Engineering Commons^™

Bioengineering Extracellular Matrix Scaffolds For Volumetric Muscle Loss, Kevin Roberts

Graduate Theses and Dissertations

Volumetric muscle loss overwhelms skeletal muscle’s ordinarily capable regenerative machinery, resulting in fibrosis and severe functional deficits which have defied clinical repair strategies. My work spans the design and preclinical evaluation of implants intended to drive the cell community of injured muscle toward a regenerative state, as well as the development of an understanding of the molecular responses of this cell community to biomaterial interventions. I demonstrate a new class of biomaterial by leveraging the productive capacity of sacrificial hollow fiber membrane cell culture; I show specifically that unique threads of whole extracellular matrix can be isolated by solvent degradation …

Investigation Of The Effect Of Age On Regenerative Outcomes Following Treatment Of Volumetric Muscle Loss Injuries, John Taehwan Kim

Graduate Theses and Dissertations

Volumetric muscle loss (VML) is a traumatic injury in skeletal muscle resulting in the bulk loss of more than 20% of the muscle’s volume. Included in the bulk loss of muscle is the skeletal muscle niche comprised of nerve bundles, vasculature, local progenitor cells, basal lamina, and muscle fibers, overwhelming innate repair mechanisms. The hallmark of VML injury is the excessive accumulation of non-contractile, fibrotic tissue and permanent functional deficits. Though predominant in the younger demographic, the elderly population is also captured within VML injuries. There are many factors that change with aging in skeletal muscle that may further hinder …

Visualizing Ischemic Skin Flap Necrosis Through Phasor Analysis Of Autofluorescence Lifetime Images, Hallie Ramser Toomer

Graduate Theses and Dissertations

Necrotic skin flaps are difficult to predict and treat due to the lack of quantitative biomarkers. Label-free multiphoton microscopy is well suited for non-invasively monitoring skin metabolism through NAD(P)H and other intrinsic fluorophores, and offers immediate future directions for assessing necrosis in the clinic. The objective of this study was to assess whether phasor FLIM could be used to evaluate skin flap status and treatment efficacy in ex vivo skin sections. Phasor maps revealed differences in growth factor treatment and region, but changes in skin flap autofluorescence at 755nm excitation and 460nm emission were not just related to NAD(P)H. A …

Growth Of Indium Nitride Quantum Dots By Molecular Beam Epitaxy, Steven P. Minor

Graduate Theses and Dissertations

Over the last decade, the evolution of the global consciousness in response to decreasing environmental conditions from global warming and pollution has led to an outcry for finding new alternative/clean methods for harvesting energy and determining ways to minimize energy consumption. III-nitride materials are of interest for optoelectronic and electronic device applications such as high efficiency solar cells, solid state lighting (LEDs), and blue laser (Blu-ray Technology) applications. The wide range of direct band gaps covered by its alloys (0.7eV-6.2eV) best illustrates the versatility of III-nitride materials. This wide range has enabled applications extending from the ultraviolet to the near …

Engineered Carbon-Nanocatalyst Composites And Carbon Mixed ‎Matrix Membranes ‎For Water And Wastewater Treatment ‎, Mojtaba Abolhassani

Graduate Theses and Dissertations

Carbonaceous materials such as graphene oxide, and activated ‎carbon have a wide range of ‎applications in water and wastewater treatment due to the high surface ‎area, unique structure, ‎and chemical and thermal stability. Carbon-based materials can be used as a ‎membrane, an ‎adsorbent, a support for nanomaterials, or ‎as a filler within membranes to remove contaminants ‎from water. In this research, the specific carbon materials and how their properties influence their ‎use and performance in ‎specific engineering applications is explored. ‎

Here, membrane filtration and adsorption/degradation of the water and wastewater using carbon-‎based material are investigated. The research firstly focuses …

Probabilistic Models For Order-Picking Operations With Multiple In-The-Aisle Pick Positions, Jingming Liu

Graduate Theses and Dissertations

The development of probability density functions (pdfs) for travel time of a narrow aisle lift truck (NALT) and an automated storage and retrieval (AS/R) machine is the focus of the dissertation. The multiple in-the-aisle pick positions (MIAPP) order picking system can be modeled as an M/G/1 queueing problem in which storage and retrieval requests are the customers and the vehicle (NALT or AS/R machine) is the server. Service time is the sum of travel time and the deterministic time to pick up and deposit a pallet (TPD).

