Engineering Commons^™

Qsar Modeling Of Chemical Penetration Enhancers Using Novel Replacement Algorithms, Hui Qiu

Theses

The applications of transdermal delivery are limited because of the resistance of the skin to drug diffusion. Only potent drugs, with molecular weight less than 500 Da, are suitable to cross the skin barrier. Chemical Penetration Enhancers (CPEs) are used to promote the absorption of solutes across the dermal layers. In this investigation, a Quantitative Structure-Activity Relationship (QSAR) model is applied to relate chemical penetration enhancer structures with the flux enhancement ratio through a statistical approach.

A database, consisting of 61 non-polar CPEs, is selected for the study. Each compound is represented by 777 QSAR descriptors, which encode the physical …

Effect Of Tablet Compression On The Dissolution Of Aspirin Tablets Using A Novel Off-Center Paddle Impeller (Opi) Dissolution Testing System, Chuan Sun

Theses

In the pharmaceutical industry, dissolution testing is routinely carried out to determine the dissolution rate of oral solid dosage forms. Among several testing devices, the USP Dissolution Apparatus 2 is the device most commonly used. However, despite its widespread use, this apparatus has been shown to produce test failures and to be very sensitive to a number of small geometry changes.

The objective of this study was to determine whether a novel dissolution system termed “OPI” for “off-center paddle impeller” was sensitive enough to determine differences in tablet dissolution profiles caused by different compression pressure during the tablet manufacturing process. …

Dissolution Of Different Commercial Aspirin Tablets Using A Novel Off-Center Paddle Impeller (Opi) Dissolution Testing System, Yang Qu

Theses

Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. In this work, a modified Apparatus 2, termed "OPI" System for "off-center paddle impeller," in which the impeller is placed 8 mm off center in the vessel is tested to determine its sensitivity to differentiate between the dissolution profiles of differently formulated and manufactured tablets. Dissolution tests are conducted with both the OPI System and the Standard System using three …

Current Measurements In Electrospinning, Clinton K. Lien

Theses

Electrospinning provides an economical method of producing nanofibers. The current carried by the main spinning jet is found to be one of the factors in determining the diameter of the fiber product. However, current sources such as the corona discharge and secondary jets will lead to a systematic overestimation of the actual current value.

In this research, experiments with different configurations are set up to investigate the influence of various parameters on the measured current. It is noticed that the measured current is nearly independent on the flow rate of the solution and the external cover. A large amount of …

Novel Algorithms For Fair Bandwidth Sharing On Counter Rotating Rings, Mete Yilmaz

Dissertations

Rings are often preferred technology for networks as ring networks can virtually create fully connected mesh networks efficiently and they are also easy to manage. However, providing fair service to all the stations on the ring is not always easy to achieve.

In order to capitalize on the advantages of ring networks, new buffer insertion techniques, such as Spatial Reuse Protocol (SRP), were introduced in early 2000s. As a result, a new standard known as IEEE 802.17 Resilient Packet Ring was defined in 2004 by the IEEE Resilient Packet Ring (RPR) Working Group. Since then two addenda have been introduced; …

Driver Injury Severity At U.S. Highway-Rail Crossings, Wei Hao

Dissertations

There are approximately 240,000 highway-rail grade crossings in the United States and highway-rail grade crossing areas have been considered in this study as these are locations where crashes frequently occur. Existing studies on crash models at highway- rail grade crossings can be classified into two categories: accident frequency prediction models and driver injury severity models. Accident frequency prediction at highway-rail grade crossings have been investigated by previous studies using varied statistical models. Few studies, however, have focused on driver injury severity studies. Three drawbacks will be addressed in this research including limitations in traditional highway- rail grade crossings studies, limited …

Separation Of Various Organic-Organic And Aqueous-Organic Solutions Via Pervaporation, John Tang

