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Articles 961 - 990 of 6294
Full-Text Articles in Engineering
Assessing Soil Properties & Suitability For Optimized Irrigation Development In Sudan, Northern Africa, Suhib O. Hamid
Assessing Soil Properties & Suitability For Optimized Irrigation Development In Sudan, Northern Africa, Suhib O. Hamid
Department of Agricultural and Biological Systems Engineering: Masters Project Reports
In Chapter 1, soil properties essential for efficient irrigation are thoroughly assessed. Factors such as soil texture, infiltration rates, and nutrient content are analyzed to provide insights into the selection of modern irrigation systems. Utilizing data collected from 3,192 locations through GPS and laboratory analyses, alongside sophisticated ranking systems, the research determines the most suitable irrigation methods for specific soil series. Findings highlight the remarkable efficiency of drip irrigation across various soil types, contrasting with the consistently lower performance of surface irrigation. The chapter emphasizes the significance of considering soil variability, evapotranspiration, and investment factors in selecting irrigation methods for …
Assessing Even Flat-Fan Nozzles For Spot Spray Herbicide Applications, Thiago H. Vitti
Assessing Even Flat-Fan Nozzles For Spot Spray Herbicide Applications, Thiago H. Vitti
Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research
Herbicide efficiency in row-crop agriculture can be improved using precision technologies for controlling weeds and minimize agronomic, economic, and environmental impacts. Site-specific weed management technologies, such as spot-sprayers, allow herbicides to be sprayed only where weeds are present in the field. Understanding application parameters and their influence on weed control for site-specific spot-spray applications is essential. This research involved laboratory and greenhouse studies to investigate the coverage and coefficient of variation (CV) of even flat-fan spray nozzles under different spot-spray application scenarios, as well as the effect of weed size and application method on the control of various weed species …
Sustainable Waste-To-Bioproducts Engineering Center Laboratory Safety Project, Claudine Mock
Sustainable Waste-To-Bioproducts Engineering Center Laboratory Safety Project, Claudine Mock
All Graduate Reports and Creative Projects, Fall 2023 to Present
Laboratory accidents are common in teaching and research labs; these accidents can be injurious or even fatal. The consequences of each type of laboratory accident are different based on the activities performed and the hazardous materials used in each facility. However, the most common issue related to laboratory accidents is the lack of proper safety measures (e.g., poor handling of hazardous materials, not reporting incidents immediately, etc.). This project aimed to establish and strengthen best practices and procedures to ensure laboratory safety at the Utah State University Sustainable Waste-to-Bioproducts Engineering Center. To achieve this goal, different practices and measures were …
Effortless Mindfulness Toolkit: Easy Meditation Scripts To Begin Each Class., Brett Whysel
Effortless Mindfulness Toolkit: Easy Meditation Scripts To Begin Each Class., Brett Whysel
Open Educational Resources
The Effortless Mindfulness in the Classroom Toolkit is an open educational resource designed to create happier classrooms, boost student engagement, and foster a sense of community through brief, effective mindfulness exercises. This comprehensive toolkit provides educators with everything they need to seamlessly integrate mindfulness practices into their teaching routines, regardless of prior experience. The toolkit includes introductory slides, 15 ready-to-use meditation scripts, and accompanying audio recordings, covering a variety of mindfulness techniques such as focused breathing, body scans, and loving-kindness meditations. Each meditation is paired with a reflective prompt to deepen student engagement and reinforce the benefits of mindfulness. Additionally, …
Vision-Based Autonomy Stacks For Farm Tractors And Intelligent Spraying Systems In Orchards, Shengli Xu
Vision-Based Autonomy Stacks For Farm Tractors And Intelligent Spraying Systems In Orchards, Shengli Xu
All Dissertations
Autonomous tractors equipped with intelligent sprayers have become a pivotal aspect of smart farming (SF), marking a transformative shift in traditional agricultural practices and holding the potential to revolutionize the farming industry. With 2,453,620 fruit-bearing acres in the United States as of 2022, there is a pressing need for the implementation of autonomous systems for farm tractors and intelligent spraying systems in orchards. These advancements can significantly reduce labor costs, address labor shortages, and minimize spray loss. Furthermore, to enhance profitability and productivity, it is essential to develop low-cost yet effective vision-based autonomy systems that can operate efficiently across various …
Development Of An Egg-Specific Mass Spectrometry Targeted Method For Processed Food Matrices, Liyun Zhang
Development Of An Egg-Specific Mass Spectrometry Targeted Method For Processed Food Matrices, Liyun Zhang
