Digital Commons Network^™

Development And Validation Of A Novel Clinical Risk Score To Predict Hypoxaemia In Children With Pneumonia Using The Who Prepare Dataset, Rainer Tan, Arjun Chandna, Tim Colbourn, Shubhada Hooli, Carina King, Norman Lufesi, Eric D Mccollum, Charles Mwansambo, Joseph L Mathew, Clare L Cutland, Shabir A Madhi, Marta Nunes, Sudha Basnet, Tor A Strand, Kerry-Ann F O'Grady, Brad Gessner, Emmanuel Addo-Yobo, Noel Chisaka, Patricia Hibberd, Prakash M Jeena, Juan M Lozano, William B Maleod, Archana Patel, Donald M Thea, Ngoc Tuong Vy Nguyen, Marilla Lucero, Syed Mohammad Akram Uz Zaman, Shinjini Bhatnagar, Nitya Wadhwa, Rakesh Lodha, Satinder Aneja, Mathuram Santosham, Shally Awasthi, Ashish Bavdekar, Monidarin Chou, Pagbajabyn Nymadawa, Jean William Pape, Glaucia Paranhos-Baccala, Valentina S Picot, Mala Rakoto-Andrianarivelo, Vanessa Rouzier, Graciela Russomando, Mariam Sylla, Philippe Vanhems, Jianwei Wang, Romina Libster, Alexey W Clara, Fenella Beynon, Gillian Levine, Chris A Rees, Mark I Neuman, Shamim Qazi, Yasir Bin Nisar, World Health Organization Prepare Study Group

Faculty, Staff and Students Publications

Background: Hypoxaemia predicts mortality at all levels of care, and appropriate management can reduce preventable deaths. However, pulse oximetry and oxygen therapy remain inaccessible in many primary care health facilities. We aimed to develop and validate a simple risk score comprising commonly evaluated clinical features to predict hypoxaemia in 2-59-month-old children with pneumonia.

Methods: Data from seven studies conducted in five countries from the Pneumonia Research Partnership to Assess WHO Recommendations (PREPARE) dataset were included. Readily available clinical features and demographic variables were used to develop a multivariable logistic regression model to predict hypoxemia (oxygen saturation < 90%) at presentation to care. The adjusted log coefficients were transformed to derive the PREPARE hypoxemia risk score and its diagnostic value was assessed in a held-out, temporal validation dataset. The model and risk score were analysed by evaluating the area under the receiver operating characteristic curve (AUC), sensitivity and specificity.

Results: We included 14 …

Retinal Ganglion Cell Migration And Viability Requires The Kinase Lkb1, Robert D Mackin, Ritika V Bhalla, Viktor Akhanov, Qudrat T Abdulwahab, Courtney A Burger, Melanie A Samuel

Faculty, Staff and Students Publications

The arrangement of neurons into ordered layers underlies circuit function in many nervous system regions. This is particularly true in the mammalian retina. Here, fate-committed retinal ganglion cells (RGCs) migrate from the apical to the inner retina, where they form connections that enable vision. The mechanisms that permit ganglion cell migration and whether distinct ganglion cell types use different migration modes are unknown. We show that the serine/threonine kinase LKB1 regulates ganglion cell migration and nuclear positioning. In the absence of LKB1, many ganglion cells remain in the apical retina. Misplaced cells show modified morphologies and display altered cytoskeletal proteins. …

Leveraging A Randomized Trial To Assess Relationships Between Transeptal Puncture, Brain Emboli, And Migraine Symptoms, Adi Elias, Roderick Tung, Edward P Gerstenfeld, Trisha F Hue, Feng Lin, Jing Cheng, J Peter Weiss, Wendy S Tzou, Henry Hsia, Ashkan Ehdaie, Daniel H Cooper, T Jared Bunch, Jeffrey Arkles, Babak Nazer, Adam Lee, Alexios Hadjis, Duy T Nguyen, Mihail G Chelu, Joshua D Moss, Jonathan C Hsu, Miguel Valderrábano, Prashant D Bhave, Gabrielle Montenegro, Anthony S Kim, William P Dillon, Gregory M Marcus

Faculty, Staff and Students Publications

Background: Catheter ablation procedures with transseptal punctures (usually for atrial fibrillation) are often associated with migraine-related visual auras, but the mechanism remains unknown. Whether this phenomenon is mediated by the creation of an atrial septal defect from transseptal puncture or by silent acute brain emboli detected on magnetic resonance imaging related to the procedure remains to be investigated.

