Biomedical Engineering and Bioengineering Commons^™

Subject-Specific Finite Element Models Of The Human Knee For Transtibial Amputees To Analyze Tibial Cartilage Pressure For Gait, Cycling, And Elliptical Training, Jonathon Stearns

Master's Theses

It is estimated that approximately 10-12% of the adult population suffers from osteoarthritis (OA), with long reaching burdens personally and socioeconomically. OA also causes mild discomfort to severe pain in those suffering from the disease. The incidence rate of OA for individuals with transtibial amputations is much than average in the tibiofemoral joint (TF). It is well understood that abnormal articular cartilage stress, whether that be magnitude or location, increases the risk of developing OA. Finite element (FE) simulations can predict stress in the TF joint, many studies throughout the years have validated the technology used for this purpose. This …

Diy Incubator, Aryan Zia, Grace Spurlock, Garrett Janney

Biomedical Engineering

This project report provides detailed information on designing and building a DIY Incubator. The device is indicated for growing and maintaining BSL-1 mammalian or bacterial cell culture with a temperature control in the range of 25-45°C ± 1°C. The device is made fully programmable via an Arduino, and is structurally designed to fit two T75 cell culture flasks at a time. The device is able to return to a specified temperature set point within 10 minutes and maintains 5% CO2 partial pressure conditions. The incubator has a small physical footprint, with an overall dimension of 22in x 16in x 15.5in …

Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso

Biomedical Engineering

The purpose of this scope of work is to highlight the progress and development of SoloStand sponsored by Derek Herrera, chief technical officer and founder of SpinalSingularity. SoloStand is an attachment to a wheelchair that will benefit paraplegics that use wheelchairs. A portable and customizable attachment to a wheelchair will allow the user to do everyday tasks without transferring into a separate standing wheelchair and travel more easily. This document outlines everything that has been done in fulfillment of our senior project requirements.

Total Knee Arthroplasty Gap Balancer, Christina Grigorian, Andrew Beckley, Alexandra Rockett

Biomedical Engineering

California Polytechnic State University’s Biomedical Engineering Department worked in conjunction with local San Luis Obispo orthopedic surgeon Dr. Dimitri Delagrammaticas. The goal of the project was to create a surgical tool that assists a surgeon in measuring knee gap distance and balancing collateral ligament tension during a total knee arthroplasty (TKA) surgery. The final product of this project was completed in five months and initially began with understanding our sponsor’s expectations for the device. A portion of time was devoted to conducting research to understand the process of a knee replacement surgery, the requirements of the device, and the limitations …

Left Atrial Appendage Printing Process, Areli Reyes, Brandon James Mukai, Mia Noelle Von Knorring

Biomedical Engineering

The left atrial appendage senior design team aims to assist in closing off the left atrial appendage that is susceptible to coagulation due to non-valvular atrial fibrillation. Coagulation in the left atrial appendage (LAA) can be life threatening as it can lead to a stroke. Dr. Chris Porterfield performs a procedure that uses the Boston Scientific Watchman to close the appendage. He finds that sizing the Watchman properly is difficult with limited visuals from live CT scans. He proposed converting the CT scans into a 3D printed model of the left atrial appendage and left atrium so he can visually …

Cumulative Shear In Vitro Model, Jared Olson, Alex Deppe, Braden Andrews

Biomedical Engineering

The purpose of our project is to find a reliable method of Subclinical Atherosclerosis detection by measuring the pressure drop across an artery. This model is intended to display how a pressure change correlates with arterial shear rate, and how a decrease in shear rate is ultimately related to atherosclerosis wherein early detection could prove life saving for millions of patients worldwide.

On-Body Pressure For Subcutaneous Infusion Of Drug, Hannah Cole, Kayla Meacham, Eleanor Moran, Kaylee Voss

Biomedical Engineering

No abstract provided.

