Engineering Commons^™

Structures Of The Insecticidal Toxin Complex Subunit Xpta2 Highlight Roles For Flexible Domains, Cole L. Martin, David W. Chester, Christopher D. Radka, Lurong Pan, Zhengrong Yang, Rachel C. Hart, Elad M. Binshtein, Zhao Wang, Lisa Nagy, Lawrence J. Delucas, Stephen G. Aller

Markey Cancer Center Faculty Publications

The Toxin Complex (Tc) superfamily consists of toxin translocases that contribute to the targeting, delivery, and cytotoxicity of certain pathogenic Gram-negative bacteria. Membrane receptor targeting is driven by the A-subunit (TcA), which comprises IgG-like receptor binding domains (RBDs) at the surface. To better understand XptA2, an insect specific TcA secreted by the symbiont X. nematophilus from the intestine of entomopathogenic nematodes, we determined structures by X-ray crystallography and cryo-EM. Contrary to a previous report, XptA2 is pentameric. RBD-B exhibits an indentation from crystal packing that indicates loose association with the shell and a hotspot for possible receptor binding or a …

Solar-Powered Mobility: Charting The Course For A Brighter Future With Solar Vehicles, Ravi Nayak

Electronic Theses, Projects, and Dissertations

Solar-powered vehicles utilize photovoltaic panels to harness solar energy, offering a promising solution to reduce greenhouse gas emissions and promote sustainable transportation. This research project focused on the challenges and limitations of solar-powered vehicles and aims to provide solutions for their widespread adoption. The research questions explored in this study are: (Q1) How do different geographical locations and climate regions affect the feasibility and practicality of solar-powered vehicles due to variations in sunlight availability? (Q2) How has the adoption of solar-powered vehicles contributed to the reduction of greenhouse gas emissions? (Q3) What policies and incentives can promote the adoption of …

Examining Biological Algal Harvest For Use In Clemson University’S Algal Carbon Capture System Using Freshwater Mussel Elliptio Complanata, Jack Grimes

All Theses

Capture of atmospheric carbon by freshwater algae is being proposed in Clemson University’s outdoor algal carbon capture system, formerly described as the Partitioned Aquaculture System (Drapcho and Brune, 2000). Several algal species have been present in the system, depending on cultivation conditions. However, mechanical harvesting of the algae has proven difficult because of the cost of chemical flocculants, the energy cost of filtration due to small particle size of algae, and the relatively dilute algal cell concentrations in the system. Prior research on algal filtration by freshwater mussels has indicated its potential for use as a biological filter. This research …

Preparation Of High Entropy Titanite Pyrochlore And Radiation Stability Study, Adam Gootgeld

All Theses

Pyrochlore has been studied as a host phase for safe storage of radionuclides and exists naturally with long-term stability with good long-range order [1]. High entropy oxides show promising tunable properties that could demonstrate favorable bulk deposit of radioactive materials such as spent nuclear fuel (Uranium and other actinides). It is proposed that using high entropy oxides (HEOs) as the cation in this framework will shift the gibbs free energy so that radioactive nuclear waste will be stabilized for safe, long-term, eco-friendly storage. We have established a consistent method to fabricate high entropy titanite pyrochlores. In this study, ion beam …

Towards Validating Satellite Remote Sensing Of Aerosols With Ground-Based Low-Cost Sensors, Francine Roberts

All Theses

Poor ambient air quality has significant impacts on the environment and human health. Extensive regulation and monitoring has resulted in improvements since the first iteration of the Clean Air Act was passed in 1955. However, work still needs to be done in regard to higher spatial and temporal monitoring. Temporally, sensors used for regulatory purposes often only report every other or every third day. Spatially, they are often spread across vast distances due to cost. The following research is working towards improving the spatiotemporal measurements of particulate matter (PM), specifically in South Carolina. The two methods available for improving the …

Computational And Experimental Study On Undoped And Er-Doped Lithium Tantalate Nanofluorescent Probes, Mkhitar A. Hobosyan, Andrea Pelayo Carvajal, Bhupendra B. Srivastava, Tamanna Zakia, Mohammed Uddin, Karen S. Martirosyan, Eric Rodriguez, Kofi Nketia Ackaah-Gyasi, Nicholas Dimakis

