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Articles 2011 - 2040 of 6299

Full-Text Articles in Engineering

A Protein-Based Therapeutic Combination For The Treatment Of Hard-To-Heal Wounds, Graham L. Strauss Jul 2022

A Protein-Based Therapeutic Combination For The Treatment Of Hard-To-Heal Wounds, Graham L. Strauss

USF Tampa Graduate Theses and Dissertations

Chronic wounds present many clinical challenges in relation to the successful treatment and closure of the damaged tissue. Most current treatment methods focused on one or two aspects to drive wound closure, while most chronic wounds are multifactorial environments with many of those dependencies relying on the termination of one another to effectively gain tissue construction, closure, and full skin thickness and composition. Natural wound healing processes allude to potential biologics that can impede the chronic breakdown of tissue, while restoring deposition of new tissue, and effectively leading to a healed wound. Proteases secreted by the body’s immune system lay …

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Table Of Contents Jun 2022

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

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Estimation Of Storage Tank Capacities For Different Roofing Areas For Rainwater Harvesting In Dodoma Urban, Tanzania, Ombeni J. Mdee Jun 2022

Estimation Of Storage Tank Capacities For Different Roofing Areas For Rainwater Harvesting In Dodoma Urban, Tanzania, Ombeni J. Mdee

Tanzania Journal of Engineering and Technology (TJET)

This study uses a mass balance model and economic analysis technique to present an estimation of roofing areas and storage tank capacity for Rainwater Harvesting (RWH) system. The water-saved benefits were estimated using the monthly rainfall of over 39 years from 1981 to 2020 and five roofing areas. The proposed roof-storage-ratio method presents the minimum requirement of roof area and storage tank size when the ratio value is closer to 1. The benefit-cost ratio and percentage of reliability indicated the optimal roofing areas ranging between 200 and 300 m2 for storage tank capacity between 20 and 25 m3, with a …

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Biomimetic Strategies To Control Therapeutic Release From Novel Dna Nanoparticles, Robert J. Mosley Jun 2022

Biomimetic Strategies To Control Therapeutic Release From Novel Dna Nanoparticles, Robert J. Mosley

Theses and Dissertations

The inherent chemical, mechanical, and structural properties of nucleic acids make them ideal candidates for the formulation of tunable, personalized drug nanocarriers. However, none so far have exploited these properties for the controlled release of therapeutic drugs. In this dissertation, a biomimetic approach to controlling drug release is exhibited by specifically manipulating the architecture of novel, DNA nanoparticles to take advantage of drug binding mechanisms of action. Rationally designed DNA strands were immobilized on gold surfaces via a terminal thiol modification. Immobilized monomers can be manipulated to form distinct monolayer architectures including flat, folded, coiled, or stretched structures. Increasing the …

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Positive Rate-Dependent Action Potential Prolongation By Modulating Potassium Ion Channels, Candido Cabo Jun 2022

Positive Rate-Dependent Action Potential Prolongation By Modulating Potassium Ion Channels, Candido Cabo

Publications and Research

Pharmacological agents that prolong action potential duration (APD) to a larger extent at slow rates than at the fast excitation rates typical of ventricular tachycardia exhibit reverse rate dependence. Reverse rate dependence has been linked to the lack of efficacy of class III agents at preventing arrhythmias because the doses required to have an anti-arrhythmic effect at fast rates may have pro-arrhythmic effects at slow rates due to an excessive APD prolongation. In this report we show that, in computer models of the ventricular action potential, APD prolongation by accelerating phase 2 repolarization (by increasing IKs) and decelerating …

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Student Self-Grading Form, Brett Whysel Jun 2022

Student Self-Grading Form, Brett Whysel

Open Educational Resources

This is a word document that students use at the beginning, midpoint, and end of a semester to set relevant goals, measure progress towards goals, and self-grade. It is intended to build motivation, metacognition, and accountability. Instructors may use it on its own or to supplement other assessment tools, and improve the accuracy, validity, and fairness of final grades.

