Engineering Commons^™

High Throughput Cellular Screening Technologies For Engineering Enhanced-Solubility And Deimmunized Biologics, Andrew Y. Chang

Dartmouth College Ph.D Dissertations

High throughput cell-based screening methodologies have become core development tools for the generation and engineering of various biotherapeutics. For example, SpCas9 variants for use in CRISPR-Cas9 therapeutics have been engineered for enhanced specificity using a high throughput directed evolution approach in E. coli. Additionally, antibodies are routinely discovered and engineered for high affinity binding using yeast surface display. These high throughput techniques typically involve generation of large protein libraries which require innovative screening strategies depending on the target protein’s function. In this thesis work, we describe high throughput protein library screening approaches to address recombinant biologic aggregation and immunogenicity …

Characterization Of Virgin, Re-Used, And Oxygen-Reduced Copper Powders Processed By The Plasma Spheroidization Process, M. Hossein Sehhat, David Perez-Palomino, Connor Wiedemeier, Tristan Cullom, Joseph William Newkirk

Mathematics and Statistics Faculty Research & Creative Works

Fabrication of parts with high mechanical properties heavily depend on the quality of powder deployed in the fabrication process. Copper powder in three different powder types were spheroidized using radio-frequency inductively coupled plasma (ICP) spheroidization process (TekSphero-15 system). The characterized powders include virgin powder as purchased from the powder manufacturer, powder used in electron beam powder bed fusion (EB-PBF) process, and reconditioned powder, which was used powder that underwent an oxygen-reduction treatment. The goal of spheroidizing these powder types was to evaluate the change in powder morphology, the possibility of enhancing the powder properties back to their as-received conditions, and …

Marineepi: A Gui-Based Matlab Toolbox To Simulate Marine Pathogen Transmission, Gorka Bidegain, Tal Ben-Horin, Eric N. Powell, John M. Klinck, Eileen E. Hofmann

CCPO Publications

The Graphical User Interface (GUI) MarineEpi is presented as a Matlab toolbox for easily (i) constructing disease transmission models for different marine host-pathogen systems, (ii) running simulations by specifying initial conditions and model parameters, and (iii) interpreting the resulting time series of the host and pathogen population dynamics. MarineEpi users can generate models for systems in which pathogen transmission occurs through contact with infected individuals (SI), contact with dead infected individuals (SID), contact with environmental pathogens released by infected individuals (SIP), and contact with environmental pathogens released by dead infected individuals (SIPD). MarineEpi is a freely available GUI that provides …

Running Shoe Pedometer, Benjamin Kasper

Williams Honors College, Honors Research Projects

Running shoe pedometer aims to solve the issue of worn out running shoes. It can be difficult to know just how many miles you have run in your shoes and when a new pair is needed. Running in old shoes and worn out shoes is heavily linked to injury. My proposed project is a device that is powered by the compressive forces on the shoes soles that counts the number of steps the wearer takes using a microcontroller. Then, when the shoe reaches milestone that indicate it has been used 75% 90% and 100% of its expected life, it will …

A Survey And Evaluation Of Android-Based Malware Evasion Techniques And Detection Frameworks, Parvez Faruki, Rhati Bhan, Vinesh Jain, Sajal Bhatia, Nour El Madhoun, Rajendra Pamula

School of Computer Science & Engineering Faculty Publications

Android platform security is an active area of research where malware detection techniques continuously evolve to identify novel malware and improve the timely and accurate detection of existing malware. Adversaries are constantly in charge of employing innovative techniques to avoid or prolong malware detection effectively. Past studies have shown that malware detection systems are susceptible to evasion attacks where adversaries can successfully bypass the existing security defenses and deliver the malware to the target system without being detected. The evolution of escape-resistant systems is an open research problem. This paper presents a detailed taxonomy and evaluation of Android-based malware evasion …

A Survey And Evaluation Of Android-Based Malware Evasion Techniques And Detection Frameworks, Parvez Faruki, Rhati Bhan, Vinesh Jain, Sajal Bhatia, Nour El Madhoun, Rajendra Pamula

School of Computer Science & Engineering Faculty Publications

Android platform security is an active area of research where malware detection techniques continuously evolve to identify novel malware and improve the timely and accurate detection of existing malware. Adversaries are constantly in charge of employing innovative techniques to avoid or prolong malware detection effectively. Past studies have shown that malware detection systems are susceptible to evasion attacks where adversaries can successfully bypass the existing security defenses and deliver the malware to the target system without being detected. The evolution of escape-resistant systems is an open research problem. This paper presents a detailed taxonomy and evaluation of Android-based malware evasion …

The Evolution Of Ai On The Commercial Flight Deck: Finding Balance Between Efficiency And Safety While Maintaining The Integrity Of Operator Trust, Mark Miller, Sam Holley, Leila Halawi

