Engineering Commons^™

Heat And Mass Transfer In The Lyophilizatiuon Of Pharmaceuticals In Vials By Conduction Heating, William Warren Walsh

Theses

This thesis investigates the lyophilization of pharmaceuticals in vials by conductive heat transfer. The process phase diagram and methods of determining the solution eutectic temperature are reviewed. The theoretical considerations of heat and mass transfer pertaining to this process are discussed.

Lyophilization tests of distilled water and of mannitol solutions are used to indicate the relationship between vacuum chamber total pressure and the product/vial interface temperature. Experiments with 10% lactose solutions are used to determine the effect of shelf fluid temperature, product height and chamber vacuum on product/vial interface temperature. Test on a pharmaceutical product are used to confirm the …

The Transferability Of Force Constants Among Olefins, John Martin Comerford

Theses

A normal coordinate analysis of the in-plane vibrations of ethylene was performed using a modified valence force field, a modified Urey-Bradley force field and a hybrid orbital force field. The B_2u species of isobutene was also analyzed. An attempt was made to transfer force constants from ethylene and thereby solve the A₁ species of isobutene, but a solution could not be obtained. This suggests that simple transference of force constants is not feasable in this case.

The potential energy distributions obtained for ethylene are discussed. The normal coordinates calculated in this work are appended.

A Modified Redlich-Kwong Equation For Nonpolar And Slightly Polar Gases, David G. Skamenca

Theses

The PVT prediction capability of the Redlich-Kwong equation is substantially improved through the use of a generalized correlation based on the acentric factor. No experimental data is required to obtain the improved constants. Only the acentric factor and the critical properties of the pure gas are needed. The correlation of improved constants is limited to non-polar and slightly polar pure gases and mixtures in the supercritical temperature range.

The correlation applies to a reduced temperature range 1.00 le; T_R le; 1.60 and a reduced pressure range of 0.030 le; P_R le; 3.00. The correlation reduces deviations by as …

A Computer Program For The Design Of Packed Extraction Columns, George P. Gaccione

Theses

A computer program for the design of packed extraction columns has been developed. This program can operate with a minimum of data of the type that can easily be determined or estimated. The program can be used to investigate design alternates during the preparation of project cost estimates and for the final design of extraction columns.

Viscoelastic Properties Of Polymer Melts, Wu-Shiong Lee

Theses

Thirteen samples of molten polymers were used to test Spriggs and Careau Models. Two empirical equations, one for apparent viscosity and the other which is new, for primary normal stress difference, were checked with these samples also.

In order to test the models, material functions were sought for some specific flow patterns under which the experimental data were collected, and then these functions were compared with data.

Careau Model was found to be better than Spriggs Model in representing molten polymer properties but still yield large deviations. Two empirical equations fitted data quite well and were expected to be useful …

Combined Feedforward-Feedback Control Of A Fluidized-Bed Reactor, Reginald Eugene Mitchell

Theses

Feedforward control, feedback control, and combined feedforward-feedback control were studied on an analog computer to evaluate their effectiveness in controlling a fluidized-bed reactor used for the decomposition of cumene. Proportional, proportional-integral, proportional-derivative, and proportional-integral-derivative modes of control were investigated. Step changes in set-point and load were used as disturbances. The Ziegler-Nichols method and the process reaction curve method of Cohen and Coon were compared in determining values of KC, Ti, and Td which gave optimum control of the fluidized-bed reactor.

Control equation were obtained from the block diagrams of the systems and solved on an EAI TR-20 Analog Computer.

It …

Correlation And Prediction Of Diffussion Coefficients In Binary Gas Systems, Raymond Gerald Bailey

Theses

A correlation was developed for estimating binary gas diffusion coefficients by the reference substance method, in this case using the viscosity of air and subsequently its corresponding temperature. The derivation was made by the linear least square analysis of 65 different binary systems comprising 161 separate data points at temperatures ranging from 193°K. to 1200°K. At any given temperature only the critical molal volume and the molecular weights of the two gases of interest are required to calculate the diffusion coefficient. The correlation based on the viscosity of air had an average error of 7.67%. The correlation using temperature had …

The Relation Of Heat Transfer To Power Consumption Of Liquids In Turbulent Flow, John D. Bien

Theses

The relationship between the heat transfer ability and the power input requirement of liquid coolants in a turbulent heat transfer condition was investigated. A correlation in terms of the liquid physical properties and the required volumetric flow was proposed and the use of this correlation in selection of liquids as coolant was discussed. The optimum condition for a high heat transfer/power input ratio was also discussed.