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Functional Requirements For A Samd14-Capping Protein Complex In Stress Erythropoiesis, Suhita Ray, Linda Chee, Yichao Zhou, Meg A. Schaefer, Michael J. Naldrett, Sophie Alvarez, Nicholas T. Woods, Kyle J. Hewitt Jun 2022

Functional Requirements For A Samd14-Capping Protein Complex In Stress Erythropoiesis, Suhita Ray, Linda Chee, Yichao Zhou, Meg A. Schaefer, Michael J. Naldrett, Sophie Alvarez, Nicholas T. Woods, Kyle J. Hewitt

Nebraska Center for Biotechnology: Faculty and Staff Publications

Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals—involving cooperation between stem cell factor (SCF)/Kit signaling and other signaling inputs—are required for the increased erythroid precursor activity in anemia. Our prior work revealed that the sterile alpha motif (SAM) domain 14 (Samd14) gene increases the regenerative capacity of the erythroid system in a mouse genetic model and promotes stress-dependent Kit signaling. However, the mechanism underlying Samd14’s role in stress erythropoiesis is unknown. We identified a protein-protein interaction between Samd14 and the α- and β-heterodimers of the F-actin capping protein (CP) complex. Knockdown of …

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A Simplified Model For The Intermediate Structure Of Strong Fire Whirls, Forman A. Williams Jun 2022

A Simplified Model For The Intermediate Structure Of Strong Fire Whirls, Forman A. Williams

Progress in Scale Modeling, an International Journal

A model is described for the overall structure of intense fire whirls, based on a spatially evolving vortex, with circulation enhancement driven by the axial acceleration of low-density gas in the core through the axial pressure gradient. The axial acceleration increases the entrainment rate into the core which, through mass conservation, increases the circulation if the angle between the tangential and radial velocity components remains fixed. The two-zone model employs general balance equations for regions inside and outside a cylinder of fixed radius, each inviscid, the inside region being presumed to have a constant density small compared with the (constant) …

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Reduced-Scale Experiments And Numerical Simulations Of Informal Settlement Dwelling Fires, Vigneshwaran Narayanan, Antonio Cicicone, Ayden D. Botha, Richard Shaun Walls Jun 2022

Reduced-Scale Experiments And Numerical Simulations Of Informal Settlement Dwelling Fires, Vigneshwaran Narayanan, Antonio Cicicone, Ayden D. Botha, Richard Shaun Walls

Progress in Scale Modeling, an International Journal

Informal settlement dwellings (ISDs) house approximately one billion people in the developing world and this number is expected to double by the year 2030. Contemporary research on ISD fires has focused on understanding the fire dynamics within individual dwellings (micro-scale) and fire spread in settlements consisting of multiple dwellings (macro-scale). This paper aims to do two primary things: investigate if scaling methods that were derived for compartments with thermally thick boundaries can be applied to ISDs (compartments with thermally thin boundaries), and if they can adequately represent the most important phenomena associated with full-scale ISD fires; and demonstrate Fire Dynamics …

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Climate Projections Over The Great Lakes Region: Using Two-Way Coupling Of A Regional Climate Model With A 3-D Lake Model, Pengfei Xue, Xinyu Ye, Jeremy S. Pal, Philip Y. Chu, Miraj Kayastha, Chenfu Huang Jun 2022

Climate Projections Over The Great Lakes Region: Using Two-Way Coupling Of A Regional Climate Model With A 3-D Lake Model, Pengfei Xue, Xinyu Ye, Jeremy S. Pal, Philip Y. Chu, Miraj Kayastha, Chenfu Huang

