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2018

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Articles 1681 - 1710 of 8951

Full-Text Articles in Engineering

Multispecies Fruit Flower Detection Using A Refined Semantic Segmentation Network, Philipe A. Dias, Amy Tabb, Henry P. Medeiros Oct 2018

Multispecies Fruit Flower Detection Using A Refined Semantic Segmentation Network, Philipe A. Dias, Amy Tabb, Henry P. Medeiros

Electrical and Computer Engineering Faculty Research and Publications

In fruit production, critical crop management decisions are guided by bloom intensity, i.e., the number of flowers present in an orchard. Despite its importance, bloom intensity is still typically estimated by means of human visual inspection. Existing automated computer vision systems for flower identification are based on hand-engineered techniques that work only under specific conditions and with limited performance. This letter proposes an automated technique for flower identification that is robust to uncontrolled environments and applicable to different flower species. Our method relies on an end-to-end residual convolutional neural network (CNN) that represents the state-of-the-art in semantic segmentation. To enhance …


Delineating Operating And Support Costs In Aircraft Platforms, Garrett B. O'Hanlon, Jonathan D. Ritschel, Edward D. White, Gregory E. Brown Oct 2018

Delineating Operating And Support Costs In Aircraft Platforms, Garrett B. O'Hanlon, Jonathan D. Ritschel, Edward D. White, Gregory E. Brown

Faculty Publications

As the costs of Department of Defense (DoD) Weapon Systems increase, the ability to estimate the Operating and Support (O&S) costs accurately for the various weapon systems has become vital to long-term affordability. This research focuses on the O&S costs of the Air Force fixed-wing arsenal (i.e., platforms) for 1996–2016. First, the Cost Element Structure (CES) for 52 aircraft platforms and seven operational mission categories is analyzed to derive the descriptive statistics per aircraft category through examination of actual historical costs. Second, testing to identify statistical differences within the O&S CES construct across various Air Force aircraft categories is conducted. …


A Deterministic-Stochastic Method For Computing The Boltzmann Collision Integral In O(Mn) Operations, Alexander Alekseenko, Truong Nguyen, Aihua W. Wood Oct 2018

A Deterministic-Stochastic Method For Computing The Boltzmann Collision Integral In O(Mn) Operations, Alexander Alekseenko, Truong Nguyen, Aihua W. Wood

Faculty Publications

We developed and implemented a numerical algorithm for evaluating the Boltzmann collision integral with O(MN) operations, where N is the number of the discrete velocity points and M < N. At the base of the algorithm are nodal-discontinuous Galerkin discretizations of the collision operator on uniform grids and a bilinear convolution form of the Galerkin projection of the collision operator. Efficiency of the algorithm is achieved by applying singular value decomposition compression of the discrete collision kernel and by approximating the kinetic solution by a sum of Maxwellian streams using a stochastic likelihood maximization algorithm. Accuracy of the method is …


Evaluating Annual Fixed Wing Maintenance Costs, Kirsten Bunecke, Edward D. White, Jonathan D. Ritschel, Brett A. Bush Oct 2018

Evaluating Annual Fixed Wing Maintenance Costs, Kirsten Bunecke, Edward D. White, Jonathan D. Ritschel, Brett A. Bush

Faculty Publications

This article serves two purposes: first, to empirically model the annual percentage increase of operations and support (O&S) costs for fixed wing aircraft; and second, to place into the archival realm another reference for other researchers to consider when investigating other O&S topics. For this study of 21 different airframes grouped together at the Mission- Design Series (MDS), maintenance subcategories 3.1 Consumable Materials and Repair Parts, 3.2 Depot Level Repairables (DLR), and 3.4 Depot Maintenance accounted for an average 91.5% of annual organic maintenance costs. For contractor-maintained MDS, subcategory 3.7, Contractor Logistics Support (CLS) accounted for 96.6% of annual maintenance …


Dynamic Power System Training Simulation Platform And Tools For The Operational Management Of Smart Grids In The Liberalized Energy Market, Darlus France Mengapche Oct 2018

Dynamic Power System Training Simulation Platform And Tools For The Operational Management Of Smart Grids In The Liberalized Energy Market, Darlus France Mengapche

