Digital Commons Network^™

Pan-Cancer, Multi-Omic Correlates Of Survival Transcending Tumor Lineage Across 11,019 Patients Reveal Targets And Pathways, Yiqun Zhang, Fengju Chen, Chad J Creighton

Faculty, Staff and Students Publications

Molecular correlates of cancer patient overall survival (OS) can provide new insights. Here, we systematically cataloged pan-cancer, multi-omic correlates of OS transcending tumor lineage across 11,019 patients, involving multiple cancer types while correcting for cancer-type-intrinsic OS differences. Significant fractions of genes with mRNA associated with OS in pan-cancer analyses showed concordant associations at the levels of DNA copy number alteration or methylation. Pan-cancer gene signatures of T-cell and macrophage tumor infiltrates were associated with better and worse OS, respectively. Pathways implicated by molecular OS associations included metabolism, PI3K/Akt, Wnt, and TGF-beta receptor. Significant fractions of worse OS-associated genes were essential …

Exact Solutions Of M-Fractional Complex Ginzburg-Landau Equation Via Two Analytical Methods, Nematollah Kadkhoda, Mojtaba Baymani, Maad M. Mijwil, Mostafa Abotaleb

Iraqi Journal for Computer Science and Mathematics

This article investigates the M-fractional complex Ginzburg-Landau (CGL) equationby utilizing the modified simplest equation method and the modified G'G-expansion method. The CGL holds significant importance in the realm of oscillatory phenomena and optical fibers. By implementing a fractional complex transformation, the M-fractional CGL equation is transformed into an ordinary differential equation (ODE).By employing these methodologies, bright periodic solutions, periodic solutions, and dark wave solutions relevant to phenomena witnessed in nonlinear optics or plasma environments are ascertained.It is demonstrated that these methods are very powerful and efficient to solve many fractional differential equations.

Reason for Expression of Concern: …

From Industrial Automation To Intelligent Automation: The Impact Of Iiot On Process Control - A Review?, Ali S. Allahloh, Mohammad Sarfraz, Duraid Y. Mohammed, Nadeen Khaleel Ibrahim, Hayder Hussein Thary

Iraqi Journal for Computer Science and Mathematics

The Industrial Internet of Things (IIoT) is reshaping process control, turning torrents of plant data into near-instant insight. Field evidence already shows unplanned-downtime cuts of 55%, maintenance-budget savings of 40%, and gains in overall-equipment-effectiveness of roughly 15%; nevertheless, fewer than 30% of facilities have pushed beyond pilot scale to full, always-on predictive maintenance. To clarify why, this review screens 312 Scopus records published between 2010 and 2023, then subjects 62 peer-reviewed studies and a broad set of industry reports to deep content analysis, bibliometric mapping, and thematic clustering.The results reveal four tightly connected research fronts—IIoT/Industry 4.0 core technologies, classical process-control …

The Impacts Of Fluconazole On Invasive Fungal Infection, Colonization, And Overall Mortality In Preterm Infants: An Updated Systematic Review And Meta-Analysis, Tiehui Huang, Xue Zhang, Xueqiao Lei

Journal of Pediatric Infectious Diseases

Objective: Invasive fungal infection is not uncommon in preterm infants, and fluconazole has been reported to prevent fungal infection. The impacts of fluconazole on invasive fungal infection in preterm infants can be evaluated using an updated systemic review and meta-analysis of randomized clinical trials. Methods: The log risk ratio was transformed using the risk ratio and 95% confidence interval to assess the impacts of fluconazole on fungal infection in preterm infants. After selection, eleven randomized clinical trials of 1097 preterm infants with fluconazole prophylaxis and 953 preterm infants in the control group were enrolled. The focused outcome was the risk …

Energy Consumption Patterns In Residential Buildings: A Comparative Study Of Air Conditioning Systems, Asmaa R Elantary

