Bilingual, Multilingual, and Multicultural Education Commons^™

Elucidating The Expression Profile Of Ezh2 Isoforms In Endometriosis: An Immunohistochemical Study, John Soto-Vargas, Idhaliz Flores, Phd, Mariano Colón-Caraballo, Andrés Velázquez-Garcia

Journal of Health Disparities Research and Practice

Endometriosis is an estrogen-dependent gynecological disease that affects 1 out of 10 women of reproductive age causing severe pelvic pain and infertility. Factors including genetics, environment, inflammation, and recently epigenetics have been shown to play roles in the pathophysiology of this disease. Histone methylation is an epigenetic modification that modulates gene expression by causing changes in the chromatin structure. Trimethylation of histone 3 at lysine residue 27 (H3K27me3) is a histone mark related to gene repression. EZH2 is the histone methyltransferase (HMT) responsible of catalyzing H3K27me3. It has been shown that the EZH2 is involved in carcinogenesis; however, the specific …

Glioblastoma Stem Cells, Michael Quintero, Qi Cui, Yanhong Shi, Phd

Journal of Health Disparities Research and Practice

Glioblastoma multiforme(GBM) is the most common and malignant primary brain tumor in humans. GBM accounts for 55% of all primary brain cancers, with a median survival rate of 14.6 months. The grim prognosis of GBM can be attributed to glioma stem cells (GSCs), which initiate tumor formation through the stem-like properties of self-renewal and differentiation. The ability of GSCs to resist radiation and chemotherapy contributes to the high rate of tumor recurrence in GBM patients. Consequently, novel therapies that effectively target the population of GSCs are of vital importance.

A promising is to induce the differentiation of GSCs. Previous studies …

Rgs2 And Human Adipogenesis, Kaia Partlow, Alma Madrigal, Yuanxiang Zhao, Phd

Journal of Health Disparities Research and Practice

Obesity is characterized by excess adipose tissue and is one of the leading public-health issues of the industrialized world. Gain of adipose tissue can result from accumulation of fat in existing adipocytes (fat cells), as well as increased commitment of stem cells into new adipocytes through a process known as adipogenesis. Although a number of key adipogenic transcription factors such as PPARgamma2 and CEBPalpha are well characterized, the temporal and spatial molecular and cellular events that occur during adipogenesis are still largely unknown. Better understanding of these events could have important implications in finding treatments for obesity.

Human mesenchymal stem …

Dietary Restriction In Drosophila Melanogaster Increases Flight Duration, Nelson Nunez, Mark Frye, Phd, Mehmet Keles, Phd Candidate

Journal of Health Disparities Research and Practice

Caloric restriction extends the lifespan in several model animals, including fruit flies, but less is known about the influence upon endurance and sensory-motor performance. For this experiment, all flies will be raised on standard media. At the point of eclosion, they will be transferred to rich, standard, or restricted media. The endurance of a fruit fly can be tested by monitoring how long it is able to maintain active flight. Flight power is quantified by measuring wing beats per second and total wing stroke amplitude. Sensory-motor performance is measured by the animal’s ability to actively fixate on a black bar …

Application Of The Transtheoretical Model In Hispanic And African American Populations To Assess Deceased Kidney Donor Noncompliance, Cynthia Mancilla, Amy D. Waterman, Phd, Crystal Kynard-Amerson, Mph, Aubre Parnicky, Msw

Journal of Health Disparities Research and Practice

Given existing health disparities such as financial barriers, lack of education and inadequate health care in minority communities, the rates of deceased kidney donation continues to decline. The transtheoretical model (TTM) assesses the patients’ willingness to pursue deceased kidney donation through application of a stage structured curriculum.

Patients are evaluated into five different stage groups; pre-contemplation, contemplation, preparation, action, and maintenance. This assessment of behavior change as applied to the willingness of a patient to pursue a deceased kidney donor transplant can be tracked over time and used to help determine what stage of change a patient is in during …

Exploration Of Antagonist Efficacy For Lpra2 Like Peptide, Ayobami Loye, Ruben R. Gonzalez-Perez, Phd

Journal of Health Disparities Research and Practice

Leptin is a small protein hormone that controls satiety and is produced by adipocytes. Obese people have increased levels of circulating leptin. Excessive leptin levels cause a break down in the control of leptin signaling pathways leading to increased angiogenesis, proliferation, cell migration, invasion, and anti-apoptotic events. Obesity and leptin signaling have been linked to cancer progression. Literature shows that LPrA2 is an effective leptin antagonist as it decreases proliferation of breast cancer cells in vitro.

