Engineering Commons^™

Unsupervised Learning Framework For Large-Scale Flight Data Analysis Of Cockpit Human Machine Interaction Issues, Abhishek B. Vaidya

Open Access Theses

As the level of automation within an aircraft increases, the interactions between the pilot and autopilot play a crucial role in its proper operation. Issues with human machine interactions (HMI) have been cited as one of the main causes behind many aviation accidents. Due to the complexity of such interactions, it is challenging to identify all possible situations and develop the necessary contingencies. In this thesis, we propose a data-driven analysis tool to identify potential HMI issues in large-scale Flight Operational Quality Assurance (FOQA) dataset. The proposed tool is developed using a multi-level clustering framework, where a set of basic …

Effect Of Humidity On The Creep Response Of Cellulose Nanocrystals Films, Marianne C. Valone

Open Access Theses

Cellulose nanocrystals (CNCs) are a derivative of cellulose, the Earth’s most abundant source of a sustainable polymer. There are many applications for CNCs such as batteries, antimicrobial films, flexible displays and drug delivery. This research is focused on CNCs films and the mechanical properties once humidity was introduced.

The creation of self-aligned CNCs films was utilized to perform dynamic mechanical analysis (DMA) testing. The Forest Products Lab (FPL) in Madison, Wisconsin provided the CNCs used. Both 3.5 wt.% and 9.1 wt.% films were made and tested. A DMA method was created to test the creep response of the CNCs films …

Densified Collagen-Fibril Biomaterials For Bone Tissue Engineering, Lauren E. Watkins

Open Access Theses

Millions of craniofacial bone defects occur annually as a result of trauma, congenital defects, disease, or tooth extraction. When present in the oral cavity, these defects are associated with adverse impacts on speech, mastication, and aesthetics. Thus, there is a clinical need for interventional strategies to restore and preserve alveolar bone mass to improve the success of future treatment options intended to reestablish functionality and aesthetics. Guided bone regeneration using bone grafts and a membrane represent the current standard of care for repairing alveolar bone defects, but face a number of limitations related to resorption time and structural integrity. Improvements …

Targeted Metabolomics On The Shikimate And Aromatic Amino Acid Biosynthetic Pathways, Robert E. Wheeler

Open Access Theses

The shikimate and aromatic amino acid biosynthesis pathways are some of the most studied biosynthetic pathways in nature due to their fundamental importance. Interest in this field stems from synthesis of the essential amino acids, tryptophan, tyrosine and phenylalanine. The pathways also are important as generating the precursors of thousands of secondary metabolites and lignin. Inhibiting the pathway has led to discovery of herbicides, pesticides as well as tuberculosis drugs. However there is currently a lack of a comprehensive targeted method for detecting and quantifying the majority of the intermediates in these pathways. Often multiple extraction and detection methods are …

Tadpole Orbits In The L4/L5 Region: Construction And Links To Other Families Of Periodic Orbits, Alexandre G. Van Anderlecht

Open Access Theses

The equations of motion in the Circular Restricted Three-Body Problem (CR3BP) allow five equilibrium solutions, that is, the Lagrange or libration points. Two of the five equilibrium solutions are the triangular or equilateral libration points, L4 and L 5. As the secondary gravitational body moves in its orbit about the larger mass, L4 and L5 lead and trail the secondary by 60 degrees, respectively. This investigation focuses on periodic solutions in the vicinity of the triangular libration points, specifically horseshoe and tadpole orbits. Horseshoe orbits are symmetric periodic solutions in the plane of primary motion encompassing both …

A Case Study Of Two-Echelon Multi-Depot Vehicle Routing Problem, Tianqi Yu

Open Access Theses

The Vehicle Routing Problem (VRP) is a classic combinatorial optimization problem and a topic still studied for practical applications. Current research focuses on single echelon distribution systems such as distribution centers serving customers. However, in typical distribution, goods flows among regional distribution centers, local warehouses and customers, defined as a two-echelon network. The two-echelon multiple depot VRP problem is documented and applied to two stages illustrated by a small scale computational example. In the first stage, the simulated annealing algorithm is employed to determine the routes between local warehouses and final customers. For the second stage, trial-and-error is applied to …

Enhancing Bioethanol Fermentation Through Removal Of Acetic Acid Using Liquid-Liquid Extraction, Mahdieh Aghazadeh