Phosphate Removal From Sewage Using A Combination Of Ferric Chloride And A Polymeric Flocculant, Ravindra C. Patel

Theses

The present work is concerned with a newer technique and approach to the problem of phosphate removal from waste water. This includes the removal of phosphate from the sample of activated sludge, i.e., a sample from the aeration tank of the secondary sewage treatment. The phosphate is removed by using ferric chloride as a precipitating agent and a cationic polyelectrolyte (P.E.) as a flocculating agent. Results of this study showed that: (a) P.E. addition gives a significant improvement in phosphate removal over that obtained by ferric chloride alone. In some cases the phosphate removal increased from 92 to 96.5 per …

The Microstructure Of Hardened Gypsum Pastes, Raafat Ishak Abdel Malek

Archived Theses and Dissertations

No abstract provided.

Temperature Protection For Fruit Trees By Air-Supported Plastic Structures, Ram T. Gadhavi

Theses and Dissertations

The greatest weather enemy in all fruit destruction is the late spring frost which moves across the country under the high pressure areas that are occasionally seen on the weather maps, and kills the fruit buds.

Traps And Trap Distribution In Commercial Zinc Sulphides Phosphors Silver Activated And Poisoned With Cobalt, Zohra Safinaz El Calamawy

Archived Theses and Dissertations

No abstract provided.

Switching Characteristics Of Calcium Borate Glasses Containing Iron, Mahmoud Aly El Hamamsy

Archived Theses and Dissertations

No abstract provided.

A Comparative Study Of The Inorganic Composition In Body Fluids Of Four Egyptian Tick Species, Samir Fouad Araman

Archived Theses and Dissertations

No abstract provided.

Particle Dynamics In The Mixing Of A Particle-Laden Stream With A Secondary Stream In A Duct, William Doyle Cranney

Theses and Dissertations

The purpose of this thesis is to review the history and discuss the present work being done in particle-gas flow, with application to air- augmentation of a particle-carrying, fuel-rich gas jet. A drawing of the model considered is shown in Figure 1, with the area of interest labeled. The thesis is intended as a thorough literature review and analysis.

Determination Of Effective Strain For The Strainhardening Of Aluminum Subjected To Completely Reversed Strain Combinations, Navin M. Patani

Theses and Dissertations

It is known that subrecrystallization plastic deformation increases the strength of a metal. The amount of strengthening that may be acquired can be approximated using a strainhardening equation and a simple given strain. The purpose of this thesis was to determine the effective strain for predicting strainhardening for annealed aluminum subjected to completely reversed strain combinations.

Triaxial Stress Effects In Weldments Associated With The Heat Affected Zone, Rohit A. Mehta

Theses and Dissertations

The welding of steel occupies an important place as a major fabricating process in industry. The welding of steel has been a subject of research for many years, and much information has been obtained about the strength of weldments.

A Feasibility Study Of The Application Of Bondgraph Modeling And Computerized Nonlinear Model Parameter Identification Techniques To The Cardiovascular System, Randall L. Taylor

Theses and Dissertations

Recent years have witnessed an increasing trend for people in the medical and engineering professions to couple their talents in a more united effort to better understand the functioning of the human body. This union of technologies has meant the introduction of new viewpoints and techniques in the field of physiological research. The engineers' basic tool, mathematical modeling, has perhaps been one of the most noticeable additions. There has been a significant amount of work done in recent years along these lines of deriving mathematical models to express the functioning of a subsystem of the body, and then, using analog, …

An Investigation Of A Computer Technique For Determining The Characteristic Parameters Of A Viscoelastic Model With Hysteresis Effects From Transient Experimental Data, Stephen Jack Clark

Theses and Dissertations

The object of this work was to develop a computer technique for determining the characteristic parameters of spring-mass system with hysteresis effects from transient experimental data. The technique was intended to be utilized to determine the parameters of models of systems where complex geometry and rate dependent properties would make a determination of the model parameters most difficult, and where the parameters typically obtained from static test would not characterize the rate dependent properties accurately.

A Survey Of Literature On The Pyrolysis Of Wood And Other Cellulosic Solids, Kenneth P. Sasine

Theses and Dissertations

The study of the ignition of wood and other cellulosic materials has resulted in the publication of a large amount of literature. As an aid in the planning and interpretation of future research, it was felt that a survey of a representative body of literature should be made. With this as its motivation, the present work was initiated.

Non-Linear Analysis Of Electrocardiogram Tracings In Detection Of Occult Coronary Artery Disease, Joseph Robert Levitt

Dissertations

The general problem of identifying significant characteristics of a system by analyzing the properties of a signal emitted by that system is common to many disciplines, biological as well as physical. In general, achievement of a satisfactory solution depends on the capability of assigning membership of candidate signals to one of a number of mutually exclusive categories:

In this study, a new technique of processing the standard electrocardiograms from human subjects has been developed. This technique employs a set of non-linear transformations which enable the assignment of electrocardiograms into one of two Mutually exclusive categories. The first category is that …

Extension And Application Of The Sedov-Berdichevskii Variational Principle, Francis X. Prendergast

Dissertations

The Sedov-Berdichevskii variational principle is extended, and this extended principle is employed in the construction of a shell theory.

