Engineering Commons^™

Development Of Multiscale And Multidimensional Light Sheet Microscopy For Image-Based Modelling Of Organogenesis, Tanveer Ashwini Ashwini Teranikar

Bioengineering Dissertations - Archive

Behavioral analysis of individual cells, in the form of structural phenotypes arising in response to mechanical stimuli or genomic alterations as small molecule intermediates of disease, are instrumental for understanding organogenesis. In this regard, dynamic cell tracking or temporal changes in cell shape, area and size are vital for modelling tissue interactions. However, optical diffraction limits imposed by lenses, hinders high resolution volume reconstruction of microscale biological processes and subcellular organelles. Thereby, isotropic intensity is restricted to limited focal volumes, reducing imaging distance to less than 1 mm for high magnification. To combat this, Light Sheet Microscopes (LSM) have emerged …

Quantification Of Dynamic Changes Of Hemodynamic And Metabolic Responses To Brachial Artery Occlusion: A Broadband Near-Infrared Spectroscopy Study, Caroline Elizabeth Carter

Bioengineering Theses - Archive

Cardiovascular disease (CVD) is a leading cause of death in the United States, and non-Hispanic African Americans are at higher risk than other racial and ethnic groups. Endothelial dysfunction is a major contributor to CVD development and progression. Remote ischemic pre/conditioning (RIC), which involves exposing cells or tissues to brief sublethal stress, has been shown to protect cardiovascular cells from ischemia and reperfusion injury, including CVD. This study aimed to investigate hemodynamic and metabolic dynamics in response to 5-min forearm arterial occlusion using broadband near-infrared spectroscopy. My thesis is a tripartite investigation that weaves RIC, mitochondrial dynamics, and health disparities …

Formation And Morphological Changes Of Stress Actin Filaments In Adipose-Derived Stem Cells, Adam Priester

Bioengineering Theses - Archive

Adipose-Derived Stem Cells (ADSCs) are a sub-type of stem cell that can be collected and isolated from the adipose tissue. Adipogenesis describes the commitment and differentiation of stem cells, including ADSCs, toward the adipocyte lineage. While much research has been completed on this process in the long term (>2 weeks), morphological changes of adipogenesis during the early phase (<24 hours) are lacking in the literature and remain to be elucidated. The current study focuses on these changes in the early and later stages of adipogenesis using adipogenic differentiation factors and fluorescent imaging analyses. Quantifiable data on morphological changes during both phases can provide insight into how these changes affect later differentiation and lay the groundwork for additional research in this area. Using fluorescent image analysis, it was shown that the eccentricity of ADSCs, a measure of cellular circularity, decreases exponentially in the early phase of adipogenesis. In contrast, the cellular area appears to increase exponentially during the same early period. During the later stages of differentiation, it was shown that actin filament length decreases exponentially and the ratio of lipid to actin length increases exponentially, demonstrating that lipid accumulation outpaces actin filament shortening and increasing circularity during the later stages. These findings may be used in future studies to further define the role of actin filament-mediated morphological changes and mechanobiology during adipogenesis.

Characterizing Technology Impacts On Driving Behaviors, Crash Risks, And Infrastructure Performances, Jobaidul Boni

Civil Engineering Dissertations - Archive

In recent years, an increase in driver distraction appears due to the rise in smartphone usage and the introduction of social media. Researchers put significant efforts in examining the impacts of distracted driving, mostly focused on distraction like texting or phone call. However, scant research exists to identify the underlying factors causing the distracted driving particularly caused by social media or showing their safety implications at complex geometries such as intersections and highways. This dissertation offers three independent studies reviewing the impact of technology on drivers' actions using field tests and simulation experiments. The first field tests conducted at three …

Evaluation Of Vertical And Lateral Load Capacity Of Recycled Plastic Pin, Sehneela Sara Aurpa

Civil Engineering Dissertations - Archive

RPPs have been in use as a sustainable and effective technique to stabilize and reinforce weak ground for geotechnical purposes. Application of RPP in stabilization of slopes and improvement of load carrying capacity of foundation soil has yielded tremendous results. However, to facilitate the seamless integration of RPPs in design of foundation requires the load carrying capacity of RPP to be known. As RPP has been in use for both its vertical and lateral load carrying capacity, exploration of the load capacity of this material is essential. The objective of the study is to determine the load carrying capacity of …

Transportation Network Criticality Estimation For Hurricane Preparedness And Response Using Vulnerability Assessments, Mehrdad Arabi

