Engineering Commons^™

Adhesives From Biomass Pyrolysis, Dongbing Li, Franco Berruti, Cedric Briens

5th International Congress on Green Process Engineering (GPE 2016)

Fast pyrolysis of waste biomass with high lignin content, such as birch wood, birch bark, hydrolysis lignin, kraft lignin or low-cost digestate from biogas production, provides oils that can be substituted for phenol in phenol-formaldehyde resins. Biomass fast pyrolysis was performed in a dedicated fluidized bed pyrolyzer that incorporated two crucial innovations: a fractional condensation train provided dry bio-oils with ~1% of moisture and much reduced acidity; autothermal pyrolysis with partial oxidation reduces operating and capital costs, as well as increasing the quality of the dry bio-oil. Dry bio-oil obtained from autothermal fast pyrolysis of kraft lignin can be used …

Performance And Emissions Of A Diesel Engine Fueled With Biodiesel Doped With A Renewable Antioxidant Additive, Alberto Gonzalo, Jorge Arroyo, Francisco Moreno, Mariano Muñoz, Carlos Monné, Ana Bautista, Noemí Gil-Lalaguna, Cristina Dueso, José Luis Sánchez

5th International Congress on Green Process Engineering (GPE 2016)

1. INTRODUCTION

Biodiesel is a mixture of alkyl esters obtained by transesterification of vegetable oils and animal fats with a short chain alcohol (mainly methanol or ethanol) and catalyzed by acids or bases (usually NaOH or KOH) [1]. Final properties of the biodiesel are similar to those of petroleum derived-diesel. Therefore, biodiesel can be used in diesel conventional engines without significant modifications or mixed in any proportion with fossil diesel.

Some of the main drawbacks of biodiesel to be used as fuel are the low oxidation stability and poor cold flow properties (freezing point and flowability of the …

Hydrothermal Treatment Of Bio-Oil For The Production Of Biodiesel Antioxidants, Noemí Gil-Lalaguna, Ana Bautista, Lucía Botella, Alberto Gonzalo, José Luis Sánchez, Jesús Arauzo

5th International Congress on Green Process Engineering (GPE 2016)

1. INTRODUCTION

Fuel consumption is inevitable for industrial development and growth of any country. In the last years, diesel fuels have gained an increasingly important role in the transportation sector. However, the rapid depletion of crude oil resources, as well as the worldwide concern about the environmental damage related to the increase in the emissions of carbon dioxide and other pollutants, has led to an increasing awareness about the development and use of renewable fuels. In this context, biodiesel appears as a good alternative to fossil diesel because of its renewable and biodegradable character, also being a non-toxic and clean fuel …

The Integrated Forest Biorefinery, An Example Of Green Engineering, Miyuru Kannangara, Mariya Marinova, Michel Perrier, Jean Paris

5th International Congress on Green Process Engineering (GPE 2016)

1. Introduction

Confronted by a steady decline in the demand for commodity papers, the pulp and paper industry has undertaken intensive R&D efforts to identify and develop new non paper products that could be manufactured from the forest biomass. The components of wood that can be separated and converted into new non paper products are the cellulose, hemicelluloses and lignin. Celluloses and hemicelluloses are polymers of various sugars and lignin is a polymer of phenylpropane units. This paper treats the specific case of lignin and hemicellulose extraction from a Kraft pulping process. Two processes have been investigated for the extraction …

Two-Stage Thermochemical Valorisation Of Sugar-Derived Humins, Paul De Wild

5th International Congress on Green Process Engineering (GPE 2016)

The majority of commercial bulk chemicals is still derived from fossil resources. The development of green biobased chemicals is high on the global research and development agenda. Lignocellulosic biomass and particularly the cellulose and hemicellulose fraction are considered interesting feeds for the production of key bulk chemicals to serve as building blocks for the chemical industry. Efficient chemo-catalytic conversion technologies for C5 and C6 sugars are under development to generate selected existing bulk chemicals, such as Levulinic acid (LA), caprolactam (CAP), butadiene (BD), furfural and 5-hydroxymethylfurfural (HMF), a very promising platform chemical for the synthesis of a.o. novel monomers for …

Process For Removal And Recovery Of Phenolic Compounds From Switchgrass, Robert M. Counce, Nikki Labbé, Michelle L. Lehmann, Jack S. Watson, Jingming Tao

5th International Congress on Green Process Engineering (GPE 2016)

Introduction

This paper describes a process for the separation and recovery of non-structural phenolic compounds from switchgrass. This process is proposed as a preliminary step of a biorefinery incorporating the organosolv process for biomass fractionation. The economics of such an addition to separate and recover phenolic compounds is then investigated.