Our first contribution is the development of travel time pdfs for retrieval operations …

Switching Trajectory Control For High Voltage Silicon Carbide Power Devices With Novel Active Gate Drivers, Shuang Zhao

Graduate Theses and Dissertations

The penetration of silicon carbide (SiC) semiconductor devices is increasing in the power industry due to their lower parasitics, higher blocking voltage, and higher thermal conductivity over their silicon (Si) counterparts. Applications of high voltage SiC power devices, generally 10 kV or higher, can significantly reduce the amount of the cascaded levels of converters in the distributed system, simplify the system by reducing the number of the semiconductor devices, and increase the system reliability.

However, the gate drivers for high voltage SiC devices are not available on the market. Also, the characteristics of the third generation 10 kV SiC MOSFETs …

Modification And Optimization Of Conducting Polymer-Modified, Redox-Magnetohydrodynamics (R-Mhd) Pumping For Enhanced And Sustained Microfluidics Applications, Md Foysal Zahid Khan

Graduate Theses and Dissertations

In this work, a novel microfluidic pumping approach, redox-magnetohydrodynamics (R-MHD) has improved by materials and device optimization to use in lab-on-a-chip applications. In R-MHD, magnetic flux (B) and ionic current density (j) interacts to generate body force (FB) in between active electrodes, according to the equation FB = j×B. This unique fluid pumping approach is scalable, tunable, generates flat flow profile, and does not require any channels or valves. Pumping performance, such as speed scales with the ionic current density (j) and duration depends on the total charge (Q). The ionic current density (j) results from the conversion of electronic …

Predicting The Mechanical Properties Of Nanocomposites Reinforced With 1-D, 2-D And 3-D Nanomaterials, Scott Edward Muller

Graduate Theses and Dissertations

Materials with features at the nanoscale can provide unique mechanical properties and increased functionality when included as part of a nanocomposite. This dissertation utilizes computational methods at multiple scales, including molecular dynamics (MD) and density functional theory (DFT), and the coupled atomistic and discrete dislocation multiscale method (CADD), to predict the mechanical properties of nanocomposites possessing nanomaterials that are either 1-D (carbyne chains), 2-D (graphene sheets), or 3-D (Al/amorphous-Si core-shell nanorod).

The MD method is used to model Ni-graphene nanocomposites. The strength of a Ni-graphene nanocomposite is found to improve by increasing the gap between the graphene sheet and a …

Fault Adaptive Workload Allocation For Complex Manufacturing Systems, Charlie B. Destefano

Graduate Theses and Dissertations

This research proposes novel fault adaptive workload allocation (FAWA) strategies for the health management of complex manufacturing systems. The primary goal of these strategies is to minimize maintenance costs and maximize production by strategically controlling when and where failures occur through condition-based workload allocation.

For complex systems that are capable of performing tasks a variety of different ways, such as an industrial robot arm that can move between locations using different joint angle configurations and path trajectories, each option, i.e. mission plan, will result in different degradation rates and life-expectancies. Consequently, this can make it difficult to predict when a …

The Role Of Inter-Particle Behavior In Iron Oxide Nanoparticle Induction Heating, Hayden Seth Carlton

Graduate Theses and Dissertations

Due to their multi-functional nature, iron oxide nanoparticles present themselves in a myriad of scientific disciplines, but perhaps the most interesting property of these nanomaterials can be seen in their immense thermal response under the influence of alternating magnetic fields. Currently popularized as an alternative cancer treatment through localized hyperthermia, iron oxide nanoparticle induction heating presents an interesting physical phenomenon that distinguishes itself from macroscopic induction heating. Understanding how a single spherical particle behaves is relatively simple and remains well documented; however, magnetic interactions of a single particle often extend over many length scales, affecting numerous neighboring particles in the …

Auto-Calibration Of Wim Using Traffic Stream Characteristics, Johnson Baker

Graduate Theses and Dissertations

This project evaluates the performance of Weigh-in-Motion (WIM) auto-calibration methods used by the Arkansas Department of Transportation (ARDOT). Typical auto-calibration algorithms compare the WIM measured weights of vehicles from the traffic stream to reference values, using five-axle tractor-trailer configured trucks for comparisons, e.g. Federal Highway Administration (FHWA) Class 9. Parameters of the existing algorithms including the Front Axle Weight (FAW) reference value, the sampling frequency required to update the calibration factor, and thresholds for Gross Vehicle Weight (GVW) bins were evaluated. The primary metric used to estimate algorithm performance was Mean Absolute Percent Error (MAPE) between the WIM and static …

