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Articles 6661 - 6690 of 9242
Full-Text Articles in Engineering
Opportunities And Challenges Of Generative Ai In Construction Industry: Focusing On Adoption Of Text-Based Models, Prashnna Ghimire, Kyungki Kim, Manoj Acharya
Opportunities And Challenges Of Generative Ai In Construction Industry: Focusing On Adoption Of Text-Based Models, Prashnna Ghimire, Kyungki Kim, Manoj Acharya
Durham School of Architectural Engineering and Construction: Faculty Publications
In the last decade, despite rapid advancements in artificial intelligence (AI) transforming many industry practices, construction largely lags in adoption. Recently, the emergence and rapid adoption of advanced large language models (LLMs) like OpenAI’s GPT, Google’s PaLM, and Meta’s Llama have shown great potential and sparked considerable global interest. However, the current surge lacks a study investigating the opportunities and challenges of implementing Generative AI (GenAI) in the construction sector, creating a critical knowledge gap for researchers and practitioners. This underlines the necessity to explore the prospects and complexities of GenAI integration. Bridging this gap is fundamental to optimizing GenAI’s …
Digital Phobia: An Inquiry For Mapping The Unseen Dimension Of New Digital Anxiety, The ‘Digiphobia’, Amarjit Kumar Singh ,Library Assistant, Md. Arshad Ali , Professional Assistant, Dr. Pankaj Mathur, Deputy Librarian,
Digital Phobia: An Inquiry For Mapping The Unseen Dimension Of New Digital Anxiety, The ‘Digiphobia’, Amarjit Kumar Singh ,Library Assistant, Md. Arshad Ali , Professional Assistant, Dr. Pankaj Mathur, Deputy Librarian,
Library Philosophy and Practice (e-journal)
Background: As technology continues to advance, individuals' interactions with digital platforms have become integral to daily life. Amidst this technological evolution, a novel concern emerges—Digital Phobia, hereafter referred to as “Digiphobia.” This phenomenon, although not previously explored in scholarly literature, necessitates an in-depth investigation due to its potential impact on individuals' well-being. Our research employs a two-step methodology to investigate its existence, implications, and manifestations.
Introduction: This research paper introduces and proposes the term "Digiphobia" as a comprehensive conceptualization of anxiety arising from interactions with digital spaces, applications, and environments. The proliferation of digital technologies has led to the emergence …
Scaffold-Based 3d Cell Culture Models In Cancer Research, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini
Scaffold-Based 3d Cell Culture Models In Cancer Research, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini
Faculty Publications
Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexity of in vivo tumors. This approach has revolutionized cancer research by providing a more accurate representation of the tumor microenvironment (TME) and enabling the study of tumor behavior and response to therapies in a more physiologically relevant context. One of the key benefits of 3D cell culture in cancer research is the ability to recapitulate the complex interactions …
Performance Of Photocatalytic Oxidizing Air Cleaners In Different Experimental Setups – A Review, Giovanni Cerrato, Nelson Fumo
Performance Of Photocatalytic Oxidizing Air Cleaners In Different Experimental Setups – A Review, Giovanni Cerrato, Nelson Fumo
Mechanical Engineering Faculty Publications and Presentations
Photocatalytic oxidizing (PCO) air cleaners are offered for the abatement of gaseous pollutants (i.e., Volatile Organic Compounds or VOCs). However, due to a lack of testing standards, the overall characterization of the technology's effectiveness has been met with conflicting results. Different studies use varying experimental setups, test conditions, and different PCO air cleaner designs. According to the literature, the majority of testing has been in controlled laboratory setups with favorable conditions. As PCO air cleaner testing is scaled up to more realistic environments and conditions, the PCO removal efficiency tends to significantly decrease. The differences in removal efficiency can be …
Model Predictive Control Of A Lab-Scale Thermal Energy Storage System In Relap5-3d, Jaron Wallace, Daniel Hill, David Thurston, John Hedengren, Matthew Memmott
