Engineering Commons^™

Electrical Double Layer In Nanopores For Detection And Identification Of Molecules And Submolecular Units, Guigen Zhang, Samuel Bearden

Biomedical Engineering Faculty Patents

Systems for detecting analytes in electrical double layer nanopore devices and methods of use are provided.

In Vivo Optical Metabolic Imaging Of Long-Chain Fatty Acid Uptake In Orthotopic Models Of Triple-Negative Breast Cancer, Megan C. Madonna, Joy E. Duer, Joyce V. Lee, Jeremy Williams, Baris Avsaroglu, Caigang Zhu, Riley Deutsch, Roujia Wang, Brian T. Crouch, Matthew D. Hirschey, Andrei Goga, Nirmala Ramanujam

Biomedical Engineering Faculty Publications

Targeting a tumor’s metabolic dependencies is a clinically actionable therapeutic approach; however, identifying subtypes of tumors likely to respond remains difficult. The use of lipids as a nutrient source is of particular importance, especially in breast cancer. Imaging techniques offer the opportunity to quantify nutrient use in preclinical tumor models to guide development of new drugs that restrict uptake or utilization of these nutrients. We describe a fast and dynamic approach to image fatty acid uptake in vivo and demonstrate its relevance to study both tumor metabolic reprogramming directly, as well as the effectiveness of drugs targeting lipid metabolism. Specifically, …

Numerical Reconstruction Of Spalled Particle Trajectories In An Arc-Jet Environment, Raghava S. C. Davuluri, Sean C. C. Bailey, Kaveh A. Tagavi, Alexandre Martin

Mechanical Engineering Faculty Publications

To evaluate the effects of spallation on ablative material, it is necessary to evaluate the mass loss. To do so, a Lagrangian particle trajectory code is used to reconstruct trajectories that match the experimental data for all kinematic parameters. The results from spallation experiments conducted at the NASA HYMETS facility over a wedge sample were used. A data-driven adaptive methodology was used to adapts the ejection parameters until the numerical trajectory matches the experimental data. The preliminary reconstruction results show that the size of the particles seemed to be correlated with the location of the ejection event. The size of …

N-Type Charge Transport In Heavily P-Doped Polymers, Zhiming Liang, Hyun Ho Choi, Xuyi Luo, Tuo Liu, Ashkan Abtahi, Uma Shantini Ramasamy, J. Andrew Hitron, Kyle N. Baustert, Jacob L. Hempel, Alex M. Boehm, Armin Ansary, Douglas R. Strachan, Jianguo Mei, Chad Risko, Vitaly Podzorov, Kenneth R. Graham

Chemistry Faculty Publications

It is commonly assumed that charge-carrier transport in doped π-conjugated polymers is dominated by one type of charge carrier, either holes or electrons, as determined by the chemistry of the dopant. Here, through Seebeck coefficient and Hall effect measurements, we show that mobile electrons contribute substantially to charge-carrier transport in π-conjugated polymers that are heavily p-doped with strong electron acceptors. Specifically, the Seebeck coefficient of several p-doped polymers changes sign from positive to negative as the concentration of the oxidizing agents FeCl3 or NOBF4 increase, and Hall effect measurements for the same p-doped polymers reveal that …

Wetting And Brazing Of Yig Ceramics Using Ag–Cuo–Tio2 Metal Filler, Wanqi Zhao, Shuye Zhang, Jian Yang, Tiesong Lin, Dusan P. Sekulic, Peng He

Mechanical Engineering Faculty Publications

The wetting and brazing of Y₃Fe₅O₁₂ (YIG) ceramics with a Ag–8CuO–2TiO₂ filler was investigated for the first time. For comparison, the wettability of a Ag–10CuO filler on YIG ceramics was similarly investigated. The Ag–8CuO–2TiO₂ filler has an equilibrium contact angle of approximately 31 °C on the YIG substrate at 1000 °C; thus, its wettability is excellent. Moreover, its wettability exceeds that of Ag–10CuO. The microstructure and the interfacial structure between the filler and the substrate were determined using scanning electron microscopy, X-ray diffraction, EPMA and transmission electron microscopy. The liquid Ag–8CuO–2TiO₂ filler …

A Methodology For Autonomous Roof Bolt Installation Using Industrial Robotics, Anastasia Xenaki

Theses and Dissertations--Mining Engineering

The mining sector is currently in the stage of adopting more automation, and with it, robotics. Autonomous bolting in underground environments remains a hot topic for the mining industry. Roof bolter operators are exposed to hazardous conditions due to their proximity to the unsupported roof, loose bolts, and heavy spinning mass. Prolonged exposure to the risk inevitably leads to accidents and injuries.

