Open Access. Powered by Scholars. Published by Universities.®

Engineering Commons™

Open Access. Powered by Scholars. Published by Universities.®

Faculty Publications

Discipline
Institution
Keyword
Publication Year
File Type

Articles 1351 - 1380 of 3295

Full-Text Articles in Engineering

The Nvidia Ai City Challenge, Milind Naphade, David Anastasiu, Anuj Sharma, Vamsi Jagrlamudi, Hyeran Jeon, Kaikai Liu, Ming-Ching Chang, Siwei Lyu, Zeyu Gao Aug 2017

The Nvidia Ai City Challenge, Milind Naphade, David Anastasiu, Anuj Sharma, Vamsi Jagrlamudi, Hyeran Jeon, Kaikai Liu, Ming-Ching Chang, Siwei Lyu, Zeyu Gao

Faculty Publications

Web image analysis has witnessed an AI renaissance. The ILSVRC benchmark has been instrumental in providing a corpus and standardized evaluation. The NVIDIA AI City Challenge is envisioned to provide similar impetus to the analysis of image and video data that helps make cities smarter and safer. In its first year, this Challenge has focused on traffic video data. While millions of traffic video cameras around the world capture data, albeit low-quality, very little automated analysis and value creation results. Lack of labeled data, and trained models that can be deployed at the edge of the city fabric, ensure that …

Go to article

An Ameliorated Prediction Of Drug–Target Interactions Based On Multi-Scale Discrete Wavelet Transform And Network Features, Cong Shen, Yijie Ding, Jijun Tang, Xinying Xu, Fei Guo Aug 2017

An Ameliorated Prediction Of Drug–Target Interactions Based On Multi-Scale Discrete Wavelet Transform And Network Features, Cong Shen, Yijie Ding, Jijun Tang, Xinying Xu, Fei Guo

Faculty Publications

The prediction of drug–target interactions (DTIs) via computational technology plays a crucial role in reducing the experimental cost. A variety of state-of-the-art methods have been proposed to improve the accuracy of DTI predictions. In this paper, we propose a kind of drug–target interactions predictor adopting multi-scale discrete wavelet transform and network features (named as DAWN) in order to solve the DTIs prediction problem. We encode the drug molecule by a substructure fingerprint with a dictionary of substructure patterns. Simultaneously, we apply the discrete wavelet transform (DWT) to extract features from target sequences. Then, we concatenate and normalize the target, drug, …

Go to article

Optimal Constrained Wireless Emergency Network Antenna Placement, Swapnil Gaikwad, David Anastasiu Aug 2017

Optimal Constrained Wireless Emergency Network Antenna Placement, Swapnil Gaikwad, David Anastasiu

Faculty Publications

Communication is paramount, especially during a natural disaster or other emergency. Even when traditional lines of communication become unavailable, emergency response teams must be able to communicate with each other and the outside world. To facilitate this need, major cities across the United States are deploying wireless emergency networks (WENs) that serve as a secure communication channel between emergency response points (police stations, shelters, food banks, hospitals, etc.) and the outside world. An important question when designing such networks is identifying the locations within the city where access points (APs) should be placed to construct a reliable WEN. We propose …

Go to article

Electron Paramagnetic Resonance Study Of Neutral Mg Acceptors In Β-Ga2O3 Crystals, Brant E. Kananen, Larry E. Halliburton, Elizabeth M. Scherrer, K. T. Stevens, G. K. Foundos, K. B. Chang, Nancy C. Giles Aug 2017

Electron Paramagnetic Resonance Study Of Neutral Mg Acceptors In Β-Ga2O3 Crystals, Brant E. Kananen, Larry E. Halliburton, Elizabeth M. Scherrer, K. T. Stevens, G. K. Foundos, K. B. Chang, Nancy C. Giles

Faculty Publications

Electron paramagnetic resonance (EPR) is used to directly observe and characterize neutral Mg acceptors (Mg0Ga) in a β-Ga2O3 crystal. These acceptors, best considered as small polarons, are produced when the Mg-doped crystal is irradiated at or near 77 K with x rays. During the irradiation, neutral acceptors are formed when holes are trapped at singly ionized Mg acceptors (Mg−Ga). Unintentionally present Fe3+ (3d5) and Cr3+ (3d3) transition-metal ions serve as the corresponding electron traps. The hole is localized in a nonbonding p orbital on a threefold-coordinated oxygen ion …

