Engineering Commons^™

Growth And Expression Of Halorhodopsin For Application In A Protein-Based Artificial Retina, Megan Ryan Gillespie

Honors Scholar Theses

Halorhodopsin (HR), a light-activated chloride ion pump, demonstrates potential for use as the scaffolding in an artificial retina. Retinal implants are needed to restore vision to people afflicted with ophthalmic diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). A protein-based chloride ion-patch would be utilized by the eye to create an influx of chloride ions, similar to ion concentrations in healthy retinas during the conversion of light stimuli to electrochemical signals. This protein-based retinal prosthesis will directly stimulate the bipolar cells of the retina, replacing the function of damaged photoreceptor cells. Other alternative treatments for AMD and …

Electronic Circuit To Mimic The Neural Network For The Saccade Controller, Justin D. Morse

Honors Scholar Theses

The proposed device is an electronic circuit that mimics the neural network controlling fast eye movements, or saccades. The device simulates the signals produced by each neuronal population during the control of a horizontal saccade and allows for observing and recording. It will serve as a valuable teaching tool in the field of neural control. Furthermore, the device will have applications in the realm of diagnosing and properly treating brain injury. Finally, this device could be incorporated into a system for controlling the eye movements of a realistic, artificially intelligent robot.

The FitzHugh-Nagumo model of the action potential is used …

Improved Tumor Contrast Achieved By Single Time Point Dual-Reporter Fluorescence Imaging, Kenneth M. Tichauer, Kimberley S. Samkoe, Kristian J. Sexton, Jason R. Gunn, Tayyaba Hasan, Brian W. Pogue

Dartmouth Scholarship

In this study, we demonstrate a method to quantify biomarker expression that uses an exogenous dual-reporter imaging approach to improve tumor signal detection. The uptake of two fluorophores, one nonspecific and one targeted to the epidermal growth factor receptor (EGFR), were imaged at 1 h in three types of xenograft tumors spanning a range of EGFR expression levels (n  =  6 in each group). Using this dual-reporter imaging methodology, tumor contrast-to-noise ratio was amplified by >6 times at 1 h postinjection and >2 times at 24 h. Furthermore, by as early as 20 min postinjection, the dual-reporter imaging signal …

Using Ground Penetrating Radar Signal Reflection To Model A Highly Transmissive Bedrock Aquifer, Daniel J. Brockmeyer Mr.

Master's Theses

The use of numerical modeling software to characterize groundwater contaminant fate and transport requires an understanding of the distribution of hydraulic properties of the aquifer. As the complexity of this distribution increases, a more sophisticated understanding is required. Modeling contaminant transport in bedrock aquifers requires that the spatial distributions of highly conductive geologic features are characterized along with the hydraulic transmissivities of those features (Shapiro, 2003). The goal of this research is to refine the numerical model of a highly transmissive crystalline aquifer by characterizing the spatial variability of the hydraulic transmissivity using the attenuation of the ground penetrating radar …

A Stochastic Simulation Model Of Alarm Response Strategies On A Telemetry Floor, Tasneem M. Pishori

Master's Theses

The large quantity of alarms characteristic of clinical settings have resulted in nursing staff suffering from a phenomenon termed ‘alarm fatigue’. Alarm fatigue is desensitization via habituation – as these commonly heard noises cause caregivers to have delayed or no response to alarms. Alarm management was ranked number one on the annual top ten list of technology hazards afflicting healthcare institutions published by the ECRI Institute for 2012. Several patient safety organizations have established alarm fatigue as a priority concern, and are working to eradicate the issue from the healthcare environment by 2017. To better understand the problem, a simplified …

High Speed Atomic Force Microscopy Techniques For The Efficient Study Of Nanotribology, James L. Bosse