Integrity Testing Of Gas Permeable Silicone Filters, Maggie M. Baker, Thomas P. Humann, Kevin J. Yerina

Biomedical Engineering

This report investigates the most reasonable, cost efficient, and reliable ways to integrity test a filter made from a permeable silicone membrane for future biomedical and pharmaceutical applications. The goal of the project was to create a fixture that a pharmaceutical company can use to quickly and reliably test the integrity of the filter. A variety of methods are outlined to test the integrity of the filter, after a series of quantitative tests, a single method was established that meet the requirements most thoroughly. The method that was determined to be most effective involves a series of components including a …

Insulative (Direct Current) Dielectrophoretic Foul-Less Filtration In Microfuidic Systems, Matthew A A Whitman

Master's Theses

Filtration is a technology that is used almost ubiquitously in society from uses raging from filtration of macroparticles from water to pharmaceutical grade filtration products to remove anything larger than a protein. However, with such a wide range of uses, most filtration products have the same issue; membrane clogging (fouling) that prevents continuous use and requires frequent maintenance. This thesis hypothesizes that by applying a direct current (DC) to an insulating array of posts, they will create a foul-less insulative dielectrophoretic filter (iDEP) that does not clog since particles will levitate above the insulating array.

This thesis tested an inherited …

Methods To Increase Algae Biomass Productivity In Raceway Pond Monocultures, Ryan S. Anderson

Master's Theses

The economics of algae biofuels and bioproducts would be improved by increased biomass productivity. Two studies on this potential are described in this thesis – one on a locally isolated filamentous yellow-green alga and the other on a planktonic strain genetically improved via selective enrichment.

Polycultures have been viewed as productive, stable, and, in some cases, harvestable by natural bioflocculation. Local native strains might have higher productivity than culture collection strains because they are already adapted to local outdoor conditions. In this study, the filamentous yellow-green alga Tribonema minus was isolated from a local volunteer polyculture. Its productivity as a …

Skier's Edge: Biomechanical Analysis, Benjamin T. Johannes

Master's Theses

ABSTRACT

Skier’s Edge: Biomechanical Analysis

Benjamin T. Johannes

The Skier’s Edge trainer can be used by novice or expert skiers. Testing was performed to analyze if the use of the Skier’s Edge could reduce in shear forces of the valgus moment on the knee joint and anterior cruciate ligament (ACL) due to lesser fatigue of muscle and a higher hamstring to quadricep (H/Q) ratio activity. This leads to a reduction of improper form and an increase in balance. Experiments performed observed the change in muscle activity with the use of the Skier’s Edge over time when compared to other forms …

Prosthetic Thumb, Allison M. Sigdestad, Sahil Sharma, Cale Foreman

Biomedical Engineering

The Prosthetic Thumb Project is a senior design project completed by Biomedical Engineering Undergraduate students at California Polytechnic State University. This senior design project is aimed at designing a prosthetic thumb for a Cal Poly Pomona student who lost their thumb in an accident last year. The patient has ultimately lost between 30-40% of functionality of his left hand, and so we would like to give him that mobility back. Originally, the patient was worried about having a prosthesis, and wanted something more stagnant that would resemble the look of the thumb he lost. However, after working with him, we …

Esophageal Temperature Mapping And Monitoring Sheath, Nicole M. Rogers, Hillary Johnson, Alexander Silva

Biomedical Engineering

The purpose of this document is to provide a product development summary for an accessory device that joins an esophageal temperature probe and a mapping catheter together to be used during cardiac ablation. Catheter ablation therapy is performed in the left atrium, utilizing extremely hot or cold temperatures to create scar tissue and treat atrial fibrillation and other arrhythmias. The close positioning of the left atria adjacent to the esophagus presents a large risk as the extreme temperatures used during ablation can lead to esophageal damage or fistulas. This device is designed to integrate correlate data from the temperature probe …

Ikioo Flying Robot, Nicholas Michael Lapidus, Bosung Josh Kim, Jenny Fong

Biomedical Engineering

No abstract provided.