This project compares the effectiveness of LPrA2 like compounds in breast cancer cell-line MDA-MB-468 (M-468 BCs). We hypothesize that the new peptide antagonists have …

Design And Optimization Of A Mycoplasma Detection Assay, Carlos J. León-Rodríguez, Richard J. Noel, Jr., Phd, Tirtsa Porrata-Doria, Ms

Journal of Health Disparities Research and Practice

Mycoplasma are among the smallest free living microorganisms. These bacteria grow slowly, lack a rigid cell wall and are not eliminated by filter sterilization methods used in tissue culture. Mycoplasma infection affects biochemical and genetic aspects of cultured cells, resulting in experimental inconsistency. Therefore, it is necessary to establish routine testing for mycoplasma contamination in tissue culture laboratories.

Our goal is to develop a reliable and cost-effective test for mycoplasma in cell culture based on established methods found in literature. We first cloned and sequenced a PCR product from a commercial mycoplasma detection kit. Sequencing revealed the 16s rRNA as …

Role Of Hiv-1 Nef Lysine Residues 4 And 7 In The Interaction With Calnexin And Inhibition Of Abca1 Activity, Valeria Kaufman, Michael Burkinsky, Md, Phd, Ruth Hunegnaw, Msc, Phd Candidate

Journal of Health Disparities Research and Practice

Patients infected with HIV are at increased risk of developing atherosclerosis, a result due partly to the functional impairment of cellular cholesterol transporter, ATP-binding cassette transporter A1 (ABCA1). This transporter mediates efflux of cholesterol from cells to high density lipoprotein, thus allowing cells to maintain normal levels of cholesterol. When ABCA1 function is inhibited, cells, and in particular macrophages, accumulate cholesterol, resulting in formation of atherosclerotic plaques. The HIV-1 protein, Nef downregulates ABCA1 and inhibits the activity of this protein, thereby reducing cholesterol efflux and promoting atherosclerosis, but the molecular mechanism by which Nef inhibits ABCA1 is unknown.

Previous studies …

Collagen Iv Assembly: Production Of A Recombinant Construct For Mechanistic Studies, Kennedy Harris, Billy Hudson, Phd, Isi Ero-Tolliver, Phd, Kyle Brown, Phd

Journal of Health Disparities Research and Practice

Basement membranes, specialized extracellular matrix, provide mechanical support for epithelial cells and shape cell behavior by interacting with cell receptors. Collagen IV, the predominant component of basement membrane, comprises six genetically distinct alpha chains (α1 to α6) that assemble to form protomers, which associate to form hexamers, in the scaffold. Non-assembly due to mutations within alpha chains give rise to kidney diseases. Yet, the mechanism of assembly is poorly understood.

Preliminary data in our lab indicated that amino acid 78 of collagen IV α2 NC1 (non-collagenous) domains may play a role in a chloride-dependent switch that supports hexamer formation. We …

Sex Differences In The Sex Differences In The Effects Of Environmental Enrichment After An Early Life Stressor, Alfredo Gutierrez, Annelyn Torres-Reverón, Phd, Raura Doreste-Méndez

Journal of Health Disparities Research and Practice

Studies have shown that environmental enrichment can compensate for the effects of an early life stressor such as maternal separation. Behavioral responses and immunohistochemical markers in rats are affected by environmental enrichment after maternal separation. In this study we seek to investigate whether sex influences the behavioral responses of environmental enrichment after maternal separation.

Prior scientific evidence suggests that there are behavioral sex differences in: 1) neural processes underlying successful or failed fear extinction (Gruene et al, 2014); (2) prenatal stress exposure and response to behavioral anxiety tests (Said et al, 2015); and (3) glutamate receptor expression in response to …

Cox2 Plays An Important Role In Maintenance Of Mammary Cancer Stem Cell Population In Human Breast Cancer Cell Lines, Mayra Garcia, Shehla Pervin, Phd, Easter Thames, Meher Parveen, Phd, Melanie Baker

Journal of Health Disparities Research and Practice

Breast cancer is a malignant growth in the adipose-rich mammary gland. Initiation and progression of breast tumors involve multiple cell types, among which mammary cancer stem cells play an important role. There are two main types of adipocytes; white adipocytes have previously been found to influence the disease while brown adipocytes, which uniquely express uncoupling protein 1 (UCP1), were recently detected in breast tumors.