Objective: This study aimed to evaluate whether randomization to a transseptal puncture during catheter ablation for ventricular arrhythmias is associated with postprocedural visual auras and assess the relationship between occipital and parietal lobes acute brain emboli and migraine-related visual auras.

Methods: In …

The Tides Of Time, The Tides Of Fate, And The Power Of Song, Tom Hillman

Journal of Tolkien Research

This paper studies the interaction of Song, Story, Time, and Fate in the context of the Elves' resistance to change by means of song and enchantment, specifically in Lothlórien until the arrival of the Fellowship of the Ring. Once Galadriel renounces the Ring and the resistance to change and the fading of the Elves, the mythic power of the Great Tales transforms the ability of Frodo and Sam to meet the fate that awaits them in Mordor.

Community Health Workers: Key To Decreasing Food Insecurity In Pregnant Individuals, Linda Waggener Dnp

Doctor of Nursing Practice Scholarly Projects

Objectives: Food insecurity (FI) in pregnant individuals (PI)s is a global threat to birthing individuals and fetuses with potential immediate and intergenerational impacts on family and community. Community Health Workers (CHWs) facilitate support including food resources for FIPIs. The Family Fresh Rx (FFRx) program, within Food as Medicine (FaM) model provides fresh fruits and vegetables, optimize nutrition, and mitigates threats to health. This Doctor of Nursing Practice (DNP) Quality Improvement (QI) project’s two objectives were CHWs’ FFRx program and referral process satisfaction evaluation through a pre, post, and four-week post refresher presentation (RP) modified System Usability Scale (mSUS) …

Speak Now With The Courage To Confront: An Educational Intervention To Address Bullying, Dominique Desiree Gomez

Doctor of Nursing Practice Scholarly Projects

Abstract

Background: Nurse-to-nurse bullying is a critical issue within the nursing profession, impacting close to half of all nurses. This phenomenon, articulated by the phrase "nurses eat their young," detrimentally influences employee retention, job satisfaction, morale, and ultimately, patient care. Furthermore, nurse-to-nurse bullying significantly affects the well-being of nursing professionals, particularly targeting novice nurses. This targeting raises substantial concerns regarding their retention, as many consider leaving the profession within their initial years of practice due to experiences of bullying. The educational intervention project titled “Speak Now with the Courage to Confront” is designed to mitigate bullying among novice nurses through …

Dr. Alison Krӧgel Faculty Spotlight, Rachel Jaeger

DU Undergraduate Research Journal Archive

An interview with Dr. Alison Krӧgel of the University of Denver's Department of Spanish Language, Literary & Cultural Studies.

Louis Pasteur: The Man Who Said, "Science Brings Men Closer To God", Alan L. Gillen, Adam Russell

Faculty Publications and Presentations

July 6, 2025, marks the 140-year anniversary of the first successful treatment of the rabies virus, discovered by Louis Pasteur. Louis Pasteur’s contributions and reputation are ever prevalent today, with “pasteurized” products being the signature of his legacy in microbiology. Through the creation of the “pasteurization” process (the gentle heating of food and drink products to eliminate pathogens), Louis Pasteur eloquently stated his motive for scientific discovery: “Man’s first look at the universe discovers only variety, diversity, multiplicity of phenomena. Let this gaze be enlightened by science . . . and simplicity and unity shine everywhere.” Ultimately, Pasteur’s work sought …

Pharmacy School Expands Global Reach Through Faculty Exchange In Japan, Marisa C. Atkinson

University of Mississippi News

OXFORD, Miss. – University of Mississippi pharmacy professor Adam Pate recently showcased and shared his knowledge and experience with an international audience in Japan.