Gesea Biosciences - Core Shell Pellet Manufacturing Device, Claire Edelman, Maria Medrano, Rachel Longoria

Biomedical Engineering

No abstract provided.

Housecalls Mobile: Virtual Stethoscope/Otoscope, Julia Kelley, Cullen Mcgee, Eduardo Uribe-Saldana

Biomedical Engineering

At the start of the project, our initial deliverables were to add a low cost camera into virtual otoscope and to add a pediatric attachment to the stethoscope. However, about half way through the first quarter (1.5 months into the project), our deliverables changed to the following: to design a housing unit for the selected otoscope camera and to increase battery life to allow for 12+ battery life. To accomplish our deliverables, we divided up the responsibilities as follows: One person headed the mechanical design, one person headed the electrical design, and one person served as a liaison between the …

Pulsed Electrical Field Ablation Modulation, Camille Lousie Dozois, Jason Tyler Arias, Courtnee Lin Madsen

Biomedical Engineering

This document comprises the steps taken by the senior project team to create a Proof-of-Concept Review for a Variable Pulsed Electric Field Ablation Catheter. First, the team did a significant amount of background research on related literature to better understand the current status of the project topic. After sufficient background information was obtained, project objectives and deliverables were finalized. Once customer requirements and the indications for use were completed, engineering specifications for the product and project were documented. All key customer requirements and engineering specs were related to the variable pulse functionality, maneuverability, as well as overall dimensioning of the …

Design And Development Of A Robotic Platform For General Neurosurgical Procedures, Mehbodniya Amir Hossein

Student Works (2020-2029)

For the first time in 1985, robots were introduced to the neurosurgical operating rooms. Since then this field of robotics have advanced with new technologies with better accuracy and safety. However, developing robots for neurosurgery is a challenging task due to the sensitive nature of these applications and additionally their high cost of development. A typical neurosurgical robot costs millions of dollars in 2018, even though the costs of components and calculations have been lowered tremendously. This is mainly due to focus of current neurosurgical robots on few highly precise and specific surgical tasks which makes their use limited. In …

Investigation Of Dielectric Properties Of Urine For Pregnancy And Bladder Cancer Detection, Chao Zhe Zhu

Student Works (2020-2029)

Detection and monitoring of pregnancy and bladder cancer are important for medical treatment and nursing. Urine has diagnostic and prognostic values for pregnancy and bladder cancer due to the presence of biomarkers. This study investigated the dielectric properties of human urine and compared them between two groups: 1) non-pregnant healthy female volunteers and pregnant healthy female volunteers, and; 2) healthy subjects and patients with bladder cancer. An open-ended probe network analyzer was used to measure the urine dielectric constant (Ɛ’) and dielectric loss (Ɛ’’) at microwave frequency ranging from 0.2GHz to 50GHz at 25˚C (room temperature), 30˚C and 37˚C (body …

Rapid Self-Assembly Of Polymer Nanoparticles For Synergistic Codelivery Of Paclitaxel And Lapatinib Via Flash Nanoprecipitation, Shani L. Levit, Hu Yang, Christina Tang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Taxol, a formulation of paclitaxel (PTX), is one of the most widely used anticancer drugs, particularly for treating recurring ovarian carcinomas following surgery. Clinically, PTX is used in combination with other drugs such as lapatinib (LAP) to increase treatment efficacy. Delivering drug combinations with nanoparticles has the potential to improve chemotherapy outcomes. In this study, we use Flash NanoPrecipitation, a rapid, scalable process to encapsulate weakly hydrophobic drugs (logP < 6) PTX and LAP into polymer nanoparticles with a coordination complex of tannic acid and iron formed during the mixing process. We determine the formulation parameters required to achieve uniform nanoparticles and evaluate the drug release in vitro. The size of the resulting nanoparticles was stable at pH 7.4, facilitating sustained drug release via first-order Fickian diffusion. Encapsulating either PTX or LAP into nanoparticles increases drug potency (as indicated by the decrease in IC-50 concentration); we observe a 1500-fold increase in PTX potency and a six-fold increase in LAP potency. When PTX and LAP are co-loaded in the same nanoparticle, they have a synergistic effect that is greater than treating with two single-drug-loaded nanoparticles as the combination index is 0.23 compared to 0.40, respectively.