Motor Control Systems Analysis, Design, And Optimization Strategies For A Lightweight Excavation Robot, Austin Jerold Crawford

Graduate Theses and Dissertations

This thesis entails motor control system analysis, design, and optimization for the University of Arkansas NASA Robotic Mining Competition robot. The open-loop system is to be modeled and simulated in order to achieve a desired rapid, yet smooth response to a change in input. The initial goal of this work is to find a repeatable, generalized step-by-step process that can be used to tune the gains of a PID controller for multiple different operating points. Then, sensors are to be modeled onto the robot within a feedback loop to develop an error signal and to make the control system self-corrective …

Volumetric Muscle Loss: The Role Of Physical Activity And Autologous Repair On Force Recovery And Signaling Pathways, Richard Perry

Graduate Theses and Dissertations

Volumetric muscle loss affects both military and civilian persons. The hallmark of this injury is incomplete muscle regeneration, excessive fibrosis, and chronic inflammatory signaling resulting in permanent functional loss. Since permanent functional loss drastically reduces quality of life, many studies have been conducted to improve force recovery. Current scientific literature considers a repair strategy of either devitalized scaffolds infused with growth factors or viable tissue plus activating factors to be the more promising interventions for optimal force recovery. PURPOSE The purpose of this study is to incorporate autologous repair and physical activity and observe the effects of muscle force recovery …

Feedforward And Feedback Signals In The Olfactory System, Srimoy Chakraborty

Graduate Theses and Dissertations

The conglomeration of myriad activities in neural systems often results in prominent oscillations. The primary goal of the research presented in this thesis was to study effects of sensory stimulus on the olfactory system of rats, focusing on the olfactory bulb (OB) and the anterior piriform cortex (aPC). Extracellular electrophysiological measurements revealed distinct frequency bands of oscillations in OB and aPC. However, how these oscillatory fluctuations help the animal to process sensory input is not clearly understood. Here we show high frequency oscillations in olfactory bulb carry feedforward signals to anterior piriform cortex whereas feedback from the aPC is predominantly …

Towards A Prototype Platform For Ros Integrations On A Ground Robot, Taylor Joseph Linville Whitaker

Graduate Theses and Dissertations

The intent of this work was to develop, evaluate, and demonstrate a prototype robot platform on which ROS integrations could be explored. With observations of features and requirements of existing industrial and service mobile ground robots, a platform was designed and outfitted with appropriate components to enable the most common operational-critical functionalities and account for unforeseen components and features. The resulting Arlo Demonstration Robot accommodates basic mapping, localization, and navigation in both two and three-dimensional space as well as additional safety and teleoperation features. The control system is centered around the Zybo Z7 FPGA SoC hosting a custom hardware design. …

Plasmonic Properties Of Nanoparticle And Two Dimensional Material Integrated Structure, Desalegn Tadesse Debu

Graduate Theses and Dissertations

Recently, various groups have demonstrated nano-scale engineering of nanostructures for optical to infrared wavelength plasmonic applications. Most fabrication technique processes, especially those using noble metals, requires an adhesion layer. Previously proposed theoretical work to support experimental measurement often neglect the effect of the adhesion layers. The first finding of this work focuses on the impact of the adhesion layer on nanoparticle plasmonic properties. Gold nanodisks with a titanium adhesion layer are investigated by calculating the scattering, absorption, and extinction cross-section with numerical simulations using a finite difference time domain (FDTD) method. I demonstrate that a gold nanodisk with an adhesive …

Hardware Ip Classification Through Weighted Characteristics, Brendan Mcgeehan

Graduate Theses and Dissertations

Today’s business model for hardware designs frequently incorporates third-party Intellectual Property (IP) due to the many benefits it can bring to a company. For instance, outsourcing certain components of an overall design can reduce time-to-market by allowing each party to specialize and perfect a specific part of the overall design. However, allowing third-party involvement also increases the possibility of malicious attacks, such as hardware Trojan insertion. Trojan insertion is a particularly dangerous security threat because testing the functionality of an IP can often leave the Trojan undetected. Therefore, this thesis work provides an improvement on a Trojan detection method known …