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Egg is a major food allergen in the United States, causing symptoms from mild reactions to severe anaphylaxis. An egg-free diet remains the only management approach for egg allergy. Therefore, individuals and families living with egg allergies rely heavily on allergen statements on packaged food products for informed food choices. Currently, no labeling regulations exist for unintentionally introduced allergens, posing risks to consumers with egg allergies. Therefore, it is critical to have an accurate and reliable detection method in allergen control and management to determine the concentration of total protein from allergenic food sources. Traditional enzyme-linked immunosorbent assays are routinely …
Integration Of Matlab And Machine Learning To Accelerate Evaluation Of Biological Activity In Agricultural Soils And Promote Soil Health Improvement Goals, Andrew Stiven Ortiz Balsero
Integration Of Matlab And Machine Learning To Accelerate Evaluation Of Biological Activity In Agricultural Soils And Promote Soil Health Improvement Goals, Andrew Stiven Ortiz Balsero
Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research
Traditionally, assessments of soil biological activity have been confined to laboratory settings, creating a disconnect with practical in-field methods. To bridge this gap, cotton fabric degradation has been used to illustrate soil microbial activity under different management practices. While effective, these demonstrations are subjective and labor-intensive.
Researchers have explored using image processing software like ImageJ and Adobe Photoshop to streamline this process. Although these tools accurately quantified fabric degradation under varying soil conditions, the methods remained labor-intensive and complex. Consequently, these methods were still not ideal for on-farm use by agricultural practitioners.
To further address labor and complexity limitations, the …
Performance And Enhanced Efficiency Induced By Cold Plasma On Sapo-34 Membranes For Co2 And Ch4 Mixtures, Fnu Gorky, Vashanti Storr, Grace Jones, Apolo Nambo, Jacek B. Jasinski, Maria L. Carreon
Performance And Enhanced Efficiency Induced By Cold Plasma On Sapo-34 Membranes For Co2 And Ch4 Mixtures, Fnu Gorky, Vashanti Storr, Grace Jones, Apolo Nambo, Jacek B. Jasinski, Maria L. Carreon
Chemical Engineering Faculty Publications and Presentations
In this study, we investigate the influence of cold-plasma-induced enhanced performance and efficiency of SAPO-34 membranes in the separation of CO2 and CH4 mixtures. Placing the herein presented research in a broader context, we aim to address the question of whether cold plasma can significantly impact the membrane performance. We subjected SAPO-34 membranes to plasma mild disturbances and analyzed their performance in separating CO2 and CH4. Our findings reveal a notable enhancement in membrane efficiency and sustained performance when exposed to cold plasma. The pulsed plasma separation displayed improved structural integrity, and the experimental results …
Epidural Stimulation For Urogenital Dysfunction In The Spinal Cord Injured Rat., Natasha Lorraine Wilkins
Epidural Stimulation For Urogenital Dysfunction In The Spinal Cord Injured Rat., Natasha Lorraine Wilkins
Electronic Theses and Dissertations
Spinal cord injury (SCI) is a devastating, life changing event that greatly impacts quality of life. SCI can have body-wide, multi-system consequences including dysfunction within the urogenital system. Challenges with the urinary system include urinary incontinence, urine retention, and detrusor-sphincter dyssynergia all of which require maintenance through the regular use of catheters. Sexual dysfunction in men, who comprise nearly 80% of the SCI population, includes erectile dysfunction, anejaculation, retrograde ejaculation, poor expulsive force during ejaculation, and poor sperm quality. The treatment for sexual function in SCI men is focused more on fertility through the collection of sperm for insemination procedures …
Developing A Comprehensive Genome-Scale Metabolic Model For The Arabidopsis Thaliana Root System, Lohani Esterhuizen
Developing A Comprehensive Genome-Scale Metabolic Model For The Arabidopsis Thaliana Root System, Lohani Esterhuizen
Department of Chemical and Biomolecular Engineering: Dissertations, Theses, and Student Research
Arabidopsis thaliana (Arabidopsis) is the most well-established model plant to date. Being the first plant to have its genome mapped, studies on Arabidopsis have provided insurmountable insights into the physiological and biochemical nature of plants. Methods that allow us to computationally study the metabolism of organisms include the use of genome-scale metabolic models (GEMs). Despite its popularity, no GEM currently maps the metabolic activity in the root system of Arabidopsis, which is the first organ to face and respond to stress conditions in the soil. This work aims to develop and implement a comprehensive GEM of the Arabidopsis root system …
Sullivan, Frank Victor, Collection, 1924-2005, Special Collections, Leonard H. Axe Library
Sullivan, Frank Victor, Collection, 1924-2005, Special Collections, Leonard H. Axe Library
Finding Aids
This collection contains materials from the life and projects of Dr. Frank “Vic” Victor Sullivan. They document contributions to: the Sperry Galligher Audubon collection of documents; reports on the planning and construction of the Kansas Technology Center at Pittsburg State University; slides of university trips and family.