Physics & Astronomy Faculty Publications

We present a combined density functional theory (DFT) and experimental work on lithium tantalate LiTaO3 (LT) and its Er-doped counterparts. We calculate the electronic and optical properties for both LT and LT:Er+3, with Er occupying either Li or Ta sites, at 4.167 mol%. The generalized gradient approximation (GGA) calculations show that the Er-4 f bands appear closer to the conduction band bottom and to the valance band top, for the first and second doped configurations, respectively. This agrees with changes in the imaginary part of the frequency dependent dielectric function between the doped configurations. There are striking differences between the …

Characterization Of Mechanically Recycled Polylactic Acid (Pla) Filament For 3d-Printing By Evaluating Mechanical, Thermal, And Chemical Properties And Process Performance, Mahsa Shabani Samghabady

All Theses

Polylactic acid (PLA) is a biopolymer made from renewable resources such as sugar and corn. PLA filament is a popular material used in Fused Deposition Modeling (FDM) 3D-printing. While this material has many advantages, all the failed parts, support structures, rafts, nozzle tests, and the many prototype iterations during the 3D-printing process contribute to the plastic pollution and release of greenhouse gases. Although PLA is biodegradable, it can take years to degrade in landfills. Instead of throwing away PLA waste and buying new filaments, PLA can be recycled. Amongst the different recycling technologies, mechanical recycling is the most environmentally friendly. …

Dynamics And Steering Of A Vibration-Driven Bristle Bot In A Pipe System, Ian Stewart

All Theses

Soft vibrational robots are robots that incorporate compliant structures into their design and are driven by oscillating actuators. A recent, popular version of a soft vibrational robot is the bristle bot, which uses flexible bristles and a vibration motor to propel itself across surfaces and through pipes. This motion is primarily driven by stick-slip dynamics resulting from asymmetric frictional forces applied at the bristle tips. Depending on the frequency of vibration of the motor, the robot experiences various resonance regions allowing it to maneuver in different directions. Attaching bristles to all sides of the robot and placing it in a …

Prairie Protector: Student Development Of Systems Thinking Habits In The Context Of Agroecosystems, Erin Ingram, Jennifer Keshwani

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Introduction: The Great Plains ecosystem offers an opportunity for young people to gain knowledge about intricate systems through practical learning. The spread of woody plants into grasslands, known as the “Green Glacier,” poses a risk to biodiversity and animal production. Although effective management strategies exist, some land managers are reluctant to use them. It is critical to cultivate a scientifically literate population that can think systematically and make informed decisions based on STEM principles to address such complex agroecosystem problems.

Methods: In this study, semi-structured focus group discussions with high school students were analyzed to determine whether Prairie …

Drinking Water Quality Management Progress In Ontario, Two Decades After Walkerton, Megan Fuller, Emma Wells, Laith Furatian, Ian Douglas, Kaycie Lane

Department of Civil and Environmental Engineering: Faculty Publications

Following the waterborne disease outbreak in Walkerton, Ontario, the province made significant efforts to implement recommendations of the public inquiry that resulted. As Ontario reformed its drinking water sector, other jurisdictions were advancing risk-based quality management frameworks for drinking water, including the World Health Organization (WHO) through its water safety plan (WSP) framework. Two decades after the Walkerton tragedy, this paper seeks to: (i) evaluate alignment of Ontario’s Drinking Water Quality Management Standard (DWQMS) with the WSP framework (ii) review readily available data for evidence that Ontario’s DWQMS implementation has improved drinking water safety and promoted a preventive approach through …

Generalized Double Statistical Convergence Sequences On Ideals In Neutrosophic Normed Spaces, Jeyaraman M., Iswariya S., Pandiselvi R.

Neutrosophic Systems with Applications

In this present research, having view in the Neutrosophic norm (u, v, w), which we presented I2-lacunary statistical convergence and I2-lacunary convergence strongly, looked into interactions between them, and made a few findings regarding the respective categories. At least went further to look at how both of such case approaches relate to I2-statistical convergence within the relevant Neutrosophic normed space.

Sales And Stock Management System, Rashmika Gaddam Ms

Electronic Theses, Projects, and Dissertations

ABSTRACT

Grocery stores using Excel for managing sales and stock management could involve maintaining separate sheets for sales and stock data, with revenue/cost. This system could provide a basic level of tracking and analysis, allowing the grocery store to monitor sales trends and stock levels. However, using Excel for this purpose is not without its challenges. For example, the manual nature of data entry in excel can result in errors and inconsistencies, particularly if multiple people are involved in maintaining the sheets. Additionally, as the volume of sales and stock data grows, the Excel spreadsheet can become unwieldy and slow, …

Systematic Investigation Of Wavy Surface Roughness Profiles Using Common Roughness Algorithms, Russell Gray

