functions, high levels of protein and/or activity of PLD2 are reported in variety of disease conditions, such as cancer metastasis and chronic inflammation …

2013 Fall Engr333 Project Final Report, 2013 Fall Engr333

ENGR 333

During the fall of 2013, the Engineering 333 class was asked the question, “what would it take for Calvin College to operate a biofuel vehicle from campus resources?” The three primary considerations included:

• Determining the optimal biofuel feedstock in terms of availability, transportation, and processing.
• Selecting a biofuel vehicle for conversion or purchase to operate on the selected feedstock.
• Designing the infrastructure and process required for operating the selected biofuel vehicle. The design and research described below proposes an environmentally sustainable and cost-effective method for integrating a biofuel vehicle into Calvin’s existing infrastructure.

2013 Fall Engr333 Student Seminar Presentation, Claire Philippi, Karl Bratt, Mike Houtman, Brandon Koster

ENGR 333

File for student presentation, given by students in the Fall 2013 class of ENGR333.

2013 Fall Engr333 Vehicle Poster, 2013 Fall Engr333

ENGR 333

Waste vegetable oil (WVO) was chosen by the class as the best fuel source for the Calvin Biofuel Vehicle Project. The class then considered vehicle options and selected a lawnmower to be powered by WVO.

2013 Fall Engr333 Fuel And Facilities Poster, 2013 Fall Engr333

ENGR 333

The objective of the project was to answer the question: “What would it take for Calvin College to operate a biofuel vehicle from campus resources.” The class split into 3 teams:

• Fuel/Feedstock
• Facilities/Infrastructure
• Vehicle

2013 Fall Engr333 Project Assignment, Matthew K. Heun

ENGR 333

The Fall 2013 ENGR333 project focused on production and use of biofuels at Calvin University.

I asked the students “What would it take for Calvin College to operate a biofuel vehicle from campus resources?”

Customer

The customer for this project was Calvin’s Physical Plant director Phil Beezhold.

A Robotic Neuro-Musculoskeletal Simulator For Spine Research, Robb W. Colbrunn

ETD Archive

An influential conceptual framework advanced by Panjabi represents the living spine as a complex neuromusculoskeletal system whose biomechanical functioning is rather finely dependent upon the interactions among and between three principal subsystems: the passive musculoskeletal subsystem (osteoligamentous spine plus passive mechanical contributions of the muscles), the active musculoskeletal subsystem (muscles and tendons), and the neural and feedback subsystem (neural control centers and feedback elements such as mechanoreceptors located in the soft tissues) [1]. The interplay between subsystems readily encourages "thought experiments" of how pathologic changes in one subsystem might influence another--for example, prompting one to speculate how painful arthritic changes …

Improved Tissue Caliper, Kenneth Ted-Luck Hung

Honors Scholar Theses

My honors thesis will be covering the work that I am doing for my senior design project. My senior design project involves building a tissue caliper for medical device company, Covidien. During medical research and development it is often necessary to measure and document the thickness of tissue samples and media (simulated tissue foam). A device known as a tissue caliper is currently used to perform such measurements. Our project requires us to design, build, calibrate, and validate an instrument, which will be capable of measuring sample thicknesses ranging from 0.10 to 1.00 inches with an accuracy of ± 0.005 …

Automation Of Orthodontic Wire Tester For Performing Three Point Bending Tests, Adithya Venkatesan

Master's Theses

Abstract

Understanding the biomechanical factors in orthodontics is important in order to improve the overall effectiveness of actual clinical treatment. An accurate method to study the threedimensional (3D) force systems and the resulting movements of teeth during orthodontic treatment is needed along with the understanding of the material properties of any orthodontic wire. Until recently, most of the orthodontic biomechanics literature was limited to twodimensional experimental studies. Recent advances in threedimensional computer modeling have also been developed but have been limited to the manual control of tooth movement. Overall, there is very little published evidence in the literature on the …

Recording Of Elevated Temperature Fatigue Crack Growth Data By Dcpd System, N. Ramachandran, N. Arakere, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The growth of "long" fatigue cracks, in α-β titanium alloy forging, subjected to cyclic stresses, is studied in this paper. The fatigue crack growth rate (FCGR) data were recorded at room temperature, 350, 450, 550 and 650°F using the Direct Current Potential Difference (DCPD) technique. The DCPD method, used in this investigation, was found to record and correlate the potential difference in terms of crack growth rate (da/dN) and Mode I stress intensity factor range satisfactorily. Various factors related to error minimization and calibration equations for compact tension specimens have been elaborated. Also discussed were the means to enhance the …

The Role Of Conflict Management On Virtual Team Performance And Satisfaction, Pilar Pazos, Anil Ustun, Rolando Delaguila