Publications

As artificial intelligence (AI) seeks to improve modern society, the commercial aviation industry offers a significant opportunity. Although many parts of commercial aviation including maintenance, the ramp, and air traffic control show promise to integrate AI, the highly computerized digital flight deck (DFD) could be challenging. The researchers seek to understand what role AI could provide going forward by assessing AI evolution on the commercial flight deck over the past 50 years. A modified SHELL diagram is used to complete a Human Factors (HF) analysis of the early use for AI on the commercial flight deck through introduction of the …

Northrop Grumman Collaboration Project, Nikkia Rae Psomas-Sheridan, Santiago Robles, Ben Elkayam, Benjamin Ulfhake

Mechanical Engineering

The Northrop Grumman Collaboration Project (NGCP) is a collaborative club project sponsored by Northrop Grumman for the students of Cal Poly San Luis Obispo (CPSLO) and Cal Poly Pomona (CPP) to create a fleet of vehicles to aid in the simulated rescue of stranded hiker. The CPSLO club is responsible for delivering an autonomous flight vehicle that can suppress a fire and retrieve a payload. Mechanical Design Team of the CPSLO team was responsible for the design of the frame, electronics housing, and payload and fire suppression systems.

Experimental Uncertainty In Measurements Of Violin Impulse Response, Andrew Piacsek, Seth Lowery

All Faculty Scholarship for the College of the Sciences

Experiments that investigate how an individual musical instrument changes in response to subtle alterations must contend with measurement uncertainty, which typically arises from inconsistencies in the measurement setup. We quantify uncertainty in violin response measurements by measuring bridge admittance and radiatively of a single instrument that is repeatedly removed and reinstalled in our measurement apparatus. From this set of baseline measurements, we calculate the average and standard deviation of admittance and radiativity. The amount of variation observed in the baseline data is compared to the change in bridge admittance that occurred over several days due to a large and abrupt …

Life Cycle Assessment Of Air Classification As A Sulfur Mitigation Technology In Pine Residue Feedstocks, Ashlee Edmonson

Theses and Dissertations--Biosystems and Agricultural Engineering

Sulfur accumulation during biofuel production is pollutive, toxic to conversion catalysts, and causes the premature breakdown of processing equipment. Air classification is an effective preprocessing technology for ash and sulfur removal from biomass feedstocks. A life cycle assessment (LCA) sought to understand the environmental impacts of implementing air classification as a sulfur-mitigation technique for pine residues. Energy demand and material balance for preprocessing were simulated using SimaPro and the Argonne National Laboratory’s GREET model, specifically focusing on comparing the global warming potential (GWP) of grid electricity versus bioelectricity scenarios. Overall, the grid electricity scenario had a GWP impact over 7 …

College Of Computing And Engineering Graduate Catalog 2023-2024, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.

Multi-Agent Learning For Game-Theoretical Problems, Kshitija Taywade

Theses and Dissertations--Computer Science

Multi-agent systems are prevalent in the real world in various domains. In many multi-agent systems, interaction among agents is inevitable, and cooperation in some form is needed among agents to deal with the task at hand. We model the type of multi-agent systems where autonomous agents inhabit an environment with no global control or global knowledge, decentralized in the true sense. In particular, we consider game-theoretical problems such as the hedonic coalition formation games, matching problems, and Cournot games. We propose novel decentralized learning and multi-agent reinforcement learning approaches to train agents in learning behaviors and adapting to the environments. …

A Secure And Distributed Architecture For Vehicular Cloud And Protocols For Privacy-Preserving Message Dissemination In Vehicular Ad Hoc Networks, Hassan Mistareehi

Theses and Dissertations--Computer Science

Given the enormous interest in self-driving cars, Vehicular Ad hoc NETworks (VANETs) are likely to be widely deployed in the near future. Cloud computing is also gaining widespread deployment. Marriage between cloud computing and VANETs would help solve many of the needs of drivers, law enforcement agencies, traffic management, etc. The contributions of this dissertation are summarized as follows: A Secure and Distributed Architecture for Vehicular Cloud: Ensuring security and privacy is an important issue in the vehicular cloud; if information exchanged between entities is modified by a malicious vehicle, serious consequences such as traffic congestion and accidents can …

Machine-Learning-Powered Cyber-Physical Systems, Enrico Casella

Theses and Dissertations--Computer Science

In the last few years, we witnessed the revolution of the Internet of Things (IoT) paradigm and the consequent growth of Cyber-Physical Systems (CPSs). IoT devices, which include a plethora of smart interconnected sensors, actuators, and microcontrollers, have the ability to sense physical phenomena occurring in an environment and provide copious amounts of heterogeneous data about the functioning of a system. As a consequence, the large amounts of generated data represent an opportunity to adopt artificial intelligence and machine learning techniques that can be used to make informed decisions aimed at the optimization of such systems, thus enabling a variety …