Model Predictive Control Of A Lab-Scale Thermal Energy Storage System In Relap5-3d, Jaron Wallace, Daniel Hill, David Thurston, John Hedengren, Matthew Memmott
Faculty Publications
Increased renewable energy penetration of an electrical grid generally creates more supply fluctuations. Traditional base-load systems, such as nuclear power, can be retrofitted with thermal energy storage (TES) systems to meet supply demand fluctuations. These systems can store energy during low electricity demand times to allow the reactor to operate at constant power while simultaneously fluctuating electricity output. The control of these systems is of vital importance and Model Predictive Control (MPC) is a leading control mechanism for optimized production plans with forecast information. This study combines high fidelity RELAP5-3D models with MPC to control an experimental benchtop system that …
Suitability Of The Height Above Nearest Drainage (Hand) Model For Flood Inundation Mapping In Data-Scarce Regions: A Comparative Analysis With Hydrodynamic Models, Navin Tony Thalakkottukara, Jobin Thomas, Melanie Watkins, Benjamin C. Holland, Thomas Oommen, Himanshu Grover
Suitability Of The Height Above Nearest Drainage (Hand) Model For Flood Inundation Mapping In Data-Scarce Regions: A Comparative Analysis With Hydrodynamic Models, Navin Tony Thalakkottukara, Jobin Thomas, Melanie Watkins, Benjamin C. Holland, Thomas Oommen, Himanshu Grover
Michigan Tech Publications
Unprecedented floods from extreme rainfall events worldwide emphasize the need for flood inundation mapping for floodplain management and risk reduction. Access to flood inundation maps and risk evaluation tools remains challenging in most parts of the world, particularly in rural regions, leading to decreased flood resilience. The use of hydraulic and hydrodynamic models in rural areas has been hindered by excessive data and computational requirements. In this study, we mapped the flood inundation in Huron Creek watershed, Michigan, USA for an extreme rainfall event (1000-year return period) that occurred in 2018 (Father’s Day Flood) using the Height Above Nearest Drainage …
Parallel Algorithm For Testing The Singularity Of An N-Th Order Matrix, Ehab Alasadi
Parallel Algorithm For Testing The Singularity Of An N-Th Order Matrix, Ehab Alasadi
Al-Bahir
Analyze the possibilities of implementing a parallel algorithm to test the singularity of the N-th order matrix. Design and implement in ( C/C++) a solution based on sending messages between nodes using the PVM system library. Distribute the load among the nodes such that the computation time is as small as possible. Find out how the execution time and calculation acceleration depend on the number of nodes and the size of the problem (indicate the table and graphs). Based on the results, estimate the communication latency, for what size the task is (well) scalable on the given architecture, and what …
Extended Event Calculus Using Neutrosophic Logic: Method, Implementation, Analysis, Recent Progress And Future Directions, Antonios Paraskevas
Extended Event Calculus Using Neutrosophic Logic: Method, Implementation, Analysis, Recent Progress And Future Directions, Antonios Paraskevas
Neutrosophic Systems with Applications
Brains do not reason as digital computers do. Computers reason in clear steps with statements that are either true or false, while humans reason with vague terms of common sense. Neutrosophy is a new branch of philosophy and machine intelligence that deals with neutralities, specifically the idea of indeterminacy that is evident and experienced in our everyday lives. Indeterminacy is interpreted as everything that falls between a concept, idea, statement, declaration, etc. and its opposite. The fundamental thesis of neutrosophy is to employ neutrosophic logic, an extension of fuzzy logic, to incorporate fuzzy truth into complex schemes of formal reasoning. …
Machiavellianism And Security: Leveraging Queries At Llms For Black Hat Operations, Niroop Sugunaraj, Prakash Ranganathan
Machiavellianism And Security: Leveraging Queries At Llms For Black Hat Operations, Niroop Sugunaraj, Prakash Ranganathan
Electrical Engineering Posters and Presentations