Doctoral

The major changes in distribution networks (medium and low voltage networks) over recent decades led to new challenges and issues in the operational management of these networks. Amongst others, issues such as load flow problems (power flow reversal, overloading of network equipment, network congestions), voltage problems (voltage limit violations, voltage increases and decreases, harmonics), power schedule management problems, network state estimation and problems with the operation of protection equipment could be encounterd. Besides, the control center staff which is confronted with new complex tasks, challenges and responsibilities, must be prepared and trained for the operational management of the future distribution …


Nanofluidic Applications Of Silica Membranes, John Michael Stout Oct 2018

Nanofluidic Applications Of Silica Membranes, John Michael Stout

Theses and Dissertations

This work presents membrane development applicable in nanofluidic devices. These membranes can also be termed suspended thin films, supported on two or more edges. I first discuss motivation and background for developing these structures. Then I derive the formative principles for nanofluidic systems. Following the derivation of the Navier-Stokes and Washburn equations, I discuss applying these theories to planar nanofluidic capillaries and finish the derivation by discussing the forces that drive liquid flow in nanochannels. I next discuss the membrane development process, starting with my work in static height traps, and develop the concept of analyzing nanoparticles using suspended membranes. …


A Hard-Real-Time Juggling Simulator To Shape Human Sensitivity To Cues And Coordination Of Muscles, Robert W. Nickl Sep 2018

A Hard-Real-Time Juggling Simulator To Shape Human Sensitivity To Cues And Coordination Of Muscles, Robert W. Nickl

Link Foundation Modeling, Simulation and Training Fellowship Reports

Many virtual reality tasks incorporate auditory and haptic (or touch) feedback, in addition to visual displays of spatial information. Non-visual feedback modalities such as the former increase realism; but they may have an ancillary benefit of increasing human motor performance and learning. One task for which this has been exhibited is paddle juggling, or vertically bouncing a ball off of a rigid elastic planar surface. For the objective of hitting the ball toward a target height, visual feedback is sufficient. Yet, previous studies have shown that non-visual feedback----specifically haptic---both is sufficient in the absence of vision to maintain stable ball …


The Development Of A Novel Motion Cuing Algorithm For Flight Training Simulators Employing Objective Metrics For Evaluation, Ahmad Qasim Momani Sep 2018

The Development Of A Novel Motion Cuing Algorithm For Flight Training Simulators Employing Objective Metrics For Evaluation, Ahmad Qasim Momani

Link Foundation Modeling, Simulation and Training Fellowship Reports

The value of a dynamic motion platform to the flight simulator is a controversial issue within the flight training community. The motion of the flight simulator platform has been shown to affect pilot performance and behavior. Moreover, its ability to provide the operator with the appropriate motion cues is essential for pilot training or research. Unwanted cues can cause the operator to develop inappropriate control behavior strategies that are not useful or might be dangerous in real flight. Performance studies show that the operator’s performance is enhanced when introducing motion which might indicate that the operator experiences a sensation closer …


Utah State University Team Takes Top Prizes At Battle Bot Competition | College Of Engineering, Usu College Of Engineering Sep 2018

Utah State University Team Takes Top Prizes At Battle Bot Competition | College Of Engineering, Usu College Of Engineering

College of Engineering News

It was the first round. Bjorn Ironsides was flitting around Hard Reset, a professional, at high speeds.


Plasmonic Resonance Of Active Dimer Systems In The Presence Of Optical Binding Forces, Md Saber Nazim Sep 2018

Plasmonic Resonance Of Active Dimer Systems In The Presence Of Optical Binding Forces, Md Saber Nazim

Student Theses and Dissertations

Optical properties of metal nanoparticles are related to the collective oscillations of conduction electrons. In metals, these electrons are loosely bound with the lattice core and therefore oscillate freely with the incident electromagnetic wave. Such oscillations are popularly known as plasmonic resonance. The term nanoparticle, in general, refers to small cluster of atoms of size ranging from one nanometer to few hundred nanometers. Plasmonic resonance in metal spherical and core-shell nanoparticles yields a number of different properties and remarkably such resonances are tunable with both the geometrical parameters of the particles involved and also with the background. When more than …


Design, Simulation, And Construction Of An Ieee 14-Bus Power System, John Albert Boudreaux Sep 2018

Design, Simulation, And Construction Of An Ieee 14-Bus Power System, John Albert Boudreaux

