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Articles 1231 - 1260 of 2086

Full-Text Articles in Engineering

Effects Of Bit Type On Maximum Torque And Axial Force Using Manual Screwdrivers, Mark Hickok Oct 2013

Effects Of Bit Type On Maximum Torque And Axial Force Using Manual Screwdrivers, Mark Hickok

Master's Theses (2009 -)

The screwdriver is a tool that has been among the most widely used hand tools for decades and continues to be used in the workplace to perform a variety of fastening tasks. Advancements in fastener technology have been complemented by the development of new types of screwdriver bits. While designs may vary, so do the force application requirements placed on the tool user. The primary objective of this experiment is to analyze the relationship between user torque and screwdriver bit design. A further objective is to utilize the results to develop an effort metric by which bits of different designs …


Characterization Of Stator Winding Short-Circuit Faults In Interior Permanent-Magnet Motor-Drive Systems, Andrew Strandt Oct 2013

Characterization Of Stator Winding Short-Circuit Faults In Interior Permanent-Magnet Motor-Drive Systems, Andrew Strandt

Master's Theses (2009 -)

This thesis contains a comprehensive analysis of experimental data collected from a case-study interior permanent-magnet electric machine experiencing winding short-circuit faults of varying severity. The experimental data collected from the faulted machine is from both motoring operation energized by a PWM sensorless ac drive as well as generating operation driven by the test bed dynamometer with a resistive winding load. For both modes of operation a complete set of three-phase voltage and current signals was recorded and analyzed. The three fault diagnosis techniques applied and compared regarding their ability to diagnose and prognosticate a winding fault in an interior permanent-magnet …


Ion Exchange Nutrient Recovery From Municipal Wastewater, Allen Williams Oct 2013

Ion Exchange Nutrient Recovery From Municipal Wastewater, Allen Williams

Master's Theses (2009 -)

Nitrogen and phosphorus discharge is regulated due to eutrophication. Typically ammonium-nitrogen is removed through nitrification which requires energy and phosphorus (P) is removed by metal salt addition to precipitate P. A more sustainable approach may be to implement nutrient recovery to form fertilizers. Most nitrogen fertilizer is formed through the energy intensive Haber-Bosch process. Phosphate rock, a limited resource, is mined for P fertilizer. Discharge regulations and the fertilizer production costs provide an economic driver for recovery. The current project used anionic and cationic ion exchange (IX) to concentrate the nutrients with recovery by struvite precipitation. Previous work lacks direct …


Supraspinal Control Of Unilateral Locomotor Performance: An Fmri Study Using A Custom Pedaling Device, Brett Arand Oct 2013

Supraspinal Control Of Unilateral Locomotor Performance: An Fmri Study Using A Custom Pedaling Device, Brett Arand

Master's Theses (2009 -)

This study aimed to develop a novel unilateral pedaling device, validate its function, and use it in an fMRI study of bilateral vs. unilateral locomotor control. The new device is MRI compatible and allows for conventional coupled bilateral pedaling, along with decoupled unilateral pedaling. It was designed with an assistance mechanism to simulate the presence of the non-contributing leg while pedaling unilaterally. During coupled bilateral pedaling, the two legs work in unison: while one leg is extending in the downstroke, it provides support to lift the other leg back up as it is flexing in the upstroke. The device uses …


Quantification Of Local Hemodynamic Alterations Caused By Virtual Implantation Of Three Commercially-Available Stents For The Treatment Of Aortic Coarctation, Sung Kwon Oct 2013

Quantification Of Local Hemodynamic Alterations Caused By Virtual Implantation Of Three Commercially-Available Stents For The Treatment Of Aortic Coarctation, Sung Kwon

Master's Theses (2009 -)

Patients with coarctation of the aorta (CoA) are prone to morbidity including atherosclerotic plaque that has been shown to correlate with altered wall shear stress (WSS) in the descending thoracic aorta (dAo). We created the first patient-specific computational fluid dynamics (CFD) model of a CoA patient treated by Palmaz stenting, and compared resulting WSS distributions to those from virtual implantation of the NumedCP and GenesisXD stents also commonly used for CoA. CFD models were created from magnetic resonance, fluoroscopy and blood pressure (BP) data. Simulations incorporated vessel deformation, downstream vascular resistance and compliance to match measured data and generate blood …


Numerical Simulation Model On Irreversibility Of Shock-Wave Process, Longhao Huang Oct 2013

Numerical Simulation Model On Irreversibility Of Shock-Wave Process, Longhao Huang