Critical infrastructure like the power grid are at risk from increasing cyber threats due to the growth of distributed energy resources ( relying heavily on internet connectivity Compromised DER endpoints are susceptible to cyber attacks and it is important to first identify evolving cybersecurity issues in widely deployed architectures, communication protocols, and networks Information produced from artificial intelligence ( based co pilots are emerging threats that can offer convenient and detailed playbooks to compromise DERs through multiple attack vectors even for a non technical black hat community and should therefore be considered as a repository for unethical hackers
Engineering Neurotoxin-Functionalized Exosomes For Targeted Delivery To The Peripheral Nervous System, Mena Asha Krishnan, Olawale A. Alimi, Tianshu Pan, Mitchell Kuss, Zeljka Korade, Guoku Hu, Bo Liu, Bin Duan
Engineering Neurotoxin-Functionalized Exosomes For Targeted Delivery To The Peripheral Nervous System, Mena Asha Krishnan, Olawale A. Alimi, Tianshu Pan, Mitchell Kuss, Zeljka Korade, Guoku Hu, Bo Liu, Bin Duan
Department of Mechanical and Materials Engineering: Faculty Publications
The administration of therapeutics to peripheral nerve tissue is challenging due to the complexities of peripheral neuroanatomy and the limitations imposed by the blood–nerve barrier (BNB). Therefore, there is a pressing need to enhance delivery effectiveness and implement targeted delivery methods. Recently, erythrocyte-derived exosomes (Exos) have gained widespread attention as biocompatible vehicles for therapeutics in clinical applications. However, engineering targeted Exos for the peripheral nervous system (PNS) is still challenging. This study aims to develop a targeted Exo delivery system specifically designed for presynaptic terminals of peripheral nerve tissue. The clostridium neurotoxin, tetanus toxin-C fragment (TTC), was tethered to the …
Alice In Cyberspace 2024, Stanley Mierzwa
Alice In Cyberspace 2024, Stanley Mierzwa
Center for Cybersecurity
‘Alice in Cyberspace’ Conference Nurtures Women’s Interest, Representation in Cybersecurity
Stick-Fixed Maneuver Points In Roll, Pitch, And Yaw And Associated Handling Qualities, Benjamin C. Moulton, Troy A. Abraham, Douglas F. Hunsaker
Stick-Fixed Maneuver Points In Roll, Pitch, And Yaw And Associated Handling Qualities, Benjamin C. Moulton, Troy A. Abraham, Douglas F. Hunsaker
Mechanical and Aerospace Engineering Student Publications and Presentations
The stick-fixed pitch maneuver point is an important measure of aircraft longitudinal dynamic response and handling quality characteristics, and includes effects of both aerodynamic and inertia properties of the aircraft about the pitch axis. In the present work, the existence of stick-fixed roll and yaw maneuver points is demonstrated, which are determined from the lateral forces, moments, and inertial properties of the aircraft. These stick-fixed roll and yaw maneuver points are directly related to the predicted lateral handling qualities. Example results are included for several aircraft that demonstrate the importance of this parameter when predicting the dynamic response of the …
Extended Event Calculus Using Neutrosophic Logic: Method, Implementation, Analysis, Recent Progress And Future Directions, Antonios Paraskevas
Extended Event Calculus Using Neutrosophic Logic: Method, Implementation, Analysis, Recent Progress And Future Directions, Antonios Paraskevas
Neutrosophic Systems with Applications
Brains do not reason as digital computers do. Computers reason in clear steps with statements that are either true or false, while humans reason with vague terms of common sense. Neutrosophy is a new branch of philosophy and machine intelligence that deals with neutralities, specifically the idea of indeterminacy that is evident and experienced in our everyday lives. Indeterminacy is interpreted as everything that falls between a concept, idea, statement, declaration, etc. and its opposite. The fundamental thesis of neutrosophy is to employ neutrosophic logic, an extension of fuzzy logic, to incorporate fuzzy truth into complex schemes of formal reasoning. …
Evaluation Of First-Order Actuator Dynamics And Linear Controller For A Bio-Inspired Rotating Empennage Fighter Aircraft, Benjamin C. Moulton, Matthew W. Harris, Douglas F. Hunsaker, James J. Joo