07.08.2024 Orsp Connect, Liz Williamson
07.08.2024 Orsp Connect, Liz Williamson
ORED Newsletter
NSF research infrastructure, IDS (Institute for Data Science), NSF Mentoring Plan Requirement, NSF Pilot for Startups and Small Businesses
Strategic Study On Leading Construction Of Modern Agricultural System By Technology Innovation, Yan Yan, Xurong Mei, Xiudong Wang
Strategic Study On Leading Construction Of Modern Agricultural System By Technology Innovation, Yan Yan, Xurong Mei, Xiudong Wang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Technology innovation is the fundamental solution to build a modern agricultural system, and it is also an important support for building the large base, large enterprise, and large industry of modern agriculture and achieving the modernization of material equipment, technology, management, agricultural informatization, and sustainable resource utilization of agriculture. This paper explains the scientific concepts and logical relationships of the agricultural production system, industrial system and management system, which are the main components of a modern agricultural system. It emphasizes that ensuring food security, promoting industrial integration and upgrading, and cultivating leading enterprises are current key tasks. Nevertheless, from the …
Corrigendum To “Evaluation Of Operational Performance Of Wusongkou Cruise Port Through Network Data Envelopment Analysis”
Journal of Marine Science and Technology–Taiwan
No abstract provided.
Analysis Of The Potential For Enhancing The Efficiency Of A Floating Photovoltaic (Fpv) System, How-Ping Wu, Ching-Yi Tseng, Chuan-Chung Jen, Yuan-Ching Chiang, Sih-Li Chen
Analysis Of The Potential For Enhancing The Efficiency Of A Floating Photovoltaic (Fpv) System, How-Ping Wu, Ching-Yi Tseng, Chuan-Chung Jen, Yuan-Ching Chiang, Sih-Li Chen
Journal of Marine Science and Technology–Taiwan
This study examined the power generation capabilities of FPV systems and the advantages of employing active cooling on floating solar panels. Floating solar panels exhibit improved efficiency due to operating at lower temperatures facilitated by the cooling effect of water evaporation. Additionally, the high availability of water renders the application of the active cooling technique economically viable. This study developed a comprehensive simulation of a floating solar system, integrating a mathematical model to validate experimental findings and a temperature model derived from an energy equation specific to floating solar panels. This model calculates the heat transfer among the three different …
Examining The Oxidation States Of Metals In Aerosols Emitted By Electronic Cigarettes, Kashala Fabrice Kapiamba, Stephen Yaw Owusu, Yangtao Wu, Yue-Wern Huang, Yi Jiang, Yang Wang
Examining The Oxidation States Of Metals In Aerosols Emitted By Electronic Cigarettes, Kashala Fabrice Kapiamba, Stephen Yaw Owusu, Yangtao Wu, Yue-Wern Huang, Yi Jiang, Yang Wang
Biological Sciences Faculty Research & Creative Works
Electronic cigarettes (ECs) emit many toxic substances, including metals, that can pose a threat to users and the environment. The toxicity of the emitted metals depends on their oxidation states. Hence, this study examines the oxidation states of metals observed in EC aerosols. X-ray photoelectron spectroscopy analysis of the filters that collected EC aerosols identified the oxidation states of five primary metals (based on surface sample analysis), including chromium(III) (close to 100%) under low power setting while a noticeable amount of chromium(VI) (15%) at higher power settings of the EC, and copper(II) (100%), zinc(II) (100%), nickel(II) (100%), lead(II) (65%), and …
Chemical And Physical Properties Of Fine Fractions From A Village Proximate To A Uranium Mine: Insights About Soil Health, Mary P. Haley
Chemical And Physical Properties Of Fine Fractions From A Village Proximate To A Uranium Mine: Insights About Soil Health, Mary P. Haley
Nanoscience and Microsystems ETDs
Thousands of abandoned uranium mines (AUM) in Native American tribal lands have not been fully remediated, leaving uranium mine wastes exposed and accessible for potential erosion and transport by wind. Analyzing the metal and organic content of the fine-grained fractions in soils could uncover the impact of mine legacy on the soil health in communities that live in proximity to AUM. This study investigates the physical and chemical properties of the fine-grained fraction (μm) of soils to quantify the effect of heavy metal-bearing particulates on the soil health in the village of Paguate and within the Jackpile-Paguate AUM located on …