Master's Theses (2009 -)

The objective of this research is to develop a better understanding of the irreversibilities associated with the shock compaction of matter, especially as a result of impact. Due to complex shock processes, experimentation alone cannot fix the material state, since properties such as internal energy, entropy as well as the shock process are not measurable. Thus, in addition to experimentation, analytical and numerical methods are also used to completely characterize the shock process, although they are restricted by underlying constitutive assumptions. Instead of using artificial irreversibility, such as artificial viscosity to simplify and stabilize the numeric shock model, this work …


Characterization Of Two-Dimensional Oculomotor Control During Goal-Directed Eye Movements In Humans, Vincent Dang Oct 2013

Characterization Of Two-Dimensional Oculomotor Control During Goal-Directed Eye Movements In Humans, Vincent Dang

Master's Theses (2009 -)

Oculomotor control is a subset of sensorimotor control that allows humans to make extremely accurate eye movements for ADL. Impairments to oculomotor control can increase the impact of sensorimotor control deficits, especially in neurodegenerative diseases such as MS. Here, a two-dimensional computational control system of saccades and smooth-pursuit eye movements was compiled from literature to systematically characterize oculomotor control in eight visually-healthy humans as a precursor to studying the relationship between oculomotor and sensorimotor control in patient populations. Subjects visually tracked a single dot on a 41 x 30.5 cm monitor in a dark room while eye positions were recorded …


An Investigation Of Phase-Change Effects During Rapid Compression Machine Experiments, Colin Banyon Oct 2013

An Investigation Of Phase-Change Effects During Rapid Compression Machine Experiments, Colin Banyon

Master's Theses (2009 -)

Rapid compression machines (RCMs) are well characterized laboratory scale devices capable of achieving internal combustion (IC) engine relevant thermodynamic environments. These machines are often used to collect ignition delay times as targets for gas-phase chemical kinetic fuel autoigntion models. Modern RCMs utilize creviced piston(s) to improve charge homogeneity and allow for an adequate validation of detailed chemistry mechanisms against experiments using computationally efficient, homogeneous reactor models (HRMs). Conventionally, experiments are preformed by introducing a premixed gas of fuel + oxidizer + diluent into the machine, which is compressed volumetrically via a piston. Experiments investigating low-vapor pressure fuels (e.g. diesels, biodiesels, …


Anaerobic Co-Digestion Planning And Research For Green Bay, Wi, Jonathan Kusowski Oct 2013

Anaerobic Co-Digestion Planning And Research For Green Bay, Wi, Jonathan Kusowski

Master's Theses (2009 -)

The aspiration to find an alternative sustainable fuel source is an ever growing concern. Anaerobic digestion might hold the answer to finding an alternative sustainable energy source. Anaerobic digestion does not only provide a renewable resource in the form of biogas, but also stabilizes wastes, preventing large amounts from being landfilled or incinerated. Anaerobic digestion of municipal wastewater sludges can often be improved by the addition of high strength industrial wastes, in a process called co-digestion. High strength industrial wastes provide an additional carbon source for the microbes to utilize and convert into usable biogas. Co-digestion also offers the opportunity …


Comparison Of Three Space Vector Pwm Methods For A Three-Level Inverter With A Permanent Magnet Machine Load, Alia Rebecca Strandt Oct 2013

Comparison Of Three Space Vector Pwm Methods For A Three-Level Inverter With A Permanent Magnet Machine Load, Alia Rebecca Strandt

Master's Theses (2009 -)

Much work exists on multilevel space vector pulse width modulation (PWM) to drive induction machines, in which the rotor currents are induced by stator rotating field effects. However, there are few investigations that analyze these modulation methods applied to permanent magnet (PM) and wound-field synchronous machines, in which the rotor induces a back emf in the stator. In this thesis, three different three-level space vector PWM switching sequences are applied to a three-level neutral-point-clamped (NP) inverter driving an internal permanent magnet (IPM) machine load. The inherent qualities of each of the switching sequences when under the influence of a forcing …


Developing Mhealth Solutions For Natural Family Planning, Md Miftah Uddin Oct 2013

Developing Mhealth Solutions For Natural Family Planning, Md Miftah Uddin

Master's Theses (2009 -)

Natural Family Planning (NFP) is a method to help couples determine the fertile and infertile times of a woman’s menstrual cycle with natural indicators of fertility. NFP methods have advantages over other methods of family planning. Proper use of NFP methods also ensures high effectiveness (close to 98%) in helping couples avoid pregnancy. However, very few physicians prescribe NFP to their patients due to lack of credibility to the fertility methods and lack of access to NFP knowledge. The Marquette University College of Nursing Institute for Natural Family Planning has been researching for many years to increase knowledge and efficiency …