Dissertations

Pervaporation, an energy saving separation process, can be useful in pharmaceutical processing. However, the organic solvents involved in pharmaceutical product synthesis are chemically demanding; very few polymers are able to withstand them. An ideal membrane would be polymeric having a high thermal, chemical and mechanical stability. Such a membrane is made of a copolymer of polydimethyldioxole and tetrafluoroethylene known as PDD-TFE of the CMS-3 variety with a very high free volume. This novel membrane is used to separate a variety of organic-organic and aqueous-organic mixtures. An earlier study based on water-ethanol-isopropanol has shown evidence that the membrane selectivity may be …

Particle Engineering Via Surface Modification During Micronization For Pharmaceutical Applications, Xi Han

Dissertations

Improving the dissolution rate of Biopharmaceutics Classification System (BCS) class II drugs is an important research area. Micronization which can increase the specific surface area is a promising method to improve the dissolution rate. Micronization alone, however, can lead to downstream processing problems related to poor flow and dispersion properties. The importance of the flowability of pharmaceutical powders is well-documented in the literature. It is, therefore, important to develop a method that can simultaneously overcome these processing issues and allow for micronizing the API. In this work, dry particle coating technique is investigated in the context of micronizing API powders …

Dynamic Response Of Highway Bridges Under A Moving Truck And Development Of A Rational Serviceability Requirement, Shabnam Darjani

Dissertations

Through the development and usage of high-strength materials, the design of more flexible bridges is unavoidable. It is assumed that limiting a bridge static deflection would control the excessive vibration caused by more flexible design. However, results of prior studies indicate that deflection limits do not necessarily address bridges vibrational issue.

This dissertation addresses the parameters affecting bridge vibration and provides simple equations to compute bridge dynamic acceleration, velocity and displacement in both transient and steady state parts of the vibration. These equations can then be used to control bridges excessive vibration; and provide human comfort and structural performance.

A …

Leaching Of Metals And Metalloids From Highway Marking Glass Beads And The Potential Environmental Impact, Nimrat K. Sandhu

Dissertations

Glass beads are embedded in pavement markings to obtain retroreflectivity which plays a crucial role in the lighting-up effect needed for safe driving. Elevated metal and metalloid concentrations of As, Sb, and Pb have recently been observed in imported glass beads. The main objective of this research was to assess the environmental impact associated with applying these imported glass beads in highway markings. To achieve this objective, total metal concentrations were measured using two techniques: hydrofluoric acid digestion followed by inductively coupled plasma mass spectroscopy (HF/ICP-MS), and field portable x-ray fluorescence (FP-XRF) spectroscopy. A number of leaching studies were conducted …

Fabrication And Evaluation Of A Collagen-Based Fiber-Gel Three-Dimensional Construct For Peripheral Nerve Repair, Mevan Lakmal Siriwardane

Dissertations

Nerve regeneration following a peripheral nerve injury often relies on growth cone- mediated guidance and the presence of Schwann cells to support the regenerating axons and remyelinate portions of denervated nerve pathways. The emphasis of this work is to develop a synthetic nervous tissue construct that contains similar basal lamina or extracellular matrix to peripheral nerve in order to achieve a level of effectiveness in nerve repair and future peripheral nerve regeneration applications. To this end, three- dimensional nervous tissue constructs consisting of type I collagen are fabricated into a composite biomaterial scaffold to promote contact-guided growth of neuronal and …

Quantification Of Neural Substrates Of Vergence System Via Fmri, Yelda Alkan

Dissertations

Vergence eye movement is one of the oculomotor systems which allow depth perception via disconjugate movement of the eyes. Neuroimaging methods such as functional magnetic resonance imaging (fMRI) measure neural activity changes activity in the brain while subjects perform experimental tasks. A rich body of primate investigations on vergence is already established in the neurophysiology literature; on the other hand, there are a limited number of fMRI studies on neural mechanisms behind the vergence system.