Civil Engineering Dissertations - Archive

The resilience of urban transportation networks is crucial for effective evacuation, and search and rescue operations as hurricane events become more severe and frequent. This dissertation presents a comprehensive approach to identifying and evaluating critical transportation links which are crucial for emergency preparedness and response. Integrating socio-economic and environmental vulnerabilities with traditional traffic management approaches, the research underscores the importance of equitable evacuation strategies that cater to the most vulnerable populations. Employing advanced spatial analysis and data analytics with real-time GPS data, the three individual papers in this dissertation offer a dynamic assessment of evacuation behaviors, capturing the complexities of …

Utilization Of Biomimetic Molecules To Control The Carbonation Of Cementitious Phases, Muhammad Intesarul Haque

Civil Engineering Dissertations - Archive

This study introduces an innovative approach to mitigate carbonation-induced degradation of C-S-H and to enhance the carbonation properties of low calcium based cementitious materials by utilizing specific biomimetic molecules. In this study, four different biomimetic molecules were utilized. Details about their chemical formula and chemical structure can be found in Chapter 1. The dissertation is broadly focused on two aspects, Part 1 (Chapter 2 and 3) evaluated the role of biomimetic molecules in reducing the carbonation degradation of C-S-H. Part 2 (Chapter 4 and 5) assessed the effectiveness of the biomimetic molecules as performance enhancing admixture of carbonation cured dicalcium …

Experimental And Numerical Analyses Of Coupled Thermo-Hydro-Mechanical Behavior In Unsaturated Soil Under One-Dimensional Heat Transfer, Nice Kaneza

Civil Engineering Dissertations - Archive

Comprehension of the behavior of unsaturated soil in response to thermal gradients, moisture gradients, and deformation is important in geotechnics. Thermal gradients control fluid density and viscosity and moisture gradients alter thermal properties of unsaturated soil. Similarly, thermal gradients affect the thermal strain of unsaturated soil and changes in porosity influence hydraulic properties of the soil. Thus, thermal, hydraulic, and mechanical properties of unsaturated soil interact with and influence each other; the combination of these interactions form a mechanism called coupled thermo-hydro-mechanical (THM) processes. Although the study of the behavior of coupled THM processes is essential in predicting the performance …

“Increasing Renewable Energy Potential Of Landfill Gas By Electrocatalytic Conversion Of Carbon Dioxide To Methane At Low Temperature.”, Asma Akter Rony

Civil Engineering Dissertations - Archive

The conversion of carbon dioxide into methane at a low temperature has great potential to reduce current international environmental issues like global warming and will create new sources of renewable energy. The overall goal of this research is to increase renewable energy production from landfill gas using an unconventional process – electrocatalytic methanation of carbon dioxide – which has not been implemented for landfill gas yet. The electrocatalytic methanation follows the Waseda process, which applies an electric field in the presence of a Ruthenium-supported cerium oxide (CeO2) catalyst. The specific objectives of this research were: 1. To explore the impact …

Tri-Dimensional Segment-Based Urban Traffic Crash Models, Farzin Maniei

Civil Engineering Dissertations - Archive

The continuous expansion of highway and freeway networks further exacerbates the risk of traffic crashes and highlights the critical importance of freeway safety management. To improve overall road safety, many organizations acknowledge the necessity of pinpointing locations experiencing higher-than-expected crashes (known as hotspot identification, HSID), identifying the factors contributing to traffic crashes, and determining the most effective preventive measures. Previous studies highlighted two major drawbacks associated with this approach: (1) HSID based on the total number of crashes can lead to incorrectly identifying hazardous areas; (2) the arbitrary selection of a fragment size (due to the lack of explicit recommendations) …

Compound Flood Modeling Of Tropical Cyclone Events In Coastal Bays And Estuaries, Nahal Maymandi

Civil Engineering Dissertations - Archive

Flooding due to tropical cyclones can cause severe impacts on coastal communities, particularly when multiple types of flooding (e.g., coastal and riverine) interact to create a compound flood event. In typical flood hazard assessments, these drivers of flooding are considered separately, even though they may interact and produce more severe flooding. Understanding the interactions between flood drivers is necessary to accurately plan for and respond to future flood events. This dissertation aims to improve the assessment of coupled coastal, fluvial, and pluvial flooding in coastal bays and estuaries impacted by tropical cyclones. To do this, a hydrodynamic model is developed …

Tests Of A Gamma Spectrometer-Neutron Counter Relationship As A Neutron Alarm Metric In Mobile Radiation Search Systems, Jackson N. Wagner, Craig Marianno