Gene Expression Analysis Reveals Dysregulation In Traumatic Brain Injury Leading To Tauopathy, Kristina M. Tosi
Gene Expression Analysis Reveals Dysregulation In Traumatic Brain Injury Leading To Tauopathy, Kristina M. Tosi
USF Tampa Graduate Theses and Dissertations
Traumatic Brain Injury (TBI) causes a cascade of detrimental events within neurons, contributing to a host of neurological diseases relating to dementia. In this study we have performed a meta-analysis comparing differentially expressed genes (DEG) in specific cell types such as neurons and microglia revealing inflammation as a common driver of neurological deficiencies post TBI. Inflammation and hypoxia are well characterized features of TBI; however, the molecular mechanisms causing tau hyperphosphorylation by tauopathy associated genes (TAG) post-TBI are currently poorly understood. Furthermore, there are limited in-vitro neuroinflammatory models that mimic primary and secondary TBI. We hypothesize that inducing hypoxia and …
The Growth Of Ethanol In Brazil: Sugarcane, Corn, And A Few Other Things, Fabio Mattos
The Growth Of Ethanol In Brazil: Sugarcane, Corn, And A Few Other Things, Fabio Mattos
Cornhusker Economics
Although we can expect more ethanol produced from corn in the coming years, it is unclear whether it will keep expanding at the same pace as in recent years or how much it will contribute to total ethanol production.
One point to keep an eye on is the typical dynamics of markets. If supply and demand conditions and price movements make corn-ethanol more profitable, ethanol plants in Brazil will keep increasing their production. If it makes more economic sense to produce corn-ethanol (as it happened recently), they will use more corn to produce ethanol.
Supply and demand conditions for ethanol, …
Integrating Remote Sensing And Machine Learning To Determine Past, Current And Future Crop Water Use From The Nubian Sandstone Aquifer System, Moaz Ishag
Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research
The agriculture sector is a significant consumer of water, and sustainable water use begins with monitoring irrigated land. Delineating irrigated land supports decision-makers and promotes the sustainable use of this crucial resource. This study focuses on the Nubian Sandstone Aquifer System (NSAS), the largest aquifers in the world, which spans Egypt, Sudan, Libya, and Chad. The study aims to: 1) quantify the increase in irrigated hectares (both pivot and non-pivot) from 2000-2001 to 2023-2024; 2) identify major irrigated crop types and their water requirements; and 3) quantify groundwater crop water use from the NSAS using remote sensing via the Google …
Unmanned Aerial Vehicle (Uav)-Based High-Throughput Phenotyping For Maize Improvement, Eric T. Rodene
Unmanned Aerial Vehicle (Uav)-Based High-Throughput Phenotyping For Maize Improvement, Eric T. Rodene
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Modern breeding programs rely heavily on efficiently screening large numbers of genotypes for agronomic traits, such as disease resistance, drought tolerance, and yield. Identifying the genetic loci or genes associated with these traits using GWAS or functional analyses will benefit future plant breeding efforts seeking to incorporate these traits into new crop varieties, whether through conventional breeding or gene editing techniques. Unmanned aerial vehicle (UAV)-based image data has been increasingly used for this task, as it allows entire test plots to be quickly and cost-effectively phenotyped. In my research, I have developed methods to improve the accuracy of machine learning …
Impact Of Non-Thermal Plasma Generated Using Air And Nitrogen On Functional Properties Of Milk Protein Dispersions, Nikitha Modupalli, Md Mahfuzur Rahman
Impact Of Non-Thermal Plasma Generated Using Air And Nitrogen On Functional Properties Of Milk Protein Dispersions, Nikitha Modupalli, Md Mahfuzur Rahman
Food Science Faculty Publications and Presentations