Evaluation Of First-Order Actuator Dynamics And Linear Controller For A Bio-Inspired Rotating Empennage Fighter Aircraft, Benjamin C. Moulton, Matthew W. Harris, Douglas F. Hunsaker, James J. Joo
Mechanical and Aerospace Engineering Student Publications and Presentations
This paper considers the problem of stabilizing a bio-inspired fighter aircraft variant at its Air Combat Maneuver Condition. The aircraft equations of motion are linearized, and an infinite-horizon linear quadratic regulator design is conducted for this aircraft. Included in the dynamics are first-order actuator models, which have the effect of slowing actuator responses. This is particularly important for the bio-inspired variant because it requires rotation of the empennage, which has relatively large inertia. The bio-inspired variant open-loop system is unstable in the short period and Dutch roll modes, which is mitigated in the closed-loop system. Monte Carlo simulation responses to …
Detection And Classification Of Sporadic E Using Convolutional Neural Networks, J. A. Ellis, Daniel J. Emmons, M. B. Cohen
Detection And Classification Of Sporadic E Using Convolutional Neural Networks, J. A. Ellis, Daniel J. Emmons, M. B. Cohen
Faculty Publications
In this work, convolutional neural networks (CNN) are developed to detect and characterize sporadic E (Es), demonstrating an improvement over current methods. This includes a binary classification model to determine if Es is present, followed by a regression model to estimate the Es ordinary mode critical frequency (foEs), a proxy for the intensity, along with the height at which the Es layer occurs (hEs). Signal-to-noise ratio (SNR) and excess phase profiles from six Global Navigation Satellite System (GNSS) radio occultation (RO) missions during the years 2008–2022 are used as the inputs of the model. Intensity (foEs) and the …
Pcl And Dmso2 Composites As Biomaterials For Additive Manufacturing, Jae-Won Jang
Pcl And Dmso2 Composites As Biomaterials For Additive Manufacturing, Jae-Won Jang
Dissertations and Theses
Tissue engineering provides a viable solution to address the shortage of organ donors for allograft transplants. Its primary objective is the replacement or regeneration of damaged tissues which is developed by combining living cells, a scaffold, and a bioreactor. Among these components, the scaffold serves as an artificial extracellular matrix (ECM), which plays a pivotal role in supporting cell adhesion, proliferation, differentiation, and overall tissue development. Additive manufacturing (AM), commonly referred to as three-dimensional (3D) printing, emerges as a promising method for scaffold fabrication due to its capability to create complex and repeatable geometries.
Polycaprolactone (PCL) has been one of …
Diagnosis Of Disease Affecting Gait With A Body Acceleration‑Based Model Using Reflected Marker Data For Training And A Wearable Accelerometer For Implementation, Mohammad Ali Takallou, Farahnaz Fallahtafti, Mahdi Hassan, Ali Al‑Ramini, Basheer Qolomany, Iraklis I. Pipinos, Sara A. Myers, F. M. Alsaleem
Diagnosis Of Disease Affecting Gait With A Body Acceleration‑Based Model Using Reflected Marker Data For Training And A Wearable Accelerometer For Implementation, Mohammad Ali Takallou, Farahnaz Fallahtafti, Mahdi Hassan, Ali Al‑Ramini, Basheer Qolomany, Iraklis I. Pipinos, Sara A. Myers, F. M. Alsaleem
Durham School of Architectural Engineering and Construction: Faculty Publications
This paper demonstrates the value of a framework for processing data on body acceleration as a uniquely valuable tool for diagnosing diseases that affect gait early. As a case study, we used this model to identify individuals with peripheral artery disease (PAD) and distinguish them from those without PAD. The framework uses acceleration data extracted from anatomical reflective markers placed in different body locations to train the diagnostic models and a wearable accelerometer carried at the waist for validation. Reflective marker data have been used for decades in studies evaluating and monitoring human gait. They are widely available for many …
Yap Mechanotransduction Under Cyclic Mechanical Stretch Loading For Mesenchymal Stem Cell Osteogenesis Is Regulated By Rock, Eunju Kim, Brandon D. Riehl, Tasneem Bouzid, Ruiguo Yang, Bin Duan, Henry J. Donahue, Jung Yul Lim