Open Access Dissertations

The concern for the ever growing human population as well as the depletion of fossil fuel resources and their impact on global warming have long been motivations for the researchers to investigate means for sustainable producing carbon-neutral energy. Second-generation biofuel refers to liquid fuels that are produced from non-food resources and reduce the total greenhouse gas emission by at least 60 %. Acetic acid has been shown to be one of the most ubiquitous fermentation inhibitors in a bioethanol production facility which slows down the bioethanol production and reduces its yield through inhibition of the ethanol producing microorganisms. The use …

Improving The Mechanistic Study Of Neuromuscular Diseases Through The Development Of A Fully Wireless And Implantable Recording Device, Rebecca A. Bercich

Open Access Dissertations

Neuromuscular diseases manifest by a handful of known phenotypes affecting the peripheral nerves, skeletal muscle fibers, and neuromuscular junction. Common signs of these diseases include demyelination, myasthenia, atrophy, and aberrant muscle activity—all of which may be tracked over time using one or more electrophysiological markers. Mice, which are the predominant mammalian model for most human diseases, have been used to study congenital neuromuscular diseases for decades. However, our understanding of the mechanisms underlying these pathologies is still incomplete. This is in part due to the lack of instrumentation available to easily collect longitudinal, in vivo electrophysiological activity from mice. There …

On The 3d Point Cloud For Human-Pose Estimation, Kai-Chi Chan

Open Access Dissertations

This thesis aims at investigating methodologies for estimating a human pose from a 3D point cloud that is captured by a static depth sensor. Human-pose estimation (HPE) is important for a range of applications, such as human-robot interaction, healthcare, surveillance, and so forth. Yet, HPE is challenging because of the uncertainty in sensor measurements and the complexity of human poses. In this research, we focus on addressing challenges related to two crucial components in the estimation process, namely, human-pose feature extraction and human-pose modeling.

In feature extraction, the main challenge involves reducing feature ambiguity. We propose a 3D-point-cloud feature called …

A Transfer Network Linking Earth, Moon, And The Triangular Libration Point Regions In The Earth-Moon System, Lucia R. Capdevila

Open Access Dissertations

In the near future, several space applications in the Earth-Moon system may require a spacecraft to hold a stable motion, but the transfer trajectory infrastructure to access such stable motions has not been fully investigated yet. The triangular libration points, L 4and L5, in the Earth-Moon system have long been thought of as ideal locations for a communications satellite. Recently, Distant Retrograde Orbits (DROs) and Near-Rectilinear Halo Orbits (NRHOs) near the Moon have been identified as motion of interest for manned and unmanned missions with a focus on operations in cislunar space. The triangular libration points, as well as …

Is Metabolism Goal-Directed? Investigating The Validity Of Modeling Biological Systems With Cybernetic Control Via Omic Data, Frank T. Devilbiss

Open Access Dissertations

Cybernetic models are uniquely juxtaposed to other metabolic modeling frameworks in that they describe the time-dependent regulation of cellular reactions in terms of dynamic "metabolic goals." This approach contrasts starkly with purely mechanistic descriptions of metabolic regulation which seek to explain metabolic processes in high resolution — a clearly daunting undertaking. Over a span of three decades, cybernetic models have been used to predict metabolic phenomena ranging from resource consumption in mixed-substrate environments to intracellular reaction fluxes of intricate metabolic networks. While the cybernetic approach has been validated in its utility for the prediction of metabolic phenomena, its central feature, …

Rearward Visibility Issues Related To Agricultural Machinery: Contributing Factors, Potential Solutions, Shawn Gregory Ehlers

Open Access Dissertations

As the size, complexity, and speed of tractors and other agricultural self-propelled machinery have increased, so have the visibility-related issues, placing significant importance on the visual skills, alertness, and reactive abilities of the operator. Rearward movement of large agricultural equipment has been identified in the literature as causing not only damage to both machine and stationary objects, but also injuries (even fatalities) to bystanders not visible to the operator. Fortunately, monitoring assistance, while not a new concept, has advanced significantly, offering operators today more options for increasing awareness of the area surrounding their machines. In this research, an attempt is …

Ultra-Thin Boron Nitride Films By Pulsed Laser Deposition: Plasma Diagnostics, Synthesis, And Device Transport, Nicholas Robert Glavin