Michigan Tech Publications, Part 1

Warming trends in the Laurentian Great Lakes and surrounding areas have been observed in recent decades, and concerns continue to rise about the pace and pattern of future climate change over the world's largest freshwater system. To date, most regional climate models used for Great Lakes projections either neglected the lake-atmosphere interactions or are only coupled with a 1-D column lake model to represent the lake hydrodynamics. This study presents a Great Lakes climate change projection that has employed the two-way coupling of a regional climate model with a 3-D lake model (GLARM) to resolve 3-D hydrodynamics essential for large …

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Bbt Side Mold Assy, Bill Hemphill Jun 2022

Bbt Side Mold Assy, Bill Hemphill

STEM Guitar Project’s BBT Acoustic Kit

This electronic document file set covers the design and fabrication information of the ETSU Guitar Building Project’s BBT (OM-sized) Side Mold Assy for use with the STEM Guitar Project’s standard acoustic guitar kit. The extended 'as built' data set contains an overview file and companion video, the 'parent' CADD drawing, CADD data for laser etching and cutting a drill &/or layout template, CADD drawings in AutoCAD .DWG and .DXF R12 formats of the centerline tool paths for creating the mold assembly pieces on an AXYZ CNC router, and support documentation for CAM applications including router bit specifications, feeds, speed, multi-pass …

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Barrier Knockdown Test Control System For The Cal Poly Kinesiology Department, Regina M. Chapuis Jun 2022

Barrier Knockdown Test Control System For The Cal Poly Kinesiology Department, Regina M. Chapuis

Computer Engineering

The goal of this project is to design and implement a new control system for the LEDs and buttons on an existing Barrier Knockdown setup in the Cal Poly Kinesiology department. The Barrier Knockdown test is a testing apparatus in which subjects knock down a series of mechanical barriers in one of three patterns. The computer system times their reaction and movement time, and the test as a whole provides students with data to study the phenomenon of Contextual Interference. This system was previously controlled by an old computer setup that ultimately crashed. This project recreates the logic and user …

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Developing A Miniature Smart Boat For Marine Research, Michael Isaac Eirinberg Jun 2022

Developing A Miniature Smart Boat For Marine Research, Michael Isaac Eirinberg

Computer Engineering

This project examines the development of a smart boat which could serve as a possible marine research apparatus. The smart boat consists of a miniature vessel containing a low-cost microcontroller to live stream a camera feed, GPS telemetry, and compass data through its own WiFi access point. The smart boat also has the potential for autonomous navigation. My project captivated the interest of several members of California Polytechnic State University, San Luis Obispo’s (Cal Poly SLO) Marine Science Department faculty, who proposed a variety of fascinating and valuable smart boat applications.

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Specialized Named Entity Recognition For Breast Cancer Subtyping, Griffith Scheyer Hawblitzel Jun 2022

Specialized Named Entity Recognition For Breast Cancer Subtyping, Griffith Scheyer Hawblitzel

Master's Theses

The amount of data and analysis being published and archived in the biomedical research community is more than can feasibly be sifted through manually, which limits the information an individual or small group can synthesize and integrate into their own research. This presents an opportunity for using automated methods, including Natural Language Processing (NLP), to extract important information from text on various topics. Named Entity Recognition (NER), is one way to automate knowledge extraction of raw text. NER is defined as the task of identifying named entities from text using labels such as people, dates, locations, diseases, and proteins. There …

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One-Stage Blind Source Separation Via A Sparse Autoencoder Framework, Jason Anthony Dabin May 2022

One-Stage Blind Source Separation Via A Sparse Autoencoder Framework, Jason Anthony Dabin

Dissertations

Blind source separation (BSS) is the process of recovering individual source transmissions from a received mixture of co-channel signals without a priori knowledge of the channel mixing matrix or transmitted source signals. The received co-channel composite signal is considered to be captured across an antenna array or sensor network and is assumed to contain sparse transmissions, as users are active and inactive aperiodically over time. An unsupervised machine learning approach using an artificial feedforward neural network sparse autoencoder with one hidden layer is formulated for blindly recovering the channel matrix and source activity of co-channel transmissions. The BSS sparse autoencoder …