We have detected Myf5, a transcription factor, which is expressed in the progenitor population of brown adipocytes, in breast cancer cell lines. We also found an association between expression of Myf5 and COX2 (or Ptgs2), which …

The Role Of Integrin-Associated Protein “Pinch” In Kidney Development, Tyrone Gamble Jr, Roy Zent, Phd, Bertha C. Elias, Phd

Journal of Health Disparities Research and Practice

PINCH (a particularly interesting new cysteine-histidine-rich protein) is a protein that binds with Integrin-linked kinase and Parvin, to form an IPP complex. This complex is formed only when integrin molecules are activated upon interaction with the basement membrane. The IPP complex then acts as a platform for other proteins to come together and regulate cell signaling to and from the extracellular matrix (ECM). This allows for various cellular activities to progress like cell adhesion, migration, proliferation, etc. There are two types of PINCH proteins, PINCH-1 and PINCH-2. Studies from our group have shown that the lack of PINCH-1 in the …

Nitric Oxide And Cyclic Gmp Signaling In Cancer Therapy, Armond Dorsey, Ferid Murad, Md, Phd, Ka Bian, Md, Phd

Journal of Health Disparities Research and Practice

The nitric oxide-3’,5’-cyclic guanosine monophosphate signaling pathway (NO-cGMP signaling pathway) is a well-known signal transduction pathway which elicits several physiological processes including: cell proliferation, vasodilation, cardiac protection, etc. In this pathway, NO binds to the ferrous heme of histidine-105 on the prosthetic heme of the β₁ subunit of soluble guanylyl cyclase, resulting in the production of cGMP. This pathway, however, is inhibited in certain cancer cells—as observed in glioma cell lines. As a result, the production of cGMP is reduced. This mechanism may facilitate uncontrolled tumor cell growth.

The cancers under research—lung carcinoma, glioma, and pancreatic carcinoma—are all highly …

Potential Cost Savings Of Not Doing Cd4 Counts In Hiv Positive People In Rhode Island With An Undetectable Viral Load, Ruth Dele-Oni, Ferdinand Schumacher, Zachary Markus, Timothy Flanigan, Md

Journal of Health Disparities Research and Practice

CD4 cells fight infections in the body. When someone contacts Human Immunodeficiency Virus (HIV), their CD4 cells are taken over by HIV which turns them into manufacturers of many copies of the virus. The Viral Load (VL) measures the amount of virus in the blood. When HIV takes over the CD4 cells, the VL increases while the number of necessary CD4 cells decreases. When patients maintain stable treatment, their CD4 counts rise, and VLs may become undetectable, indicating the virus is too little to be detected in their blood. Knowing this, is frequent CD4 counts necessary for those with undetectable …

Defining The Role For Zbp-89 In Atm-Mediated Dna Damage Response To Irradiation In The Intestine, Christine Carethers, Juanita L. Merchant, Md, Phd

Journal of Health Disparities Research and Practice

ZBP-89 (ZNF148, Zfp148) is a zinc-finger transcription factor that inhibits cellular proliferation when overexpressed in cell lines. ZBP-89 forms a protein-protein interaction with p53 and Ataxia-telangiectasia mutated (ATM). However, it is unclear how the interaction modulates the function of these two proteins in vivo.

Double strand DNA breakage induced by -irradiation induces ATM phosphoinositol kinase activity, which initiates a cascade of events culminating in cell cycle arrest, DNA repair or apoptosis. Elevated levels of ZBP-89 induce growth arrest and apoptosis in gastrointestinal cell lines. Therefore, we hypothesize that ZBP-89 facilitates cell growth arrest and activation of the DNA repair pathway …

Induction Of Dusp9 In Xenografts From Human Breast Cancer Cell Lines Increases Mammary Cancer Stem Cells, Albert Barrios, Meher Parveen, Phd, Easter Thames, Melanie Baker, Shelha Pervin, Phd

Journal of Health Disparities Research and Practice

Breast cancer remains a complex disease that kills 40,000 women every year. Initiation and progression of breast cancer is influenced by heterogeneous groups of cells, including mammary cancer stem cells (MCSCs). Progression of this dreadful disease is driven by many signaling pathways among which MAPK pathway is highly prominent. Since targeting prominent kinases in MAPK pathway has been unsuccessful to control breast cancer, it is important to examine the phosphatases that regulate the activity of these kinases.