Switchgrass has been selected as a dedicated feedstock for bioprocesses producing liquid fuels such as ethanol and advanced fuels. The University of Tennessee has been heavily involved in the development of switchgrass as one of the feedstocks for bioenergy production in the southeast (Tiller 2011). Biofuels have the potential to …

Marketable Bioproducts And Biomaterials From Research To Commercial Manufacture For Sustainability, Greenhouse Gas Emission Reductions And A Circular Economy, Richard Jewell

5th International Congress on Green Process Engineering (GPE 2016)

Enerkem produces clean fuels and green chemicals from waste with improved economics and greater sustainability than technologies that rely on fossil sources. Enerkem’s technology converts non-recyclable municipal solid waste, such as household garbage, into clean fuels and renewable chemicals.

Enerkem develops and delivers biorefineries in North America and globally, using internal process engineering groups to develop and build biorefineries that are modular and standardize plant fabrication and manufacturing.

The success of Enerkem’s process engineering acumen is demonstrated in Enerkems rollout of the world’s first commercial biorefinery to use municipal solid waste feedstock to produce methanol and ethanol. This facility, called …

Fundamental Study And Applications To Biomass Pyrolysis Of The Mechanically Fluidized Reactor, Valentina Lago, Franco Berruti, Cedric Briens

5th International Congress on Green Process Engineering (GPE 2016)

Lignin has great potential for the production of aromatics currently derived from petroleum, since it is the most abundant source of aromatics in nature. At present, Kraft lignin is used as fuel within the pulping process but, alternatively, it could be converted to high-value chemicals using thermochemical processes such as pyrolysis. Kraft lignin, however, is a very cohesive and thermally sensitive powder with foaming and agglomerating tendency under reaction conditions. Consequently, a novel reactor design, designated as Mechanically Fluidized Reactor (MFR) has been developed to successfully process Kraft lignin.

Please click Additional Files below to see the full abstract.

Using The Jiggled Bed Reactor To Develop Activated Carbons From Biomass Residues, Anastasia Colomba, Franco Berruti, Cedric Briens

5th International Congress on Green Process Engineering (GPE 2016)

Activated carbons are the most used adsorbent material. Their applications range from wastewater treatment, air purification, removal of contaminants and many others. According to “Global Activated Carbon Market Forecast & Opportunities 2017”, the demand for activated carbon is expected to increase more than 10% per year for the next 5 years to make it a $3 billion market by 2017. Current processes for the production of activated carbons from renewable resources do not provide valuable co-products. This presentation focuses on the conversion to activated carbon of the bio-char co-product of the pyrolysis process. Pyrolysis also provides valuable bio-oil, which is …

Vaccination As A Tool To Reduce Antimicrobial Resistance Worldwide, Bernard Vallat, Elisabeth Erlacher

Vaccine Technology VI

Antimicrobial resistance is a global human and animal health concern that is influenced by the non-appropriate use of antimicrobial agents in both human and veterinary medicine, as well as in the plant sector. To combat antimicrobial resistance, the World Organisation for Animal health (OIE) has developed science-based intergovernmental standards and guidelines covering terrestrial animals and aquaculture.

The OIE also contributed to the development of the WHO Global Action Plan on Antimicrobial Resistance, adopted in 2015 by the World Health Assembly. The 180 Member Countries of the OIE expressed their support to this plan of action through a Resolution, …

Plant-Based Technologies To Enable Rapid Response To Ebola Outbreak, Jerzy Karczewski, Vidadi Yusibov

Vaccine Technology VI

Ebola is a rare and deadly disease caused by infection with a strain of Ebola virus (Zaire, Sudan or Marburg). Ebola is spread through a direct contact with body fluids of infected patients. The recent Ebola outbreak affected multiple countries in West Africa and clearly demonstrated a need for development of technologies enabling production of adequate supply of vaccines and therapeutics to treat infected patients. We have undertaken efforts to develop methods and produce plant-based recombinant vaccine as well as a series of monoclonal antibodies to fight Ebola infection.