Go to article

Improving The Floris Wind Plant Model For Compatibility With Gradient-Based Optimization, Jared Thomas, Pieter Gebraad, Andrew Ning Aug 2017

Improving The Floris Wind Plant Model For Compatibility With Gradient-Based Optimization, Jared Thomas, Pieter Gebraad, Andrew Ning

Faculty Publications

The FLOw Redirection and Induction in Steady-state (FLORIS) model, a parametric wind turbine wake model that predicts steady state wake characteristics based on wind turbine position and yaw angle, was developed for optimization of control settings and turbine locations. This paper provides details on the recent changes made to the FLORIS model to make the model more suitable for gradient-based optimization. Changes to the FLORIS model were made to remove discontinuities and add curvature to regions of non-physical zero gradient. Exact gradients for the FLORIS model were obtained using algorithmic differentiation. A set of three case studies demonstrate that using …

Go to article

On-Chip, High-Sensitivity Temperature Sensors Based On Dye-Doped Solid-State Polymer Microring Lasers, Lei Wan, Hengky Chandrahalim, Cong Chen, Qiushu Chen, Ting Mei, Yuji Oki, Naoya Nishimura, Lingjie Jay Guo, Xudong Fan Aug 2017

On-Chip, High-Sensitivity Temperature Sensors Based On Dye-Doped Solid-State Polymer Microring Lasers, Lei Wan, Hengky Chandrahalim, Cong Chen, Qiushu Chen, Ting Mei, Yuji Oki, Naoya Nishimura, Lingjie Jay Guo, Xudong Fan

Faculty Publications

We developed a chip-scale temperature sensor with a high sensitivity of 228.6 pm/°C based on a rhodamine 6G (R6G)-doped SU-8 whispering-gallery mode microring laser. The optical mode was largely distributed in a polymer core layer with a 30 μm height that provided detection sensitivity, and the chemically robust fused-silica microring resonator host platform guaranteed its versatility for investigating different functional polymer materials with different refractive indices. As a proof of concept, a dye-doped hyperbranched polymer (TZ-001) microring laser-based temperature sensor was simultaneously developed on the same host wafer and characterized using a free-space optics measurement setup. Compared to TZ-001, the …

Go to article

An Ensemble Deep Convolutional Neural Network Model With Improved D-S Evidence Fusion For Bearing Fault Diagnosis, Shaobo Li, Guokai Liu, Xianghong Tang, Jianguang Lu, Jianjun Hu Jul 2017

An Ensemble Deep Convolutional Neural Network Model With Improved D-S Evidence Fusion For Bearing Fault Diagnosis, Shaobo Li, Guokai Liu, Xianghong Tang, Jianguang Lu, Jianjun Hu

Faculty Publications

Intelligent machine health monitoring and fault diagnosis are becoming increasingly important for modern manufacturing industries. Current fault diagnosis approaches mostly depend on expert-designed features for building prediction models. In this paper, we proposed IDSCNN, a novel bearing fault diagnosis algorithm based on ensemble deep convolutional neural networks and an improved Dempster–Shafer theory based evidence fusion. The convolutional neural networks take the root mean square (RMS) maps from the FFT (Fast Fourier Transformation) features of the vibration signals from two sensors as inputs. The improved D-S evidence theory is implemented via distance matrix from evidences and modified Gini Index. Extensive evaluations …

Go to article

Estimating Index Of Refraction For Specular Reflectors Using Passive Polarimetric Hyperspectral Radiance Measurements, Jacob A. Martin, Kevin C. Gross Jul 2017

Estimating Index Of Refraction For Specular Reflectors Using Passive Polarimetric Hyperspectral Radiance Measurements, Jacob A. Martin, Kevin C. Gross

Faculty Publications

Results of a method of estimating index of refraction from passive, polarimetric hyperspectral imaging radiance measurements are presented. As off-nadir viewing hyperspectral imaging platforms gain prominence, estimating index of refraction, which is invariant to viewing angle, may prove advantageous to estimating the emissivity, which is not. Results show that index of refraction can be retrieved to within 8% rms error for fused silica and sapphire glass targets, while simultaneously estimating object temperature. The accuracy and self-consistency of this technique for estimating index of refraction are shown to compare favorably to the maximum smoothness temperature–emissivity separation algorithm. Additionally, the results show …