Yanbu Journal of Engineering and Science

This study explores energy consumption patterns in residential buildings, focusing specifically on the air conditioning systems and their intricate relationship with technology, occupant behavior, and environmental impact. Utilizing a mixed-methods approach, quantitative data is gathered on energy usage from utility companies and homeowner surveys, complemented by qualitative insights from interviews and focus groups. The results indicate that households equipped with air conditioning units face significantly higher electricity bills, especially during peak summer months, largely due to the inefficiencies of older systems and the common issue of oversized units. Technological advancements, including high-efficiency air conditioning systems and smart thermostats, are crucial …

Internet Of Things For Sustainable Transportation Systems, Ayodeji Akinsoji Okubanjo, Ignatius Kema Okakwu, Oluyinka Esther Olaifa, Matthew Babatunde Olajide, Olufemi Peter Alao, Olayiwola Abisola

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

This paper highlights the opportunities for the Internet of Things in the transportation industry. The need for the Internet of Things and its architecture to address various complex challenges in the transportation sector are discussed. Various smart applications of the Internet of Things and its noticeable benefits over the existing technology are well articulated. In addition, the role of new and emerging technology such as artificial intelligence, machine learning, big data, cloud, data storage, and analysis for future sustainable transportation are highlighted with specific cases. Furthermore, smart areas of the Internet of Things in transportation are pictorially discussed. In addition, …

Utilization Of Ftir-Atr For Material Characterization And Forensic Analysis, Helmut Leodarta, Ahmed S. El-Ashwah, Punyaslok Rath, Magdy Abdelrahman, William G. Buttlar

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The growing use of chemical modifiers and additives in asphalt mixtures necessitates a reliable system for their identification and quantification, crucial for quality control, assurance, and forensic investigations. Fourier Transform Infrared (FTIR) spectroscopy offers a cost-effective method by analyzing the interaction of infrared light with chemical groups, producing distinct spectral fingerprints. This study evaluates 44 materials, including binders, warm mix additives (WMAs), rejuvenators, release agents, and concrete admixtures. It also assesses the ability of FTIR testing to identify and quantify chemical changes and aging in asphalt binders with rejuvenator addition. An Attenuated Total Reflectance (ATR) accessory was employed for practical …

Mechanical And Deformation Behavior Of Silt Reinforced With Wicking Geotextile: An Experimental Study, Yipeng Guo, Yiyong Xue, Yongjie Zhang, Wei Ruan, Yafeng Li, Xiong Zhang, Zhili Han

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Silt is widely utilized as a filling material in transportation construction, However, it frequently suffers from problems, such as excess pore water pressure buildup, settlement, and mud pumping. Wicking geotextiles have emerged as a sustainable solution by improving both drainage and reinforcement capacities, yet their optimal design parameters remain unclear. To address this gap, a series of tests were performed to investigate the effects of compaction degree, reinforcement configuration (number, spacing, position), and specimen geometry on the mechanical and consolidation of silt reinforced with wicking geotextiles. The results reveal that the failure mechanism of reinforced silt progresses through four distinct …

An Approach To The Mesostructure Sealing In Coal By Mine Water Clathrate, Haiyang Yi, Ze Li, Tao Yang, Zhuang Zhuo, Tingxiang Chu, Xianfeng Shi, Guang Xu

Mining Engineering Faculty Research & Creative Works

The sealing performance of coal mass is of significant importance for converting abandoned mines into geological repository. This study presents a novel approach to enhancing the sealing of the pore structure in coal seams, such a technique utilizes mined water as the primary substance and additive solution based crystalline. Sequent tests are implemented, including saturation test, ion chromatography test, permeability test and scanning electronic microscope observations. It was suggested that the produced crystalline decrease the porosity and permeability of the coal, with different crystal morphologies due to various ions of additive solutions. The produced rod-shaped crystals have the most remarkable …

Experiences Of Managing And Living With Autoimmune Addison’S Disease In The Younger And Newly Diagnosed Adults: An Interpretative Phenomenological Analysis, Mathew Horodner

