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Full-Text Articles in Engineering

Teknik Fermentasi Campuran Bahan Organik Sebagai Sumber Nutrisi Organik Pada Sayuran Sawi Yang Ditanam Dengan Hidroponik, Darwin H. Pangaribuan, Yohannes Cahya Ginting, Rugayah, Purba Sanjaya, Agus Karyanto, Kurnia Cahyani Dewi, Intan Puspita Sari Dec 2022

Teknik Fermentasi Campuran Bahan Organik Sebagai Sumber Nutrisi Organik Pada Sayuran Sawi Yang Ditanam Dengan Hidroponik, Darwin H. Pangaribuan, Yohannes Cahya Ginting, Rugayah, Purba Sanjaya, Agus Karyanto, Kurnia Cahyani Dewi, Intan Puspita Sari

Jurnal Kultivasi

Nutrisi organik untuk budidaya sistem sumbu hidroponik merupakan salah satu alternatif untuk mengatasi kendala mahalnya harga pupuk anorganik. Penelitian ini bertujuan untuk mengetahui metode ekstraksi terbaik antara metode air hangat, air dingin, dan fermentasi kemudian menentukan waktu fermentasi terbaik dari unsur hara organik campuran rumput laut, sabut kelapa dan daun kelor yang diharapkan memiliki kandungan nutrisi organik yang mendekati dengan formula nutrisi anorganik. Penelitian ini terdiri atas 2 percobaan: (i) percobaan pertama meneliti jenis metode ekstraksi, dan (ii) percobaan kedua meneliti waktu fermentasi terbaik. Rancangan percobaan yang digunakan adalah Rancangan Acak Kelompok (RAK) dengan faktor tunggal dan diulang sebanyak 6 …


Synthesis Of Novel Chiral Phosphorothioic Acid Organocatalysts And Application To Synthetic Methodology, Parsa Azaei Dec 2022

Synthesis Of Novel Chiral Phosphorothioic Acid Organocatalysts And Application To Synthetic Methodology, Parsa Azaei

Undergraduate Research Symposium Posters

Much research efforts have been centered towards the synthesis of novel Bronsted acid catalysts. These organocatalyst enable synthesis of natural products, pharmaceuticals, and bioactive small molecules under toxic-metal-free conditions by donating their protons, while not being consumed in the reaction. Chiral phosphorothioic acid have significant potential as novel organocatalysts due to their high modifiability of chirality and acidity under environmentally friendly conditions; however, synthesis of these organocatalysts are far and in between. Therefore, our research aimed to i) synthesize novel phosphorothioic acid organocatalysts and ii) to apply these novel catalysts toward new methodology development.


Towards Structured Planning And Learning At The State Fisheries Agency Scale, Caleb A. Aldridge Dec 2022

Towards Structured Planning And Learning At The State Fisheries Agency Scale, Caleb A. Aldridge

Theses and Dissertations

Inland recreational fisheries has grown philosophically and scientifically to consider economic and sociopolitical aspects (non-biological) in addition to the biological. However, integrating biological and non-biological aspects of inland fisheries has been challenging. Thus, an opportunity exists to develop approaches and tools which operationalize planning and decision-making processes which include biological and non-biological aspects of a fishery. This dissertation expands the idea that a core set of goals and objectives is shared among and within inland fisheries agencies; that many routine operations of inland fisheries managers can be regimented or standardized; and the novel concept that current information and operations can …


Evaluation For Using Expended Bioelectrochemical Systems As Soil Amendments For Improved Corn Plant Growth And A Drought Resistant Soil., Jackson Lee Sauers Dec 2022

Evaluation For Using Expended Bioelectrochemical Systems As Soil Amendments For Improved Corn Plant Growth And A Drought Resistant Soil., Jackson Lee Sauers

Theses and Dissertations

A long-held practice is to mix agricultural soil with a soil amendment to improve growing conditions in crops. A common soil amendment is biosolids produced from both municipal and dairy wastewater due to the macro- and micronutrients within it. Both the agricultural and wastewater industries are participating in the Circular Economy concept (CEC). Two experiments explored using expended bioelectrochemical systems (BES) that treated either synthetic dairy wastewater (DWW) or synthetic municipal wastewater (SWW) as soil amendments to improve corn plant growth when treated with three different nutrient treatments: 100%- 50%- and 0% Hoagland Nutrient Solutions. Biochar and used terracotta clay …


Performance Analysis: Using The Northern Sea Route As An Alternative To Traditional Routes, Liangkun Xu, Qing Yu Dec 2022