Characterization Of Hydride Vapor Phase Epitaxy Grown Gan Substrates For Future Iii-Nitride Growth, Alaa Ahmad Kawagy

Graduate Theses and Dissertations

The aim of this research is to investigate and characterize the quality of commercially obtained gallium nitride (GaN) on sapphire substrates that have been grown using hydride vapor phase epitaxy (HVPE). GaN substrates are the best choice for optoelectronic applications because of their physical and electrical properties. Even though HVPE GaN substrates are available at low-cost and create the opportunities for growth and production, these substrates suffer from large macro-scale defects on the surface of the substrate.

In this research, four GaN on sapphire substrates were investigated in order to characterize the surface defects and, subsequently, understand their influence on …

Asynchronous Circuit Synthesis Using Multi-Threshold Null Convention Logic, Nicholas Renoudet Mize

Graduate Theses and Dissertations

As the demand for an energy-efficient alternative to traditional synchronous circuit design grows, hardware designers must reconsider the traditional clock tree. By doing away with the constrains of a clock, asynchronous sequential circuit designs can achieve a much greater level of efficiency. The utilization of asynchronous logic synthesis flows has enabled researchers to better implement asynchronous circuit designs which have been optimized using the same industry standard tools that are already used in sequential synchronous designs. This thesis offers a new flow for such tools which implements the MTNCL asynchronous circuit architecture.

Using Peripheral Venous Pressure Waveforms To Predict Key Hemodynamic Parameters, Ali Zohair A Alalawi

Graduate Theses and Dissertations

Analysis of peripheral venous pressure (PVP) waveforms is a novel method of monitoring intravascular volume. Two cohorts were used to study the hemodynamics change of the body state and its influence on the PVP using (1) dehydration setting with infants suffering from pyloric stenosis and (2) hemorrhage setting during a craniosynostosis elective surgery. The goal of this research is to develop a minimally invasive method of analyzing the PVP waveforms and find correlations with volume loss.

Twenty-three pyloric stenosis patients PVP were acquired at five stages and were divided into euvolemic, normal fluid volume, and hypovolemic, significant fluid loss. Seven …

Role Of Local Renin-Angiotensin System In Potentiating Early Calcific Aortic Valve Disease, Jessica Perez

Graduate Theses and Dissertations

Angiotensin-II (Ang-II), a peptide hormone, is a potent vasoconstrictor and cell mitogen. It has been implicated in the development of hypertension as well as atherosclerosis. Recent work has shown that sclerotic aortic valves possess expression of angiotensin type I receptor (AT-1R) and angiotensin converting enzyme (ACE), suggesting altered angiotensin signaling during disease. The role of altered angiotensin signaling on aortic valve mechanics, however, is not clearly understood. We seek to understand the direct effects of the renin angiotensin signaling (RAS) system on the biological and biomechanical properties of aortic valve tissue and develop a finite constitutive model that mimics the …

Diffuse Reflectance Spectroscopy To Quantify In Vivo Tissue Optical Properties: Applications In Human Epithelium And Subcutaneous Murine Colon Cancer, Gage Joseph Greening

Graduate Theses and Dissertations

Colorectal cancer is the 4th most common and 2nd deadliest cancer. Problems exist with predicting which patients will respond best to certain therapy regimens. Diffuse reflectance spectroscopy has been suggested as a candidate to optically monitor a patient’s early response to therapy and has been received favorably in experimentally managing other cancers such as breast and skin. In this dissertation, two diffuse reflectance spectroscopy probes were designed: one with a combined high-resolution microendoscopy modality, and one that was optimized for acquiring data from subcutaneous murine tumors. For both probes, percent errors for estimating tissue optical properties (reduced scattering coefficient and …

H2 Control For Improved Stability Of Multi-Area Electric Power System With High Levels Of Inverter-Based Generation, Muthanna Abdulkareem Al-Sarray

Graduate Theses and Dissertations

Increased generation capacity from non-dispatchable energy resources such as wind and solar has created challenges to ensuring the reliable delivery of electric power. This research develops a systematic three-step method of assessing the reliability of electric power systems under a variety of different possible fault conditions to ensure that overall system stability is preserved in a manner the meets regulatory requirements. The first step is a risk-based reliability method (RBRM) that accounts for the probability of a line outage versus the severity of impact. This allows system planners to judiciously allocate expenses for reliability improvements based on the greatest economic …