The current thesis presents the development of a robotic assembly capable of carrying out the entire sequence of roof bolting operations in full and partial autonomous sensor-driven rock bolting operations to achieve a high-impact health and safety intervention …

Study Of Renewable Energy Penetration On A Benchmark Generation And Transmission System, Oluwaseun M. Akeyo, Aron Patrick, Dan M. Ionel

Electrical and Computer Engineering Faculty Publications

Significant changes in conventional generator operation and transmission system planning will be required to accommodate increasing solar photovoltaic (PV) penetration. There is a limit to the maximum amount of solar that can be connected in a service area without the need for significant upgrades to the existing generation and transmission infrastructure. This study proposes a framework for analyzing the impact of increasing solar penetration on generation and transmission networks while considering the responses of conventional generators to changes in solar PV output power. Contrary to traditional approaches in which it is assumed that generation can always match demand, this framework …

Analysis Of Graded Sensorimotor Rhythms For Brain-Computer Interface Applications, Chase Allen Haddix

Theses and Dissertations--Biomedical Engineering

The emerging field of neural engineering is tasked with applying engineering principles towards understanding neuroscience. A by-product of such a venture has been the development of a class of assistive devices known as brain-computer interfaces (BCIs) which link brain activity to actions performed by external devices. One application of this technology is in the rehabilitative sector for individuals with neuromuscular diseases and disorders. Despite tremendous efforts in the last few decades, a reliable signal that reflects fine motor control has yet to be adequately investigated. This gap in knowledge has limited the potential of BCIs to restore movement and communication. …

Biofilm And Cell Adhesion Strength On Dental Implant Surfaces Via The Laser Spallation Technique, James D. Boyd, Arnold J. Stromberg, Craig S. Miller, Martha E. Grady

Statistics Faculty Publications

OBJECTIVE: The aims of this study are to quantify the adhesion strength differential between an oral bacterial biofilm and an osteoblast-like cell monolayer to a dental implant-simulant surface and develop a metric that quantifies the biocompatible effect of implant surfaces on bacterial and cell adhesion.

METHODS: High-amplitude short-duration stress waves generated by laser pulse absorption are used to spall bacteria and cells from titanium substrates. By carefully controlling laser fluence and calibration of laser fluence with applied stress, the adhesion difference between Streptococcus mutans biofilms and MG 63 osteoblast-like cell monolayers on smooth and rough titanium substrates is obtained. The …

Cross Approximation Methods For Integral Equation Matrices With Complex Structure, Jordon N. Blackburn

Theses and Dissertations--Electrical and Computer Engineering

Electrical and computer engineers rely on electromagnetic field (EM) theory to formulate and design systems that utilize information or energy obtained from a signal. Over time these systems have been increased in scale and complexity and adapted to handle a wider array of problems. This has motivated substantial developments in computational sciences including the area of computational electromagnetics (CEM).The focus of CEM is the simulation of electromagnetic fields. At the University of Kentucky, the CEM group has developed several modeling tools that are based on the application of approximation theory to integral equations. This allows the physical problem to be …

Impact Of Preferential Flow, Source Water Connectivity, And Agricultural Management Practices On Sediment And Particulate Phosphorus Dynamics In Midwestern Tile-Drained Landscapes, Saeid Nazari

Theses and Dissertations--Biosystems and Agricultural Engineering

Tile drainage is recognized as a significant transporter of sediment and particulate phosphorus (PP) in the Midwestern U.S., leading to proliferation of Harmful Algal Blooms (HABs). Numerous studies have focused on Dissolved Reactive Phosphorus (DRP) and Nitrogen (N) flux dynamics in tile-drained landscapes; however, the impact of preferential flow and agricultural management practices on fate and transport of sediment and PP has remained poorly understood. The overarching objective of this study was to improve understanding of sediment P delivery in tile-drained landscapes. This dissertation focuses on four studies. In the first study, forms and flow pathway dynamics of total phosphorus …

Review On Carbon Dioxide Utilization For Cycloaddition Of Epoxides By Ionic Liquid-Modified Hybrid Catalysts: Effect Of Influential Parameters And Mechanisms Insight, Jimmy Nelson Appaturi, Rajabathar. Jothi Ramalingam, Muthu Kumaran Gnanamani, Govindasami Periyasami, Prabhakarn Arunachalam, Rohana Adnan, Farook Adam, Mohammed D. Wasmiah, Hamad A. Al‐Lohedan