Walden Dissertations and Doctoral Studies

There is a lack of knowledge regarding the experiences of managing and living with autoimmune Addison’s disease (AD) in the younger and newly diagnosed adults. AD research usually focuses on biological or medication studies. Thus, the purpose of this qualitative study was to understand the lived experiences of the younger and newly diagnosed adults living with autoimmune AD. Consisting of the complex integration of biological, psychological, and social factors, Engel’s biopsychosocial model served as the study’s conceptual framework. I conducted this study to include the experiences of managing and living with autoimmune AD in the younger (18–35) and newly diagnosed …

Plant-Based And Plant-Predominant Diets Among Healthcare Students: A Systematic Review, Raman Abbaspour, Sarah Weisbrodt, Samal Nauhria, Madeline Chan, Ali Kasim Rawji, Parham Bokaei Jazi, Sabyasachi Maity

School of Podiatric Medicine Publications

This systematic review explores the effects of vegetarian diets on the physical and mental well-being of health sciences students, a demographic known for high academic and psychological stress. We conducted a comprehensive search across major databases, adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and identified 22 relevant studies. Our findings suggest that vegetarian diets are associated with lower incidences of chronic diseases such as coronary heart disease and obesity and promote better cardiovascular and metabolic health outcomes compared to non-vegetarian diets. Notably, vegetarian students could display lower systolic blood pressure and waist circumferences. Contrary to …

The Scylla And Charybdis Of Paternalism And Moral Complicity, J.L.A. Donohue

Philosophy Faculty Publications and Presentations

In some circumstances avoiding complicity seems to require acting paternalistically, while avoiding paternalism seems to require moral complicity in another's wrongful projects. In order to solve the conflict we will need to investigate the concepts of paternalism and moral complicity and, more importantly, our moral interest in them in the first place. Why do the wrongs of paternalism and moral complicity matter to us? And what does this tell us about what it means to set out to treat others well, where that includes both respecting their agency and helping them to act rightly? I will suggest that adopting a …

Chaperone-Usher Pathway Pili Adhesin Conformations And Inhibitors In Urinary Tract Infections, Edward Lopatto

Arts & Sciences Graduate Student Theses and Dissertations

Antibiotic resistant bacteria are becoming increasingly difficult-to-treat resulting in increased morbidity and mortality, especially for common infections such as urinary tract infections (UTIs). Globally, UTIs afflict over 400 million people a year. Numerous different gram-negative and gram-positive bacterial species cause UTIs, including uropathogenic Escherichia coli (UPEC), Klebsiella pneumoniae, and Acinetobacter baumannii. Many of these bacterial species are listed as pathogens of urgent concern by the Center for Disease Control due to the dangerous rise and prevalence of antibiotic resistance necessitating development of new therapeutic measures. Bacteria utilize adhesin factors, such as chaperone-usher pathway (CUP) pili to gain a foothold in …

Cortical Functional Organization In Early Childhood, Jiaxin Tu

Arts & Sciences Graduate Student Theses and Dissertations

The advent of connectivity-based methods, particularly those utilizing spontaneous BOLD signals, has significantly advanced brain mapping and deepened our understanding of the human brain's functional architecture. While prior research has explored functional organization in early childhood, most studies have focused on coarse, group-level distinctions aligned with adult literature, often within narrow age ranges. This dissertation extends these investigations by examining cortical functional organization in greater detail among healthy infants and toddlers aged 1 to 5 years. Chapter 1 employs spontaneous BOLD signals in sleeping infants and toddlers to derive a group-level functional organization at the resolution of areas and networks. …

Neural Associations Between Fingerspelling, Print, And Signs: An Erp Priming Study With Deaf Readers, Brittany Lee, Sofia E. Ortega, Priscilla M. Martinez, Katherine J. Midgley, Phillip J. Holcomb, Karen Emmorey