Boise State University Theses and Dissertations

Roughness is an important parameter in rock engineering. Sine wave-based simulated wavy profiles were used to investigate systematic changes of amplitude and frequency on roughness indices. Profiles were 1000 mm in length with amplitude ranging from 0-10 mm and frequency ranging from 0-10 Hz. The roughness algorithms used were Root Mean Square (RMS), Energy, Sinuosity, Z2, Mean Absolute Angle (MAA), and Modified Divider a-Value. Roughness indices were visualized as contour plots. Similarities of the shapes and spacing of the contours as well as the magnitude of the roughness indices prompted the pairing of RMS and Energy algorithms, Z2 and MAA …

Miniature, Submersible Electromagnetic Pumps Of Molten Lead And Sodium For Gen-Iv Nuclear Reactors Development, Ragai M. Altamimi

Nuclear Engineering ETDs

Heavy metals and alkali Liquid Metals are suitable coolants for Generation IV terrestrial nuclear reactors for operating at elevated temperatures for achieving plant thermal efficiency more than 40% and the thermochemical generation of hydrogen fuel. In addition, the low vapor pressure of these liquids eliminates the need for a pressure vessel and instead operates slightly below ambient pressure. A primary issue with the uses of these coolants is their compatibility with nuclear fuel, cladding and core structure materials at elevated temperatures more than 500oC. Therefore, in pile and out-of-pile test loops have been constructed or being considered for quantifying the …

Generalization Through Diversity: Improving Unsupervised Environment Design, Wenjun Li, Pradeep Varakantham, Dexun Li

Research Collection School Of Computing and Information Systems

Agent decision making using Reinforcement Learning (RL) heavily relies on either a model or simulator of the environment (e.g., moving in an 8x8 maze with three rooms, playing Chess on an 8x8 board). Due to this dependence, small changes in the environment (e.g., positions of obstacles in the maze, size of the board) can severely affect the effectiveness of the policy learned by the agent. To that end, existing work has proposed training RL agents on an adaptive curriculum of environments (generated automatically) to improve performance on out-of-distribution (OOD) test scenarios. Specifically, existing research has employed the potential for the …

Learning To Send Reinforcements: Coordinating Multi-Agent Dynamic Police Patrol Dispatching And Rescheduling Via Reinforcement Learning, Waldy Joe, Hoong Chuin Lau

Research Collection School Of Computing and Information Systems

We address the problem of coordinating multiple agents in a dynamic police patrol scheduling via a Reinforcement Learning (RL) approach. Our approach utilizes Multi-Agent Value Function Approximation (MAVFA) with a rescheduling heuristic to learn dispatching and rescheduling policies jointly. Often, police operations are divided into multiple sectors for more effective and efficient operations. In a dynamic setting, incidents occur throughout the day across different sectors, disrupting initially-planned patrol schedules. To maximize policing effectiveness, police agents from different sectors cooperate by sending reinforcements to support one another in their incident response and even routine patrol. This poses an interesting research challenge …

Context-Aware Event Forecasting Via Graph Disentanglement, Yunshan Ma, Chenchen Ye, Zijian Wu, Xiang Wang, Yixin Cao, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

Event forecasting has been a demanding and challenging task throughout the entire human history. It plays a pivotal role in crisis alarming and disaster prevention in various aspects of the whole society. The task of event forecasting aims to model the relational and temporal patterns based on historical events and makes forecasting to what will happen in the future. Most existing studies on event forecasting formulate it as a problem of link prediction on temporal event graphs. However, such pure structured formulation suffers from two main limitations: 1) most events fall into general and high-level types in the event ontology, …

The Heterogeneous Vehicle Routing Problem With Multiple Time Windows For The E-Waste Collection Problem, Aldy Gunawan, Minh P.K Nguyen, Vincent F. Yu, Dang Viet Anh Nguyen

Research Collection School Of Computing and Information Systems

Waste from electrical and electronic equipment (WEEE) or e-waste describes end-of-life electronic products that are discarded. Due to their toxic and negative impacts to humans' health, many publications have been proposed to handle, however, studies related to e-waste collection and transportation to waste disposal sites are not widely studied so far. This study proposes a mixed integer linear programming (MILP) model to solve the e-waste collecting problem by formulating it as the heterogeneous vehicle routing problem with multiple time windows (HVRPMTW). The model is validated with newly developed benchmark instances that are solved by commercial software, CPLEX. The model is …