LSU Master's Theses

Today’s bulk power system is massive, complex, and very dynamic. The U.S. power grid spans from coast to coast and even as far reaching as Canada. With the addition of new technologies such as renewable energies and power electronics to aid in power conversion and control, the power system grows more complex by the day. The most common approach of analyzing power system stability is through computer modeling and simulation. Due to the vast size and inaccessibility of transmission systems, real time testing can prove difficult. The motivation of this project was to design, simulate, and construct an IEEE 14 …


Detection Of Hydrogen Peroxide Production In The Isolated Rat Lung Using Amplex Red, Said H. Audi, Nina Friedly, Ranjan K. Dash, Andreas M. Beyer, Anne V. Clough, Elizabeth R. Jacobs Sep 2018

Detection Of Hydrogen Peroxide Production In The Isolated Rat Lung Using Amplex Red, Said H. Audi, Nina Friedly, Ranjan K. Dash, Andreas M. Beyer, Anne V. Clough, Elizabeth R. Jacobs

Biomedical Engineering Faculty Research and Publications

The objectives of this study were to develop a robust protocol to measure the rate of hydrogen peroxide (H2O2) production in isolated perfused rat lungs, as an index of oxidative stress, and to determine the cellular sources of the measured H2O2 using the extracellular probe Amplex red (AR). AR was added to the recirculating perfusate in an isolated perfused rat lung. AR’s highly fluorescent oxidation product resorufin was measured in the perfusate. Experiments were carried out without and with rotenone (complex I inhibitor), thenoyltrifluoroacetone (complex II inhibitor), antimycin A (complex III inhibitor), potassium …


The Santa Clara, 2018-09-27, Santa Clara University Sep 2018

The Santa Clara, 2018-09-27, Santa Clara University

The Santa Clara

No abstract provided.


Batch Sizing In Sustainable Production Systems With Imperfect Quality, Farnaz Ghazi Nezami, Mojtaba Heydar Sep 2018

Batch Sizing In Sustainable Production Systems With Imperfect Quality, Farnaz Ghazi Nezami, Mojtaba Heydar

Industrial & Manufacturing Engineering Presentations And Conference Materials

In classic Economic Production Quantity (EPQ), an optimal batch size is determined to minimize total production cost including setup and inventory holding costs, and defective parts are not allowed. In this paper an imperfect EPQ system is studied to minimize the overall cost, where setup cost, scarp rate, batch size, and electrical power demand are determined by the model. In this imperfect production system, a percentage of the batch is defective in each cycle, which will be reworked at an extra charge. In addition, the model considers electrical power demand charge which accounts for a large percentage of industrial utility …


Ultrafine Mineral Associations In Superhigh-Organic-Sulfur Kentucky Coals, James C. Hower, Debora Berti, Michael F. Hochella Jr. Sep 2018

Ultrafine Mineral Associations In Superhigh-Organic-Sulfur Kentucky Coals, James C. Hower, Debora Berti, Michael F. Hochella Jr.

Center for Applied Energy Research Faculty and Staff Publications

Two high-organic-sulfur Kentucky coals, the eastern Kentucky River Gem coal and the western Kentucky Davis coal, are examined by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), both including elemental analysis by energy-dispersive spectroscopy (EDS). From the SEM–EDS analysis, it is observed that the western Kentucky coal had areas with Pb and Cd in addition to the expected Fe and S and the eastern Kentucky coal had individual Fe–S-rich areas with La and Ni and with Si, Al, Cr, Ni, and Ti. TEM and selected area electron diffraction (SAED) analyses demonstrate that anglesite with a rim of Pb-bearing amorphous …


Light Scattering Measured With Spatial Frequency Domain Imaging Can Predict Stromal Versus Epithelial Proportions In Surgically Resected Breast Tissue, David M. Mcclatchy, Elizabeth J. Rizzo, Wendy A. Wells, Candice C. Black, Keith D. Paulsen, Stephen C. Kanick, Brian W. Pogue Sep 2018

Light Scattering Measured With Spatial Frequency Domain Imaging Can Predict Stromal Versus Epithelial Proportions In Surgically Resected Breast Tissue, David M. Mcclatchy, Elizabeth J. Rizzo, Wendy A. Wells, Candice C. Black, Keith D. Paulsen, Stephen C. Kanick, Brian W. Pogue