International Journal of Nuclear Security

A mobile radiological search system (MRSS) is frequently used in nuclear security to interdict illicit nuclear material. One difficulty an MRSS faces is in characterizing its detectors’ background responses, particularly in its neutron counter(s). This difficulty adds complications to identifying the presence of neutron-emitting radiological materials during an operation. Fortunately, previous work has identified a power law relationship between muons registered by the MRSS’s gamma detectors and background neutrons. This relationship can be applied to estimate the MRSS’s background neutron count rate using that muon count rate. To test the usability of such an estimate, an MRSS was used to …

Simulation Modelling Of Silicon Gated Field Emitter Based Electronic Circuits, Robert Hay, Ranajoy Bhattacharya, Winston Chern, Girish Rughoobur, Akintunde I. Akinwande, Jim Browning

Electrical and Computer Engineering Faculty Publications and Presentations

Vacuum transistors (VTs) are promising candidates in electronics due to their fast response and ability to function in harsh environments. In this study, several oscillator and logic gate circuit simulations using VTs are demonstrated. Silicon-gated field emitter arrays (Si-GFEAs) with 1000 × 1000 arrays were used experimentally to create a VT model. First, transfer and output characteristics sweeps were measured, and based on those data, an LTspice vacuum transistor (VT) model was developed. Then, the model was used to develop Wein and Ring oscillator circuits. The circuits were analytically simulated using LTspice, where the collector bias voltage was 200 V …

Integrating Ai Into Uavs, Huong Quach

Cybersecurity Undergraduate Research Showcase

This research project explores the application of Deep Learning (DL) techniques, specifically Convolutional Neural Networks (CNNs), to develop a smoke detection algorithm for deployment on mobile platforms, such as drones and self-driving vehicles. The project focuses on enhancing the decision-making capabilities of these platforms in emergency response situations. The methodology involves three phases: algorithm development, algorithm implementation, and testing and optimization. The developed CNN model, based on ResNet50 architecture, is trained on a dataset of fire, smoke, and neutral images obtained from the web. The algorithm is implemented on the Jetson Nano platform to provide responsive support for first responders. …

Applications Of The Guided-Mode Resonance Sensor In Multiparametric, Transmissive, And Picomolar Regimes, Joseph Anthony Buchanan-Vega

Electrical Engineering Dissertations - Archive

Guided-mode resonance (GMR) sensors are developed and implemented for multiparametric label-free sensing, transmission sensing, enhanced reflection sensing, and low analyte concentration sensing; these are the topics presented in this work. The complete biosensor – capable of label-free multiparametric data collection – is designed, fabricated, and implemented. Multiparametric data collection has previously been relegated to one variable on the sensor surface and one bulk media variable. We use a lookup table and the novel application of an inversion algorithm to simultaneously determine two variables on the sensor surface and one bulk media variable. Multiparametric data sets are required to monitor multiple …

Investigation Of Rate Pressure Product As A Metric To Quantify Cardiac Workload In Sleep Apnea Events, Carlos Cruz

Bioengineering Theses - Archive

An investigation on the use of rate pressure product (RPP) to measure the cardiac workload in sleep apnea patients is presented. RPP is the product of systolic blood pressure (SBP) and heart rate (HR). The application of RPP to quantify cardiac workload is combined with the detection of respiratory events occurring in close proximity (less than 30 seconds apart). These two combined factors provide a unique framework for analyzing sleep apnea events and are the primary novelty of the study. Close proximity events are referred to as respiratory event chains (RECs). Statistical analyses were conducted on various RPP metrics as …

The Effects Of Poloxamer 188 On Wound Closure In A Mouse Brain Endothelium Model, Mia Claire Grubbs

Bioengineering Theses - Archive

The blood-brain barrier (BBB) plays a crucial role in maintaining central nervous system homeostasis and, if structurally and functionally compromised, can lead to severe neurological consequences. This thesis explores the therapeutic potential of Poloxamer 188 (P188) in the context of BBB wound healing. P188, FDA-approved copolymer that is known for its cytoprotective properties, is examined for its impact on endothelial monolayers through in vitro scratch wound assays. The study aims to establish a consistent endothelial monolayer model, quantify wound healing dynamics, and assess the efficacy of P188 at varying concentrations. The thesis goals include detailed methodologies such as cell culture …

Process Improvement Of Cu(Ii)-Trymethylamine-Based Active Clay Measurement Test And Total Clay Measurement Test, Christopher Michael Remily

