Biomedical Engineering and Bioengineering Commons^™

Sustainable Modification Of Stone Column Technique With Polyethylene Terephthalate (Pet) Plastic For Strengthening The Expansive Clay, Ng Jun Shen, Muzamir Hasan

Journal of Sustainable Construction Materials and Technologies

This research investigated the modification of stone column application by the association of PET plastic as a coarse aggregate material for sustainable material replacement. Clay soil improvement with a granular material fabricated column substantially affected its soil-bearing capacity. Subsequently, it avoided severe problems such as soil settlement and structural instability. Previous studies have mentioned the function and alteration of stone columns using materials like bottom ash and fly ash. Still, no attention has been paid to the utilization of PET plastic for this area. This study examined the feasibility and reliability of materials, PET plastic, and kaolin clay S300 before …

Effect Of Reinforcement Thickness And Content On The Properties Of Compressed Earth Blocks, Salah Eddine Mokeddem, Abdelmadjid Hamouine, Rabia Abdeldjebar, Atef Hamaidi

Journal of Sustainable Construction Materials and Technologies

This study explores the mechanical, hygroscopic, and thermal behavior of stabilized and unstabilized compressed earth blocks (CEB) by incorporating date palm wood chips (DPWC) as a natural fiber additive. The investigation covers a range of DPWC thicknesses (1 mm, 2 mm, 3 mm) and content variations (0% to 1% by weight), focusing on the interaction between the bio-based reinforcement and the stabilized soil matrix, which is stabilized with 10% white Portland cement. The mixtures were compressed at a pressure of 5 MPa using a hydraulic press, providing a detailed examination of how these parameters impact the structural integrity and functional …

Hands-Free Balance Protocol And Development Of An Iphone App For Self-Assessment, Jacob Matties

Master's Theses

For many clinical populations, the measurement of balance is a critical task. Previous studies have agreed that smartphone IMUs provide a valid measure of balance that can be significantly correlated with force plate measurements and is sensitive enough to distinguish between various balance poses, but many balance assessment protocols require uncommon equipment or the use of hands during assessment. These limit accessibility of balance assessment. To eliminate the need for hands or any additional equipment, this study assessed the use of a smartphone recording the root mean square of 3D acceleration magnitude. The goal of the study was to determine …

Cruising On The Beach (Cob), Juan Diego Molina Ii, Ashley Kianna Burga

Biomedical Engineering

This report details the design and development process of Cruising on the Beach (COB), a modular motorized wheelchair intended to improve beach accessibility for high school students with mobility impairments. The project aimed to create an affordable, portable, and sand-capable device using balloon wheels, an adjustable control panel, and a customizable base. Extensive background research, market analysis, design modeling, and test plans were completed. However, final fabrication was not achieved due to financial constraints and limited access to industrial machining tools needed for custom metal components. Despite these setbacks, the project delivered a robust conceptual design and a fully …

Deciphering And Translating Bioinspired Structures For Engineering Materials Design Via Computational Modeling And Machine Learning, Zhangke Yang

All Dissertations

Nature has evolved extraordinary structural materials—such as nacre, bone, and the mantis shrimp’s dactyl club—that achieve remarkable combinations of strength, toughness, and impact resistance. These properties arise from sophisticated synergies between structure and composition. Inspired by these biological systems, this dissertation presents a comprehensive investigation into bioinspired materials, uncovering fundamental mechanisms and providing guidance on designing materials with superior mechanical properties.

This dissertation begins by examining the "brick-and-mortar" structure of nacre, which informs the design of layered polymer-graphene nanocomposite films. Using coarse-grained molecular dynamics simulations, I elucidate mechanisms of dynamic wave propagation and energy dissipation in these systems, providing critical …

Dust Analyses In Ventilation Ducts, Karolina Vyhlidalova, Petr Vlček, Olga Rubinová, Jiří Bernard

Journal of Sustainable Construction Materials and Technologies

The paper describes the importance of monitoring the dust in the atmosphere of human life. It deals with the issue of dust in air ducts, approaching the methods that can be used to detect the amount of dust. For conditions for buildings in the Czech Republic there is created the methodology of quantitative and qualitative evaluation of dust sediment for the needs of HVAC and other building surfaces. The scale for visual evaluation was created and it has been elaborated the assessment of kind of particles contained in dust.