Dartmouth Scholarship

This study aims to determine if light scatter parameters measured with spatial frequency domain imaging (SFDI) can accurately predict stromal, epithelial, and adipose fractions in freshly resected, unstained human breast specimens. An explicit model was developed to predict stromal, epithelial, and adipose fractions as a function of light scattering parameters, which was validated against a quantitative analysis of digitized histology slides for N  =  31 specimens using leave-one-out cross-fold validation. Specimen mean stromal, epithelial, and adipose volume fractions predicted from light scattering parameters strongly correlated with those calculated from digitized histology slides (r  =  0.90, 0.77, and 0.91, respectively, p-value× …


Synthesis And Characterization Of Polymer-Silica Composite Hydrogel Particles And Influence Of Hydrogel Composition On Cement Paste Microstructure, Matthew J. Krafcik, B Bose, Kendra Erk Sep 2018

Synthesis And Characterization Of Polymer-Silica Composite Hydrogel Particles And Influence Of Hydrogel Composition On Cement Paste Microstructure, Matthew J. Krafcik, B Bose, Kendra Erk

School of Materials Engineering Faculty Publications

The objective of this research is to define the fundamental structure-property relationships of water-swollen polymer hydrogel particles that are employed as internal curing agents in cementitious mixtures, in addition to reporting a novel synthesis procedure for combining pozzolanic materials with hydrogel particles. Solution polymerization was performed to incorporate amorphous nanosilica particles within acrylic-based polymer hydrogel particles of varying chemical compositions (i.e., monomer ratio of acrylic acid (AA) to acrylamide (AM)). Experiments were designed to measure the absorption capacity and kinetics of hydrogel particles immersed in pure water and cementitious pore solution, as well as determine the impact of particles on …


Finite-Time Sliding Mode And Super-Twisting Control Of Fighter Aircraft, Kaushik Raj, Venkatesan Muthukumar, Sahjendra N. Singh, Keum W. Lee Sep 2018

Finite-Time Sliding Mode And Super-Twisting Control Of Fighter Aircraft, Kaushik Raj, Venkatesan Muthukumar, Sahjendra N. Singh, Keum W. Lee

Electrical & Computer Engineering Faculty Research

The development of two nonlinear robust higher-order flight control systems for roll-coupled maneuvers of fighter aircraft with uncertain parameters is discussed in this article. The objective is to independently control the output variables (roll angle, pitch angle and sideslip angle) using aileron, elevator and rudder control surfaces. For a nominal model of aircraft, first a finite time stabilizing (FTS) control law, based on the notion of geometric homogeneity, is designed. Then for robust control in the presence of parameter uncertainties, (i) a discontinuous sliding mode (DSM) control law and (ii) a super-twisting (STW) continuous control law is designed. It is …


Ozone-Surface Exchange And Transport And Transformation Near Ventilation Air Supply, Pradeep Ramasubramanian Sep 2018

Ozone-Surface Exchange And Transport And Transformation Near Ventilation Air Supply, Pradeep Ramasubramanian

Dissertations and Theses

Ozone in indoor environments can pose a health risk to human occupants; around half of exposure to this pollutant occurs inside buildings. One approach to reducing indoor O3 levels is to mitigate O3 as it enters a building via outdoor air ventilation supply. Often, mechanical systems that introduce outdoor air into buildings are placed on building rooftops. At the urban scale, greenery has been shown to reduce levels of some harmful pollutants, including ozone and cities like Portland, OR, are mandating green roofs be built on large commercial buildings to increase urban green surfaces. We investigate if rooftop …


Asee Tuee Phase Iv Report 2018 - Views Of Faculty & Professional Societies, Byron G. Garry Sep 2018

Asee Tuee Phase Iv Report 2018 - Views Of Faculty & Professional Societies, Byron G. Garry

ASEE Best Practice Series Presentations

No abstract provided.


Single-Use And Sustainability: Continued Studies Using Lca Tools, William Whitford Sep 2018

Single-Use And Sustainability: Continued Studies Using Lca Tools, William Whitford

Single-Use Technologies III: Scientific and Technological Advancements

The issue of plastic materials in our environment has been of recent interest. The biotechnology community has responded by examining the effects of single-use systems employed in biomanufacturing. It is natural to emphasize a particular set of environmental concerns over others, and especially the more visible ones. But, in supporting truly sustainable manufacturing systems, it is important to consider all relevant types of pollution or environmental stress. The Life Cycle Assessment (LCA) is a science-based approach for evaluating the environmental impacts, benefits, trade-offs, and burden shifts of a process in an objective format. It considers production process’ materials, equipment and …