Several approaches were carried out to develop vaccines based on recombinant …

How To Deliver New Vaccines Under Very Short Timelines: The Zapi Project, Jean-Christophe Audonnet

Vaccine Technology VI

The ZAPI project is the first One Health project in the European Innovative Medicine Initiative (IMI) program. Its objective is to define and validate unique methodologies that can be applied when new zoonotic infectious diseases will occur in Europe or other regions of the world. The project is supporting an entirely new approach for “anticipating the unexpected”, and is defining new ways to alleviate the technical constraints which are typically encountered with the classical vaccine development processes.

The ZAPI project involves a total of 20 partners, from academic, biotech, and industry origin. One important feature of ZAPI is that it …

Development, Manufacturing, And Supply Of Msd’S Ebola Vaccine, Jeffrey T. Blue

Vaccine Technology VI

Ebola was first discovered in 1976 and is a member of the filoviridae family of viruses. There are multiple strains of Ebola and infection can lead to hemorrhagic fever and death. In March 2014, a historic Ebola outbreak occurred in three Western African countries, Guinea, Liberia, and Sierra Leone. Over 28,000 cases were reported and led to more than 11,000 deaths, more than ten times the amount of cases compared to all past outbreaks combined. On August 8^th 2014, the World Health Organization declared a Public Health Emergency of International Concern (PHEIC). Merck Sharp & Dohme (MSD) partnering with …

Improving Global Human Health Through Norovirus Virus-Like Particle Manufacturing, Scot Shepard

Vaccine Technology VI

Norovirus infection is the most common cause of acute gastroenteritis in the U.S., estimated to afflict 21 million people per year. For scale-up manufacturing of a norovirus vaccine candidate, the baculovirus expression system has been used in 1000 L working volume stirred-tank bioreactors for production of two distinct norovirus virus-like particles (VLP). Downstream processing using methods for enveloped virus inactivation and a series of orthogonal chromatography steps results in norovirus VLP that contain low residual levels of host-cell protein, host cell and baculovirus DNA, and are free of replicating baculovirus. Emphasis has been placed on employing single-use technologies including disposable …

Session V: Getting Vaccines To The Market: Case Studies, Rebecca Sheets, Grimalkin Partners, Danilo Casimiro

Vaccine Technology VI

This is a presentation of Session V.

(No Abstract)

Determining Whether Adsorption State Is A Critical Attribute In Aluminum Adjuvanted Vaccines, Garry Morefield

Vaccine Technology VI

Aluminum based adjuvants have a long history of safe and effective use in vaccine products. When developing vaccine formulations incorporating aluminum adjuvants it is important to understand whether adsorption state is a critical attribute of the vaccine. Investigations initiate with obtaining an understanding of how the antigen of interest interacts with aluminum adjuvant surfaces. The balance of attractive versus repulsive interaction forces (including electrostatic, ligand exchange, and hydrophobic interactions) determines the resulting adsorption state of the antigen. Once the interaction of aluminum adjuvant and antigen is understood, formulations can be prepared along the spectrum of aluminum adjuvant surfaces to obtain …

Controlled, Pulsatile Release Of Thermostabilized Inactivated Polio Vaccine From Plga-Based Microspheres, Stephany Y. Tzeng, Rohiverth Guarecuco, Kevin J. Mchugh, Evan M. Rosenberg, Yingying Zeng, Robert Langer, Ana Jaklenec

Vaccine Technology VI

Many vaccines, such as the inactivated polio vaccine (IPV), must be administered in several doses for full efficacy. Because patient access is a major challenge for vaccination efforts in developing countries, administering multiple doses per patient is impractical in those areas. Single-administration vaccines would greatly improve efforts to vaccinate populations in Third World countries, and the World Health Organization (WHO) Expanded Program for Immunization describes an ideal vaccine as one that is heat-stable, requires only one shot, and is easy to administer. Although already existing technologies, such as microspheres composed of poly(lactic-co-glycolic acid) (PLGA), are able to encapsulate …

Development Of Typhax, A Salmonella Typhi Vi Polysaccharide Protein Capsular Matrix Vaccine, Kevin P. Killeen

Vaccine Technology VI

Matrivax Research & Development Corporation is researching and developing a novel technology termed Protein Capsular Matrix Vaccine (PCMV) as an alternative to polysaccharide-protein conjugate vaccines. In a PCMV, polysaccharide antigens are entrapped in a cross-linked protein ‘carrier’ matrix. This process is simpler than conjugate vaccines and should yield polysaccharide vaccines that elicit T_H-cell ‘memory’, are highly efficacious, and less expensive to manufacture.