Assessment Of Long Time Approximation Equation To Determine Thermal Conductivity Of High Porous Materials With Nss Probe, Hussein Humaish, Bastien Ruet, Laurent Marmoret, Hassen Beji

Journal of Sustainable Construction Materials and Technologies

Recent economic changes have increased the focus on energy conservation in buildings. Improve insulation represents one of the biggest challenge to save energy. The TP02 Huksefux® Non Steady State Probe (NSSP) has been used to determine the thermal conductivity of the building insulation materials. Usually, the long term approximation equation (linear form) is applied to determine the thermal conductivity when using hot wire techniques. Long term approximation has been successfully used to characterize glycerol: a fluid which doesn’t present contact resistance and porosity. But, an S-shaped appears for more porous materials. So to generalize the possibility of using this method, …

Development Of 6d Electromagnetic Actuation For Micro/Nanorobots In High Viscosity Fluids For Drug Delivery, Mostafa Abdelaziz, Maki Habib

Mechanical Engineering

This research focuses on the development, design, implementation, and testing (with complete hardware and software integration) of a 6D Electromagnetic Actuation (EMA) system for the precise control and navigation of micro/nanorobots (MNRs) in high-viscosity fluids, addressing critical challenges in targeted drug delivery within complex biological environments, such as blood vessels. The primary objective is to overcome limitations in the actuation efficiency, trajectory stability, and accurate path-tracking of MNRs. The EMA system utilizes three controllable orthogonal pairs of Helmholtz coils to generate uniform magnetic fields, which magnetize and steer MNRs in 3D for orientation. Another three controllable orthogonal pairs of Helmholtz …

Optimizing A Perfusion-Compression Bioreactor Via Python Integration, Umamah Amer

Honors Theses

Bioreactors are widely used in tissue engineering to support cell and tissue growth under controlled conditions. Perfusion-compression bioreactors, like the one developed in our lab, can be used to replicate the physiological loading of bone on 3D-printed scaffolds. When seeded with osteogenic cells and subjected to mechanical loading, these scaffolds serve as a model to study osteogenesis. To simulate physiological conditions, the bioreactor must apply 1000 compression cycles at forces up to 200 N, three times daily over 14 days. Upon implementation, validation testing and experimental studies exposed several limitations in the bioreactor’s control code. The system was initially programmed …

Bilateral Gait Trainer For Transtibial Amputees, Desmond Greer, Odinachi Anene, Andrew Wallace, Noah Hill

Bioengineering Senior Theses

Lower limb amputation affects over 2.3 million individuals in the U.S., with peripheral vascular disease and diabetes as leading causes. Prosthetic rehabilitation is critical for restoring mobility, yet barriers like therapist shortages, cost, and inconsistent at-home training limit patient outcomes. This thesis presents the design, development, and testing of a bilateral gait training device that addresses these challenges by providing real-time haptic feedback and quantitative gait metrics for at-home rehabilitation. The device integrates force-sensitive resistors embedded in insoles to monitor plantar pressure distribution, haptic actuators (eccentric rotating mass motors) mounted on thigh straps to deliver corrective feedback, and an Arduino-based …

Advancing Tka Biomechanics: From Joint Simulator To Boundary Condition Development, Yashar Ali Behnam

Electronic Theses and Dissertations

This dissertation addresses four specific aims that collectively attempted to advance the experimental and computational analysis of total knee arthroplasty (TKA) components. The first study focused on the development of a novel whole knee joint simulator capable of simultaneous tibiofemoral and patellofemoral knee loading. This simulator employs custom fixturing to facilitate dynamic, unconstrained, muscle-driven PF articulation alongside controlled TF contact mechanics. Validation against experimental measurements showed strong agreement, demonstrating the simulator's potential as a valuable tool for future TKA design and surgical technique investigations.

The second study verified implant-specific physiological boundary conditions which accurately simulate activities of daily living using …

Determinants Of Knee Motion In Health, Disease, And Repair, Sean Edward Higinbotham

Electronic Theses and Dissertations

The human knee joint is a complex and intricate structure, enabling a wide range of motions and facilitating various dynamic activities throughout a person's lifetime. The combination of the knee's complexity and its role as a primary load-bearing joint has made it susceptible to regular wear and tear, leading to pain and the development of Osteoarthritis (OA), to which, the only treatment currently is total knee arthroplasty (TKA). Despite TKA being a mature procedure, 20% of patients receiving a TKA are dissatisfied with their “new” knee. To reduce that 20% dissatisfaction and improve surgical outcomes, orthopedic companies are developing advanced …

Investigating Spatial Mapping Of Lipid And Protein Alterations Within Cells And Tissues Using Raman Microspectroscopy, Elnaz Sheikh