The results demonstrated that vergence system shares neural sources and also shows differentiation within the boundaries of frontal eye fields (FEF) and midbrain of the …

Mathematical Modeling Of Heavy Metals Diffusion And Removal From Cylindrical Cement Forms Coated With Bio-Film, Mojdeh Tabatabaie

Dissertations

A mathematical model is developed to predict bioleachi ng of heavy metals from long cylindrical shape cementitious samples. In this model, the metal concentration difference within the solid and its surface is considered as the main driving force for transport of metals to the surface of a sample at a given temperature and pressure. Fick’s first and second law are applied to explain the motion of contaminants in a long and uniform cylindrical solid. In addition, the model considers Michaelis-Menten type kinetics, a special case of the widely accepted Langmuir-Hinshelwood reaction mechanism, at the surface of the encapsulating cylinder. The …

Quantification Of Human Motion On Roller Coaster Rides, Chirag Burman

Theses

Case reports have been published of people experiencing symptoms of traumatic brain injury (TBI) and/or ailments of the vascular tissue around the head. These reports pointed towards G-forces, a scalar measure without a specified direction, which represent the measure of the acceleration of an object divided by acceleration caused by gravity (9.81 m/s²), as a cause of said injuries. Research has been conducted on quantifying the G-forces experienced while on roller coasters, as well as the change in heart rate. However these studies have not been able to show a link between roller-coasters and symptoms.

This thesis aims …

Safety Performance Comparison Between Light Rail Transit And Subway, Nehemie Jasmin

Theses

Along with the expansion and addition of guide way transit systems, such as light rail and subway, there came the need to compare the safety performance of each mode. The multimodal transportation systems with many different technologies, operating characteristics and diversified environments made it more difficult to compare their safety.

In order to evaluate the potential for intermodal comparison of safety performance measures, the thesis has focused on the subway and Light Rail Transit (LRT) modes at the national level. Starting with clear definitions of each safety category, the analysis utilizes mostly the National Transit Database (NTD) from recent years …

Fuzzy Logic For Task Space Telemanipulation Of A Five Fingered Robotic Hand, Raaghavann Srinivasan

Theses

This work presents a fuzzy logic based HandyMan (Hand gesture commands for grasping and manipulation) system to recognize the operator's hand gestures during task space telemanipulation. A combination of joint positions may be shared between at least two manipulation gestures. To avoid misinterpretation of gestures by the gesture recognition system, six new manipulation gestures were introduced. The gestures are produced by the user wearing a CyberGlove™.

This system replaces the previous HandyMan gesture recognition method. The output of the fuzzy system drives the state machines to implement the gestures with the robot hand.

The experimental results show that the proposed …

Diffuse Axonal Injury Effect On Myelinating Cells And Axons, Jennifer Alison Zalk

Theses

There is no supporting evidence whether myelin degeneration in diffuse axonal injury (DAI) of the white matter is due to death of myelinating oligodendrocytes or secondary axotomy. Cortical neurons are not able to remain healthy in culture to have their axons myelinated. Dorsal root ganglion (DRG) neurons have been shown to be myelinated by cortical oligodendrocytes in culture. An in vitro stretch injury model was used to analyze the DRG axon pathology during and after injury. DRG myelinating Schwann cells are analyzed to demonstrate what is expected from injury to oligodendrocytes. DRG axons demonstrated a high tolerance to stretch …

Optimizing Feeder Bus Network Based On Access Mode Shifts, Zhaodong Huang

Dissertations

The methodology introduced in this dissertation is to optimally find a feeder bus network in a suburban area for an existing rail system that connects the suburban area with the Central Business District (CBD). The objective is to minimize the total cost, including user and supplier costs. Three major access modes (walk, feeder bus, and auto) for the rail station are considered and the cost for all modes makes up the user cost. The supplier cost comes from the operating cost of the feeder bus network. The decision variables include the structure of the feeder bus network, service frequencies, and …

Blind Recognition Of Analog Modulation Schemes For Software Defined Radio, Haifeng Xiao

Dissertations

With the emergence of software defined radios (SDRs), an adaptive receiver is needed that can configure various parameters, such as carrier frequency, bandwidth, symbol timing, and signal to noise ratio (SNR), and automatically identify modulation schemes. In this dissertation research, several fundamental SDR tasks for analog modulations are investigated, since analog radios are often used by civil government agencies and some unconventional military forces. Hence, the detection and recognition of "old technology" analog modulations remain an important task both for civil and military electronic support systems and for notional cognitive radios.