Automation Of Energy Demand Forecasting, Sanzad Siddique Oct 2013

Automation Of Energy Demand Forecasting, Sanzad Siddique

Master's Theses (2009 -)

Automation of energy demand forecasting saves time and effort by searching automatically for an appropriate model in a candidate model space without manual intervention. This thesis introduces a search-based approach that improves the performance of the model searching process for econometrics models. Further improvements in the accuracy of the energy demand forecasting are achieved by integrating nonlinear transformations within the models. This thesis introduces machine learning techniques that are capable of modeling such nonlinearity. Algorithms for learning domain knowledge from time series data using the machine learning methods are also presented. The novel search based approach and the machine learning …


Applying An Improved Mrps-Gmm Method To Detect Temporal Patterns In Dynamic Data System, Shaobo Wang Oct 2013

Applying An Improved Mrps-Gmm Method To Detect Temporal Patterns In Dynamic Data System, Shaobo Wang

Master's Theses (2009 -)

The purpose of this thesis is to introduce an improved approach for the temporal pattern detection, which is based on the Multivariate Reconstructed Phase Space (MRPS) and the Gaussian Mixture Model (GMM), to overcome the disadvantage caused by the diversity of shapes among different temporal patterns in multiple nonlinear time series. Moreover, this thesis presents an applicable software program developed with MATLAB for users to utilize this approach. A major study involving dynamic data systems is to understand the correspondence between events of interest and predictive temporal patterns in the output observations, which can be used to develop a mechanism …


Admittance Selection For Force Guided Assembly With Optimal Motion, Fernando Rodriguez Anton Oct 2013

Admittance Selection For Force Guided Assembly With Optimal Motion, Fernando Rodriguez Anton

Master's Theses (2009 -)

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Current robots lack the precise relative positioning necessary to complete automatic assembly tasks. Several solutions have been proposed. Some approaches use complex vision and force sensing systems to generate corrective motion if misalignment is present in the assembly task. Other solutions rely on generating elastic behavior, known as compliance, between the end eector and the held movable part. This compliant mechanism helps guide the movable part of the assembly into its proper position. The project focuses on designing a process by which passive compliant systems can achieve successful assembly for a range of misalignment and generate error-reducing motion that …


Theoretical Analysis Of Torsionally Vibrating Microcantilevers For Chemical Sensor Applications In Viscous Liquids, Tao Cai Oct 2013

Theoretical Analysis Of Torsionally Vibrating Microcantilevers For Chemical Sensor Applications In Viscous Liquids, Tao Cai

Dissertations (1934 -)

Dynamically driven microcantilevers excited in the transverse (or out-of-plane) direction are widely used as highly sensitive chemical sensing platforms in various applications. While these devices work very well in air, their performance in liquids is not efficient because of the combination of increased viscous damping and effective fluid mass. In order to improve the characteristics of microcantilevers in liquid environments, some other vibration modes such as the torsional mode and lateral (or in-plane) flexural mode have been proposed.
In this work, the characteristics of torsionally vibrating rectangular microcantilevers with length L, width b and thickness h in viscous liquids are …


Dynamic Balance Control During Treadmill Walking In Chronic Stroke Survivors, Eric Richard Walker Oct 2013

Dynamic Balance Control During Treadmill Walking In Chronic Stroke Survivors, Eric Richard Walker

Dissertations (1934 -)

Maintaining dynamic balance is an important component of walking function that is likely impaired in chronic stroke survivors, evidenced by an increased prevalence of falls. Dynamic balance control requires maintaining the center of mass (COM) within the base of support during movement. During walking, dynamic balance control is achieved largely by modifying foot placement to adjust the base of support. However, chronic stroke survivors have difficulty with both precision control of foot placement, as well as reduced control of COM movement. The objective of this dissertation was to characterize dynamic balance control strategies during walking in chronic stroke survivors. Additionally, …


Theoretical Analysis Of Laterally Vibrating Hammerhead Microcantilever Sensors In A Viscous Liquid, Jinjin Zhang Oct 2013

Theoretical Analysis Of Laterally Vibrating Hammerhead Microcantilever Sensors In A Viscous Liquid, Jinjin Zhang

Dissertations (1934 -)