Typhoid fever, caused by Salmonella enterica serovar Typhi, is a disease that afflicts ~16 million people worldwide, resulting in 600,000 deaths, annually. Although typhoid fever vaccines are commercially available, there are significant limitations. Ty21a is an …

Combining Doe With An Empirical Approach To Improve Vaccine Formulation Development, Jill Livengood, Tim Powell, Melissa Bushey

Vaccine Technology VI

Vaccine development and formulation is based upon understanding of the candidate’s target product profile, and leverages knowledge and experience in pharmaceutical products. Developing an optimal formulation takes into account factors such as ensuring route of administration, product stability, and identifying Quality Target Product Profiles that are suitable for the product’s intended use. Based upon such knowledge and experience, multiple excipient formulations may be first identified for initial screening. Achieving the QTPP is a measure of results, and can be achieved with screening formulations by aggressive accelerated stability study conditions to enable the final formulation components to be down-selected. This presentation …

Characterization Of Ha And Na-Containing Vlps Produced In Suspension Cultures Of Hek 293 Cells, Amine Kamen, Alina Venereo-Sanchez, Rénald Gilbert, Aziza Manceur, Parminder Chahal, Sven Ansorge, Wangxue Chen

Vaccine Technology VI

Virus like particles (VLPs) can be formulated into promising vaccines to prevent influenza infection. In addition of having a structure and composition that mimic the wild type virus, VLPs are safe since they are devoid of viral genes and consequently are not infectious. One approach to scale up the manufacturing of VLPs is to produce them in a serum-free suspension culture using a stable mammalian cell line. Importantly, with VLPs synthetized by mammalian cells, the post-translational modifications of the surface antigens should be similar to the wild type virus, and therefore should trigger a potent and specific immune response for …

Vaccines: Reaching For Higher Branches After The Low Hanging Fruit Has Been Picked, Michael G. Kurilla

Vaccine Technology VI

Vaccines represent one of the most significant advances by medicine in addressing infectious diseases being responsible for the elimination of a few and the virtual eradication of several other scourges. In addition, medicine is also beginning to appreciate the potential applicability of vaccines beyond infectious diseases to areas such as oncology. During any emerging infectious disease public health event, availability of a vaccine figures prominently in the assessment of the capability to address the threat most effectively. A more rapid deployment of new vaccines would enable more effective management of emerging threats. Efforts to streamline manufacture and production of vaccines …

Immunization With Surface Immunogenic Protein Induces A Decrease Of Vaginal Colonization By Group B Streptococcus In An Experimental Mouse Model, Jorge A. Soto, Abel E. Vasquez, Diego Diaz-Dinamarca, Daniel A. Soto, Robert Rojas, Alexis M. Kalergis

Vaccine Technology VI

The Group B streptococcus (GBS) is the leading cause of neonatal sepsis and meningitis in developed countries and an emerging pathogen in adults. A neonatal infection occurs predominantly during the delivery by either inhalation or ingestion of contaminated secretions of the mother’s vagina. Maternal screening by rectovaginal GBS colonization at 35–37 weeks of gestation, with subsequent intra-partum antibiotic prophylaxis (IAP) at the onset of labor, is implemented in some countries to prevent newborn invasive by GBS. Currently, there are not vaccines to prevent the devastating consequences of GBS and a glycoconjugate vaccine is under clinical experimentation (Clinical Trials Phase III). …

Conference Program (Vaccine Technology Vi), Laura A. Palomares, Tarit Mukhopadhyay, Manon Cox, Nathalie Garçon

Vaccine Technology VI

No abstract provided.

Production Of A Nanoplasmid™ With A Large Gene Insert Using The Hypergro™ Fermentation Process, Aaron Carnes, Neha Tiwari, Jill Beilowitz, Carlos Sampson, Dorothy Peterson, Jim Williams

Vaccine Technology VI

Plasmid based DNA vaccines are emerging as a promising alternative to traditional vaccines due to several advantages, including faster production of DNA plasmids using E. coli. However, further increases in transgene expression are needed to meet efficacy requirements for various non-viral gene therapy and DNA vaccination applications. While existing minicircle DNA technology has been shown to offer improved levels and durations of transgene expression by removal of the bacterial region from the plasmid, low manufacturing yields may be a barrier to widespread use of minicircle DNA for vaccination.