Master's Theses

As mechanical devices scale down to micro/nano length scales, it is crucial to understand friction and wear at the nanoscale (nanotribology) especially at technically relevant sliding velocities. Accordingly, three novel techniques have been developed to study nanotribology, leveraging recent advances in high speed AFM. The first method utilizes high line-scanning rates coupled with sinusoidal scanning along the AFM fast scan axis, enabling rapid friction measurements as a function of velocity up to 20 mm/sec. The second method rapidly acquires friction versus force curves through disabling the feedback loop during scanning and relating the resulting lateral data with the correspondingly varying …

Nanocharacterization Of Porous Materials With Atomic Force Microscopy, Yasemin Kutes

Master's Theses

Scanning Probe Microscopy techniques have proven very useful in the investigation of porous nanostructured surfaces. Especially, Atomic Force Microscopy (AFM) has been widely used due to its compatibility with non-conducting surfaces. In particular, AFM often complements other techniques like scanning and transmission electron microscopy by providing quantitative surface information coupled with nanoscale spatial resolution. Its ability to operate in fluid is also important, as this allows researchers to mimic the physiological environment of biological materials and systems. In this work, two main types of porous materials are studied with AFM, including Phosphoric Acid Fuel Cell (PAFC) electrode catalyst layers, and …

Creating A Pedestrian Level-Of-Service Index For Transit Stops: Evidence From Denver’S Light Rail System, Patrick Gallagher

Master's Theses

No abstract provided.

Development And Application Of A Portable System To Reliably Measure Grip Forces Using Thin-Film Force Sensors, Shane Vincent Tornifoglio

Master's Theses

Accurate tracking of hand grip force is an important consideration needed for a robust understanding in the study of human biomechanics. One aspect where it proves useful is in hand-arm vibration, such as from gripping a power tool. Depending on how firmly the user is gripping the tool, they may change their exposure levels to the tool vibration, which can lead to potential disorders such as Hand-Arm Vibration Syndrome (HAVS).

A small, battery powered portable force unit has been developed to supply power to, and condition, the signals from eight thin-film force sensors. This gives a better understanding of the …

Eurotech Students In Germany: Preparation, Experience And Outcome, Daisy A. Michaels

Master's Theses

Higher education study abroad programs for U.S. students are on the rise. A variety of undergraduate disciplines are being coupled with international components to bring U.S. students to a higher level of global awareness to meet the demands of today’s economy. The University of Connecticut’s Eurotech Program is an example of this trend. Its students earn degrees in both German and engineering in a five year program. They are given practical training through study and internships in Germany under the auspices of the Baden-Württemberg Exchange Program. One of the Eurotech Program’s major goals is to enhance job opportunities for its …

Computer-Aided Engineering Tools For Structural Health Monitoring Under Operational Conditions, Priscilla O. Mensah-Bonsu

Master's Theses

This thesis presents two different applications of computer-aided non-destructive approaches for structures monitored under operational conditions. The first part of the thesis is the development of a graphical user interface (GUI) software for real-time autonomous assessment of structural health condition based on the signature vibration properties of the structure under study. The program, called ConImote2, operates on the wireless sensor network platform called imote2. ConImote2 is created in the Matlab platform for accessibility and to enable extension of its capabilities by the user. The primary goal of creating the program is to overcome the issue of data inundation from SHM …

A Comprehensive Methodology For Assessing Biomechanical Risks Associated With Hand Tool Use: Applied To Laparoscopic Surgical Instruments, Drew R. Seils

Master's Theses

Biomechanical risk factors are physical stressors that act on the neuromuscular structures of the human body and are present in all occupational settings. Repetition and intensity of tasks performed can magnify the effects of the biomechanical risks that a worker is exposed to.