The extension of the principle is accomplished by the use of Lagrangian multipliers, and a redefinition of terms in order to maintain the original generality of the principle. The Euler equations of the extended variational principle provide, in addition to those obtained in the original principle, elastic and plastic kinematic relations, and, elastic and plastic constitutive relations. Also, the Euler equations of the original principle are obtained in a physically more meaningful form. Examples are given which show how this principle …

Reliability Aspects Of Semiconductor Surface Protective Coatings, Robert Edward Mcmillan

Dissertations

This research was directed towards the occurrence and im-portance of surface leakage in reverse biased semiconductor diodes and the relation of this leakage to the reliability of a device under use conditions. As a result of this study, it is possible to predict one important leakage mechanism after such back-biased diode units have been subjected to long periods of temperature and humidity. This theory is consistent with tests of commercially available units, some of which have very slight surface leakage and others very large surface leakage.

Further, the usefulness of various possible passivating coatings is critically analyzed on the basis …

Dynamic Stress Concentrations About An Epilliptical Discontinuity In An Elastic Solid, Kenneth Roy Schroll

Dissertations

The redistribution of dynamic stresses caused by the presence of an elliptical discontinuity in an infinite isotropic homogeneous elastic solid is examined. The solutions are obtained for the special cases of the rigid immovable inclusion and the vacuous cavity inclusion, and numerical results are presented.

The solutions to the wave equations in elliptical coordinates are expressed in series of the elliptical geometry eigenfunctions. Application of the boundary conditions, vanishing displacements for the rigid immovable inclusion and vanishing stresses for the cavity inclusion, yields in each case two infinite sets of linear algebraic equations for the expansion coefficients of the series …

Oscillations In Pulse Frequency Modulated Control Systems, Warren Joseph Guy

Dissertations

This dissertation is concerned with oscillations and their stability which occur in a control system containing two nonlinearities, separated by linear elements. Specifically the nonlinearities are Integral Pulse Frequency Modulators and the linear elements are described by ordinary differential equations which are linear. The IPFM can be modelled by a quantizer with hysteresis and many other PFM laws are related to IPFM, thus the study applies to more than just IPFM alone.

Boundaries on the system parameters are identified within which free oscillation may be possible. These boundaries give sufficient conditions for stability and necessary conditions for instability. Also since …

The Application Of A Non-Newtonian Rheological Equation To Low-Density Polyethylene, Jeffrey N. Goldstein

Theses

A generalized non-Newtonian equation describing the rheology of molten thermoplastics is verified for low-density polyethylenes. The equation is extended to account for both rheological temperature dependency and polyethylene molecular weight dependency. The prediction of the rheology of new polyethylenes without additional experimentation is thus possible.

The Oxidation Of Sulfur Dioxide In A Regenerative Reactor, Raymond Henry Edgecomb

Theses

A novel dual-unit sulfuric acid converter is depicted that performs in cyclic operation in unsteady state. A mathematical model and IBM 1130 Computer program were developed to show the temperature and conversion profiles in commercial-sized vanadium oxide catalyst beds. In the catalytic oxidation of sulfur dioxide conversions of 95-97% were attained without benefit of conventional heat exchangers. A single exchanger operating in conjunction with the dual-unit system might attain conversions as high as 99%.

A Computer Program For The Optimization Of Binary Distillation In A Dual-Column System, Richard Vincent O'Lenick

Theses

A computer program is presented for the optimization of a two-column distillation system involving a two-component mixture. The economic reflux ratios in each column are determined using the McCabe-Thiele Method. Activity coefficients are computed by either the Wilson equation, the Margules equation, or both. The program is general and may be used for any binary system where the assumption of constant molal overflow is valid.

Options in the program permit use of either column in separate calculation schemes.

While the optimization effort was prepared in general terms, the initial work was directed toward the acetone-water system. Full data for this …

Packed Column Simulation, Frederick W. Schmidt

Theses

The most difficult and time consuming aspect of the design of packed columns is the hydraulic part. If the designer wants to try many different conditions, many repetitive calculations will have to be performed. Also, some inaccuracy is incurred when trying to use the U.S. Stoneware curves. The graphs are hard to read and almost impossible to interpolate between the parametric lines. The purpose of the program is to give a more accurate calculation by using equations for the pressure drop lines, interpolating between them and correcting for gas density for each foot of packing. The program also allows changes …

A Comparative Analysis Of Multicomponent Distillation Minimum Reflux Methods, Joesph H. F. Loozen

Theses

One of the most important factors to know in the design of distillation columns is the minimum reflux ratio. Numerous procedures have been developed for the determination of the value of the minimum reflux ratio for multicomponent mixtures requiring various degrees of computational effort. Shortcut techniques are obviously advantageous with respect to computation time. After reviewing the available methods, those by Underwood, Colburn, Scheibel and Montross, Murdoch and Holland, and Shiras et al. were selected for further evaluation, mainly on the basis of practical potential.

Comparison of these procedures was accomplished by calculating the minimum reflux ratio for a large …