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Assessing Structural And Functional Brain Alterations And Work-Related Fatigue In Non-Hyposmic And Hyposmic Covid-19 Survivors, Rakibul Hafiz May 2022

Assessing Structural And Functional Brain Alterations And Work-Related Fatigue In Non-Hyposmic And Hyposmic Covid-19 Survivors, Rakibul Hafiz

Dissertations

In the year 2019, life began to change at the advent of a global pandemic caused by the novel coronavirus. Mask mandates and mass vaccinations have mitigated the effects significantly, yet cases keep rising with new variants, especially, in densely populated countries, like India. Recent neuroimaging evidence shows the virus can attack the central nervous system (CNS). However, exactly which brain regions undergo structural and functional changes remain largely unknown. Many patients experience 'loss of/reduced sense of smell' (i.e., hyposmic) and an alarming number of survivors develop persistent symptoms ('long-COVID') for several months after initial infection. Fatigue is the most …

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Integrating Deep Learning And Hydrodynamic Modeling To Improve The Great Lakes Forecast, Pengfei Xue, Aditya Wagh, Gangfeng Ma, Yilin Wang, Yongchao Yang, Tao Liu, Chenfu Huang May 2022

Integrating Deep Learning And Hydrodynamic Modeling To Improve The Great Lakes Forecast, Pengfei Xue, Aditya Wagh, Gangfeng Ma, Yilin Wang, Yongchao Yang, Tao Liu, Chenfu Huang

Michigan Tech Publications, Part 1

The Laurentian Great Lakes, one of the world’s largest surface freshwater systems, pose a modeling challenge in seasonal forecast and climate projection. While physics-based hydrodynamic modeling is a fundamental approach, improving the forecast accuracy remains critical. In recent years, machine learning (ML) has quickly emerged in geoscience applications, but its application to the Great Lakes hydrodynamic prediction is still in its early stages. This work is the first one to explore a deep learning approach to predicting spatiotemporal distributions of the lake surface temperature (LST) in the Great Lakes. Our study shows that the Long Short-Term Memory (LSTM) neural network, …

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A Detailed Parameter Study Into The Dermal Absorption Of Chemical Warfare Agents And The Effects Of Pharmacokinetics, Koko Lear May 2022

A Detailed Parameter Study Into The Dermal Absorption Of Chemical Warfare Agents And The Effects Of Pharmacokinetics, Koko Lear

Theses

Chemical warfare agents (CWAs) are substances of varying toxicity profiles. These chemicals exhibit complex dynamics and pose a serious health risk when released into the environment. A mathematical model based on Fick’s second law of diffusion was developed to comprehend how these compounds were absorbed into the skin. The analysis applied to both small and large doses and, successfully, predicted experimental results. This work also includes the effects of CWA physicochemical properties on evaporation and dermal absorption through the stratum corneum. A sensitivity analysis was conducted to assess the impacts of small variations in the initial dose, environmental conditions, and …

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Feral Horses And Bison At Theodore Roosevelt National Park (North Dakota, United States) Exhibit Shifts In Behaviors During Drone Flights, Javier Lenzi, Christopher J. Felege, Robert Newman, Blake Mccann, Susan N. Ellis-Felege May 2022

Feral Horses And Bison At Theodore Roosevelt National Park (North Dakota, United States) Exhibit Shifts In Behaviors During Drone Flights, Javier Lenzi, Christopher J. Felege, Robert Newman, Blake Mccann, Susan N. Ellis-Felege

Biology Faculty Publications

Drone use has been rapidly increasing in protected areas in North America, and potential impacts on terrestrial megafauna have been largely unstudied. We evaluated behavioral responses to drones on two terrestrial charismatic species, feral horse (Equus caballus) and bison (Bison bison), at Theodore Roosevelt National Park (North Dakota, United States) in 2018. Using a Trimble UX5 fixed-wing drone, we performed two flights at 120 m above ground level (AGL), one for each species, and recorded video footage of their behaviors prior to, during, and after the flight. Video footage was analyzed in periods of 10 s intervals, and the occurrence …