Yap Mechanotransduction Under Cyclic Mechanical Stretch Loading For Mesenchymal Stem Cell Osteogenesis Is Regulated By Rock, Eunju Kim, Brandon D. Riehl, Tasneem Bouzid, Ruiguo Yang, Bin Duan, Henry J. Donahue, Jung Yul Lim
Department of Mechanical and Materials Engineering: Faculty Publications
While yes-associated protein (YAP) is now recognized as a potent mechanosensitive transcriptional regulator to affect cell growth and differentiation including the osteogenic transcription of mesenchymal stem cells (MSCs), most studies have reported the YAP mechanosensing of static mechanophysical cues such as substrate stiffness. We tested MSC response to dynamic loading, i.e., cyclic mechanical stretching, and assessed YAP mechanosensing and resultant MSC osteogenesis. We showed that cyclic stretching at 10% strain and 1 Hz frequency triggered YAP nuclear import in MSCs. YAP phosphorylation at S127 and S397, which is required for YAP cytoplasmic retention, was suppressed by cyclic stretch. We also …
Grand Challenges In Membrane Transport, Modeling And Simulation, Jacob Monroe, Chidambaram Thamariselvan, Ranil Wickramasinghe
Grand Challenges In Membrane Transport, Modeling And Simulation, Jacob Monroe, Chidambaram Thamariselvan, Ranil Wickramasinghe
Chemical Engineering Faculty Publications and Presentations
Today, membranes play an increasing role in separation processes across a wide range of industries, including water treatment, biomedical applications, bioseparations, and gas separations (Yeom et al., 2022). Numerous different membrane types exist, which can be broadly categorized as either porous or non-porous, where pores may be or may not be filled with a separate phase from the bulk solvent and membrane phases. In addition, various driving forces exist - pressure, concentration, electric field, etc.—that lead to transport across the membrane. For a porous membrane, solute transport is usually governed by convective flow through the pores. Micron-sized pores are used …
Soil Improvement Using Fungal Mycelium Of Trichoderma Virens And Construction Techniques Of Mud Dauber, Park Joon Soo
Soil Improvement Using Fungal Mycelium Of Trichoderma Virens And Construction Techniques Of Mud Dauber, Park Joon Soo
LSU Doctoral Dissertations
Traditional ground improvement techniques involve high energy consumption and expensive and invasive earthworks. To develop sustainable ground improvement techniques, extensive research has explored biological processes and strategies. This dissertation identifies two organisms, fungal mycelium and mud dauber wasp, as sources of utilization and inspiration for the development of sustainable soil improvement techniques.
Filamentous fungi can form a root-like interconnected complex network known as fungal mycelium. Fungal mycelium can extend through soil pores and secrete hydrophobic compounds, binding soil particles and increasing soil water repellency. This dissertation conducted experimental studies to investigate the effects of fungal mycelium on hydraulic and mechanical …
Side Lobe Level Reduction And Array Thinning Of Concentric Circular Antenna Arrays, Alzahraa H. Nosier, Ahmed M. Elkhawaga, Mohamed E. Nasr, Nessim M. Mahmoud, Amr H. Hussein
Side Lobe Level Reduction And Array Thinning Of Concentric Circular Antenna Arrays, Alzahraa H. Nosier, Ahmed M. Elkhawaga, Mohamed E. Nasr, Nessim M. Mahmoud, Amr H. Hussein
Mansoura Engineering Journal
This paper presents a new beamforming technique based on the hybrid combination of the convolution algorithm (CA) and the genetic algorithm (GA) for reducing side lobe level (SLL) and array thinning of concentric circular antenna arrays (CCAA), which is denoted as C/GA technique. The CA determines the excitations of the elements, while the GA optimizes the radii of the circular arrays to adjust the half-power beamwidth (HPBW). For CCAA consisting of uniform feeding circular arrays, we assume that there are excitation coefficients that are distributed symmetrically around the array center and arranged in a vector. The excitation vector is convolved …
Zinc And Bismuth Additives' Impacts On The Physical Properties Of Lead-Free Alloys Used In Electronic Appliances, Hesham Elzanaty, Rizk Mostafa Shalaby
Zinc And Bismuth Additives' Impacts On The Physical Properties Of Lead-Free Alloys Used In Electronic Appliances, Hesham Elzanaty, Rizk Mostafa Shalaby