NTC’s minimalized Nanoplasmid™ vectors utilize RNA-OUT (R_OUT) antibiotic-free selection …

Life Cycle Assessment Of Low Cost Retrofit Options Of Educational Building Considering Renewable And Non‐Renewable Energies, Akram Avami, Atiyeh Soleimani Javid

Life Cycle Assessment and Other Assessment Tools for Waste Management and Resource Optimization

Commercial and building sectors account for 34% of total energy consumption in Iran. Increasing demand of the level of comfort along with population growth necessitate much more attention about energy requirements in the country. Such phenomenons have already raised concerns about the security of energy supply and heavy environmental impacts. These concerns can significantly be reduced by implementing retrofit options in existing buildings.

The Department of Energy Engineering of Sharif University of Technology is selected as the case study with 181KWh/m2 annual heating and cooling demand, 29 KWh/m2 annual lightening and 15 KWh/m2 electrical appliances energy demand. Environmental concerns are …

The Challenges Of Nuclear Waste Management From A Life Cycle Perspective, Andrea Paulillo, Stephen Palethorpe, Andrew M. Illiken, Roland Vclift, Paola Lettieri

Life Cycle Assessment and Other Assessment Tools for Waste Management and Resource Optimization

As nuclear industry grows and expands, the yearly amount of waste produced increases and it adds to the large quantity of nuclear wastes generated, and not yet disposed, in the last 50 years from existing plants. Consequently, the development of an international agreed policy to manage nuclear wastes is key to support such growth. Many countries, such as USA, Sweden, Canada, have opted for a direct disposal of Spent Nuclear Fuel (SNF) (Open Cycle); whilst others, such as the UK, Japan and France, have preferred reprocessing SNF (Closed Cycle). Other countries are yet to take a final decision (e.g. Spain, …

Lca Applied To Residual Organic Fertilizing Materials ‐ An Overview Of Substitution Methodological Options And Quantitative Substitution Rates, Marilys Pradel, Claire Déchaux

Life Cycle Assessment and Other Assessment Tools for Waste Management and Resource Optimization

LCA case studies applied to waste management options of organic products face several LCA methodological choices and among them, the multifunctionality question. Indeed, studies dealing with waste management aim to assess the environmental impacts of different organic waste treatments that enhance the organic waste fertilizing and amending properties. This is expressed in LCA studies by a primary function (to treat the waste) and secondary functions (to fertilize or provide an organic amendment to agricultural soils).The induced multifunctionality is often treated by system expansion by subtracting the secondary functions, leading to potentially avoided impacts. When dealing with residual organic fertilizing materials, …

Lca Applied To Residual Organic Fertilizing Materials ‐ An Overview Of Emission Inventory Data At The Spreading Operation, Claire Déchaux, Marilys Pradel

Life Cycle Assessment and Other Assessment Tools for Waste Management and Resource Optimization

LCA case studies applied to waste management options of organic products face several inventory completeness issues and among them, the spreading operation emissions. Indeed, organic products contain nutrient elements which turn into air, water and soil emissions after their spreading. LCA practitioners need to consider these quantitative data in order to carry out relevant assessments. Emission data obtained from experimental measurements, as they are specific to each residual organic fertilizing material and each pedoclimatic condition, cannot be used as generic data. Moreover, when the LCA case study is processed based on the primary function “to treat the waste”, the secondary …

Retrofit Design Of Energy Efficient Buildings Using Life Cycle Assessment Case Study On Research Institute Building, Fereshteh Aramoun, Masoomeh Bararzadeh, Akram Avami

Life Cycle Assessment and Other Assessment Tools for Waste Management and Resource Optimization

Energy use in educational buildings constitutes a major proportion of the energy consumption and anthropogenic emissions. Such buildings account for 34% of total energy consumption in the Iran. To find the most beneficial retrofits in the educational buildings to satisfy energy demands increasing in recent years and decreasing the heavy environmental impacts, in this paper the multi-story educational building “Sharif Energy Research Institute” located in Tehran is chosen as a case study to assess its thermal loads in the first step and life cycle assessment in the second step.

The Sharif Energy Research Institute building’s base load is calculated based …

Energy From Waste In A 2° World: Lca And Australian Carbon Policy, Mary Stewart

Life Cycle Assessment and Other Assessment Tools for Waste Management and Resource Optimization

No Abstract.

Please click PDF to see the presentation.