Go to article

An Advanced Multi-Sensor Acousto-Ultrasonic Structural Health Monitoring System: Development And Aerospace Demonstration, Joel Smithard, Nik Rajic, Stephen Van Der Velden, Patrick Norman, Cedric Rosalie, Steve Galea, Hanfei Mei, Bin Lin, Victor Giurgiutiu Jul 2017

An Advanced Multi-Sensor Acousto-Ultrasonic Structural Health Monitoring System: Development And Aerospace Demonstration, Joel Smithard, Nik Rajic, Stephen Van Der Velden, Patrick Norman, Cedric Rosalie, Steve Galea, Hanfei Mei, Bin Lin, Victor Giurgiutiu

Faculty Publications

A key longstanding objective of the Structural Health Monitoring (SHM) research community is to enable the embedment of SHM systems in high value assets like aircraft to provide on-demand damage detection and evaluation. As against traditional non-destructive inspection hardware, embedded SHM systems must be compact, lightweight, low-power and sufficiently robust to survive exposure to severe in-flight operating conditions. Typical Commercial-Off-The-Shelf (COTS) systems can be bulky, costly and are often inflexible in their configuration and/or scalability, which militates against in-service deployment. Advances in electronics have resulted in ever smaller, cheaper and more reliable components that facilitate the development of compact and …

Go to article

Custom 3d Printer And Resin For 18 Μm × 20 Μm Mi- Crofluidic Flow Channels, Hua Gong, Bryce P. Bickham, Adam T. Woolley, Gregory P. Nordin Jul 2017

Custom 3d Printer And Resin For 18 Μm × 20 Μm Mi- Crofluidic Flow Channels, Hua Gong, Bryce P. Bickham, Adam T. Woolley, Gregory P. Nordin

Faculty Publications

While there is great interest in 3D printing for microfluidic device fabrication, to-date the achieved feature sizes have not been in the truly microfluidic regime (μm). In this paper we demonstrate that a custom Digital Light Processor stereolithographic (DLP-SLA) 3D printer and a specifically-designed, low cost, custom resin can readily achieve flow channel cross sections as small as 18 μm × 20 μm. Our 3D printer has a projected image plane resolution of 7.6 μm and uses a 385 nm LED, which dramatically increases the available selection of UV absorbers for resin formulation compared to 3D printers with 405 nm …

Go to article

Investigation Of Mimo Channel Characteristics In A Twosection Tunnel At 1.4725 Ghz, Rongchen Sun, David W. Matolak, Cheng Tao, Liu Liu, Zhenhui Tan, Tao Zhou Jul 2017

Investigation Of Mimo Channel Characteristics In A Twosection Tunnel At 1.4725 Ghz, Rongchen Sun, David W. Matolak, Cheng Tao, Liu Liu, Zhenhui Tan, Tao Zhou

Faculty Publications

This paper presents results from a wide band single-input–single-output (SISO) and 16 16 virtual multiple-input–multiple-output (MIMO) measurement campaign at a center frequency of 1.4725 GHz in a 100-meter long tunnel laboratory which is terminated by a vertical wall with a metallic door. The path loss, root-mean-square delay spread (RMS-DS) characteristics, and power delay profiles (PDPs) are described. In addition, we provide results for the MIMO channel amplitude matrix, which offers a new perspective in understanding MIMO characteristics in tunnel scenarios. Our measurement results are analyzed and compared to ray tracing simulations. The relationships among the angle spread, channel matrix singular …

Go to article

Implementing Conditional Inequality Constraints For Optimal Collision Avoidance, Nathan E. Smith, Christopher D. Arendt, Richard G. Cobb, Jonah A. Reeger Jul 2017

Implementing Conditional Inequality Constraints For Optimal Collision Avoidance, Nathan E. Smith, Christopher D. Arendt, Richard G. Cobb, Jonah A. Reeger

Faculty Publications

Current Federal Aviation Administration regulations require that passing aircraft must either meet a specified horizontal or vertical separation distance. However, solving for optimal avoidance trajectories with conditional inequality path constraints is problematic for gradient-based numerical nonlinear programming solvers since conditional constraints typically possess non-differentiable points. Further, the literature is silent on robust treatment of approximation methods to implement conditional inequality path constraints for gradient-based numerical nonlinear programming solvers. This paper proposes two efficient methods to enforce conditional inequality path constraints in the optimal control problem formulation and compares and contrasts these approaches on representative airborne avoidance scenarios. The first approach …

Go to article

Improving Resource Management In The Afghan Air Force, Jonathan D. Ritschel, Tamiko L. Ritschel Jul 2017

Improving Resource Management In The Afghan Air Force, Jonathan D. Ritschel, Tamiko L. Ritschel

Faculty Publications

The nascent Afghan Air Force (AAF) is rapidly changing with new platforms programmed and existing platforms expanding. As US and coalition forces draw down, the transition of financial responsibility from American to Afghan processes is on the horizon.

