Theta Burst Brain Stimulation In Painful Diabetic Neuropathy Patients: Investigating Neural Mechanisms, Bhushan Thakkar

Theses and Dissertations

Chronic pain (CP) is a significant contributor to disability and disease burden globally. In 2019, approximately 50.2 million adults (20.4% of the US population) experienced chronic pain, contributing to $560-635 billion in direct medical costs. In addition, the worldwide prevalence of diabetes mellitus has reached epidemic proportions and is set to increase to 629 million by 2045. Almost 50% of patients with diabetes present with diabetic neuropathy (DN), and one in five patients with diabetes presents with painful DN (pDN) which is the most common cause of neuropathic pain (NP) in the US. Symptomatic treatment is the mainstay of management …

Sources Of Variability And Uncertainty In Food-Energy-Water Nexus Systems, Heydi Calderon-Ambelis, Deepak R. Keshwani

Department of Agricultural and Biological Systems Engineering: Faculty Publications

A nexus approach contributes to the strategic allocation of resources to secure food, energy, and water for the world population. Integrated models considering the complex interactions across food, energy, and water (FEW) enhance decision-making and strategic planning towards resilience. However, a significant number of the existing integrated models leave unaddressed the inherent variability and uncertainty present in the FEW sectors. Here, we review the importance of characterizing variability over spatial and temporal scales and the importance of decreasing the uncertainty present within a FEW nexus systems. The review also discusses existing modeling tools that address variability and uncertainty on single …

The Third International Hackathon For Applying Insights Into Large-Scale Genomic Composition To Use Cases In A Wide Range Of Organisms, Kimberly Walker, Divya Kalra, Rebecca Lowdon, Guangyi Chen, Fritz J. Sedlazeck, Ben Busby, Chia-Sin Liew, Et Al.

Nebraska Center for Biotechnology: Faculty and Staff Publications

In October 2021, 59 scientists from 14 countries and 13 U.S. states collaborated virtually in the Third Annual Baylor College of Medicine & DNANexus Structural Variation hackathon. The goal of the hackathon was to advance research on structural variants (SVs) by prototyping and iterating on open-source software. This led to nine hackathon projects focused on diverse genomics research interests, including various SV discovery and genotyping methods, SV sequence reconstruction, and clinically relevant structural variation, including SARS-CoV-2 variants. Repositories for the projects that participated in the hackathon are available at https://github.com/collaborativebioinformatics.

Neural Processing Of Semantic Content In Movies, Maximilian Nentwich

Dissertations and Theses

Naturalistic stimuli, such as movies, contain interacting, multimodal and semantic features and allow for free exploration through eye movements. The full extent of neural responses to features such as motion, film cuts and eye movement behavior has not been established. The main hypothesis of this thesis is that complex multimodal and semantic stimuli in naturalistic movies engage a widespread ensemble of locations across the entire brain. To address this question I analyzed simultaneous intracranial and eyetracking data from over 6,000 electrodes across 23 patients with intractable epilepsy. Responses to fast eye movements – saccades – and film cuts are widespread …

Exosome- And Microrna-Based Therapeutic Approach For Tendinopathy, Angela Wang Ilaltdinov

Dissertations and Theses

Tendinopathy, characterized by degeneration and chronic inflammation, is a significant clinical burden. Current treatments focus on symptom management but do not sufficiently address its underlying pathology; however, stem cell-based approaches aimed at repairing diseased tissues may overcome this limitation. Therapeutic effects of stem cells may be due in part to paracrine actions, including some mediated by exosomes – extracellular vesicles secreted by cells that play a role in cell communication. MicroRNA (miRNA), small non-coding RNA carried by exosomes, are likely responsible for many exosome effects. Exosomes and miRNA therapies show promise in treating diseases such as cancer and arthritis, but …

The Improvement Of The Regional Regulatory Governance System For Radiation Risk Management: Spatial Analysis On Radiation Hazards In South Korea, Sangwon Lee, Jaewon Lim, Chan Goo Yi