Mansoura Engineering Journal
The goal of the current analysis was to analytically inspect how the addition of zinc and bismuth would alter the binary structure of the lead-free solder Sn-5Sb. Binary arrangement results have been stretched to the ternary arrangements Sn–5Sb–XBi or XZn (0 ≤ X ≤ 4wt.%) solder that were composed through rapid solidification processing (RSP) using the melt–spun method. The created phases were revealed through metallographic study of the formed alloys using XRD. High elastic modulus E = 32.5 GPa and good electrical resistivity = 26x10-8 .m are two characteristics of binary Sn-Sb doped with Bi. The alloy Sn–5Sb–4Zn owns the …
Improvement Of Convective Drying Equipment, A Ponasenko, Jasur Safarov, Shaxnoza Sultanova
Improvement Of Convective Drying Equipment, A Ponasenko, Jasur Safarov, Shaxnoza Sultanova
Technical science and innovation
Drying of agricultural raw materials is an energy-consuming but integral process. Therefore, increasing the efficiency of drying and improving the quality indicators of dried material at minimum material and energy costs is relevant for producers of agricultural products. By present time numerous researches on improvement of constructions and processes of work of dryers providing satisfactory parameters of energy saving have been carried out. In some scientific materials it is shown that the use of generative gas and straw as fuel allows to reduce energy costs for the drying process in the fluidised bed dryer by 10-30%, the quality of seeds …
Existing Methods For Monitoring Power Autotransformers, Nurali Berdiyorovich Pyrmatov, Dilafruz Rustamjon Qizi Abdullabekova
Existing Methods For Monitoring Power Autotransformers, Nurali Berdiyorovich Pyrmatov, Dilafruz Rustamjon Qizi Abdullabekova
Technical science and innovation
autotransformers, methods, diagnostics, efficiency, monitoring.Particular attention is given to analyzing the gas composition of transformer oil, which is a sensitive indicator of various defects such as thermal breakdown and heating. In addition, methods based on the measurement of external magnetic field strength are discussed. This technique provides a unique opportunity to detect magnetic anomalies associated with possible defects in the structural components of the transformer. The article emphasizes that successful monitoring requires an integrated approach, combining different techniques. The authors analyze the advantages and limitations of each method and offer practical recommendations for integrating these methods into maintenance systems. In …
Mathematical Modeling Of Fruit Drying And System Analysis Of The Process (On The Example Of Persimmon), Gani Dadayev, Jasur Safarov, Shakhnoza Sultanova, Qobiljon Muxiddinov
Mathematical Modeling Of Fruit Drying And System Analysis Of The Process (On The Example Of Persimmon), Gani Dadayev, Jasur Safarov, Shakhnoza Sultanova, Qobiljon Muxiddinov
Technical science and innovation
Vegetable raw materials, as an object of drying, are characterized by a large amount of water and a low content of dry substances. Vegetable raw materials have a capillary-porous structure. Food products contain both bound and free moisture at the same time. The removal of moisture from the material during drying depends on the total moisture content and the form of connection of moisture with the material. Adsorption and osmotic - bound moisture is retained at the interface of colloidal particles with the environment. Food products contain both bound and free moisture at the same time. The quantitative ratio between …
Capacitive Electrode Based Moisture Measurement Converter Errors And How To Eliminate Them, Hamdam Jabborov, Temurbek Rashidov
Capacitive Electrode Based Moisture Measurement Converter Errors And How To Eliminate Them, Hamdam Jabborov, Temurbek Rashidov
Technical science and innovation
The article discusses the errors associated with the moisture measuring transducer that is based on the cylindrical electrode, along with their sources and calculation formulas for error elimination. The initial capacitance of the capacitive electrode humidity converter is dependent on its geometric parameters, such as the radii of the electrodes and their length. Accurate calculation of these geometric parameters enables the reduction of regular measurement errors in the input and switching circuit of the moisture converter to a minimum value, resulting in a significant increase in the informativeness and accuracy of the output signal. Consequently, some sources of measurement errors …