Performance Analysis: Using The Northern Sea Route As An Alternative To Traditional Routes, Liangkun Xu, Qing Yu

Journal of Marine Science and Technology–Taiwan

The grounding accident of M/V EVER GIVEN in the Suez Canal causes a catastrophic loss on shipping companies. Alternatively, previous studies have presented encouraging findings of the remarkable benefits of time and cost saving in the Northern sea route (NSR) due to extend the ice-free time and shorten the distance. Ships using the NSR could shorten as much as 40% of the sailing distance from China (Shanghai) to Europe (Rotterdam) compared with the traditional route via the Suez Canal. This paper investigates the economic potential of using the NSR as a cost-effective route in comparison with Suez Canal Route (SCR) …


Numerical And Approximate Analytic Solutions Of Second- Order Nonlinear Boundary Value Problems, Chein-Shan Liu, Jian-Hung Shen, Yung-Wei Chen Dec 2022

Numerical And Approximate Analytic Solutions Of Second- Order Nonlinear Boundary Value Problems, Chein-Shan Liu, Jian-Hung Shen, Yung-Wei Chen

Journal of Marine Science and Technology–Taiwan

The shooting method consists of guessing unknown initial values, transforming a second-order nonlinear boundary value problem (BVP) to an initial value problem and integrating it to obtain the values at the right end to match the specified boundary condition, which acts as a target equation. In the shooting method, the key issue is accurately solving the target equation to obtain highly precise initial values. Due to the implicit and nonlinear property, we develop a generalized derivative-free Newton method (GDFNM) to solve the target equation, which offers very accurate initial values. Numerical examples are examined to show that the shooting method …


Optimization Of Circular Silencers Internally Hybridized With Multiple Reverse Chambers Using The Ga Method, Min-Chie Chiu, Ying-Chun Chang, Tian-Syung Lan, Ho-Sheng Chen Dec 2022

Optimization Of Circular Silencers Internally Hybridized With Multiple Reverse Chambers Using The Ga Method, Min-Chie Chiu, Ying-Chun Chang, Tian-Syung Lan, Ho-Sheng Chen

Journal of Marine Science and Technology–Taiwan

A noise abatement method using an eigen function in conjunction with an optimizer (Genetic Algorithm) under a space-constrain situation is proposed in this study concerning a high order wave propagation effect. An eigen function is used to describe an acoustical field and shorten the acoustical model in a four-pole transfer matrix form. The system’s four-pole matrix estimates the Transmission Loss (TL) for the silencers by multiplying individual four-pole matrices.

Additionally, a case study of an air compressor’s broadband noise elimination is introduced. Three types of circular reverse silencers (silencers A-C) internally hybridized with multiple straight chambers are adopted to efficiently …


Numerical Investigation Of The Uncertainty Of Typhoon Wave Parameters Retrieval Using Hf Radar, Toan Duy Dao, Hwa Chien Dec 2022

Numerical Investigation Of The Uncertainty Of Typhoon Wave Parameters Retrieval Using Hf Radar, Toan Duy Dao, Hwa Chien

Journal of Marine Science and Technology–Taiwan

The aim of this study was to identify the sources of uncertainties of typhoon wave field monitoring using HF radar and to quantitatively assess the bias of the wave parameters, such as significant wave height and mean period, retrieved under various conditions. The strategy was to apply a purely numerical simulation of the Doppler-range spectra and then compare the estimation results to the target. For the quantitative investigation, a numerical test-bed was established. The test-bed was used to simulate the Doppler spectra based on Barrick’s (1972) theory by using the input of the directional wave spectra. The typhoon wave spectra …


A Fused Data Based Real-Time Collision Warning System For Ferries In The Yangtze River, Xiaojia Liu, Ke Zhang, Han Xue, Yingtang Li Dec 2022

A Fused Data Based Real-Time Collision Warning System For Ferries In The Yangtze River, Xiaojia Liu, Ke Zhang, Han Xue, Yingtang Li

Journal of Marine Science and Technology–Taiwan

The risks for ferries in the Yangtze River are relatively high, as they frequently cross the main traffic flows, leading to more intersections with other upwards and downwards ships. Although some studies have developed many models to assess collision risks in the Yangtze River, collision warning studies on ferries are scant. Meanwhile, most of the current collision studies evaluate risk based on AIS data, which are incapable of providing real-time ship information as they are discrete-time series data. In this work, fused data combining radar and AIS data are applied in a real-time ship collision warning model to assess the …