Public Policy and Leadership Faculty Research

Since the 2011 Fukushima nuclear power plant accident, nuclear regulators have strength-ened safety standards or decided to decommission the nuclear power plant. The vast majority of radiation is from nuclear power plants, so safety measures are also concentrated in nuclear power plants. Radioactive materials located much closer to the people are scattered around the nation. However, it is difficult for citizens to predict the radiation risk around them because regulatory agencies do not provide adequate information on radiation. The main goal of this study is to analyze the spatial distribution patterns of radioactive materials that serve as indicators for potential …

Adapting Colorado River Basin Depletions To Available Water To Live Within Our Means, Jian Wang, David E. Rosenberg

Publications

The Colorado River’s two largest reservoirs are drawing down because releases exceed inflows and releases adapt to reservoir elevations instead of elevation and inflow triggers. To help slow reservoir drawdown and sustain target elevations, we introduced a new rule that adapted basin depletions to available water. We simulated inflow-based operations and validated existing operations in a new open-source exploratory model for the Colorado River Basin. We developed the exploratory model to more easily adapt Upper and Lower Basin depletions to available water, reduce run time, and lower costs to use compared to the proprietary RiverWare Colorado River Simulation System (CRSS) …

Efficient Removal Of Lead Ions From Aqueous Media Using Sustainable Sources On Marine Algae, Hannah Namkoong, Erik Biehler, Gon Namkoong, Tarek M. Abdel-Fattah

Electrical & Computer Engineering Faculty Publications

The goal of this project is to explore a new method to efficiently remove Pb(II) ions from water by processing Undaria pinnatifida into immobilized beads using sodium alginate and calcium chloride. The resulting biosorbent was characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDS). Using immobilized U. pinnatifida, we investigated the effect of various factors on Pb(II) ion removal efficiency such as temperature, pH, ionic strength, time, and underlying biosorption mechanisms. For Pb(II) ion biosorption studies, Pb(II) ion biosorption data were obtained and analyzed using Langmuir and Freundlich adsorption models. It …

Development Of Phase Change Thermal Storage Medium: Cooking With More Power And Versatility, Martin Osei

Masters Theses

With an Insulated Solar Electric Cooker (ISEC), a 100 W solar panel directly cooks food while providing 5W off-grid electricity access; but it cooks slowly. Storing the day’s energy with phase change thermal storage allows ISEC to cook more rapidly as well as cook after sunset. The ISEC is made by sticking a 3ohm resistive to an aluminum pot (inner phase change assembly PCA) where another cooking pot fits. The resistive heater is surrounded by a bigger pot (outer PCA) that contains the PCM and is tightly sealed. The solar panel is connected to the resistive heater with a thermal …

Biomechanical Evaluation Of Hand Representation For Typing In Virtual Reality, Mobasshira Zaman

Graduate Research Theses & Dissertations

Virtual reality (VR) is becoming popular in the workplace recently. Text entry is thus now important for efficient office use and occupational use of VR, and VR paired with a conventional keyboard is suitable for long text entry. There has been a lack of research on physical demand, posture, motion, and cognitive demand, along with the performance of typing on VR. Presence of virtual hands while typing in VR may affect typing performance, physical demand, and posture. The focus of this study was to evaluate the biomechanical effect of hand representation for typing on VR using a conventional keyboard. Fifteen …

Study Protocol To Analyze The Effects Of Posture And Exoskeleton On Human Exposure To Hand-Transmitted Vibration, Parisa Torkinejad Ziarati

Graduate Research Theses & Dissertations

Exposure to power hand tool-generated vibrations may lead to several health disorders collectively known as hand-arm vibration (HAV) syndromes. Power hand tools are often used in overhead postures in the manufacturing and construction industries. However, HAV risks are examined in the front-of-body posture in the existing safety standards and guidelines. Therefore, it is important to understand the effects of overhead working posture on vibration transmissibility (VT) in the upper extremities (UEs) and the spine. Secondly, there is a rising trend of using occupational exoskeletons (Exos) in the manufacturing and construction industries, especially involving overhead work with power hand tools. However, …

Submaximal Electromyography-Driven Musculoskeletal Modeling Of The Human Trunk During Static Tasks: Equilibrium And Stability Analyses, Farshid Ghezelbash, Aboulfazl Shirazi-Adl, Denis Gagnon, Ali Shahvarpour, Navid Arjmand, Amir Hossein Eskandari, Christian Larivière