Open Access Dissertations

This work describes, for the first time, a pulsed laser deposition (PLD) technique for growth of large area, stoichiometric ultra-thin hexagonal and amorphous boron nitride for next generation 2D material electronics. The growth of boron nitride, in this case, is driven by the high kinetic energies and chemical reactivities of the condensing species formed from physical vapor deposition (PVD) processes, which can facilitate growth over large areas and at reduced substrate temperatures. The use of optical emission spectroscopy during plasma growth provides insight into chemistry, kinetic energies, time of flight data, and spatial distributions within a PVD plasma plume ablated …

Coupled Orbit-Attitude Mission Design In The Circular Restricted Three-Body Problem, Davide Guzzetti

Open Access Dissertations

Trajectory design increasingly leverages multi-body dynamical structures that are based on an understanding of various types of orbits in the Circular Restricted Three-Body Problem (CR3BP). Given the more complex dynamical environment, mission applications may also benefit from deeper insight into the attitude motion. In this investigation, the attitude dynamics are coupled with the trajectories in the CR3BP. In a highly sensitive dynamical model, such as the orbit-attitude CR3BP, periodic solutions allow delineation of the fundamental dynamical structures. Periodic solutions are also a subset of motions that are bounded over an infinite time-span (assuming no perturbing factors), without the necessity to …

Influence Of The 3d Microenvironment On Glioblastoma Migration And Drug Response, Ruth Marisol Herrera Perez

Open Access Dissertations

Glioblastoma (GBM) is a highly invasive brain cancer characterized by poor prognosis. Despite significant efforts by the basic and clinical research community our understanding of GBM progression and recurrence has been incremental. Improvements in therapeutic response have been dismal, and GBM continues to be the deadliest tumor of the central nervous system, with patient average survival rate of 12 months. Synergistic relationships that the tumor cells establish with the brain microenvironment have been proven fundamental for successful tumor progression and maintenance. Yet, many in vitro GBM studies are performed in formats that fail to recapitulate the most essential component of …

Optimal Monitoring And Mitigation Of Systemic Risk In Lending Networks, Zhang Li

Open Access Dissertations

This thesis proposes optimal policies to manage systemic risk in financial networks. Given a one-period borrower-lender network in which all debts are due at the same time and have the same seniority, we address the problem of allocating a fixed amount of cash among the nodes to minimize the weighted sum of unpaid liabilities. Assuming all the loan amounts and cash flows are fixed and that there are no bankruptcy costs, we show that this problem is equivalent to a linear program. We develop a duality-based distributed algorithm to solve it which is useful for applications where it is desirable …

Coupled Resonator Based Wireless Power Transfer For Bioelectronics, Henry Mei

Open Access Dissertations

Implantable and wearable bioelectronics provide the ability to monitor and modulate physiological processes. They represent a promising set of technologies that can provide new treatment for patients or new tools for scientific discovery, such as in long-term studies involving small animals. As these technologies advance, two trends are clear, miniaturization and increased sophistication i.e. multiple channels, wireless bi-directional communication, and responsiveness (closed-loop devices). One primary challenge in realizing miniaturized and sophisticated bioelectronics is powering. Integration and development of wireless power transfer (WPT) technology, however, can overcome this challenge.

In this dissertation, I propose the use of coupled resonator WPT for …

Energy Efficiency In Data Collection Wireless Sensor Networks, Miquel Andres Navarro Patino

Open Access Dissertations

This dissertation studies the problem of energy efficiency in resource constrained and heterogeneous wireless sensor networks (WSNs) for data collection applications in real-world scenarios. The problem is addressed from three different perspectives: network routing, node energy profiles, and network management. First, the energy efficiency in a WSN is formulated as a load balancing problem, where the routing layer can diagnose and exploit the WSN topology redundancy to reduce the data traffic processed in critical nodes, independent of their hardware platform, improving their energy consumption and extending the network lifetime. We propose a new routing strategy that extends traditional cost-based routing …

Direct Drug Screening And Lipid Profiling Using Ambient Mass Spectrometry, Yuan Su

Open Access Dissertations

Mass spectrometry (MS) stands in an outstanding position in analysis of biological specimens owing to its abundant structural information, high accuracy, incomparable sensitivity, high speed, and the large variety of its applications. The ion source, an instrumental part for converting the analyte into ions, has played an important role in analyzing biological specimens by MS. However, the performance of conventional spray-based ionization methods always suffers from chemical interferences derived from complex biological matrices. A series of sample extraction, purification, and separation steps is required before the ionization, so as to ensure excellent performance of MS analysis. In order to simplify …

Advancing Multiple Model-Based Control Of Complex Biological Systems: Applications In T Cell Biology, Jeffrey P. Perley

Open Access Dissertations

Activated CD4+ T cells are important regulators of the adaptive immune response against invading pathogens and cancerous host cells. The process of activation is mediated by the T cell receptor and a vast network of intracellular signal transduction pathways, which recognize and interpret antigenic signals to determine the cell's response. The critical role of these early signaling events in normal cell function and the pathogenesis of disease ultimately make them attractive therapeutic targets for numerous autoimmune diseases and cancers.