Theoretical Analysis Of The Leakage Through The Cement Line Of A Single Osteon, Gaffar Gailani, Stephen Cowin

Publications and Research

This work focuses on the Lacunar–Canalicular Porosity (PLC) of cortical bone which includes the osteons. Osteons are semicylindrical porous structures saturated with fluid within the bone and are approximately 250" role="presentation">μ" role="presentation">μm in diameter. The outer boundary of the osteon is called the cement line. Some studies suggested that the cement line is less highly mineralized and produced evidence that it has less calcium and phosphorus and more sulfur than the neighboring bone lamellae. Most authors assume that the cement line is impermeable, while others assume that some canaliculi are crossing the cement line which will make it …

Lung Nodule Malignancy Prediction From Computed Tomography Images Using Deep Learning, Rahul Paul

USF Tampa Graduate Theses and Dissertations

Lung cancer has a high incidence and mortality rate. The five-year relative survival rate for all lung cancers is 18%. Due to the high mortality and incidence rate of lung cancer worldwide, early detection is essential. Low dose Computed Tomography (CT) is a commonly used technique for screening, diagnosis, and prognosis of non-small cell lung cancer (NSCLC). The National Lung Screening Trial (NLST) compared low-dose helical computed tomography (LDCT) and standard chest radiography (CXR) for three annual screens and reported a 20% relative reduction in lung cancer mortality for LDCT compared to CXR. As such, LDCT screening for lung cancer …

Initial Development Of Corn Seedlings After Seed Priming With Nanoscale Synthetic Zinc Oxide, Michel Esper Neto, David W. Britt, Lorena Moreira Lara, Anthony Cartwright, Rayssa Fernanda De Santos, Tadeu Takeyoshi Inoue, Marcelo Augusto Batista

Biological Engineering Faculty Publications

Nanofertilizers are increasingly explored for sustainable micronutrient delivery in agriculture. Pre-treating seeds with nanofertilizers prior to planting (i.e., seed priming) reduces concerns about nanoparticle (NP) fertilizer non-target dispersion; however, priming formulations and concentrations must be carefully selected to avoid germination inhibition and toxicity. Here we investigate changes in corn seed germination and seedling development after seed priming with ZnO NPs, ZnO bulk and ZnCl₂. To evaluate the effects sterile seeds were immersed in priming solutions of 0, 20, 40, 80, 160 mg L⁻¹ Zn for the three Zn sources. Following an 8 h priming the seeds were …

Bone Marrow-Derived And Elicited Peritoneal Macrophages Are Not Created Equal: The Questions Asked Dictate The Cell Type Used, Cheryl M. Zajd, Alexis M. Ziemba, Grace M. Miralles, Terry Nguyen, Paul J. Feustel, Stanley M. Dunn, Ryan J. Gilbert, Michelle R. Lennartz

Chemical and Biochemical Engineering Faculty Research & Creative Works

Macrophages are a heterogeneous and plastic population of cells whose phenotype changes in response to their environment. Macrophage biologists utilize peritoneal (pMAC) and bone marrow-derived macrophages (BMDM) for in vitro studies. Given that pMACs mature in vivo while BMDM are ex vivo differentiated from stem cells, it is likely that their responses differ under experimental conditions. Surprisingly little is known about how BMDM and pMACs responses compare under the same experimental conditionals. While morphologically similar with respect to forward and side scatter by flow cytometry, reports in the literature suggest that pMACs are more mature than their BMDM counterparts. Given …