Experimental Study Of The Effect Of A Solid Wing Conveyor On Marine Debris Collection, Erik Sugianto, Jeng-Horng Chen Dec 2022

Experimental Study Of The Effect Of A Solid Wing Conveyor On Marine Debris Collection, Erik Sugianto, Jeng-Horng Chen

Journal of Marine Science and Technology–Taiwan

Marine debris is a global problem that has not been resolved. This has encouraged the emergence of marine debris cleaning technologies, one of which is a conveyor ship. However, how effective conveyors are in collecting waste has not been studied. In this paper, experimental research on conveyors as marine debris collectors is investigated. The capability of catamarans with or without solid wing conveyors to collect marine debris is explored. Three kinds of marine debris collection models are used: no-wing conveyor, a 12.5-cm-long wing conveyor, and an 18.75-cm-long wing conveyor. Artificial marine debris (AMD) is spread on the water surface in …


Solving Nonlinear Boundary Value Problems With Nonlinear Integral Boundary Conditions By Local And Nonlocal Boundary Shape Functions Methods, Chein-Shan Liu, Yung-Wei Chen, Jian-Hung Shen Dec 2022

Solving Nonlinear Boundary Value Problems With Nonlinear Integral Boundary Conditions By Local And Nonlocal Boundary Shape Functions Methods, Chein-Shan Liu, Yung-Wei Chen, Jian-Hung Shen

Journal of Marine Science and Technology–Taiwan

The paper considers the second-order nonlinear boundary value problem (NBVP), which is equipped with nonlinear integral boundary conditions (BCs). Two novel iterative algorithms are developed to overcome the difficulty of NBVP with double nonlinearities involved. In the first iterative algorithm, two nonlocal shape functions incorporating the linear integral terms are derived, and a nonlocal boundary shape function (NBSF) is formulated to assist the solution. Let the solution be the NBSF so that the NBVP can be exactly transformed into an initial value problem. The new variable is a free function in the NBSF, and its initial values are given. For …


Clove Essential Oil And Nanoclays-Based Active Food Packaging, Kalpani Y. Perera, Shubham Sharma, Amit K. Jaiswal, Swarna Jaiswal Dec 2022

Clove Essential Oil And Nanoclays-Based Active Food Packaging, Kalpani Y. Perera, Shubham Sharma, Amit K. Jaiswal, Swarna Jaiswal

Articles

Active food packaging materials enhance the shelf-life of food products while reducing food waste. The current study aims to develop a biodegradable active food packaging material. The food packaging material was developed with the incorporation of clove essential oil, sodium alginate, gelatin, and nanoclay films were prepared. The influences of nanoclay and clove on the surface, optical, mechanical, chemical, barrier, and pH-indicating properties were studied. The lightness and yellowness increased by 1.06 folds and 3.34 folds when compared to clove (control), respectively. The UV barrier property 0.08±0.01nm in all films, while 8.37 folds reduction in transparency has been observed as …


Nanoclays And Curcumin Based Food Packaging Material For Intelligent Food Packaging Applications, Kalpani Y. Perera, Swarna Jaiswal, Amit K. Jaiswal, Shubham Sharma Dec 2022

Nanoclays And Curcumin Based Food Packaging Material For Intelligent Food Packaging Applications, Kalpani Y. Perera, Swarna Jaiswal, Amit K. Jaiswal, Shubham Sharma

Articles

Bionanocomposite packaging eco-friendly alternatives with enhanced characteristics. This study aimed to develop a bionanocomposite intelligent packaging. Sodium alginate, gelatin, Curcumin (Cur), glycerol, and Nanoclay (NC) films were prepared. The influences of nanoclay and curcumin on the surface, optical, mechanical, chemical, barrier, and pH-indicating properties were studied. The results showed that the lightness of films was reduced by 1.28 folds compared to NC (control) film, while the yellowness of films increased by 5.82 folds. Film transparency was reduced by 9.3 folds and a 3.46 folds increase in UV barrier properties was observed compared to NC (control) film. The highest tensile strength …


Cold Plasma Technology In Food Packaging, Kalpani Y. Perera, Jack Prendeville, Amit K. Jaiswal, Swarna Jaiswal Dec 2022

Cold Plasma Technology In Food Packaging, Kalpani Y. Perera, Jack Prendeville, Amit K. Jaiswal, Swarna Jaiswal

Articles

Cold plasma (CP) is an effective strategy to alter the limitations of biopolymer materials for food packaging applications. Biopolymers such as polysaccharides and proteins are known to be sustainable materials with excellent film-forming properties. Bio-based films can be used as an alternative to traditional plastic packaging. There are limitations to biopolymer packaging materials such as hydrophobicity, poor barrier, and thermos-mechanical properties. For this reason, biopolymers must be modified to create a packaging material with the desired applicability. CP is an effective method to enhance the functionality and interfacial features of biopolymers. It etches the film surface allowing for better adhesion …


2022 - The Third Annual Fall Symposium Of Student Scholars Dec 2022

2022 - The Third Annual Fall Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Fall 2022 Symposium of Student Scholars, held on November 17, 2022. Includes abstracts from the presentations and posters.