Études primaires

Conventional electromyography-driven (EMG) musculoskeletal models are calibrated during maximum voluntary contraction (MVC) tasks, but individuals with low back pain cannot perform unbiased MVCs. To address this issue, EMG-driven models can be calibrated in submaximal tasks. However, the effects of maximal (when data points include the maximum contraction) and submaximal calibration techniques on model outputs (e.g., muscle forces, spinal loads) remain yet unknown. We calibrated a subject-specific EMG-driven model, using maximal/submaximal isometric contractions, and simulated different independent tasks. Both approaches satisfactorily predicted external moments (Pearson’s correlation ∼ 0.75; relative error = 44%), and removing calibration tasks under axial torques markedly improved …

Histological Comparison Of Shark Dermis Across Various Ecomorphologies, Olivia Schuitema

UNF Graduate Theses and Dissertations

The integument plays essential roles in the structural support, protection, and hydrodynamic capability among fishes. Most shark skin research has been done on the external epidermal layer containing the dermal denticles, while the larger dermis layer has been mostly ignored. The dermis layer in sharks is composed of two layers, the upper stratum laxum and the lower stratum compactum, holding supportive collagen and elastin fibers. There may be morphological and compositional differences in the dermis layers across various species of sharks, although the extent of such is unknown. These potential differences may be represented by various dermal thicknesses and different …

Using Skeleton Correction To Improve Flash Lidar-Based Gait Recognition, Nasrin Sadeghzadehyazdi, Tamal Batabyal, Alexander Glandon, Nibir Dhar, Babajide Familoni, Khan Iftekharuddin, Scott T. Acton

Electrical & Computer Engineering Faculty Publications

This paper presents GlidarPoly, an efficacious pipeline of 3D gait recognition for flash lidar data based on pose estimation and robust correction of erroneous and missing joint measurements. A flash lidar can provide new opportunities for gait recognition through a fast acquisition of depth and intensity data over an extended range of distance. However, the flash lidar data are plagued by artifacts, outliers, noise, and sometimes missing measurements, which negatively affects the performance of existing analytics solutions. We present a filtering mechanism that corrects noisy and missing skeleton joint measurements to improve gait recognition. Furthermore, robust statistics are integrated with …

Therapeutic Injectable Iron-Chelating Hydrogels, Debbie Campbell-Rance

Theses and Dissertations

ABSTRACT

Therapeutic Injectable Iron-Chelating Hydrogels for Improved Central Nervous System Regeneration

By

Debbie S. Campbell-Rance

A dissertation submitted in partial fulfillment of the requirements of the degree of Doctor of Philosophy at Virginia Commonwealth University 2021.

Director: Xuejun Wen, M.D., Ph.D., AIMBE Fellow, Alice T. and William H. Goodwin Jr. Endowed Chair Professor in Regenerative Medicine, Institute for Engineering and Medicine, Department of Chemical and Life Science Engineering

Severe traumatic brain and spinal cord injuries are major global public health and socioeconomic problems in terms of mortality and morbidity. Currently there are two main lines of treatment under development for …

Ammonia Cycling And Emerging Particulate Matter Pollutants Under Arable Land-Use Management: A Modelling Approach, Vivien Pohl

Doctoral

Air quality monitoring in Ireland is under the jurisdiction of the Environmental Protection Agency in compliance with the Gothenburg Protocol, EU/national legislation, and the National Clean Air Strategy. Particulate Matter (PM) has been acknowledged as a key atmospheric pollutant, with serious public health impacts and no safe threshold of exposure in place to-date. Ammonia (NH3) emissions are linked to the secondary production of PM through atmospheric reactions occurring with acidic atmospheric components such as sulfuric acid, nitric acid, and hydrochloric acid. These reactions result in the formation of ammonium sulfate, ammonium nitrate and ammonium chloride, among others. More than 95% …

Recovering And Upgrading Kraft Lignin For Application In Flexible Polyurethane Foam, Peng Quan

Dissertations, Master's Theses and Master's Reports

Lignin is the second abundant natural polymer and has been highlighted as a potential substitute for fossil-based raw materials. However, the inherent molecular heterogeneity and the complex recovery processes result in the challenge of controlling the molecular properties and value-added applications of lignin in large scale. To address those issues, a novel acid-liquefaction process was developed in this study to recover Kraft lignin with improved molecular homogeneity directly from black liquor.

