Engineering Commons^™

Exploration Of The Sludge Biodiesel Pathway, Zachary Christman

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Wastewater sludge is an overlooked source of fat, oil, and grease (FOG) that could be converted into biodiesel. The United States produces about 8 million tons of sludge per year. The disposal cost for this amount of sludge is about 2 billion US dollars. The widespread availability and low cost of sludge compared to other biodiesel raw materials make it an economical choice for a renewable fuel. Using sludge as a raw material can produce 25 to 30 mg per gram of fatty acid methyl ester (FAME); the main component of biodiesel. Sludge biodiesel has the potential of transforming a …

Characterizing The Dormancy And Repair Of A Circumneutral Passive Remediation System Receiving Iron And Sulfate-Rich Amd, Garrett Struble

Electronic Theses and Dissertations

The Wingfield Pines remediation system is a ~20-acre circumneutral, gravity-fed system constructed in 2009 to passively remediate Fe from an ~2000 gallon/minute effluent. In 2017, a fracture to the system’s underground cavern caused the AMD effluent to bypass the system, flowing directly into Chartiers Creek and leaving the system decommissioned between 2017-2019. Soil slurry and water samples were collected in the weeks prior to the system’s reinstalment in September 2019 through January 2020 in order to determine the effect of the repair on remediation efficiency and microbial community composition. This study acted as the first to describe the temporary decommissioning …

U-251mg Spheroid Generation Using A Scaffold Based Method Protocol, Lara Carroll, Brijesh K. Tiwari, James F. Curtin, Janith Wanigasekara

Articles

3D cell culture is a technique that is used to grow cells in vitro that will mimic an in vivo environment. 3D cell models are a helpful learning tool for researchers to better understand disease mechanisms and to explore different therapeutic properties of drugs. 3D cell cultures can be developed using patient derived cancer cells. Once they have been grown, these 3D cells can be used to screen for small molecule drugs or for genetic modification in for analysis of disease pathways or to predict drug treatments toxicity or efficacy. 3D cell cultures are a big step towards the more …

Pharyngeal Constriction As A Cause For Late Acquisition And Speech Sound Disorders Of Rhotic Sounds In English, Spanish, And French, Connor Mahon

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This paper attempts to explain why rhotic sounds are cross-linguistically late developing among the sound inventory of children. Included is a summary of the current literature regarding classification of rhotic sounds, an examination of the articulatory movement of the tongue root, and an overview of the clinical implications on the field of speech-language pathology. The evidence presented supports the hypothesis that pharyngeal constriction is characteristic of rhotic sounds in many languages, and that it is related to the relative late acquisition and higher rate of speech sound disorders, as seen in English, Spanish, and French.

Glial Endothelial Brain Cell Co-Cultures For Testing Signaling Response And Delivery Of Novel Materials Across Blood Brain Barrier, Neela Prajapati

Doctoral Dissertations

The brain accounts for 20% of overall energy metabolism in the body though it just comprises 2% of the total body mass but has a limited capacity of storing energy unlike other critical organs in the body such as the heart and liver. This energy along with oxygen and nutrients is supplied by cerebral blood flow (CBF), any interruption of which can cease the brain function within seconds with a potential irreversible neuronal injury, within minutes. Vascular cells along with astrocytes and neurons are a part of a recently developed concept known as the Neurovascular Unit responsible for Neurovascular coupling …

Topological Changes In The Functional Brain Networks Induced By Isometric Force Exertions Using A Graph Theoretical Approach: An Eeg-Based Neuroergonomics Study, Lina Ismail

Electronic Theses and Dissertations, 2020-2023

Neuroergonomics, the application of neuroscience to human factors and ergonomics, is an emerging science focusing on the human brain concerning performance at work and in everyday settings. The advent of portable neurophysiological methods, including electroencephalography (EEG), has enabled measurements of real-time brain activity during physical tasks without restricting body movements. However, the EEG signatures of different physical exertion activity levels that involve the musculoskeletal system in everyday settings remain poorly understood. Furthermore, the assessment of functional connectivity among different brain regions during different force exertion levels remains unclear. One approach to investigating the brain connectome is to model the underlying …