Dynamically driven prismatic microcantilevers excited in the in-plane flexural mode have been investigated and used in liquid-phase sensing applications. However, the performance is restricted due to their limited surface sensing area and higher stiffness in shorter and wider prismatic microcantilevers. To increase the surface sensing area, and further improve sensing characteristics, it has been proposed to investigate symmetric hammerhead microcantilevers vibrating laterally in viscous liquid media. In this work, a theoretical model is proposed and the characteristics of the microcantilevers with symmetric shaped hammerheads (isosceles trapezoid, semi-circle, uniform rectangle and composite rectangle) are investigated. In the analysis, the stem of …


Industrial Symbiosis: Corn Ethanol Fermentation, Hydrothermal Carbonization, And Anaerobic Digestion, Patrick J. Mcnamara, Lindsey R. Jader, Frederick J. Schendel, Nicholas J. Hahn, Brandon M. Wood, Kenneth J. Valentas, Paige M. Novak, Steven J. Heilmann Oct 2013

Industrial Symbiosis: Corn Ethanol Fermentation, Hydrothermal Carbonization, And Anaerobic Digestion, Patrick J. Mcnamara, Lindsey R. Jader, Frederick J. Schendel, Nicholas J. Hahn, Brandon M. Wood, Kenneth J. Valentas, Paige M. Novak, Steven J. Heilmann

Civil and Environmental Engineering Faculty Research and Publications

The production of dry-grind corn ethanol results in the generation of intermediate products, thin and whole stillage, which require energy-intensive downstream processing for conversion into commercial animal feed products. Hydrothermal carbonization of thin and whole stillage coupled with anaerobic digestion was investigated as alternative processing methods that could benefit the industry. By substantially eliminating evaporation of water, reductions in downstream energy consumption from 65% to 73% were achieved while generating hydrochar, fatty acids, treated process water, and biogas co-products providing new opportunities for the industry. Processing whole stillage in this manner produced the four co-products, eliminated centrifugation and evaporation, and …


Characterization And Limitations Of Diffusion Tensor Imaging Metrics In The Cervical Spinal Cord In Neurologically Intact Subjects, Aditya Vedantam, Michael B. Jirjis, Brian D. Schmit, Marjorie C. Wang, John L. Ulmer, Shekar N. Kurpad Oct 2013

Characterization And Limitations Of Diffusion Tensor Imaging Metrics In The Cervical Spinal Cord In Neurologically Intact Subjects, Aditya Vedantam, Michael B. Jirjis, Brian D. Schmit, Marjorie C. Wang, John L. Ulmer, Shekar N. Kurpad

Biomedical Engineering Faculty Research and Publications

Purpose

To characterize diffusion tensor imaging (DTI) metrics across all levels of the cervical spinal cord (CSC) and to study the impact of age and signal quality on these metrics.

Materials and Methods

DTI metrics were calculated for gray matter (GM) and white matter (WM) funiculi throughout the CSC (C1–T1) in 25 healthy subjects (22-85 years old). Signal-to-noise ratios (SNRs) and mean DTI metrics were measured for the upper (C1-3), middle (C4-6) and lower (C7-T1) cervical segments. Age-related changes in DTI metrics were analyzed for the individual segment groups.

Results

Fractional anisotropy (FA), mean diffusivity (MD) and transverse apparent diffusion …


Effect Of Tilt Sensor Versus Heel Loading On Neuroprosthesis Stimulation Reliability And Timing For Individuals Post-Stroke During Level And Non- Level Treadmill Walking, M. Barbara Silver-Thorn Oct 2013

Effect Of Tilt Sensor Versus Heel Loading On Neuroprosthesis Stimulation Reliability And Timing For Individuals Post-Stroke During Level And Non- Level Treadmill Walking, M. Barbara Silver-Thorn

Biomedical Engineering Faculty Research and Publications

Study background: Non-level walking may adversely affect stimulation of neuroprostheses as initial programming is performed during level walking. The objectives of this study were to assess stimulation reliability of tilt and heel sensor-based neuroprosthesis stimulation during level and non-level walking, examine stimulation initiation and termination timing during level and non-level walking, and determine whether heel or tilt sensor-based stimulation control is more robust for non-level ambulation. Methods: Eight post-stroke individuals with drop foot who were able to actively ambulate within the community were selected for participation. Each subject acclimated to the neuroprosthesis and walked on a treadmill randomly positioned in …


Neural Dynamics Of Phonological Processing In The Dorsal Auditory Stream, Einat Liebenthal, Merav Sabri, Scott A. Beardsley, Jain Mangalathu-Arumana, Anjali Desai Sep 2013