Engineering Management & Systems Engineering Faculty Publications

The role that input factors from project planning processes play on conflict emergence and conflict resolution in virtual teams is not well understood. Of particular interest for this paper is the role that factors during planning stages play in preventing interpersonal conflict, supporting conflict resolution and ultimately enhancing team outcomes in virtual team settings. This study examines the relationships among commitment to team goals, conflict management and team outcomes in virtual teams. First we provide an in depth review of relevant empirical findings. Next, we describe a study examining the relationships between three sets of variables: 1) goal commitment, 2) …

Implementation Of Physiologic Pressure Conditions In A Blood Vessel Mimic Bioreactor System, Kevin Mark Okarski

Master's Theses

ABSTRACT

Implementation of Physiologic Pressure Conditions in a Blood Vessel Mimic Bioreactor System

Kevin Mark Okarski

Tissue engineering has traditionally been pursued as a therapeutic science intended for restoring or replacing diseased or damaged biologic tissues or organs. Cal Poly’s Blood Vessel Mimic Laboratory is developing a novel application of tissue engineering as a tool for the preclinical evaluation of intravascular devices. The blood vessel mimic (BVM) system has been previously used to assess the tissue response to deployed stents, but under non-physiologic conditions. Since then, efforts have been made to improve the vessel and bioreactor’s ability to emulate in …

Bioengineering Instructional Framework For Technology Education, Philip A. Reed, Technology Education Department, Old Dominion University, Virginia Bioengineering Writing Team

STEMPS Faculty Publications

No abstract provided.

Bie6810 - Biochemical Engineering, Spring 2004, Ron Sims

Biological and Irrigation Engineering - OCW

Biochemical processes, thermodynamics, and kinetics are used in the application of engineering principles to analyze, design, and develop processes using biocatalysts. Processes covered in the course include those that are involved in the formation of desirable compounds and products or in the transformation, or destruction of unwanted or toxic substances.

Bie6300 - Irrigation & Conveyance Control Systems, Spring 2004, Gary P. Merkley

Biological and Irrigation Engineering - OCW

This is a course regarding measurement of flow rates and water levels. Calibration, design, and selection of open-channel flow measurement structures. Design of irrigation conveyance and distribution system infrastructure.

Bie6150 - Surface Irrigation Design, Spring 2004, Wynn Walker

Biological and Irrigation Engineering - OCW

This course was originally developed for the United States Department of Agriculture. It contains nearly 20 video lecture presentations with accompanying slides in English, Arabic, and French, an online textbook, homework assignments, and downloadable surface irrigation simulation software also developed by Dr. Walker. This course highlights design and evaluation of surface irrigation systems, field measurements for evaluating and improving uniformity and efficiency, simulation of surface systems, and land leveling computation and equipment. Note: The simulation software is designed to run on a PC only.

Dwell Fatigue I : Damage Mechanisms, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The mechanisms controlling deformation and failure under high temperature creep-fatigue conditions of materials are examined in this paper. The materials studied are solder alloys, copper alloys, low alloy steels, stainless steels, titanium alloys, and Ni-based alloys. The deformation and failure mechanisms were different (fatigue, creep, oxidation and their interactions) depending upon test and material parameters employed. Deformation mechanisms, such as cavity formation, grain boundary damage, intergranular (IG) and transgranular (TG) damage, oxidation, internal damage, dislocation cell concentration, and oxide mechanisms are very important in order to gain more knowledge of fatigue behavior of materials. The observed mechanisms can be categorized …

A New Creep-Fatigue Life Prediction Model, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

A published creep-fatigue life prediction model is modified in this paper and assessed with data on Inconel 718 under different test conditions. It has been shown that the method developed within the viscosity concepts correlates the low-cycle fatigue data well. This paper reports the modification over the previous model.

Applicability Of Modified Diercks Equation With Nrim Data, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The applicability of the modified Diercks equation (MDE) was assessed with elevated temperature low cycle fatigue (ETLCF) data generated by the National Research Institute for Metals (NRIM) for lCr-Mo-V, 1.25Cr-Mo, 2.25Cr-Mo and 9Cr-lMo steels respectively. The modified Diercks equation was assessed with data generated with symmetrical, slow-fast and hold-time waveforms for low alloy steels. The following characteristics were observed: Symmetrical waveforms: Five strain rates were used with these waveforms where predicted life was by a factor of ± x2 for 77%, 87%, 82% and 92% of data points for lCr-Mo-V, 1.25Cr-Mo, 2.25Cr-Mo and 9CrlMo steels respectively. Slow-fast waveforms: Diercks equation …