Involvement Of The Ino80 Chromatin Remodeling Complex In Cell Division And Genomic Stability, Ethan Chen

Biomedical Engineering Undergraduate Honors Theses

Cell division is a vital biological process for growth and development in both single and multi-cellular organisms—whereby the cell must duplicate its organelles and genome in entirety and appropriately distribute the copied contents to the daughter cells. Cells undergo a cycle of two distinct phases: interphase and mitosis. During interphase, the cell replicates its genomic DNA (in the form of chromosomes) located within the nucleus. DNA replication is carried out in a euchromatin state, where the chromosome structure is loose and easily accessible by DNA polymerase and other replication enzymes. Upon the completion of replication, chromatin is condensed into highly …

Economic And Ecosystem Impacts Of Gm Maize In South Africa, Kristiina Ala-Kokko

Graduate Theses and Dissertations

White maize in South Africa is the only staple crop produced on a widespread commercial basis for direct human consumption using genetically modified (GM) cultivars. Using a combined economic and environmental approach, we estimate the total welfare benefits attributable to GM white maize in South Africa for 2001-2018 are $694.7 million. Food security benefits attributable to GM white maize in South Africa also manifest through an average of 4.6 million additional white maize rations annually. To achieve these additional annual rations using conventional hybrid maize, the additional land required would range from 1,088 hectares in 2001 to 217,788 hectares in …

Regression Analysis Of Pacing When Running A Marathon, Hawkin Starke

Industrial Engineering Undergraduate Honors Theses

Regression analysis can be an effective way of examining performance in the marathon event. By splitting up the race into segments or in runner terminology “splits” the significance of each segment as it relates to the total finish time can be explored. Because the idea of splits is already ingrained into the minds of runners, it makes intuitive sense to use these as the metrics to define a race. Additionally, marathons generally make participant age and gender date publicly available which can then be used to find trends within specific demographics. This tailors trends to smaller groups of people, making …

Mapping The Domain Of Rna Helicase Ddx1 That Interacts With The Ns1 Of Influenza A Viruses, Elise Wyatt

Biomedical Engineering Undergraduate Honors Theses

Of the known influenza virus strains, influenza A viruses (IAVs) are the most catastrophic due to their highly contagious nature and possibly life-threatening symptoms. IAVs invade a host cell and enter the nucleus where they use the cell’s nuclear machinery for replication of their viral RNA genome which is then exported to neighboring cells to establish a productive infection. Host pathogen recognition receptors (PRRs) respond to viral infection by signaling the cell to produce type I interferons (IFNs) to fight the foreign invader. Non-structural protein 1 (NS1) of IAVs, a major component in the regulation of viral replication, opposes host …

Light Intensity Control For Plc-Based Hydroponic Demonstration System, Christian Hitt

Biological and Agricultural Engineering Undergraduate Honors Theses

In order to demonstrate a skill set obtained through the University of Arkansas Biological Engineering, a group of students and I developed a hydroponic system where plants could be grown in a chamber. System parameters such as air quality, irrigation, and lighting were controlled by a Programmable Logic Computer (PLC) and an array of sensors and actuators. Each student focused on a certain aspect of this system, mine being the lighting. Developing this system involved researching the relationship between light intensity and plant growth, designing a system to suspend the lights above the growth chamber, and develop a system to …

Aiming For The Sun- Averting The Fate Of Icarus: De-Risking Solar Energy Projects, Manu Srivastava

Asian Management Insights

Climate change is increasingly accepted as an existential threat to civilisation and ‘business as usual’ is considered a luxury we cannot afford any more.