Cheating With The Fifth Amendment: Weaponizing The Fifth Amendment Privilege To Undermine Equitable Dissolution Of Marriages, Elizabeth I. Boals

Loyola of Los Angeles Law Review

Despite widespread adoption of no-fault divorce, many U.S. states still consider adultery in the allocation of alimony and property. In sixteen of those states, adultery remains a criminal offense—enabling spouses accused of infidelity to invoke the Fifth Amendment privilege against self-incrimination during divorce proceedings. This Article explores how such invocations obstruct discovery, delay litigation, and create strategic advantages for wealthier or culpable spouses, especially in fault-based or hybrid divorce regimes. After surveying the historical development of divorce law and the expansion of Fifth Amendment protections into civil contexts, the Article critiques current remedies—adverse inferences, implied waivers, and immunity—as ineffective or …

Courts And Social Justice, Shai Dothan

Loyola of Los Angeles Law Review

Many scholars have argued that courts are either harmful or useless when it comes to improving social justice in society. There are three main reasons offered in support of this argument: (1) Courts are elitist institutions that support the high social class of the judges at the expense of the rest of society, (2) the structure of litigation is geared towards harming the rights of people with modest economic means, (3) even when courts try to impose a higher standard of social justice, they are not able to initiate real social change. The purpose of this paper is to investigate …

Educating Healthcare Providers To Prevent And Mitigate The Effects Of Zoom Fatigue, Andrea Lima

Doctor of Nursing Practice Scholarly Projects

Zoom Fatigue (ZF), or physical and neuropsychological responses to excessive videoconferencing (VC), increased during the COVID-19 pandemic. Like burnout, ZF can compromise patient safety by causing decreased job satisfaction, social isolation, disrupted focus, and difficulty empathizing with patients. This Plan-Do-Study-Act quality improvement project aimed to assess feelings about VC, raise awareness of the adverse effects of overuse, and empower primary care providers (PCPs) to improve their work experiences. A group of on-site PCPs at a tertiary care medical center in the Southwest, who continued holding exclusive virtual team meetings after the pandemic, was asked to complete the 15-question Zoom Exhaustion …

Coordinating Instruments For Multi-Messenger Astrophysics, Daisy Wang, Ye Htet, Marion Sudvarg, Roger Chamberlain, Jeremy Buhler, James Buckley

Computer Science Faculty Research & Creative Works

In multi-messenger astrophysics, signals of multiple types (e.g., gravitational waves, neutrinos, electromagnetic waves) are combined in an effort to learn more about the observed phenomena of interest. The Advanced Particle-astrophyics Telescope (APT) is a mission concept for a space-borne instrument that detects gammaray bursts (GRBs) omnidirectionally, facilitating multi-messenger observations by identifying and localizing celestial events of interest. Here, we describe the on-instrument computations for APT and its Antarctic Demonstrator (ADAPT) as well as techniques for follow-up observations of transient events.

The Employment Situation Of Veterans: June 2025, Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

In June 2025, U.S. employment rose by 147,000, with gains in state government and health care, while the overall unemployment rate remained steady at 4.1%. Veteran unemployment slightly increased overall, though trends varied by age, gender, and race, with younger veterans and Hispanic veterans seeing improvements, while older veterans and Post-9/11 veterans experienced higher unemployment rates.

Psychopharmacological Therapy Positively Modulates Disease Activity In Inflammatory Bowel Disease: A Systematic Review, Federica Di Vincenzo, Antonio Maria D'Onofrio, Angelo Del Gaudio, Elena Chiera, Gaspare Filippo Ferrajoli, Francesco Pesaresi, Alessio Simonetti, Marianna Mazza, Georgios Demetrios Kotzalidis, Mauro Pettorruso, Giovanni Martinotti, Loris Riccardo Lopetuso, Antonio Gasbarrini, Gabriele Sani, Gionata Fiorino, Franco Scaldaferri, Giovanni Camardese

Faculty, Staff and Students Publications

Depression, anxiety, and perceived stress are common comorbidities in patients with inflammatory bowel disease (IBD) and may negatively influence the disease course. Likewise, severe IBD may contribute to the development or worsening of psychiatric symptoms. Despite the established relevance of the gut-brain axis and frequent use of psychotropic medications in IBD patients, limited evidence exists regarding the effects of psychiatric treatments on gastrointestinal disease activity. Therefore, the aim of this systematic review is to evaluate the effectiveness of psychiatric therapies on gastrointestinal symptoms and disease activity in patients with IBD. The work was conducted in accordance with PRISMA guidelines. Searches …

Dopamine Partial Agonists In Pregnancy And Lactation: A Systematic Review, Alexia Koukopoulos, Delfina Janiri, Miriam Milintenda, Sara Barbonetti, Georgios D Kotzalidis, Tommaso Callovini, Lorenzo Moccia, Silvia Montanari, Marianna Mazza, Lucio Rinaldi, Alessio Simonetti, Mario Pinto, Giovanni Camardese, Gabriele Sani