Masters Theses

Foundry work requires a mold made of a mixture of sand, “active clay” to absorb gas, and binders to combine the two and hold the molds shape. When the metal is melted to be poured into the mold, the solubility dramatically increases, causing gas to be temporarily dissolved in the metal. This gas causes small surface pits to form once the metal cools, causing part failure. This causes the need to absorb the gas. Since the clay is used in the process, there needs to be a way to determine how much remains active, which is done with a dye …

Potential Security Vulnerabilities In Raspberry Pi Devices With Mitigation Strategies, Briana Tolleson

Cybersecurity Undergraduate Research Showcase

For this research project I used a Raspberry Pi device and conducted online research to investigate potential security vulnerabilities along with mitigation strategies. I configured the Raspberry Pi by using the proper peripherals such as an HDMI cord, a microUSB adapter that provided 5V and at least 700mA of current, a TV monitor, PiSwitch, SD Card, keyboard, and mouse. I installed the Rasbian operating system (OS). The process to install the Rasbian took about 10 minutes to boot starting at 21:08 on 10/27/2023 and ending at 21:18. 1,513 megabytes (MB) was written to the SD card running at (2.5 MB/sec). …

An Apparatus To Quantify Lengthwise Flexural Rigidity Profiles Of Endovascular Devices, Charles B. Suskin

McKelvey School of Engineering Graduate Student Theses & Dissertations

Endovascular procedures require access to distal anatomical sites through the vasculature using catheters and guidewires. Quantitative frameworks for device behavior during procedures hold the potential to drive device design through greater understanding of the mechanical behavior of endovascular devices, and offer the potential to personalize care based on a patient's particular vascular anatomy. However, data that would facilitate this technology are lacking, partly due to undisclosed material properties from manufacturers and partly due to the intricate variations along the length of each device due to material changes and the intersections between them. We developed a three-point bend test methodology on …

Enhanced Fabrication Of Microdroplet Generator Nozzle Arrays: Optimizing Koh Etching For Microfluidic Applications, Hongyu Bai

McKelvey School of Engineering Graduate Student Theses & Dissertations

Ultrasonic microdroplet generators are useful devices with broad applications ranging from aerosolized drug delivery to three-dimensional (3D) printing-based additive manufacturing. One such technology comprises a microfabricated array of nozzles with droplet production driven by a piezoelectric transducer. The present study focuses on refining a critical fabrication step, anisotropic wet etching of pyramidal nozzles using a basic potassium hydroxide (KOH) solution. Given the integral role of nozzle geometry in device operation, high-precision techniques including Reactive Ion Etching (RIE), Deep Reactive Ion Etching (DRIE), and KOH wet etching were employed. A tapering geometry is preferred for acoustic wave focusing and efficient droplet …

A Bioinspired Astrocyte-Derived Coating Promotes The In Vitro Proliferation Of Human Neural Stem Cells While Maintaining Their Stemness, Andrea C. Jimenez-Vergara, Jacob Avina, Travis Jackson Block, Anne Sheldrake, Carson Koch, Anna Gonzalez, Jennifer Steele, Ana M. Díaz-Lasprilla, Dany J. Munoz-Pinto

Engineering Faculty Research

The repair of neuronal tissue is a challenging process due to the limited proliferative capacity of neurons. Neural stem cells (NSCs) can aid in the regeneration process of neural tissue due to their high proliferation potential and capacity to differentiate into neurons. The therapeutic potential of these cells can only be achieved if sufficient cells are obtained without losing their differentiation potential. Toward this end, an astrocyte-derived coating (HAc) was evaluated as a promising substrate to promote the proliferation of NSCs. Mass spectroscopy and scanning electron microscopy were used to characterize the HAc. The proliferation rate and the expression of …

Model Of Surface Waves On A Viscoelastic Material In A Cylindrical Container With Edge Constraints, Phillip Wilson

All Theses

A theoretical model is developed for the resonant frequencies and mode shapes of pinned edge surface waves on a viscoelastic fluid contained in a finite depth cylindrical container. A boundary integral approach is used to map the governing equations to the domain boundary. The surface waves obey an eigenvalue operator equation that depends on four dimensionless parameters: the cylinder aspect ratio, the Bond number, the Ohnesorge number, and the elastocapillary number. A solution is constructed using a Rayleigh-Ritz variational procedure over a constrained function space, which is able to effectively incorporate the pinned edge boundary condition. Mode shapes are defined …

Evaluation Of The Long-Term Performance Of Ogfc In South Carolina, Rishiraj Brahmbhatt