Neural Dynamics Of Phonological Processing In The Dorsal Auditory Stream, Einat Liebenthal, Merav Sabri, Scott A. Beardsley, Jain Mangalathu-Arumana, Anjali Desai

Biomedical Engineering Faculty Research and Publications

Neuroanatomical models hypothesize a role for the dorsal auditory pathway in phonological processing as a feedforward efferent system (Davis and Johnsrude, 2007; Rauschecker and Scott, 2009; Hickok et al., 2011). But the functional organization of the pathway, in terms of time course of interactions between auditory, somatosensory, and motor regions, and the hemispheric lateralization pattern is largely unknown. Here, ambiguous duplex syllables, with elements presented dichotically at varying interaural asynchronies, were used to parametrically modulate phonological processing and associated neural activity in the human dorsal auditory stream. Subjects performed syllable and chirp identification tasks, while event-related potentials and …


A Review Of Micro-Contact Physics For Microelectromechanical Systems (Mems) Metal Contact Switches, Benjamin F. Toller, Ronald A. Coutu Jr., John W. Mcbride Sep 2013

A Review Of Micro-Contact Physics For Microelectromechanical Systems (Mems) Metal Contact Switches, Benjamin F. Toller, Ronald A. Coutu Jr., John W. Mcbride

Electrical and Computer Engineering Faculty Research and Publications

Innovations in relevant micro-contact areas are highlighted, these include, design, contact resistance modeling, contact materials, performance and reliability. For each area the basic theory and relevant innovations are explored. A brief comparison of actuation methods is provided to show why electrostatic actuation is most commonly used by radio frequency microelectromechanical systems designers. An examination of the important characteristics of the contact interface such as modeling and material choice is discussed. Micro-contact resistance models based on plastic, elastic-plastic and elastic deformations are reviewed. Much of the modeling for metal contact micro-switches centers around contact area and surface roughness. Surface roughness and …


Validation Of Earthquake Simulations And Their Effects On Tall Buildings Considering Spectral Shape And Duration, Ting Lin, Gregory Deierlein, Nenad Bijelic Sep 2013

Validation Of Earthquake Simulations And Their Effects On Tall Buildings Considering Spectral Shape And Duration, Ting Lin, Gregory Deierlein, Nenad Bijelic

Civil and Environmental Engineering Faculty Research and Publications

No abstract provided.


Changes In Hemodynamic Responses In Chronic Stroke Survivors Do Not Affect Fmri Signal Detection In A Block Experimental Design, Nutta-On Promjunyakul, Brian D. Schmit, Sheila Schindler-Ivens Sep 2013

Changes In Hemodynamic Responses In Chronic Stroke Survivors Do Not Affect Fmri Signal Detection In A Block Experimental Design, Nutta-On Promjunyakul, Brian D. Schmit, Sheila Schindler-Ivens

Physical Therapy Faculty Research and Publications

The use of canonical functions to model BOLD-fMRI data in people post-stroke may lead to inaccurate descriptions of task-related brain activity. The purpose of this study was to determine whether the spatiotemporal profile of hemodynamic responses (HDRs) obtained from stroke survivors during an event-related experiment could be used to develop individualized HDR functions that would enhance BOLD-fMRI signal detection in block experiments. Our long term goal was to use this information to develop individualized HDR functions for stroke survivors that could be used to analyze brain activity associated with locomotor-like movements. We also aimed to examine the reproducibility of HDRs …


Hypoxia Preconditioning Increases Survival And Decreases Expression Of Toll-Like Receptor 4 In Pulmonary Artery Endothelial Cells Exposed To Lipopolysaccharide, Irshad Ali, Rahul Nanchal, Fouad Husnain, Said H. Audi, G. Ganesh Konduri, John C. Densmore, Meetha Medhora, Elizabeth R. Jacobs Sep 2013

Hypoxia Preconditioning Increases Survival And Decreases Expression Of Toll-Like Receptor 4 In Pulmonary Artery Endothelial Cells Exposed To Lipopolysaccharide, Irshad Ali, Rahul Nanchal, Fouad Husnain, Said H. Audi, G. Ganesh Konduri, John C. Densmore, Meetha Medhora, Elizabeth R. Jacobs