Hard-Hearted Scrolls: A Noninvasive Method For Reading The Herculaneum Papyri, Stephen Parsons

Theses and Dissertations--Computer Science

The Herculaneum scrolls were buried and carbonized by the eruption of Mount Vesuvius in A.D. 79 and represent the only classical library discovered in situ. Charred by the heat of the eruption, the scrolls are extremely fragile. Since their discovery two centuries ago, some scrolls have been physically opened, leading to some textual recovery but also widespread damage. Many other scrolls remain in rolled form, with unknown contents. More recently, various noninvasive methods have been attempted to reveal the hidden contents of these scrolls using advanced imaging. Unfortunately, their complex internal structure and lack of clear ink contrast has prevented …

Deep Learning-Based Intrusion Detection Methods For Computer Networks And Privacy-Preserving Authentication Method For Vehicular Ad Hoc Networks, Ayesha Dina

Theses and Dissertations--Computer Science

The incidence of computer network intrusions has significantly increased over the last decade, partially attributed to a thriving underground cyber-crime economy and the widespread availability of advanced tools for launching such attacks. To counter these attacks, researchers in both academia and industry have turned to machine learning (ML) techniques to develop Intrusion Detection Systems (IDSes) for computer networks. However, many of the datasets use to train ML classifiers for detecting intrusions are not balanced, with some classes having fewer samples than others. This can result in ML classifiers producing suboptimal results. In this dissertation, we address this issue and present …

Portable Hepa Filtration Successfully Augments Natural-Ventilation-Mediated Airborne Particle Clearance In A Legacy Design Hospital Ward, Mehael Fennelly, S. Hellebust, J. Wenger, D. O'Connor, G.W. Griffith, B.J. Plant, A.P.C. Microbiome Institute

Articles

As the severe acute respiratory syndrome coronavirus-2 pandemic has proceeded, ventilation has been recognized increasingly as an important tool in infection control. Many hospitals in Ireland and the UK do not have mechanical ventilation and depend on natural ventilation. The effectiveness of natural ventilation varies with atmospheric conditions and building design. In a challenge test of a legacy design ward, this study showed that portable air filtration significantly increased the clearance of pollutant aerosols of respirable size compared with natural ventilation, and reduced spatial variation in particle persistence. A combination of natural ventilation and portable air filtration is significantly more …

Actividad 3: ¡Advertencia!, Patrick Young

Tema 5: ¿Por qué la gallina cruzó la calle?

En un ciclo de ingeniería y diseño se producen múltiples repeticiones de diseño. Esto es así desde el inicio de la idea hasta la instalación de una estructura de paso para animales. En el diseño hay que tener en cuenta más factores que los mencionados anteriormente, como la temperatura, las precipitaciones, el tráfico de vehículos, el ruido y los gases de escape de los vehículos.

Actividad 3: ¡Construye Rápido!, Patrick Young

Tema 1: Estructura y proceso

Uno de los costos de cualquier proyecto de carretera es el impacto económico de desviar el tráfico durante la construcción. Los métodos que minimizan las interrupciones reducen costos y suelen mejorar la seguridad. Los métodos de construcción acelerada de puentes (ABC, por sus siglas en inglés) incluyen la prefabricación de la mayor parte posible del puente fuera del lugar de la obra. Las piezas grandes se llevan al lugar y se instalan según un plan que minimiza el tiempo necesario para desviar el tráfico.

Activity 4: Testing Student-Made Concrete Decks, Patrick Young

Theme 1: Structure and Process

When a structural beam is loaded from above, the force creates compression on the upper surface and tension on the lower surface. Concrete can withstand ten times as much compression as it can tension. Since concrete is much less capable of supporting tension, it is along the bottom that steel reinforcement is most important.

Activity 3: Traffic Management, David Hernandez, Peg Steffen

Theme 3: Traffic Management

Traffic management in busy urban areas is an extremely complex problem. Issues such as traffic congestion from home to work, suburban growth, preservation of scenic landscapes and historic neighborhoods, and the ability to walk, bike, and access public transit make traffic management a challenge. Traffic Management can include lane closures, detours, pedestrian access, and speed limits. It also includes intersections engineered for safe passage of vehicles in a stream of traffic that must cross each other's paths. Complicating factors for intersections include bikes, pedestrians, and emergency vehicles.