Communication Sciences and Disorders Faculty Articles and Research

Fingerspelling is a leading predictor of reading ability for deaf people who use a signed language, but few neuroimaging studies have examined how it supports reading. We used event-related potentials to investigate how fingerspelled words prime printed words. Twenty-four skilled deaf adult readers completed a Go/No-Go task while viewing printed English word targets following related and unrelated primes in one of three conditions: printed English words, American Sign Language (ASL) signs, and fingerspelled words. N400 priming effects were strong across all three conditions. Early N400 effects were similar for printed word primes and fingerspelled word primes, suggesting shared orthographic representations. …

Introduction To Sociology: Socialization, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper offers a comprehensive examination of socialization and identity development through a comparative lens, focusing on American, Chinese, and Japanese cultures. It explores how distinct cultural values—individualism, loyalty, and cooperation—shape personal and collective identities from childhood through old age. Utilizing the life course perspective, the analysis considers how factors such as generation, socioeconomic status, race, and gender influence the trajectory of human development. The evolution of childhood is traced across historical and cultural contexts, highlighting shifting perceptions, the impact of industrialization on children's roles, and the persistent influence of class and ethnicity on access to education and well-being. …

Studying Effect Of Temperature On Photovoltaic Characteristics Of Photovoltaic Modules Based On Cigs Solar Cells, Farrux Anvar O‘G‘Li Akbarov, Anvar Akbarovich Alimov

Technical science and innovation

The article presents the experimental results of the temperature dependence of the load current-voltage characteristics of a solar photovoltaic (PV) module based on a polycrystalline semiconductor binary compound Cu(In,Ga)Se₂ under normal sunlight P_rad=800±5 W/m², in a temperature range of (32÷60) ^оС. It was found that the temperature dependence of the photocurrent has two slopes, which is explained by a change in the generation-recombination mechanism. An increase in the short-circuit current with an increase in the temperature of the photovoltaic module is explained by an increase in the drift length of minority charge carriers, due …

An Action Research Study On Ai Video Vs. Written Feedback: Enhancing Undergraduate Academic Writing And Critical Thinking, Sandra Baroudi, Nida Mubeen, Suha Karaki

All Works

This action research explores how AI-assisted feedback formats influence students’ academic writing and critical thinking, a gap particularly relevant in the digital learning landscape. This study involved 40 undergraduate Emirati students divided into two groups, receiving either AI-generated video or written feedback across three assignments. Using a quantitative design, data were gathered using standardized critical thinking and academic writing skills rubrics. Additionally, students completed post-surveys to capture their perceptions, engagement levels and use of AI tools in the learning process. Results showed written feedback significantly improvemed critical thinking (M = 2.80, SD = 0.75) compared to video feedback (M = …

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Seeking Into Cell-Free Therapies For Bone-Affected Lysosomal Storage Disorders, Andrés Felipe Leal, Harry Pachajoa, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Lysosomal storage disorders (LSDs) constitute a group of monogenic systemic diseases resulting from deficiencies in specific lysosomal enzymes that cause the intralysosomal accumulation of non- or partially degraded substrates, leading to lysosomal dysfunction. In some cases of LSDs, the bone is more severely affected, thus producing skeletal manifestations in patients. Current therapies, such as enzyme replacement therapy (ERT) and gene therapy (GT), show limited efficacy in correcting skeletal abnormalities. Increasing evidence suggests that microenvironmental disturbances also contribute significantly to disease pathogenesis. Therefore, therapeutic strategies targeting lysosomal dysfunction and microenvironmental dysregulation are needed. Mesenchymal stem-cell-derived extracellular vesicles (MSC-EVs) are emerging as …

Pharmacological Considerations For Healthcare Providers When Caring For Muslim Patients: A Practical Guide, Layla Abubshait, Nissa Tasnim, Taha Cangoz