Scientists increasingly rely on predictive mathematical models and control-theoretic tools to design effective strategies to manipulate cellular processes for the advancement …

Characterization Of Pool Boiling Heat Transfer From Porous-Coating-Enhanced Surfaces, Suchismita Sarangi

Open Access Dissertations

Development of techniques for enhancement and optimization of thermal management technologies has been a highly active area of research in recent decades in response to the rapid emergence of compact, high-power electronic systems. Immersion cooling by boiling is one of the preferred methods for high power density applications, due to its passive nature and high heat transfer coefficients obtained. Pool boiling heat transfer has been extensively studied in recent decades to understand the inherent mechanisms yielding the high heat transfer rates, as well as to further enhance the heat transfer by simple modifications or additions to existing approaches. This thesis …

2016 Directory Of Indiana State, County, City And Town Officials Responsible For Road And Street Work, Indiana Ltap

Indiana Local Technical Assistance Program (LTAP) Directory

Contact information for local agency officials and employees responsible for Indiana’s local road infrastructure.

The Impact Of Damage Accumulation On The Kinetics Of Network Strength Recovery For A Physical Polymer Gel Subjected To Shear Deformation, Travis Thornell, Krithika Subramaniam, Kendra Erk

School of Materials Engineering Faculty Publications

Shear rheophysical experiments were used to quantify the kinetics of strength recovery of model thermoreversible polymer gels that were fractured and ultimately sheared to different total magnitudes of strain (700 and 4000%) before resting for set periods of time. Relationships between the amount of strength recovered and the normalized ratio of resting times to characteristic relaxation times were developed. It was found that gels displayed fully healed networks within timescales that were 2-3 orders of magnitude greater than the gel’s characteristic relaxation time. Gels deformed to 700% applied strain either healed slower at lower gel concentrations as compared to experiments …

Food Processing In Haiti, Maggie R. Del Ponte

Engagement & Service-Learning Summit

No abstract provided.

Health Monitoring Device, Prim Boonwisut, Askar Zhapbassov, Tahmeed Rafee

Engagement & Service-Learning Summit

No abstract provided.

Human-System Integration, Jiahui Cai, Xianpeng Wang, Xinyue Cao, Siyu Liu, Wanyu Wu, Xiao Shi, Yutong Xu

Engagement & Service-Learning Summit

No abstract provided.

Development Of Distributed Off-Grid Renewable Energy System For Rural African Communities, Mateo Sebastian Guerrero, Menghong Feng

Engagement & Service-Learning Summit

Our Hybrid Energy System team is committed to develop low-cost renewable energy solutions to rural African communities where access to electricity from government grid is not available. According to a World Bank’s report, only 24% of sub-Saharan countries have access to electricity. Our team has been working with local partners to build renewable energy systems since 2008. From 2015 the team has been working on micro hydropower turbine and vertical-axis wind turbine with solar energy system combined. Our current efforts include a prototype design of a wind-solar system, using a new concept of vertical axis wind turbine to harvest wind …

A Smart System: Driver Safety For The Car Savvy And Not Through Mobile Application, Veronica Cruz, Jonathan La Plain

Engagement & Service-Learning Summit

No abstract provided.

Application Of Smart Factory Design In Nuclear Energy Industry With Focus On Safety, Olivia Crasta, Cem Yilmaz

Engagement & Service-Learning Summit

No abstract provided.

Purdue Tap, Carly Turow

Engagement & Service-Learning Summit

Purdue TAP provides high-value solutions that help Indiana businesses maximize their success by increasing profits, reducing costs, and implementing growth and innovation engineering systems. Our organization serves more than 500 companies annually by implementing continuous improvement principles in the areas of productivity, growth and technology. Purdue TAP has helped our clients collectively achieve over $1 billion of economic impact in Indiana since 2005.