Activity 3: Rooting For You, Karen Ye

Theme 4: Please Pass the Salt

Snow and ice removal are needed in winter for safe roads. Salt is very effective along with other chemicals, but these may cause harm to plants, wildlife, and humans. Salt seeps into groundwater and may create problems with water resources. High levels of salt affects the amount of oxygen in water, organism growth, reproduction, and food sources. Whether the chemicals cause harm to an organism depends on the amount of chemicals and how long the organism is exposed to them. Salt can also reduce soil minerals and absorb water that plants need. Other impacts on plants include leaf damage, stunted …

Activity 1: Cooler Than Me, Karen Ye

Theme 4: Please Pass the Salt

All matter is made up of atoms and molecules. Even though we can’t see them with our bare eyes, these tiny particles are constantly moving. The temperature of a substance is a measure of its average kinetic energy (the energy it has due to the motion of the particles). As the temperature increases, particles gain more energy, move more quickly and spread further apart.

No matter where one lives in Illinois, you are impacted by winter weather. Deicing and snow removal account for a large portion of state and local highway budgets. Salt is commonly used for melting snow and …

Actividad 3: Ayudándote A Crecer, Patrick Young

Tema 4: Por favor, pásame la sal

Es necesario quitar la nieve y el hielo en invierno para que las carreteras sean seguras. La sal, junto con otros productos químicos, es muy eficaz para hacerlo, pero estos pueden ocasionarle daño las plantas, a la vida silvestre y a los seres humanos. La sal se filtra al agua subterránea y puede ocasionar problemas con los suministros de agua. Los niveles elevados de sal afectan la cantidad de oxígeno en el agua, el crecimiento de los organismos, la reproducción y las fuentes de alimentos. La posibilidad de que las sustancias químicas le ocasionen daño a un organismo depende de …

Actividad 4: Consejo De Información, Patrick Young

Tema 3: Tráfico

En 1969, la Encuesta Nacional Sobre los Viajes de las Familias (NHTS, por sus siglas en inglés) comenzó a recopilar información sobre los hábitos de viaje de los estadounidenses. El tipo de transporte utilizado, la duración, la distancia y el propósito del viaje son algunos ejemplos de información recopilada a través de las encuestas. Organizaciones como compañías de seguros y de automóviles, agencias de transporte y el gobierno analizan y utilizan la información para tomar decisiones.

Actividad 4: Invierno Ecológico, Patrick Young

Tema 4: Por favor, pásame la sal

Además de la sal, existen otros materiales que se utilizan para mitigar los peligros del hielo y aumentar la tracción. Estos materiales adicionales incluyen arena, cloruro de calcio y una mezcla de salmuera y jugo de remolacha. El uso de cada método conlleva contrapartidas.

Actividad 1: Crear Una Criatura, Patrick Young

Tema 5: ¿Por qué la gallina cruzó la calle?

La fauna salvaje representa un peligro para los conductores. Los animales implicados en los accidentes de carretera tienen una gran variedad de formas, tamaños, métodos de locomoción, tolerancia al ruido y patrones de migración, así como necesidades de comida, agua y espacio.

Actividad 2: Un Poco De Sal: Folleto Para El Estudiante, Patrick Young

Tema 4: Por favor, pásame la sal

La densidad se define como la cantidad de masa que ocupa una cierta cantidad de volumen. Agregar sal o azúcar al agua aumenta su densidad, ya que hay más partículas (masa) empaquetadas en una cantidad similar de espacio (volumen). El agua de enfriamiento también puede aumentar su densidad, ya que las partículas se mueven más lentamente a temperaturas más bajas y estarán más empaquetadas. Cuando se combinan dos sustancias con diferentes densidades, la de menor densidad flotará mientras que la de mayor densidad se hundirá. Cuanto mayor sea la diferencia de densidad, más distintas serán las capas y más difícil …

Actividad 2: Control De La Ira, Patrick Young

Tema 3: Tráfico

La furia al volante suele ser el resultado de una ira explosiva causada por inconvenientes, incidentes e irresponsabilidad mientras se conduce. En su mayor parte, la furia al volante genera gritos, bocinazos, pegarse al coche de adelante, zigzaguear y bloquear el tráfico. Sin embargo, las muertes por furia al volante están aumentando. Existen estrategias para ayudar a disminuir la furia al volante. Los carteles aéreos advierten sobre el tráfico, el clima y los incidentes de coches o camiones que se avecinan. Las aplicaciones de tráfico y viaje, que ofrecen varias sugerencias de rutas, tiempos de viaje y peligros en la …

Actividad 3: Red De Semáforos, Patrick Young

Tema 3: Tráfico

La organización del tráfico en las zonas urbanas congestionadas es un problema extremadamente complejo. Uno de los desafíos fundamentales tiene lugar en las intersecciones en las que los vehículos de un flujo de tráfico deben cruzarse entre sí. Los factores que complican la situación incluyen bicicletas, peatones y vehículos de emergencia.

Una de las formas más comunes de controlar el derecho de paso en las intersecciones es el semáforo. Es más barato que construir numerosas rampas y pasos elevados, pero restringe el flujo de tráfico básicamente a una dirección a la vez. Un sistema de control activo es útil para …