Center for Applied Energy Research Faculty and Staff Publications

The storage, utilization, and control of the greenhouse (CO₂) gas is a topic of interest for researchers in academia and society. The present review article is dedicating to cover the overall role of ionic liquid-modified hybrid materials in cycloaddition reactions. Special emphasis is on the synthesis of various cyclic carbonate using ionic liquid-based modified catalysts. Catalytic activity studies have discussed with respect to process conditions and their effects on conversion and product selectivity for the reaction of cycloaddition of CO₂ with styrene oxide. The reaction temperature and the partial pressure of CO₂ have found to play …

Scalable Approaches For Auditing The Completeness Of Biomedical Ontologies, Fengbo Zheng

Theses and Dissertations--Computer Science

An ontology provides a formalized representation of knowledge within a domain. In biomedicine, ontologies have been widely used in modern biomedical applications to enable semantic interoperability and facilitate data exchange. Given the important roles that biomedical ontologies play, quality issues such as incompleteness, if not addressed, can affect the quality of downstream ontology-driven applications. However, biomedical ontologies often have large sizes and complex structures. Thus, it is infeasible to uncover potential quality issues through manual effort. In this dissertation, we introduce automated and scalable approaches for auditing the completeness of biomedical ontologies. We mainly focus on two incompleteness issues -- …

Evaluation Of Liquid Ice Melting Additives For Winter Maintenance Applications, Erin Lammers-Staats

Theses and Dissertations--Civil Engineering

Winter weather can often pose difficulties for transportation agencies as they work to clear roads of snow and ice quickly so that motorists can travel safely and efficiently. Kentucky has made efforts to maximize efficiency within its winter maintenance program by focusing on optimized equipment usage and personnel time management. This study’s objective was to evaluate novel anti-icers and calculate how their performance compared to the current performance of brine and calcium chloride mixture. New brine additives claim to offer better results, but there is very little guidance about how to systematically evaluate new anti-icers. The author developed a testing …

Geophysical Techniques Used For The Analysis And Prediction Of Soil Strength And Mechanical Behavior, Matthew A. Hurley

Theses and Dissertations--Civil Engineering

Determining soil properties involves extensive laboratory testing of samples at discrete timing and location. Non-destructive analysis methods, such as electrical and seismic, presents alternatives to means of gathering soil properties accompanied with increased flexibility due to spatial and temporal applications. This research examined the ability of seismic wave data to predict soil behavior such as stress-strain and pore pressures using a modified version of Duncan and Chang (1970). Friction angle predictions were also analyzed using shear wave velocity and a modified form of the Santos and Gomez-Correria (2001) equation. This research also analyzed the use of electrical data to predict …

Context Classification Of Roadways Using Nationally Available Gis Data, Laura Wright

Theses and Dissertations--Civil Engineering

A Context Classification System based on context attributes of the area surrounding a roadway provides detailed information about the environment of a roadway corridor, while enabling practitioners to cater roadway projects to the community they are within. This study sought to create a system that would automatically classify roadway segments into the correct context, using data sources that are available nationwide. The proposed approach was tested by classifying the roadways in Highway District 7 of the Kentucky Transportation Cabinet. This process would make context classification approachable to more organizations, as it would reduce the amount of time required to apply …

Characterization Of Modulation And Coherence In Sensorimotor Rhythms Using Different Electroencephalographic Signal Derivations, Stephen Dundon

Theses and Dissertations--Biomedical Engineering

Electroencephalography (EEG) is a widely used technique for monitoring and analyzing brain activity in experimental, diagnostic, and therapeutic applications. Since EEG is sensitive to noise and artefact sources, referential signals at different locations can be combined in different ways to improve signal quality and better localize cortical activity. Four signal derivations were compared against referential EEG in terms of their ability to measure the alpha rhythm modulation (or reactivity) and spatial coherence associated with an eye closure task: a common average reference (CAR), a local average reference (LAR), a large Laplacian (LL), and a focal Laplacian (FL) estimated using a …

Work-Related Changes In The Trunk Stiffness Of Nursing Personnel, Clare Tyler

Theses and Dissertations--Biomedical Engineering

Low back pain (LBP) is a significant issue related to spinal stability and, therefore, to trunk stiffness. Due to the nature of their work, nursing personnel are exposed to potential risk factors for LBP, such as lifting and trunk flexion, which have been reported in the literature to lead to decreases in trunk stiffness. Consequently, the purpose of this study was to investigate potential occupational effects on the trunk stiffness in nursing personnel. Twenty-four nursing personnel participated in this study and completed two sessions (pre-shift and post-shift) during which two passive flexion tests (with and without an ~7.5-lb load) were …

Sediment Transport Investigation In A Karst Basin Defines Governing Transport Processes And Explains Hysteresis Patterns, Leonie Bettel

Theses and Dissertations--Civil Engineering

Water resources researchers have advanced our understanding of sediment transport in karst aquifers and cave systems in recent years. However, we find knowledge gaps for sediment transport in karst including knowledge of processes controlling sediment hysteresis patterns from sensor datasets, and knowledge of dominant sediment transport processes that lead to sediment transport formulas for prediction. To address these gaps, we analyze a new suspended sediment, electrical conductivity and water flowrate datasets from sinking streams and a phreatic cave system for an epigenetic karst basin in the inner bluegrass region of Kentucky USA.