Go to article

Insights On Osmotic Tolerance Mechanisms In Escherichia Coli Gained From An Rpoc Mutation, Yuqi Guo, James Winkler, Katy Kao Jun 2017

Insights On Osmotic Tolerance Mechanisms In Escherichia Coli Gained From An Rpoc Mutation, Yuqi Guo, James Winkler, Katy Kao

Faculty Publications

An 84 bp in-frame duplication (K370_A396dup) within the rpoC subunit of RNA polymerase was found in two independent mutants selected during an adaptive laboratory evolution experiment under osmotic stress in Escherichia coli, suggesting that this mutation confers improved osmotic tolerance. To determine the role this mutation in rpoC plays in osmotic tolerance, we reconstructed the mutation in BW25113, and found it to confer improved tolerance to hyperosmotic stress. Metabolite analysis, exogenous supplementation assays, and cell membrane damage analysis suggest that the mechanism of improved osmotic tolerance by this rpoC mutation may be related to the higher production of acetic acid …

Go to article

Minimum Required Detection Range For Detect And Avoid Of Unmanned Aircraft Systems, Jared Kevin Wikle, Tim Mclain, Randal W. Beard, Laith Rasmi Sahawneh Jun 2017

Minimum Required Detection Range For Detect And Avoid Of Unmanned Aircraft Systems, Jared Kevin Wikle, Tim Mclain, Randal W. Beard, Laith Rasmi Sahawneh

Faculty Publications

For unmanned aircraft systems to gain full access to the National Airspace System, they must have the capability to detect and avoid other aircraft. To safely avoid an- other aircraft, an unmanned aircraft must detect the intruder aircraft with ample time and distance to allow the ownship to track the intruder, perform risk assessment, plan an avoidance path, and execute the maneuver. This paper describes two analytical methods for finding the minimum detection range to ensure that these detection and avoidance steps can be carried out. The first method, time-based geometric velocity vectors, includes the bank-angle dynamics of the ownship; …

Go to article

Symmetry Driven Control Of Optical Properties In Wo3 Films, Andreas Herklotz, Stefania Rus, Santosh Kc, Valentino Cooper, Amanda Huon, Er-Jia Guo, Thomas Ward Jun 2017

Symmetry Driven Control Of Optical Properties In Wo3 Films, Andreas Herklotz, Stefania Rus, Santosh Kc, Valentino Cooper, Amanda Huon, Er-Jia Guo, Thomas Ward

Faculty Publications

In this work, we demonstrate that the optical bandgap of WO3 films can be continuouslycontrolled through uniaxial strain induced by low-energy helium implantation.The insertion of He into epitaxially grown and coherently strained WO3 films canbe used to induce single axis out-of-plane lattice expansion of up to 2%. Ellipsometricspectroscopy reveals that the optical bandgap is reduced by about 0.18 eVper percent expansion of the out-of-plane unit cell length. Density functional theorycalculations show that this response is a direct result of changes in orbital degeneracydriven by changes in the octahedral rotations and tilts.

Go to article

Magnetic Behavior And Spin-Lattice Coupling In Cleavable, Van Der Waals Layered Crcl3 Crystals, Michael Mcguire, Genevieve Clark, Santosh Kc, W. Chance, Gerald Jellison, Valentino Cooper, Xiaodong Xu, Brian Sales Jun 2017

Magnetic Behavior And Spin-Lattice Coupling In Cleavable, Van Der Waals Layered Crcl3 Crystals, Michael Mcguire, Genevieve Clark, Santosh Kc, W. Chance, Gerald Jellison, Valentino Cooper, Xiaodong Xu, Brian Sales

Faculty Publications

CrCl3 is a layered insulator that undergoes a crystallographic phase transition below room temperature and orders antiferromagnetically at low temperature. Weak van der Waals bonding between the layers and ferromagnetic in-plane magnetic order make it a promising material for obtaining atomically thin magnets and creating van der Waals heterostructures. In this work we have grown crystals of CrCl3, revisited the structural and thermodynamic properties of the bulk material, and explored mechanical exfoliation of the crystals. We find two distinct anomalies in the heat capacity at 14 and 17 K confirming that the magnetic order develops in two stages on cooling, …