Using xenograft model from breast cancer cell lines, our lab has found that during the initial stages of xenograft development (week 1-4, 100-200mg …

Preparing Underrepresented High School Students To Increase Diversity In The Research And Health Professions, Dolores E. Caffey-Fleming, Ms, Mph, Christopher Reid, Md, Phd

Journal of Health Disparities Research and Practice

This article introduces the work that was done through the Coordinating Center at Charles R. Drew University of Medicine and Science.

The Step Up Program, Lawrence Agodoa, Md

Journal of Health Disparities Research and Practice

The Short-Term Research Experience Program for Underrepresented Persons (STEP-UP) was established as part of the NIDDK Strategic Plan on Minority Health Disparities. This article provides an overview and introduction of this program. All of the articles that are included in this special issue reflect the work of our coordinating centers, the mentors and their staff, as well as the students.

Diversifying The Curriculum: An Analysis Of Diversity Course Policies At The University Of California San Diego, Maria Lourdes Amparo

Capstone Collection

As U.S. higher education institutions and the larger society become increasingly global and racially and ethnically diverse, educational institutions are faced with the challenge of adapting their policies and academic curriculum to reflect and meet the demands of a changing environment. As part of a comprehensive plan to address campus climate issues at the University of California, San Diego (UC San Diego), the UC San Diego Academic Senate revised the undergraduate graduation requirement in 2011 to include one course that focuses on Diversity, Equity, and Inclusion (DEI). In addition to having a diverse student population, UC San Diego is ranked …

Cross-Cultural Confidence: A Program Design For Accessible Intercultural Competence On Campus, Erika Clement

Capstone Collection

Internationalization is currently one of the greatest issues facing higher education today. Colleges and universities have sought to produce graduates who are globally ready and capable of effectively navigating intercultural situations due to increasing diversity in the workplace and globalization; however, it has become apparent that efforts towards this end have not paid off as well as it was assumed they would. Now that US universities are admitting greater numbers of international students, intercultural competence and programs which build connections across cultural groups have become increasingly important on campus.

This capstone seeks to fashion an accessible, effective, on-campus program for …

Factors That Affect Willingness To Borrow Student Loans Among Community College Students, Kathleen K. Menges, Christoph Leonhard

Journal of Student Financial Aid

Research suggests that student loan borrowing has increased at the community college level. This trend is worrisome to many, as research is inconclusive regarding whether loans are positively correlated with achieving a college degree. Many also contend that choosing not to borrow a student loan due to loan aversion can negatively impact a student’s chance of reaping the financial benefits of a college degree. This study surveyed three community colleges in the Midwest to better understand how acculturation, time perspective, and financial literacy impact community college students’ willingness to borrow student loans. Except for financial literacy, none of the variables …

From Marginality To Mattering: Linguistic Practices, Pedagogies And Diversities At A Community-Serving Senior College, Andrea Springirth, Hannah Göppert

Publications and Research

The cultural diversification of colleges and universities which initially targeted the needs of a specific minoritized group raises questions concerning the inclusion of every individual and the maintenance of the advances which have been made for the original population. This paper provides insight into the challenges and merits at the intersection of linguistic and racial/ethnic diversification within CUNY’s Medgar Evers College. Historically tied to the Black Campus Movement, the college is committed to being an agent of social transformation for the surrounding community. Aiming to understand the perspectives on language and diversity of the key stakeholders at the college, a …

Beyond Behavior, Craig C. Laupheimer

Scholarship and Engagement in Education

Teaching to engage students with Attention Deficit Hyperactivity Disorder (ADHD) can inspire the whole classroom and make teaching and learning engaging and exciting. Although teachers and students alike face a challenging educational landscape, much can be done to empower students with special needs. Teaching with the whole classroom in mind with an emphasis on hands on, explorative and inspirational learning experiences to accommodate for these students strengthens and causes student engagement and agency. This article highlights the challenges and potential breakthroughs possible for classroom instruction specifically where the ADHD student is concerned and looks towards teaching mindfulness and empowerment as …

Promoting Education Abroad, Kayla Mitchell, James Materson

Celebration of Student Scholarship Poster Sessions Archive

No abstract provided.