After reviewing the current literature on ergonomics in laparoscopic surgery it was clear that a comprehensive approach to quantitatively reporting on the biomechanical risk factors associated with surgical hand tools had never been performed. Utilizing an opto-electronic motion capture system meant the exact surgeon posture was recorded during simulated surgical tasks. Electromyography was used to evaluate muscle …

Laboratory And Field Evaluation Of Two Warm-Mix Additives In Connecticut And Validation Of An Alternative Moisture Susceptibility Test, Alexander K. Bernier

Master's Theses

The first official state Warm-Mix Asphalt (WMA) pavement project in Connecticut was constructed between July 20th and 22nd, 2010 and it involved three experimental sections, i.e. one section with a conventional HMA (control section) and two WMA sections with different technologies, wax and foamed asphalt. All three sections are located on Route 70 in central Connecticut. The materials were collected in loose form and reheated and compacted in laboratory conditions (laboratory fabricated specimens). This paper discusses the effect of mix type on the results from several tests conducted in the laboratory, such as Semi-Circular Bending, Hamburg Wheel Tracking, Indirect Tensile, …

Advanced Design Optimization For Composite Structure: Stress Reduction, Weight Decrease And Manufacturing Cost Savings, Shayan Ahmadian

Master's Theses

An injection moldable chopped fiber composite actuator with detailed drawing and tolerances was designed within one year. A vendor was selected and a quote for injection molding tooling cost for production was obtained and the first prototype was built in addition of six months. The risks are identified and material characterization tests are proposed.

The objective of this project was redesigning an aluminum made actuator with a continuous fiber composite for weight saving purposes. After searching the literature and consulting with experts in the field it was concluded that manufacturing costs associated with continuous fiber composite are 3 times as …

Ceas E-News 05.04.2012, College Of Engineering And Applied Sciences

College of Engineering and Applied Sciences News

2012 CEAS Outstanding Seniors, Academic All-Mid-American Conference, Dr. Anthony Vizzini Appointed to State Board of Professional Engineers by Governor Snyder, Team 1677 Quantum Ninja Win FIRST Robotics Competition, Inaugural Service Learning Award, Spring 2012 Tau Alpha Pi Induction Ceremony, WMU SAE Chapter Wins World Congress Competition!, BroncoBike Team Wins Human Assisted Green Energy Vehicle Design Competition

An Energy Cost Optimization Method For A Large-Scale Hybrid Central Cooling Plant With Multiple Energy Sources Under A Complex Electricity Cost Structure, Yin Guo

Department of Industrial and Management Systems Engineering: Dissertations, Theses, and Student Research

The cooling energy cost could be a significant portion of the total energy cost for a large organization or building complex during summer. A hybrid system or thermal energy storage system is usually applied to reduce the energy cost. However, without proper integration and operation, the advantage of using such systems could be limited.

This study presents a general energy cost optimization methodology and mathematical model for a hybrid cooling system under a complex electricity cost structure. The model considers the efficiency of the hybrid cooling system and multiple energy sources. The energy cost evaluation reflects a complex cost structure …

An Enhanced Self-Adaptive Mapreduce Scheduling Algorithm, Xiaoyu Sun

School of Computing: Dissertations, Theses, and Student Research

MapReduce is a framework for processing huge amounts of data in a distributed environment and Hadoop is Apache’s open source implementation of MapReduce, which is widely used. However, Hadoop’s performance is currently limited by its default task scheduler, which assumes that cluster nodes are homogeneous when estimating the task progress and choosing slow tasks for re-execution. In practice, the homogeneity assumption does not always hold. Longest Approximate Time to End (LATE) is a scheduling algorithm that takes heterogeneity into account. It, however, still depends on a static method to estimate the task execution time. As a result, neither Hadoop default …

Prestressed Concrete Wind Turbine Supporting System, Ibrahim Lotfy

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Wind energy is one of the most commercially developed and quickly evolving renewable energy technologies worldwide. Wind turbines are commonly supported on tubular steel towers. As the turbines are growing and the towers are elevating, an increase in structural strength and stiffness is required to withstand the applied forces. Recent studies established concrete as a more economic and durable alternative to steel especially when the tower height exceed 240ft. Presently, concrete towers are not common due to their perceived heavy weight and assembly complexity. One of the systems that have been mentioned in the literature consists of precast rings that …