This study focuses on improving the functionalities of milk protein concentrate (MPC) using a nonthermal plasma jet and plasma-activated water (PAW) with atmospheric air and nitrogen as source gases. The 5% and 10% MPC dispersions were directly treated with a plasma jet, and PAW was used to make the MPC dispersions. The dispersions were analyzed for changes in protein structure and functional properties. The treatment altered the secondary structure of MPC protein structure by increasing β-components and changing the order of random coils. The solubility of the PAW-treated 5% protein dispersions doubled due to plasma-induced modification of hydrophilic and covalent …
Response To Replication Stress And Maintenance Of Genome Stability By Wrn, The Werner Syndrome Protein, David K. Orren, Amrita Machwe
Response To Replication Stress And Maintenance Of Genome Stability By Wrn, The Werner Syndrome Protein, David K. Orren, Amrita Machwe
Markey Cancer Center Faculty Publications
Werner syndrome (WS) is an autosomal recessive disease caused by loss of function of WRN. WS is a segmental progeroid disease and shows early onset or increased frequency of many characteristics of normal aging. WRN possesses helicase, annealing, strand exchange, and exonuclease activities and acts on a variety of DNA substrates, even complex replication and re- combination intermediates. Here, we review the genetics, biochemistry, and probably physiological functions of the WRN protein. Although its precise role is unclear, evidence suggests WRN plays a role in pathways that respond to replication stress and maintain genome stability particularly in telomeric regions.
Assessing Soil Properties For Optimized Irrigation Development In Sudan, Northern Africa, Suhib Hamid, Derek M. Heeren, Aaron R. Mittelstet, Saleh Taghvaeian, Randall S. Ritzema
Assessing Soil Properties For Optimized Irrigation Development In Sudan, Northern Africa, Suhib Hamid, Derek M. Heeren, Aaron R. Mittelstet, Saleh Taghvaeian, Randall S. Ritzema
Department of Agricultural and Biological Systems Engineering: Presentations and White Papers
Sustainable irrigation methods maximize agricultural productivity in Northern African countries like Sudan. This project evaluates soil properties to develop optimized irrigation strategies for Sudan's arid and semi-arid climate. Assessing soil characteristics such as texture, infiltration rates, and nutrient content informs the selection of modern irrigation systems. Data from 3,192 locations, collected using GPS and ring infiltrometers for infiltration rates, alongside laboratory analyses for soil properties, were employed. A ranking system determined suitable irrigation systems for specific soil classes, considering factors like slope, wind, crop tolerance, available water capacity (AWC), drainage, germination, capital cost, labor cost, maintenance, and evapotranspiration (ET). The …
Carbon-Based Nanocomposite Membranes For Membrane Distillation: Progress, Problems And Future Prospects, Chhabilal Regmi, Yuwaraj K. Kshetri, S. Ranil Wickramasinghe
Carbon-Based Nanocomposite Membranes For Membrane Distillation: Progress, Problems And Future Prospects, Chhabilal Regmi, Yuwaraj K. Kshetri, S. Ranil Wickramasinghe
Chemical Engineering Faculty Publications and Presentations
The development of an ideal membrane for membrane distillation (MD) is of the utmost importance. Enhancing the efficiency of MD by adding nanoparticles to or onto a membrane’s surface has drawn considerable attention from the scientific community. It is crucial to thoroughly examine state-of-the-art nanomaterials-enabled MD membranes with desirable properties, as they greatly enhance the efficiency and reliability of the MD process. This, in turn, opens up opportunities for achieving a sustainable water–energy–environment nexus. By introducing carbon-based nanomaterials into the membrane’s structure, the membrane gains excellent separation abilities, resistance to various feed waters, and a longer lifespan. Additionally, the use …
Dynamic Metabolic Flux Analysis Amidst Data Variability: Sphingolipid Biosynthesis Case Study In Arabidopsis Thaliana Cell Cultures, Abraham Boluwatife Osinuga
Dynamic Metabolic Flux Analysis Amidst Data Variability: Sphingolipid Biosynthesis Case Study In Arabidopsis Thaliana Cell Cultures, Abraham Boluwatife Osinuga
Department of Chemical and Biomolecular Engineering: Dissertations, Theses, and Student Research