Biomedical Engineering Faculty Research and Publications

Pulmonary or systemic infections and hypoxemic respiratory failure are among the leading causes of admission to intensive care units, and these conditions frequently exist in sequence or in tandem. Inflammatory responses to infections are reproduced by lipopolysaccharide (LPS) engaging Toll-like receptor 4 (TLR4). Apoptosis is a hallmark of lung injury in sepsis. This study was conducted to determine whether preexposure to LPS or hypoxia modulated the survival of pulmonary artery endothelial cells (PAECs). We also investigated the role TLR4 receptor expression plays in apoptosis due to these conditions. Bovine PAECs were cultured in hypoxic or normoxic environments and treated with …


Profile Synthesis Of Planar Variable Joints, Brian James Slaboch Sep 2013

Profile Synthesis Of Planar Variable Joints, Brian James Slaboch

Dissertations (1934 -)

Reconfigurable mechanisms provide quick changeover and reduced costs for low volume manufacturing applications. In addition, these mechanisms provide added flexibility in the context of a constrained environment. A subset of planar reconfigurable mechanisms use variable joints to provide this added adaptability.

In this dissertation, the profile synthesis of planar variable joints that change from a rotational motion to a translational motion was investigated. A method was developed to perform automated profile synthesis. It was shown that combinations of higher variable joints can be used to create kinematically equivalent variable joints that are geometrically different.

The results were used to create …


Novel Paradigms For Visual Field Mapping With Functional Magnetic Resonance Imaging, Yan Ma Sep 2013

Novel Paradigms For Visual Field Mapping With Functional Magnetic Resonance Imaging, Yan Ma

Dissertations (1934 -)

The overall goal of this study is to evaluate the existing, and develop new visual field mapping paradigms, which consist of visual stimulation scheme, post-processing and displaying tools using fMRI for both research and clinical applications.

We first directly compared phase mapping and random multifocal mapping paradigms with respect to clinically relevant factors. Multifocal mapping was superior in immunity to noise and was able to accurately decompose the response of single voxels to multiple stimulus locations. In contrast, phase mapping activated more extrastriate visual areas and was more efficient per run in achieving a statistically efficient response in a minimum …


How Industry Benefits From Student Design, Jay R. Goldberg Sep 2013

How Industry Benefits From Student Design, Jay R. Goldberg

Biomedical Engineering Faculty Research and Publications

No abstract provided.


Ex Vivo Diffusion Tensor Imaging Of Spinal Cord Injury In Rats Of Varying Degrees Of Severity, Michael Jirjis, Shekar N. Kurpad, Brian D. Schmit Sep 2013

Ex Vivo Diffusion Tensor Imaging Of Spinal Cord Injury In Rats Of Varying Degrees Of Severity, Michael Jirjis, Shekar N. Kurpad, Brian D. Schmit

Biomedical Engineering Faculty Research and Publications

The aim of this study was to characterize magnetic resonance diffusion tensor imaging (DTI) in proximal regions of the spinal cord following a thoracic spinal cord injury (SCI). Sprague–Dawley rats (n = 40) were administered a control, mild, moderate, or severe contusion injury at the T8 vertebral level. Six direction diffusion weighted images (DWIs) were collected ex vivo along the length of the spinal cord, with an echo/repetition time of 31.6 ms/14 sec and b = 500 sec/mm2. Diffusion metrics were correlated to hindlimb motor function. Significant differences were found for whole cord region of interest (ROI) drawings for fractional …


Outer Retinal Structure In Best Vitelliform Macular Dystrophy, David B. Kay, Megan E. Land, Robert F. Cooper, Adam M. Dubis, Pooja Godara, Alfredo Dubra, Joseph Carroll, Kimberly E. Stepien Sep 2013

Outer Retinal Structure In Best Vitelliform Macular Dystrophy, David B. Kay, Megan E. Land, Robert F. Cooper, Adam M. Dubis, Pooja Godara, Alfredo Dubra, Joseph Carroll, Kimberly E. Stepien

Biomedical Engineering Faculty Research and Publications

Importance Demonstrating the utility of adaptive optics scanning light ophthalmoscopy (AOSLO) to assess outer retinal structure in Best vitelliform macular dystrophy (BVMD).

Objective To characterize outer retinal structure in BVMD using spectral-domain optical coherence tomography (SD-OCT) and AOSLO.

Design, Setting, and Participants Prospective, observational case series. Four symptomatic members of a family with BVMD with known BEST1 mutation were recruited at the Advanced Ocular Imaging Program research lab at the Medical College of Wisconsin Eye Institute, Milwaukee.

Intervention Thickness of 2 outer retinal layers corresponding to photoreceptor inner and outer segments was measured using SD-OCT. Photoreceptor mosaic AOSLO images within …