Go to article

Computational Study Of Mos2/Hfo2 Defective Interfaces For Nanometer-Scale Electronics, Santosh Kc, Roberto Longo, Robert Wallace, Kyeongjae Cho Jun 2017

Computational Study Of Mos2/Hfo2 Defective Interfaces For Nanometer-Scale Electronics, Santosh Kc, Roberto Longo, Robert Wallace, Kyeongjae Cho

Faculty Publications

Atomic structures and electronic properties of MoS2/HfO2 defective interfaces are investigated extensively for future field-effect transistor device applications. To mimic the atomic layer deposition growth under ambient conditions, the impact of interfacial oxygen concentration on the MoS2/HfO2 interface electronic structure is examined. Then, the effect on band offsets (BOs) and the thermodynamic stability of those interfaces is investigated and compared with available relevant experimental data. Our results show that the BOs can be modified up to 2 eV by tuning the oxygen content through, for example, the relative partial pressure. Interfaces with hydrogen impurities as well as various structural disorders …

Go to article

Thermophysical Properties Of Thin Fibers Via Photothermal Quantum Dot Fluorescence Spectral Shape-Based Thermometry, Troy Munro, Liwang Liu, Heng Ban, Christ Glorieux Jun 2017

Thermophysical Properties Of Thin Fibers Via Photothermal Quantum Dot Fluorescence Spectral Shape-Based Thermometry, Troy Munro, Liwang Liu, Heng Ban, Christ Glorieux

Faculty Publications

To improve predictions of composite behavior under thermal loads, there is a need to measure the axial thermophysical properties of thin fibers. Current methods to accomplish this have prohibitively long lead times due to extensive sample preparation. This work details the use of quantum dots thermomarkers to measure the surface temperature of thin fibers in a non-contact manner and determine the fibers’ thermal diffusivity. Neural networks are trained on extracting the temperature of a sample from fluorescence spectra in calibrated, steady-state conditions, based on different spectral features such as peak intensity and peak wavelength. The trained neural networks are then …

Go to article

The Effects Of Tether Placement On Antibody Stability On Surfaces, Thomas A. Knotts, Rebecca W. Grawe Jun 2017

The Effects Of Tether Placement On Antibody Stability On Surfaces, Thomas A. Knotts, Rebecca W. Grawe

Faculty Publications

Despite their potential benefits, antibody microarrays have fallen short of performing reliably and have not found widespread use outside of the research setting. Experimental techniques have been unable to determine what is occurring on the surface of an atomic level, so molecular simulation has emerged as the primary method of investigating protein/surface interactions. Simulations of small proteins have indicated that the stability of the protein is a function of the residue on the protein where a tether is placed. The purpose of this research is to see whether these findings also apply to antibodies, with their greater size and complexity. …

Go to article

Effect Of Cohorts On Student Retention In Engineering, Patricia Backer, Cindy Kato Jun 2017

Effect Of Cohorts On Student Retention In Engineering, Patricia Backer, Cindy Kato

Faculty Publications

Project Succeed is a campus-wide initiative funded by the U.S. Department of Education. Its focus is to improve the 5-year graduation and retention rates and close the achievement gap for Under-Represented Minorities (URMs) across all majors at San José State University (SJSU). There are three major goals: strengthen SJSU’s core academic performance in retention and graduation; provide an improved supportive environment for URM students; and enhance the delivery and integration of academic and co-curricular support services. For Fall 2015, newly matriculated students in the College of Business, College of Engineering, and Child and Adolescent Development Department (CHAD) were assigned schedules …

Go to article

Measuring The Reflection Matrix Of A Rough Surface, Kenneth W. Burgi, Michael A. Marciniak, Mark E. Oxley, Stephen E. Nauyoks May 2017

Measuring The Reflection Matrix Of A Rough Surface, Kenneth W. Burgi, Michael A. Marciniak, Mark E. Oxley, Stephen E. Nauyoks

Faculty Publications

Phase modulation methods for imaging around corners with reflectively scattered light required illumination of the occluded scene with a light source either in the scene or with direct line of sight to the scene. The RM (reflection matrix) allows control and refocusing of light after reflection, which could provide a means of illuminating an occluded scene without access or line of sight. Two optical arrangements, one focal-plane, the other an imaging system, were used to measure the RM of five different rough-surface reflectors. Intensity enhancement values of up to 24 were achieved. Surface roughness, correlation length, and slope were examined …

Go to article

Pvdf-Trfe Electroactive Polymer Mechanical-To-Electrical Energy Harvesting Experimental Bimorph Structure, William G. Kaval, Robert A. Lake, Ronald A. Coutu Jr. May 2017

Pvdf-Trfe Electroactive Polymer Mechanical-To-Electrical Energy Harvesting Experimental Bimorph Structure, William G. Kaval, Robert A. Lake, Ronald A. Coutu Jr.