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Virucidal N95 Respirator Face Masks Via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings, Mirco Sorci, Tanner D. Fink, Vaishali Sharma, Sneha Singh, Ruiwen Chen, Brigitte L. Arduini, Katharine Dovidenko, Caryn L. Heldt, Edmund F. Palermo, R Helen Zha May 2022

Virucidal N95 Respirator Face Masks Via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings, Mirco Sorci, Tanner D. Fink, Vaishali Sharma, Sneha Singh, Ruiwen Chen, Brigitte L. Arduini, Katharine Dovidenko, Caryn L. Heldt, Edmund F. Palermo, R Helen Zha

Michigan Tech Publications, Part 1

N95 respirator face masks serve as effective physical barriers against airborne virus transmission, especially in a hospital setting. However, conventional filtration materials, such as nonwoven polypropylene fibers, have no inherent virucidal activity, and thus, the risk of surface contamination increases with wear time. The ability of face masks to protect against infection can be likely improved by incorporating components that deactivate viruses on contact. We present a facile method for covalently attaching antiviral quaternary ammonium polymers to the fiber surfaces of nonwoven polypropylene fabrics that are commonly used as filtration materials in N95 respirators via ultraviolet (UV)-initiated grafting of biocidal …

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In Situ Observations Of Fish Attraction To Light-Emitting Diodes On An Undersea Observation Deck, Makoto Tomiyasu, Yoko Tanouchi, Yasuzumi Fujimori, Minato Kaji, Takuma Hayashi, Naoto Matsubara, Hiroki Yasuma, Susumu Shimizu, Seiji Katakura May 2022

In Situ Observations Of Fish Attraction To Light-Emitting Diodes On An Undersea Observation Deck, Makoto Tomiyasu, Yoko Tanouchi, Yasuzumi Fujimori, Minato Kaji, Takuma Hayashi, Naoto Matsubara, Hiroki Yasuma, Susumu Shimizu, Seiji Katakura

Journal of Marine Science and Technology–Taiwan

Many fisheries employ fishing lights to manipulate the behaviors of target fish and to attract them toward the light; however, relatively few long-time observations of fish attraction have been performed in the field. Here, an underwater observation deck was used to examine the differences in the fish-attracting effect of light-emitting diode (LED) lights on the number of attracted fish and on their behavior in the field, using white-edged rockfish as the target species. A total of 604 ± 324, 307 ± 203 and 171 ± 106 white-edged rockfish individuals were attracted to the observation window when it was illuminated with …

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Inter-Annual Variability In Growth And Maturation Of The Swordtip Squid Uroteuthis Edulis In Yilan Bay Off Northeastern Taiwan, Jing-Yu Chen, Tzu-Yun Ching, Chih-Shin Chen May 2022

Inter-Annual Variability In Growth And Maturation Of The Swordtip Squid Uroteuthis Edulis In Yilan Bay Off Northeastern Taiwan, Jing-Yu Chen, Tzu-Yun Ching, Chih-Shin Chen

Journal of Marine Science and Technology–Taiwan

The swordtip squid Uroteuthis edulis, distributed in the temperate and tropical neritic waters in the Indo-Pacific region, is a crucial component of marine ecosystems and is a target species of fisheries in the Northwest Pacific. Although studies have elucidated the growth and maturation of the squid in the southern East China Sea (ECS) shelf, few have assessed the population biology of the squid in waters in the vicinity of the southern ECS. We collected samples of swordtip squid from a trawler in Yilan Bay (YLB) between January 2011 and December 2012 to examine the growth and maturation of the squid …

