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Master's Theses

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Articles 301 - 304 of 304

Full-Text Articles in Biomedical Engineering and Bioengineering

Development Of An In-Vitro Tissue Engineered Blood Vessel Mimic Using Human Large Vessel Cell Sources, Dimitri E. Delagrammaticas May 2009

Development Of An In-Vitro Tissue Engineered Blood Vessel Mimic Using Human Large Vessel Cell Sources, Dimitri E. Delagrammaticas

Master's Theses

Tissue engineering is an emerging field that offers novel and unmatched potential medical therapies and treatments. While the vast aim of tissue engineering endeavors is to provide clinically implantable constructs, secondary applications have been developed to utilize tissue-engineered constructs for in-vitro evaluation of devices and therapies. Specifically, in-vitro blood vessel mimics (BVM) have been developed to create a bench-top blood vessel model using human cells that can be used to test and evaluate vascular disease treatments and intravascular devices. Previous BVM work has used fat derived human microvascular endothelial cells (EC) sodded on an ePTFE scaffold. To create a more …


Nano-Mechanics Of Cartilage Glycosaminoglycans Using Molecular Dynamics Methods, Kevin Neil Hendrickson Jan 2009

Nano-Mechanics Of Cartilage Glycosaminoglycans Using Molecular Dynamics Methods, Kevin Neil Hendrickson

Master's Theses

Articular Cartilage (AC) is the main load carrying material in synovial joints {Hamerman, 1962} and degeneration of AC can cause pain in the form of arthritis. Current work is centered on the method of replacing damaged cartilage inside the body (in vivo) with tissue engineered outside the body (ex vivo) {Temenoff, 2000}. In order to engineer tissue ex vivo similar to the native tissue in structure and function there must be a comprehensive understanding of the mechanical properties of AC. This work focuses on the study of glycosaminoglycans (GAGs), a molecule known to be primarily responsible for the compressive stiffness …


Design And Optimization Of A Blood Vessel Mimic Bioreactor System For The Evaluation Of Intravascular Devices In Simple And Complex Vessel Geometries, Sara M. Leifer Nov 2008

Design And Optimization Of A Blood Vessel Mimic Bioreactor System For The Evaluation Of Intravascular Devices In Simple And Complex Vessel Geometries, Sara M. Leifer

Master's Theses

Coronary artery disease affects millions of people and the ability to detect and treat the disease is advancing at a rapid rate. As a result, the development of intravascular technologies is the focus of many medical device manufacturers. Specifically, coronary stent implantation is being performed in an increasing number of patients and a number of new stent designs have been introduced to the market, resulting in the need for improved preclinical testing methods. An in vitro tissue engineered “blood vessel mimic” (BVM) system has previously been established and its feasibility for the initial testing of newly emerging intravascular technology has …


Development Of A Cell Depositing System Using Inkjet Technology, Jason Robert Ozaeta Jun 2008

Development Of A Cell Depositing System Using Inkjet Technology, Jason Robert Ozaeta

Master's Theses

In the past decade, advances in tissue engineering have allowed researchers to fabricate simple tissues. However, the process of creating these native tissues is a time consuming and inefficient process. A scaffold must first be fabricated then exposed to a sea of cells in the hopes of seeding. Furthermore, even though cells may have attached, more time must be spent in order to allow the cells to migrate to their ideal locations. To deal with this problem, researchers have investigated whether rapid prototyping principals could be adapted to facilitate the cell seeding process by placing cells in their respective locations …