Optical Enhancement In Periodic Plasmonic Gratings For Sers And Metal-Semiconductor-Metal Photodetectors (Msm-Pds) Applications, Ahmad Aziz Darweesh

Graduate Theses and Dissertations

This dissertation is aimed to numerically study the effect of plasmonic grating electrodes on the efficiency of metal-semiconductor-metal photodetectors (MSM PDs) and the sensitivity of Surface Enhanced Raman Spectroscopy (SERS). This research can benefit many areas of nanoscience and optics, including plasmonic applications, such as, super lenses, nano-scale optical circuits, optical filters, surface plasmon enhanced photo-detectors solar cells, imaging sensors, charge-coupled devices (CCD), and optical-fiber communication systems. Several parameters, wire widths and thickness, gap space, taper angle, and the incident wavelength and angle, were investigated. The goal of this research is to utilize the plasmonic phenomenon by using plasmonic gratings …

A Silicon Germanium Cmos Linear Voltage Regulator For Wireless Agricultural Applications, Aminta Naidili Castillo Robles

Graduate Theses and Dissertations

This thesis presents the design, simulation and test results of a silicon germanium (SiGe) complementary metal-oxide-semiconductor (CMOS) linear regulator. The objective of the circuit is to power other analog devices regardless of the load current and input voltage changes. The application of this regulator is to be part of a project developing a miniaturized semiconductor platform that can be inserted into stems of crops in order to measure data inside the plant and then send it wirelessly to the user. The linear regulator was designed on a BiCMOS SiGe 0.13µm which is a GlobalFoundries process. It has been tested at …

Self-Assembled Nanoantenna Enhance Optical Activity And Transport In Scalable Thin Films And Interfaces, Keith Richard Berry Jr.

Graduate Theses and Dissertations

Continued population growth and the decrease of existing energy platforms demands long-term solutions for development and implementation of scalable plasmonic metamaterials for energy and agricultural applications. Self-assembled nanoantenna into random and ordered arrangements are advanced herein for optical and thermal enhancements in scalable thin film. An analytical approach to estimating the thermal dynamics of random arrangements of nanoantenna resulted in estimates within 30% across a range of geometric parameters, nanoantenna-containing media, and thermal parameters. Multimodal thermal dynamics of polymer thin films containing gold nanoparticles (AuNPs) were observed through the natural log of the dimensionless temperature driving force plotted versus time …

Modeling Of Complex Parts For Industrial Waterjet Cleaning, Braden James

Graduate Theses and Dissertations

Industrial high-pressure waterjet cleaning is common to many industries. The modeling in this paper functions inside a collaborative robotic framework for high mix, low volume processes where human robot collaboration is beneficial. Automation of pressure washing is desirable for economic and ergonomic reasons. An automated cleaning system needs path simulation and analysis to give the operator insight into the predicted cleaning performance of the system. In this paper, ablation, the removal of a substrate coating by waterjet, is modeled for robotic cleaning operations. The model is designed to work with complex parts often found in spray cleaning operations, namely parts …

Synchrophasor-Based Fault Location Detection And Classification, In Power Systems, Using Artificial Intelligence, Hemal Falak

Graduate Theses and Dissertations

With the introduction of sophisticated electronic gadgets which cannot sustain interruption in the provision of electricity, the need to supply uninterrupted and reliable power supply, to the consumers, has become a crucial factor in the present-day world. Therefore, it is customary to correctly identify fault locations in an electrical power network, in order to rectify faults and restore power supply in the minimum possible time. Many automated fault location detection algorithms have been proposed, however, prior art requires topological and physical information of the electrical power network. This thesis presents a new method of detecting fault locations, in transmission as …

Local And Central Controllers For Microgrids, Edgar Ariel Escala Calame

Graduate Theses and Dissertations

The main objective of this thesis is to serve as a guide, so readers are able to learn about microgrids and to design simple controllers for different AC microgrid applications. In addition, this thesis has the objective to provide examples of simulation cases for the hierarchical structure of a basic AC microgrid which can be used as a foundation to build upon, and achieve more complex microgrid structures as well as more sophisticated power-converter control techniques.

To achieve these objectives, the modeling of voltage source converters and control design in the z-domain are presented. Moreover, the implementation and transient analysis …