Comparison Of Single-Use And Steel Fermenters For Kla And Aggressive Microbial Cultures, Jason Brown, Christopher Brau, Nephi Jones Sep 2018

Comparison Of Single-Use And Steel Fermenters For Kla And Aggressive Microbial Cultures, Jason Brown, Christopher Brau, Nephi Jones

Single-Use Technologies III: Scientific and Technological Advancements

Purpose built single-use fermenters enable production facilities to utilize the single-use technologies instead of traditional stainless steel fermentor vessels without modifying their existing procedures. The manufacture lead time of the single-use fermentor hardware is a fraction of traditional vessels. As each single-use bioprocess container ships sterile and validated, reducing down time between cultures and allowing for more production volume in less space. Here we demonstrate kLa studies and aerobic cultivations with up to 2vvm gas flow in comparison of the single-use fermentors to traditional stainless steel fermenters. These single-use fermentors covering 6L-300L working volumes are specifically designed to meet the …


Ultralow Dispersion Multicomponent Thin-Film Chalcogenide Glass For Broadband Gradient-Index Optics, Myungkoo Kang, Andrew M. Swisher, Alexej V. Pogrebnyakov, Liu Liu, Andrew Kirk, Stephen Aiken, Laura Sisken, Charmayne Lonergan, Justin Cook, Teodor Malendevych, Fedor Kompan, Ivan Divliansky, Leonid B. Glebov, Martin C. Richardson, Clara Rivero-Baleine, Carlo G. Pantano Sep 2018

Ultralow Dispersion Multicomponent Thin-Film Chalcogenide Glass For Broadband Gradient-Index Optics, Myungkoo Kang, Andrew M. Swisher, Alexej V. Pogrebnyakov, Liu Liu, Andrew Kirk, Stephen Aiken, Laura Sisken, Charmayne Lonergan, Justin Cook, Teodor Malendevych, Fedor Kompan, Ivan Divliansky, Leonid B. Glebov, Martin C. Richardson, Clara Rivero-Baleine, Carlo G. Pantano

Materials Science and Engineering Faculty Research & Creative Works

A novel photothermal process to spatially modulate the concentration of sub-wavelength, high-index nanocrystals in a multicomponent Ge-As-Pb-Se chalcogenide glass thin film resulting in an optically functional infrared grating is demonstrated. The process results in the formation of an optical nanocomposite possessing ultralow dispersion over unprecedented bandwidth. The spatially tailored index and dispersion modification enables creation of arbitrary refractive index gradients. Sub-bandgap laser exposure generates a Pb-rich amorphous phase transforming on heat treatment to high-index crystal phases. Spatially varying nanocrystal density is controlled by laser dose and is correlated to index change, yielding local index modification to ≈+0.1 in the mid-infrared.


A Cognitive Framework To Secure Smart Cities, Shahab Tayeb, Neha Raste, Matin Pirouz, Shahram Latifi Sep 2018

A Cognitive Framework To Secure Smart Cities, Shahab Tayeb, Neha Raste, Matin Pirouz, Shahram Latifi

Electrical & Computer Engineering Faculty Research

The advancement in technology has transformed Cyber Physical Systems and their interface with IoT into a more sophisticated and challenging paradigm. As a result, vulnerabilities and potential attacks manifest themselves considerably more than before, forcing researchers to rethink the conventional strategies that are currently in place to secure such physical systems. This manuscript studies the complex interweaving of sensor networks and physical systems and suggests a foundational innovation in the field. In sharp contrast with the existing IDS and IPS solutions, in this paper, a preventive and proactive method is employed to stay ahead of attacks by constantly monitoring network …


Chemically Modified Cellulosic Materials As Multi-Functional Agents In Polymer Composites, Jinlong Zhang Sep 2018

Chemically Modified Cellulosic Materials As Multi-Functional Agents In Polymer Composites, Jinlong Zhang

LSU Doctoral Dissertations

Comparative flame retardancy of micro wood fiber plastic composites (WPCs) with fire retardants (1,2-bis(pentabromophenyl) ethane, metal hydroxides and nanoclay) was studied. The fire additives (1,2-bis(pentabromophenyl) ethane as well as magnesium hydroxide) obviously enhanced the fire retarding properties of WPCs. Especially, 1,2-bis(pentabromophenyl) ethane significantly reduced the total heat release as well as heat release rate. In addition, a synergistic effect of 1,2-bis(pentabromophenyl) and nanoclay was achieved for the enhanced fire retarding performance of WPCs.