LSU Doctoral Dissertations

The progression of various diseases is associated with alterations in the microenvironment of cells, consisting of a variety of metabolites like lipids and proteins. It is well known that lipids and proteins are potential biomarkers for indicating alterations within the cell microenvironment induced by disease, and various methods are frequently used for their examination. To understand the chemical composition and spatial distribution of constituents in tissues and cells, confocal Raman spectroscopy and microscopy, as non-destructive tools, have shown potential for monitoring abnormalities at the cellular level with high resolution and can facilitate detection through targeting multiple biomarkers. The application of …

Emg-Based Intraoperative Neuromonitoring Using Advanced Machine Learning Approaches, Abdalla Nabil Elsharkawy, Nourhan Zayed

Mechanical Engineering

Intraoperative neuromonitoring (IONM) plays a critical role in minimizing nerve damage during surgeries by providing real-time feedback on neural integrity. This study evaluated models associated with deep learning and machine learning models for electromyography classification of signal during intraoperative neuromonitoring (IONM). The CNNLSTM model achieved the highest accuracy (85.2%), outperforming traditional models like KNN (53%), RF (62%), and CNN (76%). This demonstrates the degree to which the CNN-LSTM model can gain insight into temporal and spatial dependencies throughout the EMG signals, which makes it optimal for real-time classification in IONM applications. This implies that deep learning techniques can improve surgical …

Treating Ground Water For Agricultural And Individual Consumption, Gabby Miller, Bronson Scott, Michael Clawson

Biomedical Engineering

This project, conducted in collaboration with Cal Poly seniors and Da Vinci High School students, aims to develop a solar-powered groundwater purification system. This system is designed to provide clean water for agricultural use and individual consumption, addressing the growing concerns of groundwater contamination and accessibility needs. The final prototype integrates a gravity filtration system combined with chemical purification, utilizing aluminum sulfate and chlorine to remove particulates, bacteria, and organic compounds.

The research phase involved an extensive review of groundwater contamination issues, existing filtration technologies, and market analysis. Key design constraints included cost-effectiveness, ease of maintenance, and minimal energy consumption, …

Trpv4 Dominates High Shear-Induced Initial Traction Response And Long-Term Relaxation Over Piezo1, Mohanish Chandurkar, Manli Yang, Majid Rostami, Sangyoon J. Han

Michigan Tech Publications

Modulation of endothelial traction is critical for the responses of endothelial cells to fluid shear stress (FSS), which has profound implications for vascular health and atherosclerosis. Previously, we demonstrated that under high FSS, endothelial cells rapidly increase traction forces, followed by relaxation, with traction aligning in the flow direction. In contrast, low shear preconditioning induces a modest short-term increase in traction (min), followed by a secondary long-term (>14 hr) rise, with traction/cells aligning perpendicular to the flow. The upstream mechanosensors driving these responses, however, remain unknown. Here, we sought the roles of Piezo1 and TRPV4 ion channels in shear-induced …

Hemodynamics Of Slip Surfaces For Thrombosis Control In Implanted Cardiovascular Devices, Kieun Choi, Weiguang Yang, On Shun Pak, Jongmin Seo

Mechanical Engineering Faculty Publications

Percutaneous medical devices are preferred for the treatment of cardiovascular diseases due to their minimal intervention compared to surgery. However, complications such as thrombosis remain significant challenges. This study aims to investigate the hemodynamic effects of slip surfaces on pacemaker leads and coronary stents using computational fluid dynamics under physiological conditions. Two computational models were developed: a venous anatomical model with a pacemaker lead and a coronary artery model with a stent. Slip boundary conditions were applied to these devices, and we quantitatively analyzed critical hemodynamic parameters, including wall shear stress (WSS) and residence time (RT), which are associated with …

High Shear Stress Reduces Erg Causing Endothelial-Mesenchymal Transition And Pulmonary Arterial Hypertension, Tsutomu Shinohara, Jan-Renier Moonen, Yoon Hong Chun, Yannick C. Lee-Yow, Kenichi Okamura, Jason M. Szafron, Jordan Kaplan, Aiqin Cao, Lingli Wang, Weiguang Yang

Mechanical Engineering Faculty Publications

Background: Computational modeling indicated that pathological high shear stress (HSS; 100 dyn/cm2) is generated in pulmonary arteries (PAs; 100-500 µm) in congenital heart defects causing PA hypertension (PAH) and in idiopathic PAH with occlusive vascular remodeling. Endothelial-to-mesenchymal transition (EndMT) is a feature of PAH. We hypothesize that HSS induces EndMT, contributing to the initiation and progression of PAH.