In the first study, the liquefaction parameters were screened based on yield and molecular weight properties of the recovered lignin. Then, the recovered lignin samples were used to replace …

An Antimicrobial Polydopamine Surface Coating To Reduce Biofouling On Telemetry Tags Used In Marine Conservation Practices, Ariana Smies

Dissertations, Master's Theses and Master's Reports

Satellite telemetry tags are used to track the migration patterns of large cetaceans. These tags penetrate the dermis and remain embedded in the underlying blubber tissue. As the dermis of cetaceans is host to a diverse microbiome, and it is impossible to clean the skin before implanting the devices, the potential for infection is increased when the tags penetrate through the skin. H₂O₂ is a potential antimicrobial agent that, in addition to showing broad-spectrum efficacy against gram-negative and gram-positive bacteria, can promote wound healing outcomes by promoting proliferative factors and peptides that protect against oxidative stress. However, …

A Tool For Biometric Interpretation Of Forensic Str Dna Profiles, Ahmad Jamal Baroudi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Rapid DNA biometric identification applications are becoming more essential and widely used in human identity validation processes. Despite their powerful identification capabilities, processing a sample to generate a forensic DNA profile still takes longer compared with other rapid biometric technologies. Methods used to speed up the analysis could lead to signal artifacts similar to those arising from low copy or degraded DNA samples, making the electropherogram unsuitable for forensic interpretation and analysis. The goal of this research effort is to apply biometrics and mathematical approaches to forensic STR (Short Tandem Repeat) profiles. To accomplish this goal, a multi-function software tool …

Bodipy Based Photodynamic Therapy And Potassium Probes, Xiangshan Liu

Dissertations

Boron dipyrromethene (BODIPY) has become more and more popular in photophysical and biological applications. BODIPY based fluorescence compounds have numerous advantage properties including low toxicity, high absorption extinction coefficients, high fluorescence quantum yields, sharp fluorescence emissions, and resistance to photobleaching. All the good properties lead to the wide applications of BODIPY based compounds. In this research, two different kinds of BODIPY are synthesized. Firstly, BDBrC containing carbazole and BODIPY core is synthesized. Cellular uptake research shows BDBrC can target on lysosome and singlet oxygen generation research result indicates that BDBrC can be used in photodynamic therapy. BDBrC also shows pH-sensitive …

Usf Jamovi Tutorial Project: Open Education Resource, Aline Hitti, Saera Khan

USF OER Faculty Grant Projects

Jamovi is an open source free software that USF staff, faculty and student can download to carry out any statistical analyses. The current report summarizes the progress made on an Open Education Resource Grant funded project, which aimed to created Jamovi tutorials. In this report, student feedback and faculty reaction are summarized after one semester of using the tutorials created.

Flood Analysis And Hydraulic Competence Of Drainage Structures Along Addis Ababa Light Rail Transit, Moses Kiwanuka, Seleshi Yilma, Joel Webster Mbujje, John Bosco Niyomukiza

Journal of Environmental Science and Sustainable Development

The occurrence of flooding events and the associated risks are increasing in the urban areas of most developing countries. Flooding in any circumstance causes major stresses on affected area’s economic, social and environmental regimes. Therefore, the current study presents a flood analysis and hydraulic competence of existing drainage structures on some selected roads of Addis Ababa City, after integration with Addis Ababa Light Rail Transit (AALRT) Drainage Systems. The existing side drains and cross drainage structures located within the study area were inspected and assessed to ascertain different aspects relating to their performance. Different watersheds were delineated. Hydrological analysis was …

Mathematical Model Of The Efficiency Of Investments Aimed In The Implementation Of Water-Saving Technologies

Irrigation and Melioration

In Uzbekistan, research work is being carried out aimed at improving the economic mechanisms for the introduction of water-saving technologies for irrigating agricultural crops. At the same time, the issues related to the analysis of the effectiveness of the use of water-saving technologies when irrigating cotton, the development of mathematical methods for assessing the effectiveness of investments, as well as their introduction into practice have not been sufficiently studied. This article provides a mathematical model of the efficiency of investments aimed at introducing water-saving technologies. The results of a numerical experiment of a mathematical model show that the introduction of …