A copolymer of cellulose nanocrystals (CNCs) and poly(N-vinylcaprolactam) (PVCL) (PVCL-g-CNCs) for use as thermally-responsive polymers with low critical solution temperatures (LCSTs) was synthesized via atom transfer radical …


One Root, Many Trees: Reviving Collections Practices, Kevin Farley, Emily Davis Winthrop, Ibironke Lawal, Patricia Sobczak Sep 2018

One Root, Many Trees: Reviving Collections Practices, Kevin Farley, Emily Davis Winthrop, Ibironke Lawal, Patricia Sobczak

Charleston Library Conference

Collections are undergoing intense change and pressure from technology, budgetary uncertainties, and emerging perspectives on future approaches. Our case study—drawn from our experiences as collections librarians—examines these complex issues facing academic collections, large or small, across the profession. Through the development of “collections of distinction” within the local collection, collaborations and scholarly partnerships with colleagues and faculty, and advocacy for the importance of dedicated oversight to ensure that collections investments fulfill the academic mission, we explore possible solutions to the complicated issues defining contemporary collections practices.


Leading Through Change, Travis Mcneal Sep 2018

Leading Through Change, Travis Mcneal

Operations Management Presentations

In this webinar, you will learn how to leverage periods of change to develop better leaders. We all hear that "the only constant is change" and that "change is hard." What if there was a different narrative? What if organizations going through change actually resulted in higher performance, engagement and better leadership? It is widely known that effective change management requires sponsorship — this means every leader, from the C-Suite to the front-line supervisor. This webinar will share practical and repeatable ways to help all leaders improve the way they lead change.


Policies That Impact The Acceleration Of Electric Vehicle Adoption, Florida Solar Energy Center, Colleen Mccann Kettles Sep 2018

Policies That Impact The Acceleration Of Electric Vehicle Adoption, Florida Solar Energy Center, Colleen Mccann Kettles

FSEC Energy Research Center®

To better understand the influence of policy initiatives that relate to electric vehicles (EVs) have on accelerated deployment, this project focused on a number of successful public and private initiatives and policies designed to encourage the adoption of EVs and related infrastructure. References to databases that keep pace with this rapidly evolving and transformative industry are included, and best practices for design of laws and incentives are provided.


Polymer Interfaces And Biopharmaceuticals: Chemistry, Designs And Challenges, David W. Grainger Sep 2018

Polymer Interfaces And Biopharmaceuticals: Chemistry, Designs And Challenges, David W. Grainger

Single-Use Technologies III: Scientific and Technological Advancements

The complex interactions between biological components and polymer materials has an extensive technical history. Virtually every surface property has been invoked as being important to biological interfacial response: texture, roughness, topology, porosity, hydrophilic, hydrophobic, polar, apolar, (non)-wettable, non-fouling brushes, surface mobility, rigidity, flexibility, crystalline versus amorphous, aspect ratio. Few surface properties alone, however, provide consistent, global technical solutions to vexing biomedical technology problems, particularly with cell culture, blood, plasma, microbial milieu, and protein solutions. Bio-interface materials performance must therefore be tailored specifically to each application. Short-term contact use (minutes/hours) has different materials interface requirements than long-term (days) use; globular proteins …


Continuous Process Performance Enhancements For 50-500 L S.U.B.S, Ben Madsen, Jordan Cobia, Nephi Jones, Kevin Mullen Sep 2018

Continuous Process Performance Enhancements For 50-500 L S.U.B.S, Ben Madsen, Jordan Cobia, Nephi Jones, Kevin Mullen

Single-Use Technologies III: Scientific and Technological Advancements

Improvements in single-use systems have allowed implementation of high-density cultures in emerging bioprocess workflows while progressive advances in media optimization and improved clone genetic selection have underscored the perceived performance limitations of single-use bioreactors (S.U.B.s). This study presents how strategic enhancements to the sparge and agitation systems of Thermo Scientific™ HyPerforma™ S.U.B.s have revealed the potential for a three- to four-fold improvement of mixing and mass transfer performance compared to legacy SUB designs. This study investigates the following:

  • Bioreactor characterization, TruBio™ DeltaV™ controller optimization, online process analytics, and scalability analysis of the S.U.B. when targeting perfusion applications from 50 L …