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Study On The Improved Radiation Boundary Conditions Based On The Quadratic B-Spline Rankine Panel Method, Ming-Chung Fang, Chun-Hsien Wu May 2022

Study On The Improved Radiation Boundary Conditions Based On The Quadratic B-Spline Rankine Panel Method, Ming-Chung Fang, Chun-Hsien Wu

Journal of Marine Science and Technology–Taiwan

This study presents a higher-order Rankine source method that is based on a biquadratic B-spline scheme with an improved radiation boundary condition. This method solves flow problems under all conditions, where , including the undercritical condition ( < 0.25); this condition is present when a ship undergoes slow translational motion. The proposed method is thus more flexible than the many Rankine-source models in the literature that are applicable only to the overcritical condition ( > 0.25). Specifically, the improved radiation boundary condition is derived from upstream Seto radiation boundary conditions and by incorporating the Rayleigh damping distribution over a free surface; the improved condition is explicit and efficient for solving flow problems. In evaluations, the proposed method yields accurate solutions for unsteady flows, which are produced by an oscillating, translationally moving submerged singularity. The method is also compared …

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Sensitive Analysis Of The Static Response Of Compliant Vertical Access Risers, Fuheng Li, Haiyan Guo, Xiaomin Li, Honglu Gu May 2022

Sensitive Analysis Of The Static Response Of Compliant Vertical Access Risers, Fuheng Li, Haiyan Guo, Xiaomin Li, Honglu Gu

Journal of Marine Science and Technology–Taiwan

Compliant vertical access risers (CVARs) are considered as efficient and robust alternative options to achieve cost efficiency and safety. Design uncertainties emerge owing to the limited understanding of the effects of various parameters related to the structural properties and marine loads. In this paper, a reasonable three-dimensional (3D) numerical model of CVAR with internal flow is presented based on the slender rod theory. Accordingly, the finite element method combined with a Newton-Raphson scheme is employed to discretize and solve the equations. A sensitivity analysis is performed to investigate the influence of the structural and external load parameters on the static …

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Influence Of Boundary Conditions And Internal Fluid Types On Dynamic Characteristics Of A Deepwater Riser, Lei Guo, Zong-Ming Zhu, Zhong-Jian Pan, Zhi-Ming Guo May 2022

Influence Of Boundary Conditions And Internal Fluid Types On Dynamic Characteristics Of A Deepwater Riser, Lei Guo, Zong-Ming Zhu, Zhong-Jian Pan, Zhi-Ming Guo

Journal of Marine Science and Technology–Taiwan

Deepwater Steel Catenary Riser (DSCR) is the key structure of oil and gas production system in the ocean. To design an optimized DSCR system, the dynamic characteristics of the DSCR are analyzed by setting some different boundary condi-tions and internal fluid types. The main vibration mode of the DSCR is found orthogonal to both mass and stiffness according to the normalization condition of the main mode, and then the regular mode function and the jth order principal stiffness Kpj are obtained. Under different initial conditions, the transverse responses of DSCR represented by regular coordinates under arbitrary excitation are obtained. Then, …

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Variance Of Td-Mosaic Dual-Vortex Interactions Between In-Fa And Cempaka (2021) In The North Pacific, Tsorng-Lin Chia, Guang-Yang Pan, Ji-Chyun Liu May 2022

Variance Of Td-Mosaic Dual-Vortex Interactions Between In-Fa And Cempaka (2021) In The North Pacific, Tsorng-Lin Chia, Guang-Yang Pan, Ji-Chyun Liu

Journal of Marine Science and Technology–Taiwan

A study of the different types of dual-vortex interactions or “Fujiwara effects” between two storms is crucial for considerably improving weather forecasts. This study combined remote sensing images, empirical formulas based on the possibility of storm interaction (Liou–Liu formula), and vector addition techniques to accurately analyze In-Fa and Cempaka typhoons and the surrounding weather patterns during the 2021 typhoon season in the North Pacific. Although the distance separating the typhoons In-Fa and Cempaka was 1,800–2,040 km, the influence of middle air flow and a tropical depression (TD) caused a "vector superposition TD-mosaic double-vortex" interaction between the two typhoons. Therefore, this …