Integrative Physiology-Coupled Pilot-Centered Flight Simulation, Shawn C. Harrison Dec 2022

Integrative Physiology-Coupled Pilot-Centered Flight Simulation, Shawn C. Harrison

Electrical & Computer Engineering Theses & Dissertations

Maintaining the pilot’s physiological performance envelope within the limits of human capabilities may be crucial for avoiding hazardous physiological episodes in fighter aircraft that compromise safety. The main physiological episode of interest is impaired pilot respiration, better known as hypoxia caused by a high fraction of inspired oxygen (FiO2) at high altitudes and variation in accelerative gravitational forces (g-forces). Integrated into fighter aircraft is an Onboard Oxygen Generating System (OBOGS) developed to mitigate the necessity of gaseous and liquid oxygen cannisters [1]. OBOGS act as a life support in hypoxic environments by providing oxygen-rich air, thereby oxygenating the …


Potential Of Mechanical Grain Dryers In Addressing Exposure Of Rice Farmers To Weather Risks, Hernaiz Malanon, Zenaida Sumalde Dec 2022

Potential Of Mechanical Grain Dryers In Addressing Exposure Of Rice Farmers To Weather Risks, Hernaiz Malanon, Zenaida Sumalde

The Philippine Agricultural Scientist

Weather risks brought by prolonged rainfall and cloudy days hamper grain drying operations in the Philippines as majority still employ the sun drying method, which limits the opportunity of rice farmers to earn a higher income. While mechanical dryers are considered an important adaptation mechanism to address weather risks, more research needs to be done on their benefits and their disadvantages. This study adapted the Inter-governmental Panel on Climate Change (IPCC) concept which equates hazard, exposure, and vulnerability to quantify risk. Hazard was assessed in terms of the probability of four straight rainy- or cloudy-day occurrences based on a 30-year …


The Rise Of Terrorism In Africa And What It Means For U.S. Policymakers, Bridget Mary Hughes Dec 2022

The Rise Of Terrorism In Africa And What It Means For U.S. Policymakers, Bridget Mary Hughes

Master's Theses

This thesis utilizes three case studies to measure the rise of terrorism in Africa. This qualitative data leads the reader to one ultimate question: what does the rise in terrorism in Africa mean for the United States (U.S.) and U.S. policymakers, National Security academia, students in National Security, if anything at all? The answer is: if civilian and military compounds are being targeted by these violent extremists, as these three case studies demonstrate, it is my recommendation that U.S. policymakers cease sending troops to the African theater and, instead, allocate funding to the citizens and nonprofits of the countries whom …


Development Of Nucleic Acid Diagnostics For Targeted And Non-Targeted Biosensing, Christopher William Smith Dec 2022

Development Of Nucleic Acid Diagnostics For Targeted And Non-Targeted Biosensing, Christopher William Smith

Legacy Theses & Dissertations (2009 - 2024)

The field of nucleic acid technology is rapidly expanding with new impactful discoveriesbeing made each year. Starting from the discovery of the double-helix structure, cloning, gene editing, polymerase chain reaction (PCR), CRISPR technology, and even the late mRNA vaccines; nucleic acid technology is at the forefront of improving medicine. Nucleic acid technology is extremely versatile due to its easy programmability, automated cheap synthesis, and even its catalog for numerous chemical modifications that can be used to alter structure stability. For example, the number of permutations that can be made with DNA just by altering the code for adenine (A), cytosine …


Fiber-Based Time-Correlated Single Photon Counting As A Method For Investigating Metabolism During Tetanic Contraction Of Skeletal Muscle, Kathryn Miller Priest Dec 2022

Fiber-Based Time-Correlated Single Photon Counting As A Method For Investigating Metabolism During Tetanic Contraction Of Skeletal Muscle, Kathryn Miller Priest