Design, Fabrication, And Testing Of A Pdms Micropump With Moving Membranes, Charles Cartin

Theses and Dissertations

This paper will discuss the design, fabrication, and testing of a Poly(dimethylsiloxane) (PDMS) microfluidic pump. PDMS is commonly described as a soft polymer with very appealing chemical and physical properties such as optical transparency, low permeability to water, elasticity, low electrical conductivity, and flexible surface chemistry. PDMS microfluidic device fabrication is done easily with the use of soft lithography and rapid prototyping. PDMS microfluidic devices make it easier to integrate components and interface devices with particular users, than using typically harder materials such as glass and silicon. Fabrication and design of single and multilayer PDMS microfluidic devices is much easier …

An Investigation Of Fraxinus Americana Branch Sway Using A 3 Dimensional Motion Capture System, Anna T. Campiformio

Master's Theses

Abstract

Wind is a dominant abiotic factor that a tree experiences throughout its lifetime and can cause severe tree damage, resulting in risk of injury to humans, and economic and ecological losses. It is thought that trees develop structural properties and architectures that help withstand loading conditions by dissipating wind energy through damping mechanisms. The role of branch motion in reducing potential dangerous wind loads has been the focus of relatively few studies. Even fewer studies have examined tree sway response to natural wind loaded conditions. In this investigation, branch frequencies were calculated for three Fraxinus americana using a three-dimensional …

Bivariate Drought Analysis Using Entropy Theory, Zengchao Hao, Vijay P. Singh

2011 Symposium on Data-Driven Approaches to Droughts

Drought duration and severity are two properties that are usually needed for drought analysis. To characterize the correlation between the two drought properties, a bivariate distribution is needed. A new method based on entropy theory is proposed for constructing the bivariate distribution that is capable of modeling drought duration and severity with different marginal distributions. Parameters of the joint distribution are estimated with Newton’s method. Monthly streamflow data from Brazos River at Waco, Texas, are employed to illustrate the application of the proposed method to model drought duration and severity for drought analysis.

College Of Engineering Senior Design Competition Spring 2012, University Of Nevada, Las Vegas

Fred and Harriet Cox Senior Design Competition Projects

Senior Design Experience

Part of every UNLV engineering student’s academic experience, the Senior Design project stimulates engineering innovation and entrepreneurship. Each student in their senior year chooses, plans, designs and prototypes a product in this required element of the curriculum. Working in teams, the senior design project encourages students to use everything learned in the engineering and computer design programs to create a practical, real world solution to an engineering challenge.

Beyond the classroom...

Because of the requirement to work in teams, students also build good communication skills, presentation skills and even business writing skills. They also have to source …

College Of Engineering Senior Design Competition Spring 2018, University Of Nevada, Las Vegas

Fred and Harriet Cox Senior Design Competition Projects

Part of every UNLV engineering student’s academic experience, the senior design project stimulates engineering innovation and entrepreneurship. Each student in their senior year chooses, plans, designs, and prototypes a product in this required element of the curriculum. A capstone to the student’s educational career, the senior design project encourages the student to use everything learned in the engineering program to create a practical, real world solution to an engineering challenge. The senior design competition helps focus the senior students in increasing the quality and potential for commercial application for their design projects. Judges from local industry evaluate the projects on …

Re-Configurable Putting Green, Matthew Ralphs

Undergraduate Honors Capstone Projects

This report discusses the design of a prototype transformable putting green that can be programmed to recreate the topography of any putting green. The goal of the design was to give a realistic putting experience with real topography in an indoor environment. This report discusses the design of a pair of 4’x4’ module prototypes; a commercial implementation of this design would utilize a number of modules to create putting greens on a more realistic scale (example 12’x32’). The design of a full size transformable putting green necessitates a topographical range of up to 30”. After initial concepts and preliminary designs …