Methods: We used the Ibidi perfusion system to determine whether HSS applied to human PA endothelial cells (ECs) induces EndMT when compared with physiological laminar shear stress (15 dyn/cm2). The mechanism was investigated and targeted to prevent PAH in a mouse with …

Advancing Prosthetic Technology: 3d-Printed Robotic Arm With Micro Linear Actuators, Vu Tran, Nathan Reed, Mahdi Yazdanpour

Posters-at-the-Capitol

The increasing demand for affordable and accessible prosthetic solutions has driven innovation in the field of robotics. In this project, we present the design and development of a 3D-printed robotic prosthetic arm aimed at addressing the challenges faced by individuals with upper limb amputations. Our prosthetic arm utilizes five micro linear actuators to achieve precise and naturalistic movement. The design of the prosthetic arm prioritizes affordability and accessibility, with a focus on leveraging 3D printing technology to reduce manufacturing costs and enable customization. The use of micro linear actuators offers advantages in terms of compactness, lightweight construction, and efficient power …

The Design Of A Bioinspired Impact Mitigation System Towards The Prevention Of Brain Injuries, Bryce H. Reimer

Master’s Theses

Traumatic brain injuries (TBIs), including concussions and chronic traumatic encephalopathy (CTE), remain a major concern across contact sports, military operations, and transportation. Despite advancements in protective equipment, current strategies often fall short in preventing the mechanical conditions that contribute to long-term neurological damage. This thesis presents the design and validation of a bioinspired impact mitigation system modeled after bighorn sheep horn structures, which have evolved to endure high-energy collisions without apparent brain injury.

Using biomimetic principles, the research integrates experimental and computational methods to evaluate how horn-like geometries reduce impact-induced accelerations. A custom drop tower was built to test dynamic …

Non-Invasive Glucose Monitoring Using Ppg, Ai, And Iot-Driven Mobile Integration For Real-Time Diabetes Management, Mostafa Abdelaziz, Amr Refaie

Mechanical Engineering

Diabetes mellitus patients must regularly monitor their blood glucose levels to manage glycaemia, typically requiring capillary tests at least three times daily and laboratory tests one to two times per month. These conventional methods involve finger pricking, causing significant discomfort and stress. This study introduces an innovative non-invasive glucose monitoring approach by integrating photoplethysmography (PPG) technology with an artificial intelligence (AI) algorithm, complemented by a mobile application using Flutter, IoT systems, and Firebase cloud for real-time data access. Among the AI models tested, polynomial regression demonstrated superior accuracy in glucose prediction, achieving a Mean Squared Error (MSE) of 14.76 and …

Investigation Using Single Point Incremental Forming (Spif) To Fabricate Patient-Specific, Titanium Orbital Floor Implants, Elizabeth M. Mamros, Lauren E. Blaha Md, Christian A. Kauffman Md

Faculty Conference Papers and Presentations

The floor of the human orbit is composed of thin bone that is prone to traumatic fracture. This leads to a loss of support for the eye, which can cause vision changes. Therefore, fractures may need surgical reconstruction using a thin, sheet-like implant. Titanium implants are available off-the-shelf in standard sizes, but fitting to each patient’s unique anatomy requires surgeons to cut, file, and bend these plates. This can be time-consuming and imprecise. To both save time and ensure a perfect fit for the patient, a custom plate can be created prior to surgery. This investigation focuses on single-point incremental …

Simplified Molecular Diagnostics Methods For Environmental Testing Of Pathogens And Other Applications, Mohammad Dehghan Banadaki

Theses and Dissertations--Mechanical and Aerospace Engineering

Environmental Surveillance (ES) has emerged as a powerful tool to monitor the emergence and persistence of a pathogen within a facility or community using wastewater/water analysis. Over the past four years, implementation of ES has experienced an explosive acceleration, driven by efforts to monitor the spread of SARS-CoV-2, which has made ES a routinely used public health tool in many locations. We can now use ES to measure the emergence/presence/abundance of different viruses (e.g., SARS-CoV-2, influenza, mpox), bacteria (e.g., E. coli, V. cholerae, antibiotic-resistant strains), fungi (e.g., C. auris), and other biological markers indicative of infectious diseases. However, its broad …

Direct Numerical Simulation Of Pulsating Flow In Curved Pipes: Insights Into Aortic Dissection In Humans, Gokul Anugrah Gopakumar

Theses and Dissertations--Mechanical and Aerospace Engineering

This dissertation investigates the hemodynamics of pulsating blood flow in curved vessels through direct numerical simulations (DNS), with the overarching aim of uncovering fluid dynamic mechanisms linked to the onset and progression of aortic dissection in humans. The work is structured in two parts: (i) fundamental studies in idealized geometries and (ii) preliminary investigations in patient-specific anatomies. In the first part, curved pipe models representing the aortic arch are used to isolate the effects of pulsation frequency, amplitude ratio, and curvature ratio on transitional and turbulent flow dynamics. The simulations reveal that curvature-driven centrifugal forces shift the peak velocity toward …