Sphingolipids are pivotal for plant development and stress responses. Growing interest has been directed towards fully comprehending the regulatory mechanisms of the sphingolipid pathway. In this study, we explore its de novo biosynthesis and homeostasis in Arabidopsis thaliana cell cultures, shedding light on fundamental metabolic mechanisms. Employing 15N isotope labeling and quantitative dynamic modeling approach, we obtained data with notable variations and developed a regularized and constraint-based Dynamic Metabolic Flux Analysis (r-DMFA) framework to predict metabolic shifts due to enzymatic changes. Our analysis revealed key enzymes such as sphingoid-base hydroxylase (SBH) and long-chain-base kinase …
T. Boudieri Extract Potentiates The Effects Of Capecitabine Treatment In Human Colon Cancer Cells, Katia Sawaya, Mahmoud Khalil, Ghada Khawaja
T. Boudieri Extract Potentiates The Effects Of Capecitabine Treatment In Human Colon Cancer Cells, Katia Sawaya, Mahmoud Khalil, Ghada Khawaja
BAU Journal - Science and Technology
Resistance to chemotherapy remains a major challenge for colorectal cancer patients worldwide, hence the persistent need to uncover alternative treatments as well as new adjunct therapies in the fight against cancer. Natural extracts constitute an excellent source of bioactive substances that have a promising potential in that regard, with minimal negative side effects. We have previously demonstrated that both the ethanolic as well as the water extracts of Terfezia boudieri, a black desert truffle abundant in and part of the cuisine of the Mediterranean region, have significant antiproliferative effects against colon cancer cells. Our aim in this study was …
Optimizing The Expression Of Polyethylene Terephtalate Hydrolase-Encoding Synthetic Gene In Escherichia Coli Arctic Express (De3), Jocelyn Nataniel, Maria Ulfah, Dini Achnafani, Niknik Nurhayati, Gabriela Christy Sabbathini, Sri Rezeki Wulandari, Abinawanto Abinawanto, Is Helianti
Optimizing The Expression Of Polyethylene Terephtalate Hydrolase-Encoding Synthetic Gene In Escherichia Coli Arctic Express (De3), Jocelyn Nataniel, Maria Ulfah, Dini Achnafani, Niknik Nurhayati, Gabriela Christy Sabbathini, Sri Rezeki Wulandari, Abinawanto Abinawanto, Is Helianti
Makara Journal of Science
The waste of polyethylene terephthalate (PET) plastic waste in Indonesia is a pressing concern due to its slow degradation and potential environmental damage. One promising solution is to utilize polyethylene terephthalate hydrolase from Ideonella sakaiensis (IsPETase), an enzyme that specifically degrades PET. However, inducing the expression of IsPETase synthetic gene in Escherichia coli BL21 (DE3) has been challenging because much of it remains insoluble. This study aimed to express IsPETase in E. coli Arctic Express (DE3) and optimize the conditions to enhance its production. First, pET22b(+)pelB-IsPETase was inserted into E. coli Arctic Express (DE3). The …
06.24.2024 Orsp Connect, Liz Williamson
06.24.2024 Orsp Connect, Liz Williamson
ORED Newsletter
Research Networking Lunch (LINC), NIH podcast, CREW (Community First Research Center for Wellbeing and Creative Achievement) Premier Physics Experiment
Cellular Energy Cycle Mediates An Advection-Like Forward Cell Flow To Support Collective Invasion, Jian Zhang, Jenna Mosier, Yusheng Wu, Logan Waddle, Paul V. Taufelele, Wenjun Wang, Heng Sun, Cynthia A. Reinhart-King
Cellular Energy Cycle Mediates An Advection-Like Forward Cell Flow To Support Collective Invasion, Jian Zhang, Jenna Mosier, Yusheng Wu, Logan Waddle, Paul V. Taufelele, Wenjun Wang, Heng Sun, Cynthia A. Reinhart-King
Biomedical Engineering Faculty Publications and Presentations
Collective cell migration is a model for nonequilibrium biological dynamics, which is important for morphogenesis, pattern formation, and cancer metastasis. The current understanding of cellular collective dynamics is based primarily on cells moving within a 2D epithelial monolayer. However, solid tumors often invade surrounding tissues in the form of a stream-like 3D structure, and how biophysical cues are integrated at the cellular level to give rise to this collective streaming remains unclear. Here, it is shown that cell cycle-mediated bioenergetics drive a forward advective flow of cells and energy to the front to support 3D collective invasion. The cell division …