Evaluation Of The Cytotoxyc Effects Of Lmdf5-7 On A Human T-Cell Leukemia Cell Line, Andrea F. Ibarra Chacon

Open Access Theses & Dissertations

According to World Health Organization (WHO), cancer is the second leading cause of death worldwide, with 9.6 million deaths in 2018 . In the United States, an estimated 434,982 people were living with cancer during 2017 . Leukemia is the most common blood cancer in children from birth to 14 years old . In particular, Hispanic children in the United States experience a higher incidence rate of leukemia . Therefore, the discovery of novel cancer therapies is necessary to help those affected survive the disease. A new compound, LMDF5-7 was investigated and found to have anticancer properties that can help …

3d Printing Of High Viscosity Fluids And Its Application In 3d Printing Of Prosthetic Teeth., Abhilash Aditya

Open Access Theses & Dissertations

The advancement in technology has brought forward non-conventional manufacturing methods that are efficient and advantageous for specific applications. 3D printing is one such outcome, whose applications stretch from biomedical applications to daily products. 3D printing is a rapidly growing technology, and innovative research developments have proven versatility in creating physical objects. Simplification and constant improvement in Fused Deposition Modeling (FDM) operation result from decades of research. However, 3D printing is material-specific and contributes to shortcomings in the technology. The build-material dictates the extrusion parameters, including the material discharge rate and head speed for a continuous flow. Customization being the prime …

Control Of Noils And Fiber Length Parameters In Cotton Combers., R. El-Bealy, M. El-Messiery

Mansoura Engineering Journal

A study was made on the effect of the comber variables, top comb depth, feed length/nip, comber lap weight and setting between detaching rod and nippers on the comber waste and fiber length parameters of combed silver. The experimental design technique (11, 12) with the help of mini-computer programming used in this work to investigate the optimum condition. The results led to the relative importance of factors which affect the noils, 2.5% span length, 50% span length and length . uniformity ratio (UR%).

Cortical Dynamics Of Language, Kiefer Forseth

Dissertations and Theses (Open Access)

The human capability for fluent speech profoundly directs inter-personal communication and, by extension, self-expression. Language is lost in millions of people each year due to trauma, stroke, neurodegeneration, and neoplasms with devastating impact to social interaction and quality of life. The following investigations were designed to elucidate the neurobiological foundation of speech production, building towards a universal cognitive model of language in the brain. Understanding the dynamical mechanisms supporting cortical network behavior will significantly advance the understanding of how both focal and disconnection injuries yield neurological deficits, informing the development of therapeutic approaches.

Exploration Of Antimicrobial And Cell Proliferation Properties Of Nanofibers Incorporating Nopal (O. Cochenillifera) Extract, Cristobal Rodriguez

Theses and Dissertations

This study focused on the fabrication of Forcespinning® nanofibers composed of Opuntia cochenillifera, ‘nopal’, mucilage (N) extract, chitosan (CH), and pullulan (PL) (N/CH/PL) were developed with an optimum fiber average diameter of 406±127 nm, and studied for their ability to sustain adhesion and proliferation of mouse embryonic fibroblast (NIH 3T3) cells. After a 6-day incubation period, N/CH/PL nanofibers displayed robust cell proliferation, while also exhibiting inhibitory properties through an N extract dip-coating process against gram-negative bacteria Escherichia coli in a 24 h bacterial growth study. A demonstration of integrated natural bioactive compounds with combined biodegradable polymers, provide an enhanced …

Analyzing The Effects Of E-Hook Peptides On Kinesin-1, Ashton Ward Murrah, Baylee Hope Howard

Honors Theses

Cancer is the second leading cause of death in the United States. Cancerous growth is a result of oncogenes, or mutated genes that increase the rate of cell division in an uncontrolled manner. Cell division, which consists of mitosis and cytokinesis phases, is dependent upon the active movement of kinesin motor proteins along microtubules to rearrange the cytoskeleton for equitable distribution of genetic material to daughter cells. As kinesins are vital to this process, if we could prevent kinesin from binding to the microtubules, cell division would cease.