Integrated Compliant Structure For A Hand Exoskeleton, Tristan R. Koopman

Honors Undergraduate Theses

This thesis presents the design and prototyping of a wearable hand exoskeleton that integrates a flexible structural framework to assist with hand movement while maintaining comfort and anatomical conformity. The goal was to create a device that supports tendon-driven actuation through a compliant structure, combining elements of rigidity and flexibility to match the natural geometry and motion of the human hand. Traditional hand exoskeletons often trade off motion for structure or vice versa. This project aims to bridge that gap with a hybrid compliant design that balances flexibility and support. The design process followed an iterative approach involving rapid prototyping …

Online Parameter Adaptation Of Lqr Controllers Via Rls For Prosthetic Joint Control: Experimental Validation On A Quanser Qube-Servo 2 Platform, Cynthia Lopez-Jordan

Theses and Dissertations

This thesis develops and experimentally validates an online adaptive Linear Quadratic Regulator (LQR) control method for prosthetic joint systems using Recursive Least Squares (RLS)-based real-time parameter estimation on the Quanser QUBE-Servo 2 platform. Traditional LQR controllers assume a fxed system model, which limits adaptability and results in reduced tracking accuracy, poor robustness, and loss of optimal performance when applied to dynamically changing prosthetic joints, infuenced by load variations, user gait changes, and mechanical wear. Limited experimental validation exists for combining RLS with online LQR adaptation in prosthetic-like systems.

To address these limitations, an RLS-driven Adaptive LQR framework was implemented to …

Design And Control Of A Stroke Therapy Device, Hugh Elliott

Open Access Master's Theses

Stroke is a leading cause of physical disability around the world, and the likelihood of stroke increases as people live longer. The current number of physiotherapists is insufficient to meet the increasing demand for their services. As a result, there has been a focus on developing robotic devices that function similarly to traditional therapy, enabling multiple patients to be seen simultaneously. While many devices have been created and tested, most are expensive, complex, and require trained personnel for supervision, thereby limiting their outreach. This thesis presents the design and control of a low-cost stroke therapy device designed to promote upper …

Effects Of Changes In Strouhal And Reynolds Numbers On Beetle Wing Aerodynamics, Keith L. Thiha

Honors Undergraduate Theses

Insect flight has long been a subject of interest across the scientific community, largely due to the exceptional aerodynamic performance insects demonstrate relative to their size. Insects tend to have very high aerodynamic performance characteristics like thrust and lift generation compared to their size. This has many potential applications in improving aircraft performance, however the flow phenomena concerning insect wing aerodynamics is still an area of ongoing research. This study aims to investigate how variations in key nondimensional flow parameters—specifically the Reynolds number and Strouhal number—affect the aerodynamic performance of beetle wings. Strouhal numbers ranging from 0.2 to 0.6 were …

Finite Element Modeling And Experimental Characterization Of Overmolded Gold-Palladium Composite Leads And Their Mechanical Behavior Under Cyclic Fatigue For Long-Term Implant Applications, Tanner Davis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Auditory Nerve Interface (ANI) devices, currently in developmental stages, represent an emerging neuroprosthetic approach to restore hearing in severe sensorineural loss patients by directly stimulating the auditory nerve via the Utah Slanted Electrode Array (USEA). Conventional implant leads are comprised of multiple wires made from materials such as platinum-iridium and MP35N stainless steel that are overmolded in an insulative material. These materials are not possible to bond with to electrode array used in the ANI device, necessitating the evaluation of a new material like Au-Pd to ensure its functionality and durability under cyclic stresses. This gap necessitates characterization of alternative …

Application-Driven Materials Development Of Solid-State Conductive Composites Of Ultra-High Molecular Weight Polyethylene, Peder Solberg

Dartmouth College Ph.D Dissertations

Ultra-high molecular weight polyethylene (UHMWPE) is a linear long chain homopolymer valued for its toughness, wear resistance, and chemical inertness. In the medical field, these properties make it the material of choice for bearing surfaces despite recognized tradeoffs between wear resistance, toughness, and oxidation resistance. Electrically conductive composites of UHMWPE show promise to enable new types of smart and active load-bearing implants in a future of personalized medicine, if beneficial properties can be maintained with the addition of solid-state additives.

Clinical need-finding conducted through Dartmouth’s Training Program in Surgical Innovation revealed several potential applications for conductive, load-bearing polymers. These include: …