In this dissertation, a Cyclostationarity-Based Decision Tree classifier is …

Graphene-Coated Substrates For Biochemical And Optoelectronic Applications, Amrita Banerjee

Dissertations

Graphene - monolayer or a few layers of graphite -- has proven to possess remarkable properties: large thermal conductivity, mechanical robustness, two-dimensional ultra large electronic mobility, chemical inertness and biochemical compatibility. Realization of some applications has been impeded by lack of a large area deposition method. By using a novel methodology to deposit graphene on solid and perforated substrates, various optoelectronic and biochemical elements have been demonstrated in this thesis: (1) graphene based transistors were fabricated and their characteristics were assessed. The mobility for such transistors exceeded 5000 cm2/V·s, much larger than their silicon based counterparts. Such attribute opens up …

High Aspect Ratio Electrodes For High Yield Electroporation Of Cells, Anil B. Shrirao

Dissertations

Electroporation is a widely used process in cell biology studies. It uses an electric field to create pores on the cell membrane in order to either insert exogenous molecules inside the cells or disrupt the cell membrane to kill the cells. Current micro-fluidic electroporation devices use the planar electrodes situated at the bottom of a microchannel. These planar electrodes i) require a high voltage and ii) generate a nonuniform electric field which result in low yield of the electroporation. The standard silicon microfabrication technologies are not suitable to fabricate non-planar electrodes required to increase the yield of electroporation.

In this …

Challenges Of Permitting Ballast Water Discharges From Commercial Vessels In U.S. Waters, Paul Rodriguez

Theses

On February 5, 2009, the US Environmental Protection Agency (US EPA) issued the Vessel General Permit (VGP), under the Clean Water Act (CWA), for discharges incidental to the normal operation of vessels, including ballast water discharges. This set forth permit requirements for most commercial vessel discharges within 3 nautical miles of U.S. shore. Since it will expire in December 2013, the US EPA recently issued a draft 2013 VGP. One of the significant changes is the proposal of numerical ballast water discharge standards requiring most commercial vessels to install ballast water treatment systems onboard.

The objective of this thesis is …

Gpu Implementation Of Block Transforms, Boyan Zhang

Theses

Traditionally, intensive floating-point computational ability of Graphics Processing Units (GPUs) has been mainly limited for rendering and visualization application by architecture and programming model. However, with increasing programmability and architecture progress, GPUs inherent massively parallel computational ability have become an essential part of today's mainstream general purpose (non-graphical) high performance computing system. It has been widely reported that adapted GPU-based algorithms outperform significantly their CPU counterpart.

The focus of the thesis is to utilize NVIDIA CUDA GPUs to implement orthogonal transforms such as signal dependent Karhunen-Loeve Transform and signal independent Discrete Cosine Transform. GPU architecture and programming model are examined. …

Driver Behavior Classification And Lateral Control For Automobile Safety Systems, Jing Yang

Dissertations

Advanced driver assistance systems (ADAS) have been developed to help drivers maintain stability, improve road safety, and avoid potential collision. The data acquisition equipment that can be used to measure the state and parameter information of the vehicle may not be available for a standard passenger car due to economical and technical limitations. This work focuses on developing three technologies (longitudinal tire force estimation, driver behavior classification and lateral control) using low-cost sensors that can be utilized in ADAS.