Efficient Use Of Water Resources In The Basins Of Small Rivers, F. Gapparov, M.F. Gafforova

Irrigation and Melioration

The article provides a recommendation for the efficient use of water resources in the basins of small foothill rivers. The research was carried out on the example of the Govasay river basin located in the northern part of the Fergana Valley. The efficiency factor of the canal has been determined and a technical assessment has been given for the management of water resources in the river basin; the efficiency of the canal is 65-75%. A program for the operational management of water resources in The Govasay river basin and a GIS map of water consumers in the Govasay river basin …

Model Of Groundwater Level Control Using Horizontal Drainage, A. Arifjanov, M. Otaxonov, Z. Abdulkhaev

Irrigation and Melioration

The article describes the main factors affecting the rise in the level of groundwater in the city of Fergana and ways to eliminate them. Currently, in order to reduce the negative impact of rising groundwater levels on the environment, crops, buildings and structures, as well as underground utilities, it is proposed to design horizontal drainage in urban areas and a mathematical model has been developed for changing the groundwater level. For this, long-term data from observation wells were analyzed and the hydraulic parameters of horizontal drainage were selected taking into account the hydrogeology of the area. Taking into account the …

Results Of Proximate Analysis Of Energy Use Of Municipal Solid Waste, N.N. Abduganiev

Irrigation and Melioration

In the modern industrialized world, various raw materials are processed and used for human consumption. While some of the raw materials are converted into the desired product, the rest is thrown into the environment as waste. It is known that solid waste is a type of biomass that is formed in the course of human life. The article presents the results of a preliminary analysis of studies on the use of solid waste energy in the Urta-Chirchik district of the Tashkent region. Sorting results showed that the total volume of municipal solid waste in the district consists mainly of wood …

Shredding Of Cotton Stalks Under The Action Of Toothpicks In A Combined Unit, B. Khudayarov, U. Kuziev, B. Sarimsakov, М. Kholbutaev

Irrigation and Melioration

The article presents materials devoted to the justification of the parameters of the crown-wheel of the combined aggreagate. The technological process of work and the design of the working part, which is crushed by crushing cotton stalks, without breaking them, laying them on the movement of the unit, has been substantiated and developed. The optimal parameters of the crown-wheel and the tooth are determined by solving the regression equations that determine the optimal values of the vertical load on the teeth and its working quality. The results of theoretical and experimental research show that the amount of crushing of cotton …

Influence Of Electrophysical Methods On The Processes Of Root Formation Of Grapes, N.M. Markayev

Irrigation and Melioration

The article describes the possibilities of electrophysical processing before planting cuttings during vegetative cultivation of grape seedlings. The processes of root formation in cuttings using the electrophysical method in the article Acceleration of the process of root formation in cuttings of black raisins, treated at 71 V/m and an electric field strength of 15 hours, and an increase in the viability, quality, growth and survival of rooted seedlings up to 16.67-34% Presented the results of experiments on the increase and methods of electrotechnological processing of grape cuttings. The result of the study is the analysis and results of the processes …

Conditions, Criteria And Principles For Creating An Agri-Cultural Land Market In Uzbekistan, A.R. Nurnazarov

Irrigation and Melioration

The article analyzes the prerequisites for creating a market for agricultural land in the Republic of Uzbekistan, special attention is paid to land reform, land degradation (reduction of the bonitet score from 60 in 1991 to 50 or more at present, pasture degradation by 20-30%) and increase in economic from their use, the role of land rent in payments for land. 6 basic principles for creating a land market have been established and systematized, the relationship between X-rays and water in the irrigated farming zone, the role of the market in increasing the efficiency and effectiveness of the use of …

Economic Assessment Of The Effect Of Family Income On Students' Disciplines, Sh.A. Muratov

Irrigation and Melioration

The importance of higher education in scientific research, its role in poverty reduction and population growth has been studied theoretically. Also, when using the data of social surveys conducted by 538 respondents (students) studying in higher education institutions, they were awarded the Order of the logistics regulator in the economic assessment of the factors influencing the rate of mastery of disciplines. Factors influencing the acquisition of subjects by students: the main income of the family comes from non-farm (69,9 %), sex (52,2 %), studying at a higher education institution on a state grant (108,8 %), the student's course of study …