Faculty, Staff and Students Publications

Background/Objectives: Dopamine partial agonists are drugs initially developed to treat schizophrenia, seeking a double effect of increased dopaminergic transmission in the prefrontal cortex and decrease in the accumbens/striatum. Of these drugs, aripiprazole, brexpiprazole, and cariprazine are currently marketed and used in schizophrenia spectrum and mood disorders. It is debated whether patients with psychiatric disorders becoming pregnant should discontinue or continue their antipsychotic treatment despite some risks for the fetus, i.e., whether it is worse to have an untreated disorder or treating it with drugs. The safety of drugs for mother and baby extend from pregnancy to the postpartum, when …

Doubly Erased: Lgbtq Literature In Appalachia By Allison Carey, Lis Regula

Critical Humanities

A book review of Allison Carey's Doubly Erased: LGBTQ Literature in Appalachia

Directional Poetics: An Interview With Ed Simon On Pittsburgh, Appalachia, And The Memories Of Geography, Ed Simon, Scott C. Mcdaniel

Critical Humanities

An Interview with Ed Simon

Fire In The Hole: Appalachia’S Elemental Narrative In Harlan County, Usa And King Coal, Somak Mukherjee

Critical Humanities

In Elaine McMillion Sheldon’s documentary King Coal (2023) coal is being referred to as a matter that is “not dirty or clean, but elemental.” The acclaimed film centers on the complex histories and cultures of coal in Central Appalachia, based on the perspective of Sheldon, a coal miner’s daughter, and a West Virginia native. The elemental nature of coal is explored in the film by situating coal less as a resource and more as a mythic foundation for the community's cultural history. This article puts King Coal in conversation with Barbara Kopple's seminal Harlan County, USA (1976) which narrates the …

Appalachian Archipelagos: "Writing From Measureless Location” In C.S. Giscombe’S Geopoetics, Jay Butler

Critical Humanities

This essay begins with a speculative gesture: what if we read Appalachia not as a bounded, landlocked region, but as an archipelago—where coherence lies not in contiguity, but in multiplicity and geopoetic drift? Drawing on the poetry of C.S. Giscombe, which spans the Caribbean to Appalachia and unsettles geographic conventions by inhabiting “measureless location” – not as a metaphor but as a method, materially grounded yet elusively meaningful – and guided by R.A. Judy’s Sentient Flesh and its theory and practice of para-semiosis and poiesis-in-black, this essay follows Giscombe’s pragmatic and prismatic geopoetics as it upends dominant frameworks of …

Planetary Thinking: Hellbenders As Emissaries Of Appalachia, Tierra R. Curry

Critical Humanities

Hellbenders are prehistoric salamanders that have thrived in cold rivers since before the continents divided. Once found throughout Appalachian watersheds, due to exploitation and habitat degradation only a few dozen healthy populations survive. Monstrous yet fascinating, hellbenders were often reviled historically, but in recent decades they have gained iconic status and are now celebrated as charismatic indicators for clean rivers. Hellbenders are symbols of the wild because of their ancient history, elusive nature, and contribution to ecosystem resilience. The same forces that drove the decline of these amphibian sentinels have sacrificed public health in Appalachia. Their demise echoes the struggle …

Planetary [] Appalachia: Editor’S Introduction, Scott C. Mcdaniel

Critical Humanities

Editor's Introduction to Volume 4 Issue 1

Irs Viewpoint: Cpa Participation In Volunteer Income Tax Assistance (Vita) And Student Tax Clinics, M. Eddie Heironimus

Tax Adviser

No abstract provided.

Planning And Tax Considerations In The Use Of Revocable Trusts (Part Iii), Julian S. Bush, Howard M. Zaritsky

Tax Adviser

No abstract provided.