Grasp Based Metaheuristic To Solve The Mixed Fleet E-Waste Collection Route Planning Problem, Aldy Gunawan, Dang V.A. Nguyen, Pham K.M. Nguyen, Pieter. Vansteenwegen

Research Collection School Of Computing and Information Systems

The digital economy has brought significant advancements in electronic devices, increasing convenience and comfort in people’s lives. However, this progress has also led to a shorter life cycle for these devices due to rapid advancements in hardware and software technology. As a result, e-waste collection and recycling have become vital for protecting the environment and people’s health. From the operations research perspective, the e-waste collection problem can be modeled as the Heterogeneous Vehicle Routing Problem with Multiple Time Windows (HVRP-MTW). This study proposes a metaheuristic based on the Greedy Randomized Adaptive Search Procedure complemented by Path Relinking (GRASP-PR) to solve …

A Virtual Method For Establishing Femoral Stem Position In Total Hip Arthroplasty, Samuel Mattei

Electronic Theses and Dissertations

Total hip arthroplasty (THA) is one of the most successful orthopedic surgeries performed, in which the hip joint is reconstructed to improve functionality and decrease pain in the joint. Despite the success of these procedures, femoral stem misalignment remains an area that influences THA success. The relationship between the femoral stem geometry and implanted femoral stem size and orientation is underreported due to limitations in the collection of radiographic data used for clinical pre-operative templating. Furthermore, the influence of anatomic measurements on the direction and size of the femoral stem are not considered due to imaging technique and difficulties associated …

Prediction Of Drilling Fluid Lost-Circulation Zone Based On Deep Learning, Yili Kang, Chenglin Ma, Chengyuan Xu, Lijun You, Zhenjiang You

Research outputs 2022 to 2026

Lost circulation has become a crucial technical problem that restricts the quality and efficiency improvement of the drilling operation in deep oil and gas wells. The lost-circulation zone prediction has always been a hot and difficult research topic on the prevention and control of lost circulation. This study applied machine learning and statistical methods to deeply mine 105 groups and 29 features of loss data from typical loss block M. After removing 10 sets of noise data, the methods of mean removal, range scaling and normalization were used to pre-treat the 95 sets of the loss data. The multi-factor analysis …

Experimental Study On Fracture Plugging Effect Of Irregular-Shaped Lost Circulation Materials, Chengyuan Xu, Honglin Zhang, Jiping She, Guobin Jiang, Chi Peng, Zhenjiang You

Research outputs 2022 to 2026

Using micro-visualization experimental device for the formation of fracture plugging zone, the plugging behavior of irregular-shaped lost circulation materials (LCMs) with different types and concentrations in fractures was experimentally analyzed. The results show that the sealing time decreases significantly with the increase of material concentration. When the concentration is 20%, the sealing times of materials LCM-1∼LCM-5 are 6s, 7s, 5s, 6s, 4s, respectively. The formation of fracture plugging zone includes two stages, and the main factors affecting the formation of fracture plugging zone are flatness, roundness, convexity and concentrations. Flatness affects the retention stage of LCMs through the matching degree …

Ultrasonic Study Of Water Adsorbed In Nanoporous Glasses, Jason Ogbebor, John J. Valenza, Peter I. Ravikovitch, Ashoka Karunarathne, Giovanni Muraro, Maxim Lebedev, Boris Gurevich, Alexei F. Khalizov, Gennady Y. Gor

Research outputs 2022 to 2026

Thermodynamic properties of fluids confined in nanopores differ from those observed in the bulk. To investigate the effect of nanoconfinement on water compressibility, we perform water sorption experiments on two nanoporous glass samples while concomitantly measuring the speed of longitudinal and shear ultrasonic waves in these samples. These measurements yield the longitudinal and shear moduli of the water-laden nanoporous glass as a function of relative humidity that we utilize in the Gassmann theory to infer the bulk modulus of the confined water. This analysis shows that the bulk modulus (inverse of compressibility) of confined water is noticeably higher than that …

Strain Measurement With Multiplexed Fbg Sensor Arrays: An Experimental Investigation, Bruno Da Silva Falcão, Ausama Giwelli, Melissa N. Kiewiet, Stephen Banks, George Yabesh, Lionel Esteban, Leigh Kiewiet, Nurudeen Yekeen, Yevhen Kovalyshen, Ludwig Monmusson, Ahmed Al-Yaseri, Alireza Keshavarz, Stefan Iglauer