Graduate Theses and Dissertations

Nicotinamide adenine dinucleotide (NAD) is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation (OXPHOS) [1-5]. The reduced form of NAD, NADH, is autofluorescent, making it a measurable characteristic in the investigation of metabolic changes. The fluorescence lifetime of NADH is dependent on the state of protein binding, specifically free or bound NADH, allowing for detection of metabolic shifts between glycolysis (free NADH) and OXPHOS (bound NADH) [6-16]. Fiber-coupled time-correlated single photon counting (TCSPC) equipped with an implantable needle probe can be used to measure NADH lifetime in vivo …


Synthesis And Characterization Of Aerogels From Cellulose-Starch Mixtures For Advanced Packaging Applications, Angel Sagardui Dec 2022

Synthesis And Characterization Of Aerogels From Cellulose-Starch Mixtures For Advanced Packaging Applications, Angel Sagardui

Chemical Engineering Undergraduate Honors Theses

Biodegradable, highly porous, ultra-lightweight, and high-surface-area aerogels from microcrystalline cellulose (MCC) and corn starch mixtures were synthesized through a simple, green process, specifically supercritical carbon dioxide (SC-CO2) drying. Five weight ratios of samples were generated (pure MCC, 2:1 MCC-starch, 1:1 MCC-starch, 1:2 MCC-starch, and pure starch) and were then subjected to a variety of characterization experiments relating to textural and thermal properties as well as morphology, crystallinity, and chemical interactions. Overall, the 1:2 MCC-starch aerogel had the lowest density (0.04 g/cm3), and highest porosity (97%). Conversely, the pure MCC aerogel demonstrated the highest mechanical strength (Young’s modulus of 48.9 MPa), …


Sequence-Based Bioinformatics Approaches To Predict Virus–Host Relationships In Archaea And Eukaryotes, Yingshan Li Dec 2022

Sequence-Based Bioinformatics Approaches To Predict Virus–Host Relationships In Archaea And Eukaryotes, Yingshan Li

School of Computing: Dissertations, Theses, and Student Research

Viral metagenomics is independent of lab culturing and capable of investigating viromes of virtually any given environmental niches. While numerous sequences of viral genomes have been assembled from metagenomic studies over the past years, the natural hosts for the majority of these viral contigs have not been determined. Different computational approaches have been developed to predict hosts of bacteria phages. Nevertheless, little progress has been made in the virus-host prediction, especially for viruses that infect eukaryotes and archaea. In this study, by analyzing all documented viruses with known eukaryotic and archaeal hosts, we assessed the predictive power of four computational …


Sustainability And Health Impacts Of Pulse Crops In The United States Using Life Cycle Assessment, Prathamesh A. Bandekar Dec 2022

Sustainability And Health Impacts Of Pulse Crops In The United States Using Life Cycle Assessment, Prathamesh A. Bandekar

Graduate Theses and Dissertations

Environmental sustainability and human health impact of pulses produced and consumed in the United States was assessed using life cycle assessment (LCA). The study included three objectives 1) to estimate environmental impact of current production and consumption practices in the United States using attributional LCA; 2) to estimate environmental and human health impact of iso-caloric diets containing varying amounts of pulses using Hybrid-LCA and Combined Nutritional and Environmental-LCA (CONE-LCA); and 3) to estimate environmental impact of increased demand for pulses using consequential LCA. Scope of the study varied for each objective with system boundary encompassing cradle-to-grave activities for objective 1 …


Establishing The Efficacy Of Non-Cellular Components Of Adipose-Derived Stromal Vascular Fraction In Promoting Angiogenesis., Daniel Benson Dec 2022

Establishing The Efficacy Of Non-Cellular Components Of Adipose-Derived Stromal Vascular Fraction In Promoting Angiogenesis., Daniel Benson

Electronic Theses and Dissertations

Microvascular disease is hallmarked by pathophysiological conditions such as endothelial senescence, intimal thickening which impairs vasodilation, and regression of the capillary beds causing tissue ischemia in the myocardium or in peripheral vascular networks. Adipose-derived stromal vascular fraction (SVF) has previously demonstrated the ability to revascularize tissue. Increasing evidence shows that regenerative cells elicit their therapeutic benefit by paracrine mechanisms, leaving open extracellular vesicles (EVs) as a potential crux of the cell therapy paradigm. To test this idea, three types of gelatin methacrylate hydrogels were employed: SVF gels, EV gels derived from SVF, and blank control gels, which were used in-vitro …


Re-Engineering Cardio-Oncology Testing Using Biomimetic Heart Slice Cultures., Jessica Miller Dec 2022