Faculty Publications

Research of electrostrictive polymers has generated new opportunities for harvesting energy from the surrounding environment and converting it into usable electrical energy. Electroactive polymer (EAP) research is one of the new opportunities for harvesting energy from the natural environment and converting it into usable electrical energy. Piezoelectric ceramic based energy harvesting devices tend to be unsuitable for low-frequency mechanical excitations such as human movement. Organic polymers are typically softer and more flexible therefore translated electrical energy output is considerably higher under the same mechanical force. In addition, cantilever geometry is one of the most used structures in piezoelectric energy harvesters, …

Go to article

Estimating Human Intent For Physical Human-Robot Co-Manipulation, Eric Townsend, Erich Mielke, David Wingate, Marc D. Killpack May 2017

Estimating Human Intent For Physical Human-Robot Co-Manipulation, Eric Townsend, Erich Mielke, David Wingate, Marc D. Killpack

Faculty Publications

Human teams can be exceptionally efficient at adapting and collaborating during manipulation tasks using shared mental models. However, the same shared mental models that can be used by humans to perform robust low-level force and motion control during collaborative manipulation tasks are non-existent for robots. For robots to perform collaborative tasks with people naturally and efficiently, understanding and predicting human intent is necessary. However, humans are difficult to predict and model. We have completed an exploratory study recording motion and force for 20 human dyads moving an object in tandem in order to better understand how they move and how …

Go to article

Continuous Ethanol Production From Synthesis Gas By Clostridium Ragsdalei In A Trickle-Bed Reactor, Mamatha Devarapalli, Randy S. Lewis, Hasan K. Atiyeh May 2017

Continuous Ethanol Production From Synthesis Gas By Clostridium Ragsdalei In A Trickle-Bed Reactor, Mamatha Devarapalli, Randy S. Lewis, Hasan K. Atiyeh

Faculty Publications

A trickle-bed reactor (TBR) when operated in a trickle flow regime reduces liquid resistance to mass transfer because a very thin liquid film is in contact with the gas phase and results in improved gas–liquid mass transfer compared to continuous stirred tank reactors (CSTRs). In the present study, continuous syngas fermentation was performed in a 1-L TBR for ethanol production by Clostridium ragsdalei. The effects of dilution and gas flow rates on product formation, productivity, gas uptakes and conversion efficiencies were examined. Results showed that CO and H2 conversion efficiencies reached over 90% when the gas flow rate was maintained …

Go to article

Preliminary Study Of Optimization Of Normal Pulse Voltammetry For Actinide Measurement In Molten Salt Electrorefiners Using Licl-Kcl-Ucl3-Mgcl2 As A Surrogate Salt, Chao Zhang, Devin Rappleye, Michael Simpson May 2017

Preliminary Study Of Optimization Of Normal Pulse Voltammetry For Actinide Measurement In Molten Salt Electrorefiners Using Licl-Kcl-Ucl3-Mgcl2 As A Surrogate Salt, Chao Zhang, Devin Rappleye, Michael Simpson

Faculty Publications

Normal pulse voltammetry has been applied and optimized to develop correlations between diffusional current and concentration for UCl3 and MgCl2 in molten eutectic LiCl-KCl. This method was selected to mitigate working electrode area growth in concentrated molten salt mixtures in which a fairly wide potential range is needed to analyze all actinides. MgCl2 has been selected as a surrogate for PuCl3 based on similar standard reduction potential. Diffusional current plateaus were successfully attained by adjusting the step size to 0.03 V. Relaxation time of 15 seconds was found to be sufficient to recover after each pulse. …

Go to article

Uncertainty Quantification And Propagation Of Errors Of The Lennard-Jones 12-6 Parameters For N-Alkanes, Richard A. Messerly, Thomas A. Knotts Iv, W Vincent Wilding May 2017