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Optimal Deployment Of Flood Emergency Response Materials Under Stochastic Demands, Shangyao Yan, Jenn-Rong Lin, Chia-Fu Ku May 2022

Optimal Deployment Of Flood Emergency Response Materials Under Stochastic Demands, Shangyao Yan, Jenn-Rong Lin, Chia-Fu Ku

Journal of Marine Science and Technology–Taiwan

This study aims to develop a planning model for the deployment of flood emergency response materials under stochastic demands. For ease of modeling, a deterministic demand model is first proposed, from which the stochastic model is further extended. These models are used to determine the allocation of materials the transport truck routes and distribution of the stockpiled materials to emergency sites. The models are formulated as multiple integer network flow problems with special side constraints which are characterized as NP-hard in terms of optimization. To solve the complicated stochastic model efficiently, we also develop a solution algorithm based on a …

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Hydrodynamic Limitations To Mangrove Seedling Retention In Subtropical Estuaries, Kelly M. Kibler, Christian Pilato, Linda Walters, Melinda Donnelly, Jyotismita Taye May 2022

Hydrodynamic Limitations To Mangrove Seedling Retention In Subtropical Estuaries, Kelly M. Kibler, Christian Pilato, Linda Walters, Melinda Donnelly, Jyotismita Taye

Flow-biota Interaction and Natural Infrastructure Design

Mangrove forest sustainability hinges upon propagule recruitment and seedling retention. This study evaluates biophysical limitations to mangrove seedling persistence by measuring anchoring force of two mangrove species (Rhizophora mangle and Avicennia germinans). Anchoring force was measured in 362 seedlings via lateral pull-tests administered in mangrove forests of two subtropical estuaries and in laboratory-based experiments. Removal mechanism varied with seedling age: newly-established seedlings failed due to root pull-out while seedlings older than 3 months failed by root breakage. Anchoring force of R. mangle seedlings was consistently and significantly greater than A. germinans (GLM: p = 0.002), however force to …

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Anti-Amyloid Chimeric Antigen Receptor Macrophages For Alzheimer's Disease Immunotherapy, Qiuyun Pan May 2022

Anti-Amyloid Chimeric Antigen Receptor Macrophages For Alzheimer's Disease Immunotherapy, Qiuyun Pan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Alzheimer’s disease is the most common cause of dementia. None of the available drugs can cure the disease. Chimeric Antigen Receptor (CAR) macrophages, because of their phagocytic activity, have potential as a cellular treatment for amyloid aggregation. In this study, we generated an anti-amyloid CAR hematopoietic progenitor cell line. By inducing the progenitor cell line to differentiate into macrophages, we show that the anti-amyloid CAR-Macrophage has enhanced specific phagocytic activity towards amyloid in in vitro experiments. In addition, in ex vivo experiments, anti-amyloid CAR significantly reduces the plaque load on brain slice from APP/PS1 mice when compared to a non-targeted …

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A Circular Economy Approach To Improve E-Waste Recycling In California: Economic Potential And Policy Options, Kripa Shah May 2022

A Circular Economy Approach To Improve E-Waste Recycling In California: Economic Potential And Policy Options, Kripa Shah

Master's Projects and Capstones

The higher consumption rates of electronic devices along with their short life cycles and few repair options poses a huge challenge for E-waste industries to manage them effectively. E-waste comprises of hazardous materials and toxic constituents that can affect the environment and public health through improper disposal. However, they also contain few valuable materials that, if recovered, can reduce the dependence on virgin raw materials. Circular economy has the potential to utilize these valuable materials and gain environment and socio-economic benefits. The research explains how the adoption of a circular economy approach can help improve the E-waste recycling in California …

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