For the longitudinal tire force estimation, a low cost 1Hz positioning global system (GPS) and a steering angle sensor are used …

Advanced Intelligent Control And Optimization For Cardiac Pacemaker Systems, Wei Shi

Dissertations

Since cardiovascular diseases are major causes of morbidity and mortality in the developed countries and the number one cause of death in the United States, their accurate diagnosis and effective treatment via advanced cardiac pacemaker systems have become very important. Intelligent control and optimization of the pacemakers are significant research subjects. Serious but infrequently occurring arrhythmias are difficult to diagnose. The use of electrocardiogram (ECG) waveform only cannot exactly distinguish between deadly abnormalities and temporary arrhythmias. Thus, this work develops a new method based on frequency entrainment to analyze pole-zero characteristics of the phase error between abnormal ECG and entrained …

Investigation Of The Fracture Phenomena During The Milling Process Of Inorganic Particulates And Brittle Fracture Of Polymer Composites Using Fractal Theory, Zheng Qian

Dissertations

This dissertation investigates the applicability and usefulness of applying Fractal mathematics and to the fracture of brittle particulates in Fluid Energy Mill devices, and in particular quantifying the resulting power law particle size distributions, examining the Surface Fractal Dimension of milled particulates, and relating the Izod Impact Strength values of composites of polypropylene and Calcium carbonate particulates which are large un-milled, small milled, as well as small and produced by the simultaneous milling and coating with nano-silica to the Surface Fractal Dimension of the impact fracture surfaces.

First, the dissertation examines the behavior of un-coated and micron-sized wax pre-coated particulates …

The Incorporation Of Electrohydrodynamics And Other Modifications Into A Dry Spinning Model To Develop A Theoretical Framework For Electrospinning, Yuki Imura

Dissertations

The objective of this research was the development of a mathematical model of the electrospinning process using dry spinning modeling principles as a basis. This model is directed at the identification of parameters which influence final fiber characteristics, e.g., solvent concentration, temperature, spin line tension, and electric field. Preliminary computer simulations were performed; however, the generated data was inconclusive and was determined to be due in part to the complexity of the modeled system and the subsequent computational difficulties encountered. Although a comprehensive computational model of the electrospinning process has not yet been demonstrated, the theoretical development that was undertaken …

Virtual Reality Visual Feedback And Its Effect On Brain Excitability, Soha Saleh

Dissertations

This dissertation examines manipulation of visual feedback in virtual reality (VR) to increase excitability of distinct neural networks in the sensorimotor cortex. The objective is to explore neural responses to visual feedback of motor activities performed in complex virtual environments during functional magnetic resonance imaging (fMRI), and to identify sensory manipulations that could further optimize VR rehabilitation of persons with hemiparesis. In addition, the effects of VR therapy on brain reorganization are investigated. An MRI-compatible VR system is used to provide subjects with online visual feedback of their hand movement. First, the author develops a protocol to analyze variability in …

Energy Harvesting-Aware Design Of Wireless Networks, Fabio Iannello

Dissertations

Recent advances in low-power electronics and energy-harvesting (EH) technologies enable the design of self-sustained devices that collect part, or all, of the needed energy from the environment. Several systems can take advantage of EH, ranging from portable devices to wireless sensor networks (WSNs). While conventional design for battery-powered systems is mainly concerned with the battery lifetime, a key advantage of EH is that it enables potential perpetual operation of the devices, without requiring maintenance for battery substitutions. However, the inherent unpredictability regarding the amount of energy that can be collected from the environment might cause temporary energy shortages, which might …

Adsorption Of Particles On Fluid-Liquid Interfaces, Bhavin Dalal

Dissertations

Particles floating on fluid-liquid interfaces are of considerable interest because of their importance in a range of physical applications and biological processes, e.g., self-- assembly of particles at fluid-fluid interfaces resulting in novel nano structured materials, stabilization of emulsions, formation of pollen and insect egg rafts, etc. The aim of this dissertation is to explore the mechanism by which particles are adsorbed at fluid-liquid interfaces. It is shown that the inertia of a particle plays an important role in its motion in the direction normal to a fluid-liquid interface, and in determining the particles adsorption trajectory and orientation in …