Einstein Health Papers

Healthcare providers increasingly encounter Muslim patients with unique pharmacological considerations influenced by religious beliefs and practices. Islam, as the world's second-largest religion, includes specific guidelines affecting medication permissibility, particularly regarding alcohol and pork-derived ingredients. This educational guide examines the intersection of Islamic teachings with pharmacotherapy, providing examples of commonly prescribed medications containing alcohol or porcine-derived gelatin from our academic medical center's inpatient and outpatient formulary. We document alcohol content percentages in various medications and suggest possible alternatives as illustrative examples. Most importantly, we present a step-by-step practical framework for using National Drug Code (NDC) numbers and the DailyMed database, enabling …

8-Page Zine Extra Credit Assignment, Ricaute Rogers

Open Educational Resources

This is an 8-page minizine extra credit assignment that put into practice the concepts learned in CIS100.

Factors Associated With Falls Among Nursing Home Residents, Dorsenia Hendrix

Walden Dissertations and Doctoral Studies

Falls in nursing home facilities are prevalent, and numbers continue to rise as residents grow older and antipsychotic (AP) medications are prescribed more frequently. The purpose of this quantitative study was to investigate whether frequency of falls was related to the use of AP medications. Data (N=100) were collected from 2020 incident reports, investigation sheets, and patient charts generated by the State Department of Public Health regarding resident falls and the use of AP medications in a nursing home Facility located in the Southern United States. Social Cognitive Theory (SCT) was used to understand specific behavior patterns such as personal, …

Big Five Personality Traits As Predictors Of Funeral Directors’ Job Satisfaction, Teresa Busick

Walden Dissertations and Doctoral Studies

By 2037, annual deaths in the United States are expected to exceed 3.6 million, over 1 million more than in 2015. At the same time, the funeral service industry faces a serious staffing problem, with about 50% of funeral directors leaving the profession within 2 years. These combined challenges highlight the need to understand what contributes to job satisfaction and helps to retain these workers in this essential field. This quantitative correlational study examined whether the Big Five personality traits predict job satisfaction among funeral directors. Thus, the Big Five model of personality traits was used to guide the study. …

Improving Genetics Equity: Identifying Women Eligible For Genetic Care Services Using Mammography Clinics In Underserved Areas As Screening Hubs, Darya Kizub, Rachel Bluebond, Sierra Green, Jessica Duckworth, Sreejesh Shanker, Autumn Vara, Banu Arun

Faculty, Staff and Student Publications

PURPOSE: Fewer than 20% of underserved individuals undergo guideline-concordant hereditary breast and ovarian cancer (HBOC) genetic testing (GT). Our study aimed to determine the proportion of women eligible for HBOC GT using a cancer genetics risk assessment (CGRA) tool at breast cancer (BC) screening clinics in underserved communities and to describe the program's impact.

METHODS: Participants were women who presented for BC screening at The Rose clinics, serving low-income underserved communities in southeast Texas, and completed the CGRA. High-risk individuals received bilingual educational materials and a saliva-based GT kit. Those with a pathogenic variant (PV) or a variant of uncertain …

Chromatography In Analysis And Quality Control Of Oil And Gas Products: Modern Approaches And Prospects, Muborak Akramovna Mirshomilova, Natalia Evgenievna Sheina, Lala Bekirova

Technical science and innovation

Chromatography plays a key role in the analysis and quality control of oil and gas products. Modern chromatographic methods, including gas and liquid chromatography, provide high accuracy, sensitivity and speed of analysis. They allow you to identify impurities, control the composition and compliance of products with standards. The article considers innovative approaches, such as multidimensional chromatography and the use of automated systems. Development prospects are discussed, including integration with AI and digital technologies, which opens up new opportunities to improve the efficiency of quality control in the oil and gas industry. This article considers the role of chromatographic methods in …

Research Of Hereditarily Deformable Structures Under Seismic Impacts, Abdali Abdukarimov, Kazbek Nuratdinov

Technical science and innovation

This article examines the responses of a structure to both single-component and multi-component seismic impacts if they are generally described by three linear displacements and three rotations of the foundation relative to three orthogonal axes.