The goal of this study is to develop a method to prevent …

Estimating Irrigation In Rice Fields With A Water Balance Approach, Kristen Trinh

Biological and Agricultural Engineering Undergraduate Honors Theses

Global food production must increase to meet the demand associated with increased population growth, so irrigation water use will continue to rise. Therefore, it is important to monitor water usage particularly when an irrigation flowmeter is unavailable. A field water balance was created for a selection of rice fields in East-central Arkansas under observation in 2018 and 2019. From those, irrigation inputs are deduced from the water balance alone. First, each field had sensors that collected water table level (WTL) data. Next, other water inputs and outputs such as precipitation and evapotranspiration (ET) were collected from two modeled sources. The …

Patient-Specific Finite Element Analysis For Mandibular Fracture Fixation, Ethan Snyder

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis proposes an approach for Finite Element Analysis (FEA) of mandibular fracture fixation. Using a Computerized Tomography (CT) scan of mandible obtained from a specific person, the material characteristics, density and modulus of elasticity, were determined from a set of discrete points within the mandible that are 1mm spaced based on the Hounsfield Units of these points. The mandible geometry was sectioned to simulate a fracture. Muscle and mastication forces were added to replicate post-surgery loading. Using a standard linear miniplate, this material model was compared with two commonly used mandibular cortical shell bone models: isotropic and orthotropic. A …

Fabrication Of Forcespinning® Nanofibers Incorporating Nopal Extract, Cristobal Rodriguez, Victoria Padilla, Karen Lozano, J. Andrew Mcdonald, Luis Materon, Alejandra Chapa, Fariha Ahmad, Carlos Trevino De Leon, Robert Gilkerson

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

In this study, nanofibers composed of Opuntia cochenillifera nopal mucilage (N) extract combined with chitosan (CH) and pullulan (PL) (N/CH/PL) were produced via Forcespinning®. The developed nonwoven composite membranes are comprised of long, continuous, and homogenous fibers with fiber average diameter varying between 251±77 nm and 406±127 nm depending on the concentration of N. After crosslinking, the developed membranes were highly stable in water. The water absorption capacity of the N/CH/PL composite nanofiber membranes was shown to be 65% higher when compared to the CH/PL nanofiber membranes. Nopal dipcoated membranes show inhibition of gram-negative Escherichia coli, indicating antibacterial properties. These …

Remote Performance Modulation Of Ultrafiltration Membranes By Magnetically And Thermally Responsive Polymer Chains, Arijit Sengupta, Anh Vu, Xianghong Qian, Sumith R. Wickramasinghe

Chemical Engineering Faculty Publications and Presentations

Ultrafiltration membranes, that respond to an external magnetic field and local temperature have been developed. Surface-initiated activator-generated electron transfer (AGET) atom transfer radical polymerization (ATRP) has been used to graft poly(N-isopropylacrylamide) (PNIPAm) from the surface of 300 kDa regenerated cellulose membranes. The polymerization initiator was selectively attached to the entire membrane surface, only the outer membrane surface or only the inner pore surface. A superparamagnetic nanoparticle was attached to the end of the polymer chain. The DI water flux as well as the flux and rejection of bovine serum albumin were investigated in the absence and presence of a 20 …

Characterization Of Protein Aggregation Using A Solid-State Nanopore Device, Mitu Chandra Acharjee

Graduate Theses and Dissertations

Protein aggregation has been linked to many chronic and devastating neurodegenerative human diseases and is also strongly associated with aging. In the case of neurodegenerative diseases, α, β tubulins and tau proteins dissociate in a neuron cell and aggregate both intra and extra-cellularly. Tau and tubulin aggregations were found as one of the major causes of many neurodegenerative diseases, such as Parkinson’s, Picks, Alzheimer’s, Huntington, and Prion. Finding the state and mechanism of protein aggregation is significant. In this work, tau and tubulin aggregations were detected in ionic solutions using the solid-state nanopore technique. Besides tau and tubulin, aggregations of …

Finite Element Analysis Of Impact Resistant Composites Inspired By Peacock Mantis Shrimp, Nandati Shrestha

Thinking Matters Symposium

The fist-like club of the peacock mantis shrimp, a 5-inch marine crustacean, can strike its prey with speed faster than a .22-caliber bullet with an impact force more than 1,000 times its own weight. Although these creatures punch so fast that it even boils the water, they don’t take any damage. This incredible insusceptibility is due to the arrangement of mineralized fiber layers in which each fibrous layer is laid at a slightly rotated angle to form a helicoidal structure that acts as a shock absorber for the club. The goal is to perform a finite element analysis to investigate …