Surface Mass Transfer In Large Eddy Simulation (Les) Of Langmuir Turbulence, Cigdem Akan

USF Tampa Graduate Theses and Dissertations

Over the past century the study of gas exchange rates between the atmosphere and the ocean has received increased attention because of concern about the fate of greenhouse gases such as CO₂ released into the atmosphere. Of interest is the oceanic uptake of CO₂ in shallow water coastal regions as biological productivity in these regions is on average about three times larger than in the open ocean. It is well-known that in the absence of breaking surface waves, the water side turbulence controls gas transfer of sparingly soluble gases such as CO₂ from the air to the …

Quantification Of Preterm Infant Feeding Coordination: An Algorithmic Approach, Pallavi Ramnarain

Theses and Dissertations

Oral feeding competency is a primary requirement for preterm infant hospital release. Currently there is no widely accepted method to objectively measure oral feeding. Feeding consists primarily of the integration of three individual feeding events: sucking, breathing, and swallowing, and the objective of feeding coordination is to minimize aspiration. The purpose of this work was to quantify the infant feeding process from signals obtained during bottle feeding and ultimately develop a measure of feeding coordination. Sucking was measured using a pressure transducer embedded within a modified silicone bottle block. Breathing was measured using a thermistor embedded within nasal cannula, and …

Evaluation Of Pedestrian Risk On 700 N On Utah State University Campus, Kirk Jackson

Undergraduate Honors Capstone Projects

One of the biggest concerns that highway designers face when designing roadways is how to safely design the interface between highway users and pedestrians. This is never truer than on the Utah State University campus where pedestrian use is much higher than on an average road. Utah State University purchased 700 N, the main collector road which runs through the heart of USU’s campus, from the City of Logan in the summer of 2010. Since then, pedestrian safety on 700 N has become the first priority of USU Facilities in regards to their efforts to improve it. It has come …

In Vivo Immunotoxicological Evaluation Of Electrospun Polycaprolactone (Epcl) And Investigation Of Epcl As A Drug Delivery System For Immunomodulatory Compounds, Colleen Mcloughlin

Theses and Dissertations

Electrospun materials have potential use in many biomedical applications such as soft tissue replacements or as scaffolds to target drug delivery to local sites. Electrospinning is a polymer processing technique that can be used to create materials composed of fibers with diameters ranging from the micron to the nanoscale. We investigated the effects of microfibrous and nanofibrous electrospun polycaprolactone (EPCL) on innate, cell-mediated, and humoral components of the immune system. Results demonstrated that in both young (12 week) and old (6 month) mice, EPCL had no effect on various immune parameters. With its lack of immunotoxicity, EPCL presents an excellent …

Non-Invasive Intracranial Pressure Method And Monitor, Tarun Sinha

Theses and Dissertations

The eyes are acoustically continuous with the brain and inner ear tissues in regard to matched impedances, based on tissue densities, thus, vibration of one site will be reflected in all sites. With this being the case, the vibrational energy response of the eye due to an external source can be used to determine a correlation or draw a conclusion concerning the vibrational energy response of the brain would be. And since there is a correlation between the vibrational energies, any changes in the acoustical energy in the eye can possibly be used to determine the changes in acoustical energy …

Analysis And Testing Of Heat Transfer Through Honeycomb Panels, Daniel D. Nguyen

Aerospace Engineering

This project attempts to simulate accurately the thermal conductivity of honeycomb panels in the normal direction. Due to the large empty space of the honeycomb core, the thermal radiation mode of heat transfer was modeled along with conduction. Using Newton’s Method to solve for a steady state model of heat moving through the honeycomb panel, the theoretical effective thermal conduction of the honeycomb panel was found, ranging from 1.03 to 1.07 Q/m/K for a heat input of 2.5 W to 11.8 W. An experimental model was designed to test the theoretical results, using a cold plate and a heat plate …