A mathematical apparatus has been created that allows developing statistical theories of seismic resistance for studying hereditarily deformable structures under random seismic impacts. Using impulse transition functions, having established the explicit form of the reaction of hereditarily deformable structures to an arbitrary form of random disturbance, it is possible to determine: the mathematical expectation and moments of the outgoing process; correlation functions; spectral densities, i.e. …

Supporting Patients With Advanced Cancer And Their Spouses In Parenting Minor Children: Results Of A Randomized Controlled Trial, Kathrin Milbury, Sujin Ann-Yi, Meagan S Whisenant, Morgan Jones, Yisheng Li, Victoria Necroto, Sania D Yousuf, Mariana Chavez-Macgregor, Larrisa Meyers, Eduardo Bruera

Faculty, Staff and Student Publications

Introduction: Patients with advanced cancer and their spousal caregivers who parent minor children report unmet parenting concerns and increased psychological distress. Seeking to address these important supportive care needs, this RCT examined the feasibility, acceptability, and initial evidence for the efficacy of a novel psychosocial intervention.

Patients and methods: Patients with a metastatic solid malignancy and their spouses completed self-reported validated assessments of psychological symptoms and cancer-related parenting outcomes and were then randomized to the parent support intervention or a usual care (UC) group. Both groups were reassessed 6 and 12 weeks later. Dyads randomized to the counselor-led intervention attended …

Research On Geological Complications Occurring During Drilling Operations At Uzbekneftegaz Jsc Wells, Otabek Rajabovich Eshmurodov, Komilxodja Anvarxodjayevich Raximov, Shaxnoza Hikmatullayevna Mirsaatova, Tolib Olimovich Komilov, Sherali Halloqovich Umedov

Technical science and innovation

This article presents an analysis of maintaining wellbore stability, preventing pack-off formation, stuck pipe incidents, and drilling fluid losses. A technology aimed at ensuring successful and high-quality trouble-free well drilling is analyzed and recommended. Based on data obtained from the Surkhandarya Basin fields, many wells were not drilled to the designed depth. Geophysical data from studied fields indicate that pore pressure retained in clay formations causes wellbore instability. These data also help to identify zones prone to collapse; however, the direct measurement of pore pressure in such formations remains impossible. This research was primarily conducted in the Ustyurt region, one …

Algorithms For Combined Regular Synthesis Of Controller Parameters In Control Systems For Dynamic Objects, Khusan Zakirovich Igamberdiev, Latafat Abbas Gizi Gardashova, Yulduz Mukhtarkhodjayevna Abdurakhmanova, Uktam Farkhodovich Mamirov

Technical science and innovation

Nonlinear control system that includes m-dimensional input control signal and extended (n+s) - dimensional state vector, the last s components of which form a vector of unknown parameters θ satisfying a general difference equation is being considered. The quality criterion is determined by the loss function. The optimal control must satisfy the Bellman equation with respect to the optimal loss function. To be defined an approximate solution that preserves an active use of information. For this purpose, the system is linearized in accordance to the nominal trajectory. This problem is seen as incorrectly stated. The values of the preliminary data …

Technological Schemes For Recycling Used Mineral Oils Carbon-Based Adsorbents Derived From Petroleum Coke, Jaloliddin Sharafiddinovich Bakhtiyorov, Vais Narzullaevich Juraev, Mirzhalol Nuriddinovich Norpulatov

Technical science and innovation

Currently, the demand for mineral oils used in engine vehicles and transformers is increasing year by year worldwide. Additionally, a significant portion of used oils is burned as fuel. At present, the contact method is widely used for oil regeneration with the help of adsorbents such as aluminosilicates, zeolites, silica gels, bleaching clays, and others. The existing industrial reprocessing technologies are of great importance in the recycling of used engine and transformer oils. Furthermore, scientists worldwide are conducting research to create long-lasting carbon-based adsorbents for the regeneration of used engine and transformer mineral oils. In this regard, special attention is …