Research outputs 2022 to 2026

In conventional rock mechanics testing, radial strain measuring devices are usually attached to the sample's surface at its mid-height. Although this procedure provides a realistic picture of the lateral deformation undergone by homogeneous samples, however, this assumption may not be accurate if the tested rock has significant heterogeneity. Fibre Bragg Grating (FBG) sensors have recently been introduced to various rock testing applications due to their versatility over conventional strain gauges and radial cantilevers. FBG sensors have small size, multiplexing capability, and immunity to magnetic interference. The main objective of this study is to explore and understand the capabilities of FBG …

Investigation Of Pool Boiling Heat Transfer On Modified Copper And Aluminum Surfaces, Mariam Khaled Zaghloul

Theses

This thesis presents an investigation of pool-boiling heat transfer using the surfacemodification method. The studied boiling surfaces were smooth and rough pin-fins embedded on the copper and aluminum surfaces. This study visualizes bubble formation and departure diameter. Experimental testing aims to predict the heat transfer coefficients for different heat fluxes over smooth and rough pin-finned surfaces. The surface modification method allows changing the boiling surface characteristics, which can lead to enhanced heat transfer. Several factors were studied, including the heat-transfer coefficient, heat flux, bubble departure diameter, and formation time. Four surfaces were used for conducting the pool boiling experiment: a …

A Novel Brain Computer Interface Design, Steven Vogan

Senior Honors Theses

A brain computer interface (BCI) is a system which connects neural signals to a computer system. They have been used for controlling systems including robotics, on-screen computer control such as mouse movement, typing, and synthesizing audio signals. Invasive, or implanted, systems are often long-term medical solutions, or used for research where very clear signal is required. Non-invasive systems usually rely on exterior signals gathered through a headset using one or more electrode sensors. These signals are composed of sums of neuron activation potentials from brain activity and can be used to determine particular aspects of brain function. All BCIs rely …

Auto-Segmentation In Pancreatic And Liver Radiation Therapy, Cenji Yu

Dissertations and Theses (Open Access)

Background

Gastrointestinal cancers exhibit a high mortality rate compared to other cancer types. Among these, pancreatic cancer ranks as the fourth leading cause of cancer-related deaths worldwide. The five-year survival rate remains alarmingly low at a mere 9%. Hepatocellular carcinoma (HCC), another aggressive form of cancer, is rapidly becoming the primary cause of cancer-related deaths in the United States. The treatment of both liver cancer and pancreatic cancer heavily relies on a multidisciplinary approach. Innovative treatment strategies involving dose-escalated regimens, such as stereotactic body radiation therapy (SBRT), are emerging as an important pillar of the management of liver and pancreatic …

Protein L Functionalized Microparticles For Early Detection Of Surface Markers In Heterogeneous Colorectal Lesions, Saleh Ramezani

Dissertations and Theses (Open Access)

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths among both men and women worldwide, a statistic that can be improved with early detection. Increased understanding of the tumor landscape has identified surface antigens that can be utilized to distinguish normal and cancerous tissue lining the colonic lumen. Use of antibodies conjugated to nano/micromaterials offers a means to detect these antigens, however, the heterogeneous nature of tumors makes it unlikely that antibodies against a single antigen will have sufficient sensitivity and specificity to detect all tumors. A versatile micromaterial able to be functionalized with more than one targeting …

Examining Individuals' Use Of The Internet For Healthcare Activities Over Time: Statistical Analysis Of Nhis Data, Zachary Junkins

All Theses

Telehealth is an increasingly important component of healthcare services. Telehealth services may present an opportunity to increase the equity, accessibility, and effectiveness of healthcare. As such, it is critical that telehealth design focus on reducing the barriers to access and usability that may impair some telehealth users. I utilized data from the National Health Interview Survey (NHIS) and multiple logit regression models focused on different aspects of telehealth in order to determine demographic characteristics, behaviors, or opinions which may predict groups that are likely to face a barrier to using telehealth services. This analysis provides an exploratory look at the …

Photodynamic Therapy To Treat Triple Negative Breast Cancer In Vitro, Hunter S. Warren

All Theses

Triple negative breast cancer (TNBC) is the most resilient form of breast cancer, being one of the leading causes of death for women and making up 7% of all cancer deaths. Photodynamic therapy (PDT) offers a minimally invasive solution to TNBC as a passive-targeting treatment that reduces the need for other well established yet harsh treatments that can be taxing on the patient. PDT involves the use of a high-energy red light on the area of a tumor injected with photosensitizers (PS) that generate reactive oxygen species (ROS) in the tumor, triggering cell death. The PS tetra(hydroxyphenyl)chlorin (m-THPC) was used …