Architecture And Trilogy Of (Law, Theory And Hypothesis), Ahmed Hashim Hameed

Al-Esraa University College Journal for Engineering Sciences

The general cognitive expositions had focused on the study of the general knowledge frameworks of the field of architecture, with both concepts that influencing and influenced by them, which used to contain them without referring to their intellectual origins in order to understand their general effect and their role in the cognitive enrichment to the architectural field. This, in return, showed the importance of direction to study the role, influence and effect of trilogy (Law, theory and hypothesis) in the field of architecture, according to their general reality knowledge and their specific theoretical and intellectual characteristics. This research deals with …

The Impact Of Spatial Location Of Functions To Identify Architectural Forms As A Landmark (Case Study - Contemporary Islamic Architecture -), Ibtisam Abdulelah Mohammed Al Khafaji, Maha Haki Ismaeil

Al-Esraa University College Journal for Engineering Sciences

This research discusses the impact of spatial location of functions inside architectural form to enhance visual legibility and how it can improve the possibilities of identifying them as a landmark. The absence of a clear conceptual frame which can be used to describe this impact forms the basic research problem. The objective aim of the research is to clarify and describe this impact. To achieve this objective aim, an analytical process was used. We supposed that spatial location of functions enhances visual legibility of forms, then improves our possibility of identifying them as a landmark. For applying the conceptual frame, …

Effect Of Loading Level Of Hybrid Reinforced Concrete Deep Beams Under Repeated Loading, Sawsan Akram Hassan, Ghsoon Ali Faroun

Al-Esraa University College Journal for Engineering Sciences

This research is devoted to investigating the experimental and theoretical behavior of hybrid deep beams under monotonic and repeated two-point loading. The dimensions and the flexural reinforcement of the deep beams were kept constant. In this work, the idea of a hybrid beam is completely different. Two types of concrete were used but not in the cross-section. The first type, which is fiberous concrete (FC), was used in casting beam sides (shear spans), while the second type was conventional concrete (CC) which was used in the middle portion of the beam (between two shear spans). This was done to strengthen …

Reverse Osmosis Method For Sulphate Re-Moval From Treated Wastewater Of Al-Doura Refinery, Rana Mohammed Rasheed

Al-Esraa University College Journal for Engineering Sciences

The treated wastewater by the industrial Wastewater Treatment Plant (WWTP) commonly named (INGECO) in Al-Doura refinery suffers from highly sulfate concentrations that exceed the EPA specified limits of 250 mg/L. Therefore, laboratory water quality historical data have been reviewed and analyzed to determine the annual rate, maximum, and peak sulfate concentrations that were found to be 360 mg/L, 425 mg/L, and 550 mg/L, respectively. Through field inspection aimed at specifying the reasons for the high sulfate concentrations in the wastewater of most refinery process units, it was found that the maximum required sulfate remaining concentration should not exceed 10 mg/L …

Comparison Between Regular And Irregular Configuration In Earthquake Resistant Design, Ali Nur-Aldeen Azeez, Ali Mohsen Jaafer Al-Khafaji

Al-Esraa University College Journal for Engineering Sciences

Earthquake-resistant design is one of the greatest challenges that must be considered by the Architect because it is a serious natural disaster that affects the stability and durability of the building. Due to the connection between the seismic behavior of buildings with its formal configuration and the differences in seismic resistance between regular and irregular buildings, the research problem presented as the confusion of seismic behavior of irregular buildings and their difference from the regular buildings when earthquakes occur. The aim of the research is to clarify the differences between regular and irregular configurations, also clarifying the design considerations in …

Pedestrian Movement Within Residential Areas, Abd Alali Hamza Mohamed

Al-Esraa University College Journal for Engineering Sciences

The network of transport within residential areas, especially within residential neighborhoods, consists mainly of roads designed to provide relative safety for road users and to prioritize solutions that enhance safety. It is believed that the pedestrian movement network should be separated from the car movement network, with a focus on road design, pedestrian paths, and the types of vehicles used in these areas to ensure safety. This research explores the solutions developed in the planning of roads and walkways in traditional housing schemes within the urban fabric of old cities. It examines the approaches and conclusions of modern models of …