Three sediment patterns are common including: pulses of …

Modeling And Prioritizing Interventions Using Pollution Hotspots For Reducing Nutrients, Atrazine And E. Coli Concentrations In A Watershed, Olufemi Abimbola, Aaron Mittelstet, Tiffany L. Messer, Elaine Berry, Ann Van Griensven

Biosystems and Agricultural Engineering Faculty Publications

Excess nutrients and herbicides remain two major causes of waterbody impairment globally. In an attempt to better understand pollutant sources in the Big Sandy Creek Watershed (BSCW) and the prospects for successful remediation, a program was initiated to assist agricultural producers with the implementation of best management practices (BMPs). The objectives were to (1) simulate BMPs within hotspots to determine reductions in pollutant loads and (2) to determine if water-quality standards are met at the watershed outlet. Regression-based load estimator (LOADEST) was used for determining sediment, nutrient and atrazine loads, while artificial neural networks (ANN) were used for determining E. …

Algae-Based Beneficial Re-Use Of Carbon Emissions Using A Novel Photobioreactor: A Techno-Economic And Life Cycle Analysis, Michael H. Wilson, Aubrey Shea, John Groppo, Czarena Crofcheck, David Quiroz, Jason C. Quinn, Mark Crocker

Center for Applied Energy Research Faculty and Staff Publications

Despite the many advantages of microalgae, the feasibility of large-scale cultivation requires significant amounts of carbon dioxide (CO2) to enable high growth rates. A synergistic union typically proposed for the supply of CO2 is the coupling of algal cultivation with emissions from power plants. This study investigates the sustainability of a novel microalgae platform coupled with coal-based flue gas. The proposed system consists of a novel photobioreactor (PBR) for the production of biomass followed by a two-stage dewatering process. A systems model, which quantifies the CO2 and energy consumption of the proposed system, was developed, and the minimum biomass selling …

Energy Consumption And Lifecycle Assessment Comparison Of Cutting Fluids For Drilling Titanium Alloy, Navneet Khanna, Prassan Shah, Jwalant Wadhwa, Anjali Pitroda, Julius M. Schoop, Franci Pusavec

Institute for Sustainable Manufacturing Faculty Publications

This study analyzes four cutting conditions (dry, flood, Liquid CO 2 (LCO2), and Liquid N2 (LN 2)) based on energy consumption and ecological impacts for drilling VT-20, a Titanium alloy. The lower cutting and total energy have been consumed for LCO2 as compared to others. The Life Cycle Assessment (LCA) analysis has been performed using ReCiPe 2016 midpoint (H) to identify the impact of cutting conditions on ecosystem, human health, and natural resources. Cryogenic environment with LN 2 has been found as the most ecological cutting condition next to dry machining, while flood coolant has 94-99% of total impact considering …

2020 Kentucky Transportation Cabinet Maintenance Customer Survey, Bryan Gibson, Katherine Connair, Chris Van Dyke, Clark Graves, Doug Kreis

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) periodically surveys drivers to understand their perceptions of the agency’s maintenance activities. In 2020, Quadratics in conjunction with the Kentucky Transportation Center surveyed 2,400 licensed drivers throughout the state to gauge their perceptions of highway maintenance, identify areas of strength and weakness, and discern how drivers obtain information on traffic and weather conditions. Survey participants answered questions about five areas of highway maintenance — roadside features, pavement surfaces, shoulders, drainage, and signs/markings. Drivers reported being most satisfied with the maintenance of signs, guardrail, and striping. Pavement surfaces, potholes, and overall appearance garnered the lowest ratings. …

Modeling Of Rare Earth Solvent Extraction Process For Flowsheet Design And Optimization, Vaibhav Kumar Srivastava

Theses and Dissertations--Mining Engineering

The separation and purification of rare earth elements (REEs) into individual products has been a topic of significant interest for researchers and engineers for many decades. The prime reason for such sustained interest is due to REEs’ demand and application in modern technology, as well as the challenges associated with their separation and purification. The chemical similarity of rare earth group elements is responsible for difficult separability which makes purification of individual elements challenging. Despite associated complications, processes such as solvent extraction (SX) and ion-exchange have been successfully utilized in the separation and production of REEs on pilot and commercial …