Re-Engineering Cardio-Oncology Testing Using Biomimetic Heart Slice Cultures., Jessica Miller

Electronic Theses and Dissertations

28% of drug withdrawal from the market are due to unforeseen disruptions in cardiomyocyte contractility and electrophysiology. The most commonly used platforms for drug testing are in vivo animal models and in vitro cell culture models. While both have been of paramount importance for the discovery and detection of many cardiotoxicities and mechanisms of action, they lack the ability to model an intact human myocardium. This work aims to establish cardiac tissue slices, which are 300-micron thin tissue sections taken from the left ventricular myocardium, as an alternative platform for cardio-oncology studies, specifically cardiotoxicity testing. Additionally, this work aims to …


Evaluating The Viscoelastic Properties Of Alligator Skin Gelatin, Alligel, Compared To Mammalian And Fish Gelatins, Sarah E. Jimenez Dec 2022

Evaluating The Viscoelastic Properties Of Alligator Skin Gelatin, Alligel, Compared To Mammalian And Fish Gelatins, Sarah E. Jimenez

Honors Capstones

No abstract provided.


Large Genomes Assembly Using Mapreduce Framework, Yuehua Zhang Dec 2022

Large Genomes Assembly Using Mapreduce Framework, Yuehua Zhang

All Dissertations

Knowing the genome sequence of an organism is the essential step toward understanding its genomic and genetic characteristics. Currently, whole genome shotgun (WGS) sequencing is the most widely used genome sequencing technique to determine the entire DNA sequence of an organism. Recent advances in next-generation sequencing (NGS) techniques have enabled biologists to generate large DNA sequences in a high-throughput and low-cost way. However, the assembly of NGS reads faces significant challenges due to short reads and an enormously high volume of data. Despite recent progress in genome assembly, current NGS assemblers cannot generate high-quality results or efficiently handle large genomes …


A Study On Interactions Between Metal-Organic Frameworks And Biological Materials, Josh Phipps Dec 2022

A Study On Interactions Between Metal-Organic Frameworks And Biological Materials, Josh Phipps

Graduate Theses and Dissertations

Metal-organic frameworks or MOFs are an extremely useful tool in many areas of applications. Their popularity in recent years has arisen from their high efficiency in catalytic chemical reactions. This is made possible due to their porous interior and the ability of the MOFs components to be functionalized. These same traits make MOFs excellent for use in protein encapsulation or immobilization and have the potential to become excellent drug carriers. Their development in this utilization has been limited dramatically compared to MOFs chemical applications. This is due in part to the nature of biological processes taking longer to study, but …


Using Molecular Dynamics Simulations To Decipher Mechanistic Details Of Biomolecular Processes Of Biology And Biotechnology Oriented Applications, Adithya Polasa Dec 2022

Using Molecular Dynamics Simulations To Decipher Mechanistic Details Of Biomolecular Processes Of Biology And Biotechnology Oriented Applications, Adithya Polasa

Graduate Theses and Dissertations

Researchers in chemistry and biology often utilize computer simulations, in conjunction with experimental data, to model and predict the structures, energies, kinetics, processes, and functions of the systems that are their focus of study, ranging from single molecules to whole viruses. Here, we use molecular dynamics (MD) techniques to gain a deeper understanding of biomolecular processes in biology and biotechnology-oriented applications. Using a mixture of equilibrium and non-equilibrium MD simulations, this work describes the insertion process of YidC at the atomic level. In order to better comprehend the insertion process, several docking models of YidC-Pf3 in the lipid bilayer were …


Seeing The Big Picture: System Architecture Trends In Endoscopy And Led-Based Hyperspectral Subsystem Intergration, Craig M. Browning Dec 2022

Seeing The Big Picture: System Architecture Trends In Endoscopy And Led-Based Hyperspectral Subsystem Intergration, Craig M. Browning

Graduate Theses and Dissertations (2019 - present)

Early-stage colorectal lesions remain difficult to detect. Early development of neoplasia tends to be small (less than 10 mm) and flat and difficult to distinguish from surrounding mucosa. Additionally, optical diagnosis of neoplasia as benign or malignant is problematic. Low rates of detection of these lesions allow for continued growth in the colorectum and increased risk of cancer formation. Therefore, it is crucial to detect neoplasia and other non-neoplastic lesions to determine risk and guide future treatment. Technology for detection needs to enhance contrast of subtle tissue differences in the colorectum and track multiple biomarkers simultaneously. This work implements one …