All Theses

Since the 1970s, South Carolina has employed open graded friction courses (OGFC) on high-speed asphalt roadways to enhance wet weather safety. While these mixes have indeed enhanced safety, they still grapple with durability issues, particularly concerning raveling. This research aimed to assess the prolonged performance of OGFC pavements in South Carolina, with a specific emphasis on isolated raveling occurrences. In 2012, the South Carolina Department of Transportation (SCDOT), constructed the first Warm Mix OGFC test section in South Carolina on I-20 Eastbound in Kershaw County, spanning 3.9 miles, using the Evotherm additive and excluding fibers. Following the success of this …

Are We Day-Dreaming Our Way To The Future?, John O'Connor

Presentations

This paper explores the transformative impact of technology on society, drawing on Marshall McLuhan’s insights. It scrutinizes the consequences of profit-driven technological progress, particularly in VR, brain-computer interfaces, and AI hallucinations. Critiquing the dominance of industry leaders in AI safety discussions, the paper advocates a balanced, inclusive approach.

Philosophical perspectives on AI and VR prompt questions about their impact on human experience. The paper proposes an educational shift to cultivate human attributes alongside technological skills. Examining AI hallucinations and gaming glitches, it raises concerns about the potential blurring of reality and virtuality.

Connecting technological advancements with environmental challenges, the paper …

Novel Implementation Of Additive Manufacturing To Visualize The Human Brain Connectome, Greg Tyler

Computational and Data Sciences (MS) Theses

Additive manufacturing (AM) is an emerging technology with diverse areas of application. In this paper we explore a new application of AM that uses a subset of AM known as 3D printing, to create real life models of the human connectome. The human connectome is a color coded map of the connections in the human brain where directions are indicated by colors and the density of connections are indicated by color intensity.

There are several different algorithms for mapping the connections and describing the output. The Neu- roImaging Tools and Resource Collaboratory (NITRC) provides one such algorithm. It uses probabilistic …

Improved Version Of Double-Layer Enclosure Demo, Said Shakerin

All Faculty Articles - School of Engineering and Computer Science

The purpose of this letter is to present an improved version of one of the enclosure demonstrations previously reported as a part of a paper in this journal.¹ Specifically, I am referring to the double-layered enclosure containing air and two different colors of glycerin, blue in the front and yellow in the back. The new version has two modifications. First, a horizontal partition with two gaps (1/4-in. wide, each) is added in each layer. The role of the partition is to slow down the exchange between the glycerin and air, and therefore provide for a longer time to observe …

Early Detection Of Virality In Chinese-Language On Youtube Focus On Comments, Yulin Zeng

Computer Science and Engineering Master's Theses

Predicting the popularity of the YouTube video-sharing site in its early stages is crucial for journalists and researchers, as it helps them uncover disinformation. In addition, research on the number of comments in news and comments has always been an academic topic that has attracted much attention. These Youtube political commentary and News channels that use Chinese as the primary language have a strong influence on the first generation of Chinese immigrants in the United States. However, under our monitoring, we found that it is difficult for these videos to appear in the viral video list defined by YouTube API. …

Resilient, Sustainable, And Secure Systems Support For Ultra-Low-Power Computational Things, Nicole Tobias

All Dissertations

Wireless battery-free and energy-harvesting devices are expanding the reach and vision of the Internet of Things, where trillions of embedded computational things interconnect ubiquitously around us and inform many different aspects of our everyday lives. Designing these systems without batteries and interconnecting wires lowers maintenance, environmental, and economic costs while also extending device lifetime and deployment opportunities. Over the last decade, research on these ultra-low-power embedded sensors and systems has dramatically increased — enabling new and exciting prospects in many different scientific fields, from smart building and health monitoring applications to animal and activity tracking.

These systems are not without …

Developing High-Performance 2d Heterostructured Electrocatalysts And Photocatalysts For Hydrogen Production And Utilizationsts And Photocatalysts For Hydrogen Production And Utilization, Xiaohan Ma

All Dissertations

H₂ is a pivotal chemical in modern society, not only as a clean energy carrier but also as a versatile chemical reactant. However, traditional hydrogen production and utilization heavily rely on thermocatalysis, which is highly energy-intensive and can result in heavy carbon emission and severe environmental problems. Photocatalysis and electrocatalysis are greener alternatives to thermocatalysis that can capitalize on the renewable sunlight and electricity and thus dramatically reduce energy requirements. However, heterogeneous electro/photocatalysts are still far from application to hydrogen economy due to the lack of design principles that can lead to sufficient efficiency. To address this challenge, the …