Mems Directional Acoustic Sensors, Colby Damren

Thinking Matters Symposium

The purpose of my project is to test and verify two Micro-Electro-Mechanical-System (MEMS) microphones. The two MEMS devices are biomimetic microphones that imitate the eardrums of the Ormia Ochracea, a parasitic fly that listens for host crickets to lay their eggs. The MEMS microphones mimic the eardrum spacing of the Ormia Ochracea with a spacing of 1000um. This is roughly twice the opening of the Ormia Ochracea. The microphones will be tested for directionality inside a wooden box. This box will be lined with beveled foam to prevent any echo or outside noise from interfering with the results. These results …

Design, Simulation And Testing Of Biomimetic Directional Acoustic Sensors, Brendan Francis

Thinking Matters Symposium

The Ormia ochracea, a species of parasitic fly, has become the focal point in sound localization research because of its finely tuned hearing abilities. The female of this species uses its super highly directional hearing to pinpoint the call of a host cricket, with hypersensitivity of frequency and phase difference, to reach and dispose of its eggs on the host. The goal of this study was to further the research of a previous Project in Professor Guvench’s group which implemented MEMS (Micro Electro-Mechanical System) technology on a chip to replicate these abilities. In this iteration, however, some commercially available …

2021- The Twenty-Fifth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Twenty-fifth Annual Symposium of Student Scholars, held on April 29, 2021. Includes abstracts from the presentations and posters.

Biomedical Applications And Syntheses Of Selected Anthraquinone Dyes, Richard Sirard

Senior Honors Theses

Anthraquinones are aromatic organic compounds that have multiple applications in the biomedical field. Some anthraquinone-based compounds are used as fluorophores to contrast cell nuclei while others act as chemotherapeutic agents. However, there are not many fluorescent anthraquinone cell stains currently available. In this study, commercially available anthraquinone dyes, in addition to other dye families and compounds, were reviewed for their unique properties, advantages, and drawbacks. The development and characterization of three novel anthraquinone fluorophores revealed promising photophysical characteristics, like large Stokes shifts. One of the compounds, RBS3, was chosen for fixed and live cell staining and exhibited desirable biomedical properties. …

Detecting Recent Crop Phenology Dynamics In Corn And Soybean Cropping Systems Of Kentucky, Yanjun Yang, Bo Tao, Liang Liang, Yawen Huang, Christopher J. Matocha, Chad D. Lee, Michael Sama, Bassil El Masri, Wei Ren

Geography Faculty Publications

Accurate phenological information is essential for monitoring crop development, predicting crop yield, and enhancing resilience to cope with climate change. This study employed a curve-change-based dynamic threshold approach on NDVI (Normalized Differential Vegetation Index) time series to detect the planting and harvesting dates for corn and soybean in Kentucky, a typical climatic transition zone, from 2000 to 2018. We compared satellite-based estimates with ground observations and performed trend analyses of crop phenological stages over the study period to analyze their relationships with climate change and crop yields. Our results showed that corn and soybean planting dates were delayed by 0.01 …

Funtionalization Of Morphologically Different Nanoclays For Enhanced Mechanical Properties, Malachi Kent

Honors College Theses

Nanoclays are microscopic clays that are comprised of layered nanoparticle aluminosilicates that are naturally arranged in several morphologies. Halloysite nanotubes (HNT) are hollow, double-layered tubes, bentonite (BNT) clays are trapezoidal platelets, and nanosilica or silica dioxide (SiO₂) are spherical. These nanoclays were chosen for sustainable purposes as they are naturally derived and for economical purposes because of their cheap commercial availability. In this study, the nanoclays are functionalized with an epoxy organosilane group through reflux conditions at 120 °C for 24 hours. The pristine and functionalized nanoclays were extensively characterized with infrared radiation (IR) spectroscopy, scanning electron microscope …