Influence Of Foil Stamping Parameters On Image Quality, Khalima Abishevna Babakhanova, Mukhlisa Ergashevna Khasanova, Aziz Azimjonovich Soadatov, Nigora Junaydullaevna Sadriddinova
Influence Of Foil Stamping Parameters On Image Quality, Khalima Abishevna Babakhanova, Mukhlisa Ergashevna Khasanova, Aziz Azimjonovich Soadatov, Nigora Junaydullaevna Sadriddinova
Technical science and innovation
The paper evaluates the influence of technological process parameters, namely die temperature and pressure force, on the quality of foil stamping, which is one of the types of finishing having a wide range of applications due to giving unique decorative and protective elements to printed products. When evaluating the influence of process parameters on the linearity and coverability of the image, it was found that the pressure force has less influence on the result than the temperature. According to the data of the study, it can be concluded that the maximum percentage of completeness of covering is achieved at a …
Cancer Treatment By Targeting Hdac4 Translocation Induced By Microsecond Pulsed Electric Field Exposure: Mechanistic Insights Through Kinases And Phosphatases, Zahra Safaei
Theses and Dissertations
Epigenetic modifications, arising from sub-cellular shifts in histone deacetylase (HDAC) activity and localization, present promising strategies for diverse cancer treatments. HDACs, enzymes responsible for post-translational histone modifications, induce these epigenetic changes by removing acetyl groups from ε-N-acetyl-lysine residues on histones, thereby suppressing gene transcription. Within the HDAC group, class IIa HDACs are notable for their responsiveness to extracellular signals, bridging the gap between external stimuli, plasma membrane, and genome through nuclear-cytoplasmic translocation. This localization offers two significant mechanisms for cancer treatment: nuclear accumulation of HDACs represses oncogenic transcription factors, such as myocyte-specific enhancer factor 2C (MEF2C), triggering various cell death …
Enhancing Bridge Resilience And Overheight Vehicle Mitigation Through Innovative Sacrificial Cushion Systems, Aly Mousaad Aly, Marc Hoffmann
Enhancing Bridge Resilience And Overheight Vehicle Mitigation Through Innovative Sacrificial Cushion Systems, Aly Mousaad Aly, Marc Hoffmann
Faculty Publications
Transportation departments have made significant strides in addressing the challenges posed by the increasing weights of trucks on bridges. While there is a growing awareness of overheight vehicle collisions with bridges, implementing effective countermeasures remains limited. The susceptibility of bridges to damage from such collisions is on the rise, further exacerbated by unpredictable lateral impact forces. This study employs nonlinear impact analysis to assess the response of an unprotected vehicle-girder model, yielding realistic deformation outcomes comparable to observed impacts on the US-61 bridge. Predictions for a truck traveling at 112.65 km/h indicate deformations of 0.229 m, 0.161 m, and 0.271 …
Development Of A Xenograft For Annular Repair Using Pulsed Electric Field Exposures For Enhanced Decellularization, Prince Mensah Kwaku Atsu
Development Of A Xenograft For Annular Repair Using Pulsed Electric Field Exposures For Enhanced Decellularization, Prince Mensah Kwaku Atsu
Theses and Dissertations
Severe back injuries and chronic pain necessitate surgical replacement of damaged intervertebral disc (IVD) cartilage in advanced disease stages. Bovine IVD tissue has been exposed to an upper threshold pulsed electric field (PEF) dose, causing cell death without thermal damage to the tissue. Subsequent PEF exposures at lower magnitudes have accelerated the removal of immunogenic biomolecules though electrokinetic extraction using optimized aqueous solutions. This approach yields a natural scaffold, ready for biocompatibility and mechanical strength assessment. The effects of microsecond pulsed electric fields (µsPEF) on primary bovine AF fibroblast-like cells have been characterized in vitro. PEFs of 10 and 100 …