Exploring Effective Reading Strategies That Promote Higher Level Thinking And Comprehension For A Chinese-Speaking College Student, Panyang Wu

Masters Theses/Capstone Projects

The purpose of the case study was to explore some effective literacy strategies that prompt higher-level thinking abilities to help one Chinese English as Foreign Language (EFL) student who struggles with academic reading in college classes at a small, liberal arts college. Only one participant named Cathy was involved in the study. Cathy is a Chinese student who studied at college as a regular undergraduate student and had poor performance in her college level literacy class, as indicated by her professors and Cathy herself. Cathy was expected to improve reading comprehension by receiving an intensive one-month reading development intervention, which …

Technology, Games And Learning In An Intermediate Spanish Class, Rosalind Arthur

South East Coastal Conference on Languages & Literatures (SECCLL)

This presentation examines some theories of learning at the tertiary level of education, and tests them in a research activity involving games and learning/knowledge. Two Intermediate Spanish classes are engaged in preliminary research to measure the effectiveness of a simple game (hangman) and technology (Responseware/clickers) as practice and review tools versus traditional methods; in formative assessment.

The presentation will consist of reporting on the Quantitative results focusing on the impact of using games in learning on students in the digital age. Student attitudes based on a qualitative survey administered to the students involved will be included in the report.

Both …

Identifying Best Practices To Increase Latino Student Enrollment And Retention At Non-Hispanic Serving Institutions, Katherine Lopez

Higher Education Student Work

Latino college students are the fastest growing population in the United States, yet their educational attainment falls significantly behind compared to Asians, Whites, and Blacks (Santiago & Soliz, 2012). This study sought out to identify best practices to recruit and retain Latino students at US four year colleges and universities. Interviews with seven knowledgeable stakeholders at non-Hispanic Serving Institutions across the country were conducted. Participants were asked about specific programming and strategies used at their institutions to meet the needs of the Latino population. The findings suggested that this special population needs additional financial, cultural and academic support in order …

Diversity & Inclusion Update - Spring 2016, Office Of Diversity & Inclusion

Diversity & Inclusion Update

This Spring 2016 newsletter discusses ongoing campus initiatives to facilitate diversity and inclusion efforts on campus. Topics discussed include changes implemented following the January 2016 town hall meeting, the 2016 Campus Climate Study, the Intercultural Development Inventory, and the planning of the Inclusion Action Plan.

Exploration Of Experiences And Perceptions Of Saudi Arabian Students Within A Team Project Setting At An U.S. University, Ronald A. Mckean

Dissertations

Cultural differences between Saudi and American students produce immense challenges to a successful integrative acculturation. Positive experiences can not only enhance the education of international students, but also effect understandings and attitudes of local students, administrators, faculty, and staff. A greater implication of these experiences may be their influence on long term international relationships. Few qualitative studies have been conducted that examine the dynamics of the cultural integration of Saudi students with American students during the acculturation process.

The purpose of this qualitative research, therefore, is to describe and interpret the experiences and perceptions of Saudi Arabian students as they …

Yorba Times: Special Edition On Safety, Noah Asher Golden, Facundo Acevedo, Jesse Alonzo, Henessy Arana, Leslie Arriaga, Michelle Brait, Amy Chau, Ashley Diaz, Jeremiah Dille, Sierra Durand, Beberly Espinoza, Elora Estes, Lesley Fernandez, Darshan Gamma, Cassandra Garcia, Karla Garcia, Yasmin Garcia, Neko Gianquinto, Gisselle Gonzalez, Jacob Gonzales, Sakina Jaffery, Adrianna Herrera, Allie Hoch, Victoria Hulett, Anthony Jaimes, Leilani Lagunes, Sandra Loredo, Kate Markey, Joshua Marmolejo, Faith Martin, Melissa Medina, Layla Melendez, Dylan Moses, Michaela Moses, Brooklynn Payne, Michelle Perez, Brianna Quirarte, Ieleen Ramirez, Edwin Reyes, Jehu Sandoval, Jaqueline Ramirez, Jonathan Sanchez, Nathalie Sanchez, Christopher Santibanez, Kaylin Seeley, Genevieve Stothers, Miranda Valdez, Christopher Velasquez

Yorba-Chapman Writing Partnership Anthology of Journalistic Writing

During the Spring 2016 semester, Dr. Noah Asher Golden's Teaching of Writing K-12 students partnered with the Journalism class at Yorba Academy for the Arts. Through collaboration over a four-month period, Chapman's future teachers and Yorba's junior high journalists engaged a deep writing process to write a series of features, editorials, and news articles, all connected in some way to the overarching theme of safety. Thank you to Ms. Andrea Lopez, Ms. Tracy Knibb, and the Lloyd E. and Elisabeth H. Klein Family Foundation for supporting this project.