Uncertainty Quantification And Propagation Of Errors Of The Lennard-Jones 12-6 Parameters For N-Alkanes, Richard A. Messerly, Thomas A. Knotts Iv, W Vincent Wilding

Faculty Publications

Molecular simulation has the ability to predict various physical properties that are difficult to obtain experimentally. For example, we implement molecular simulation to predict the critical constants (i.e., critical temperature, critical density, critical pressure, and critical compressibility factor) for large n-alkanes that thermally decompose experimentally (as large as C48). Historically, molecular simulation has been viewed as a tool that is limited to providing qualitative insight. One key reason for this perceived weakness in molecular simulation is the difficulty to quantify the uncertainty in the results. This is because molecular simulations have many sources of uncertainty that propagate …

Go to article

Microstructure Correlation With Formability For Biaxial Stretching Of Magnesium Alloy Az31b At Mildly Elevated Temperatures, David T. Fullwood, Isaac Chelladurai, Michael P. Miles, John E. Carsley, Raj K. Mishra, Irene J. Beyerlein, Marko Knezevic May 2017

Microstructure Correlation With Formability For Biaxial Stretching Of Magnesium Alloy Az31b At Mildly Elevated Temperatures, David T. Fullwood, Isaac Chelladurai, Michael P. Miles, John E. Carsley, Raj K. Mishra, Irene J. Beyerlein, Marko Knezevic

Faculty Publications

Magnesium AZ31B sheets of 2 mm thickness were stretch formed using a 101.6 mm diameter punch at temperatures from 25°C - 150°C, in 25°C increments. Surface strains were measured using a digital image correlation (DIC) method. The punch height vs load curve was found to be the same for temperatures of 25°C and for 50°C, while at 75°C and above the load for a given punch height started to decrease, indicating a potential change in deformation mechanism. Electron Backscatter Diffraction (EBSD) was used to quantify features of the microstructure in the tested specimens. In particular, the gradual decrease in twinning …

Go to article

Cytosolic Delivery Of Doxorubicin From Liposomes To Multidrug-Resistant Cancer Cells Via Vaporization Of Perfluorocarbon Droplets, Jacob B. Williams, Clara M. Buchanan, Ghaleb A. Husseini, William G. Pitt May 2017

Cytosolic Delivery Of Doxorubicin From Liposomes To Multidrug-Resistant Cancer Cells Via Vaporization Of Perfluorocarbon Droplets, Jacob B. Williams, Clara M. Buchanan, Ghaleb A. Husseini, William G. Pitt

Faculty Publications

A common mechanism of multidrug resistance is the upregulation of efflux pumps in the cancer cells that can more rapidly export unwanted materials (e.g. cancer drugs) out of the cell, compared to sensitive cancer cells. This research seeks to overcome this mechanism by vaporizing a perfluoropentane emulsion droplet inside of a drug-containing liposome (eLiposome) that was endocytosed into a cancer cell. Folate attached to the eLiposome facilitates uptake into the cell as observed by confocal microscopy. Ultrasound was examined as a trigger to initiate the vaporization of the perfluoropentane droplet and release doxorubicin from folated eLiposomes (feLD). Two seconds of …

Go to article

Cytosolic Delivery Of Doxorubicin From Liposomes To Multidrug-Resistant Cancer Cells Via Vaporization Of Perfluorocarbon Droplets, Jacob B. Williams, Clara M. Buchanan, Ghaleb Husseini, William G. Pitt May 2017

Cytosolic Delivery Of Doxorubicin From Liposomes To Multidrug-Resistant Cancer Cells Via Vaporization Of Perfluorocarbon Droplets, Jacob B. Williams, Clara M. Buchanan, Ghaleb Husseini, William G. Pitt

Faculty Publications

A common mechanism of multidrug resistance is the upregulation of efflux pumps in the cancer cells that can more rapidly export unwanted materials (e.g. cancer drugs) out of the cell, compared to sensitive cancer cells. This research seeks to overcome this mechanism by vaporizing a perfluoropentane emulsion droplet inside of a drug-containing liposome (eLiposome) that was endocytosed into a cancer cell. Folate attached to the eLiposome facilitates uptake into the cell as observed by confocal microscopy. Ultrasound was examined as a trigger to initiate the vaporization of the perfluoropentane droplet and release doxorubicin from folated eLipsosomes (feLD). Two seconds of …

Go to article

First Prev Next Last