Prediction Of Generalized Anxiety Disorder Treatment Outcomes With Neurobehavioral Responses To Approach-Avoidance Conflict: A Randomized Clinical Trial., Hannah Berg, Timothy J. Mcdermott, Rayus Kuplicki, Hung-Wen Yeh, Wesley K. Thompson, Ryan Smith, Elisabeth Akeman, Namik Kirlic, Ashley Clausen, Mallory Cannon, Evan White, Christopher R. Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, James L. Abelson, Martin P. Paulus, Robin L. Aupperle

Manuscripts, Articles, Book Chapters and Other Papers

Treatments for generalized anxiety disorder (GAD) often aim to address maladaptive approach-avoidance behavior patterns. Approach-avoidance conflict (AAC) offers a potential framework for identifying treatment outcome predictors and informing optimization of GAD treatment. The current study examined whether pre-treatment neurobehavioral AAC indices predict symptom improvement in behavioral activation (BA) and exposure therapy (EXP) for GAD. Treatment-seeking adults meeting criteria for GAD completed a randomized clinical trial with pre-treatment blinding, conducted from 2016-2021. Participants were randomized to complete 10 manualized sessions of BA or EXP. Participants completed an AAC task during functional magnetic resonance imaging pre-treatment. Computational parameters of task behavior were …

Latine Students’ Stem Identity Development: Reflecting On Implicit Biases, Imposter Syndrome, Self-Efficacy, And Support Systems, Alyssa G. Cavazos, Valerie Leija, Javier Cavazos Vela

Writing and Language Studies Faculty Publications

This study used an equity ethic framework and a STEM identity model to contextualize and understand Latine students’ perceptions of STEM identity development. The purpose of this study was to investigate how Latine undergraduate students who engaged in STEM coursework perceived their learning experiences and stories of resilience through an equity ethic framework. Data were collected through interviews with 19 Latine college students attending a Hispanic-Serving Institution. Findings revealed the following themes related to Latine students’ STEM identity development and lived experiences in STEM coursework: implicit biases, imposter syndrome, self-efficacy, and support system and resources. Findings highlight the need for …

Hikikomori Risk In The Uk, Gregory Gorman, Alison Bacon, Jon May, Stephen Minton

School of Psychology

Background: Hikikomori syndrome involves voluntary withdrawal from social life, school and work, with onset typically in young adulthood. Hikikomori risk has not been examined in the UK, and these studies aimed to validate and refine the Hikikomori Risk Inventory-24 (HRI-24) screening tool in UK young adults. Methods/Results: In Study 1, participants (n = 341) completed the HRI-24. Item analysis and confirmatory factor analysis resulted in a shorter 13-item HRI (HRI-13), which demonstrated a perfect correlation with the full HRI-24. Both the HRI-13 and HRI-24 showed strong convergent and divergent validity, correlating with depression, anxiety, avoidant coping and negative early life …

Craig L. Robinson

African American Funeral Programs

Craig_L_Robinson.pdf - Funeral program for Craig Robinson

The Creation And Evaluation Of An Engineering Student Leadership Academy, Jean Mclaughlin, Thuy Vu, Seokmin Kang

Teaching and Learning Faculty Publications

This article describes the creation and evaluation designed to support student success through their inclusion in a variety of professional and technical training programs. The opportunity to develop a leadership academy specifically for engineering students allowed faculty program coordinators to deliver content that was normally not available to students at this Hispanic-Serving Institution (HSI). We implemented and evaluated the leadership academy using a mixed-methods approach involving multimedia interviews and two traditional survey data collection techniques. Traditional online surveys gave quick feedback to coordinators on what the students found valuable, with the biggest change in programming being the spreading out of …

Exploring Sex-Specific Clinical Features In Chinese Patients With Takotsubo Syndrome, Hong-Yi Duan, Ling-Lin Wang, Ling-Chun Lyu, Zhen-Hua Shi, Xiao-Ping Lin, Zheng-Yang Yu, Guo-Hua Fan, Jing Chen, Xin-Hong Yang, Wei Deng, Chang-Wu Xu, Yan Huang, Qing Zhou, Jin-Ling Chen, Hong-Ning Song, Dong Hu, Jin-Qiu Liu, Hector Barajas-Martinez, Charles Antzelevitch, Kan Liu, Hong Jiang, Dan Hu

Department of Medicine Faculty Papers

BACKGROUND: Takotsubo syndrome (TTS) is considered as a transient acute heart failure syndrome predominant in females. However, data on Chinese TTS patients are limited. Therefore, this study aimed to investigate the clinical characteristics of Chinese TTS patients, identify prognostic markers.

METHODS: A total of 258 TTS patients were enrolled. Data on clinical characteristics and in-hospital major adverse cardiovascular events (MACE) were collected and analyzed. The latter included severe heart failure, shock, malignant arrhythmia, and death.

RESULTS: The average age of TTS patients was 59.3 ± 19.2 years. Female patients accounted for 68.9%. MACE occurred in 41.4% of patients during hospitalization. …