Novel Tools For Analysis Of Disordered Sleep And Motor Behavior In Preclinical Models Of Disease, Dillon M. Huffman

Theses and Dissertations--Biomedical Engineering

Subtle changes in sleep architecture can accompany and be symptomatic of various diseases or disorders. Understanding the complex interactions between sleep and health requires the ability to characterize sleep, probe its underlying mechanisms through perturbation, and quantify dependent physiological outcomes. Rodent models have come to be accepted as a valuable tool for preclinical investigations. However, experimental tools to accomplish such research typically rely on laborious methods that limit throughput and flexibility. Thus, research tools that minimize workload could be of great value to the research community and expedite investigation of the underlying mechanisms of sleep and further the development of …

Changes In Cardiovascular, Respiratory, And Neural Activity By Music: Effects Of Breathing Pathway On Feeling Emotions, Mohammad Javad Mollakazemi

Theses and Dissertations--Biomedical Engineering

Listening to music can induce emotional and physiological changes. Increasing recognition of the palliative effects of music has led to its use as an adjuvant therapeutic tool in the treatment of various diseases. It is also well known that autonomic nervous activities and some cardiorespiratory rhythms change in correspondence with music. However, less is known about how these effects triggered by music come about. Listening to music affects synchronization between electroencephalograms (EEGs) and cardiac rhythmic activity. This interaction between cardiac and electrical responses led us to investigate whether EEG segments synchronized to different portions of the cardiac cycle can better …

Facilitating Analysis Of Toxoplasma Gondii Bradyzoite Metabolic Activity Via Image Processing And Multivariate Logistic Regression For High Throughput Classification Of Mitochondrial Morphologies, Brooke Place

Theses and Dissertations--Biomedical Engineering

Approximately a third of the population worldwide is chronically infected by the parasite Toxoplasma gondii. During chronic infection the parasite resides within tissue cysts as the poorly understood bradyzoite form. Observation of these bradyzoites via microscopic imaging within tissue cyst purified from infected mouse brains has shown metabolic activity with heterogeneous replication potential. With fluorescence microscopy imaging targeting the parasite’s actively respiring mitochondria, the parasite’s metabolic state can be further investigated as the morphology of mitochondria can be associated with specific physiologic states. However, manually classifying mitochondrial morphologies from these images can be tedious and prone to error as …

Risk-Based Construction Inspection, Shannon Rush

Theses and Dissertations--Civil Engineering

State Transportation Agencies have been experiencing staffing difficulties in the last couple of decades due to the deterioration of infrastructure and a large number of employees retiring or transitioning to the private sector. Therefore, the STA demographic has become much younger and a loss of critical knowledge has resulted from this changeover. Construction Inspection in particular has been severely impacted. Inspired by the NCHRP Synthesis 450, the Kentucky Transportation Cabinet has initiated the Risk-Based Construction Inspection project which focuses on prioritizing construction activities based on the risk associated with failure of that work item. The purpose of which is to …

Life Cycle Assessment Of Polylactic Acid Biopolymer Industrial Waste Management Techniques In Belize, Dennis J. Newby

Theses and Dissertations--Civil Engineering

In January 2020, the Government of Belize enacted an Implementation Strategy and Action Plan to phase-out single-use plastics and to transition to products like bioplastics. This work investigated the environmental effects of using alternative waste management techniques to manage polylactic acid biopolymer (PLA) waste by using life cycle assessment (LCA). The following treatment options were compared: landfill, landfill expansion, cogeneration, and anaerobic digestion. The landfill and landfill expansion processes both had a global warming potential of 0.01 kg of CO₂ eq. per kg of PLA waste managed compared to the cogeneration and anaerobic digestion processes -0.03 and -0.06 kg …

Assessing Freeway Crash Risk Using Crowdsourced Waze Incident Alerts, Eugene Boasiako Antwi

Theses and Dissertations--Civil Engineering

Traffic data obtained through crowdsourcing are becoming more accessible to traffic agencies due to advancements in smartphone technology. Traffic managers aim to use this data to complement their conventional sources of data and provide additional context in their analysis. In this study, Waze incident alerts are integrated with GPS-Probe speed data and Kentucky State Police (KSP) crashes to assess their impact on traffic flow and safety on freeways in Kentucky. The analysis showed that the presence of a vehicle on the shoulder is associated with about 36.7% of freeway crashes in Kentucky. The presence of a vehicle on the shoulder …