Digital Commons Network^™

Dnp Project: Research Study Using Mindfulness Meditation For Stress Reduction In Undergraduate Nursing Students, Jennifer Williams

Doctor of Nursing Practice Projects

Undergraduate nursing students often experience high stress from academic rigor, clinical demands, and personal challenges, contributing to mental health concerns and increased attrition. Unmanaged stress, when met with insufficient coping strategies, may contribute to students failing, leaving, or withdrawing from a nursing program. This research project addressed the need for a structured coping strategy within the curriculum at a State College to promote student resilience and reduce stress. As a quality improvement process change, the project’s purpose was to evaluate the impact of a four-week mindfulness meditation (MM) intervention on perceived stress levels of first-semester Associate Degree in Nursing (ADN) …

Autism Awareness Training For Law Enforcement Officers: A Pilot Study, Kaylie Holke, Meghan Cosier, Elissa Green Kaustinen, Cathy Scherer, Andrew Wall

Education Faculty Articles and Research

Purpose

The purpose of this study was to pilot a research-based autism training session for law enforcement officers (LEOs), test the Police Self-Efficacy for Autism (PSEA) scale as a measurement tool for the session and provide a preliminary examination of brief training. Design/methodology/approach

This study utilized a pre-post survey approach in which participants completed the PSEA scale pre- and post-training to measure the relationship between the training and self-efficacy scores. Findings

Results show a positive relationship between brief autism-specific training and officers’ self-efficacy scores across items and subscales. All four subscales and seven of thirteen items demonstrated statistical significance. Originality/value …

Cover And Contents

Turkish Journal of Physics

No abstract provided.

The Effects Of A Geopolitical Policy—Case Study Of “Korea Limitation Order” Upon The Cultural Entertainment Industry In China, Zhilin Li

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

This paper examines the impact on the South Korean Cultural Entertainment Indus- try(CEI) of China’s “Korea Limitation Order”. In November 2016, Beijing restricted South Korean artists from holding concerts and the broadcast of South Korean TV dramas and banned cooperation between the two countries in the entertainment in- dustries. This paper focuses on the effect this had on exports of cultural products and relating industries from Korea, and how Korea was able to adjust to this geopolitical shock. I examine exports from Korea to China, Japan, and the United States using data from Cultural Entertainment Industry Products Exports, such as …

Does Bilingualism On Resumes Affect Callback Rates?, Autumn Halfpenny

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

I study the influence of bilingualism in Spanish on the likelihood of receiving a callback for female customer service positions in the Chicago area. Data are collected from sixteen unique resumes submitted to 131 different job postings in an audit study, with applicants differing in bilingual ability. Bilingualism in Spanish significantly in- creases the likelihood of a callback by 17.86%-25.4%, implying bilingualism is valued in customer service roles. This suggests that bilingualism in Spanish may increase job prospects. While previous research studies this using observational and survey data, I use an audit study design with resumes to obtain causal results. …

The Effects Of Pandemic School Closures On Standardized Testing Outcomes: Evidence From Connecticut, Michael Manieri

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

During the Covid-19 pandemic, schools around the nation closed to prevent the virus’s spread. Following these closures, students’ performance on standardized exams worsened. Using a two-way fixed effect model with district and year fixed effects, I examine if the use of non-traditional schooling modes (i.e. hybrid and virtual) during the pandemic is associated with lower ELA and Math proficiency rates in Connecticut public schools. I find that Connecticut public school districts’ Math and ELA pass rates on the annual Smarter Balanced exam significantly decreased as they used higher levels of virtual and hybrid education. The magnitude of this decrease was …

Integrated Algorithm And Hardware Design For Hybrid Neuromorphic Systems, James Seekings, Mahsa Ardakani, Peyton Chandarana, Arshia Eslami, Mohammadreza Mohammadi, Ramtin Zand

Faculty Publications

This paper investigates the combined potential of neuromorphic and edge computing to develop a flexible machine learning (ML) system designed for processing data from dynamic vision sensors. We build and train hybrid models that integrate spiking neural networks (SNNs) and artificial neural networks (ANNs) using the PyTorch and Lava frameworks. We explore the effects of quantization on ANN models to assess its impact on both accuracy and energy efficiency. Additionally, we address the challenges of deploying hybrid models on hardware by implementing individual components on specific edge platforms. We also propose an accumulator circuit to bridge the spiking and non-spiking …

Understanding And Evaluating Genomic Language Models, Aadit Kapoor

Master's Theses

Large Language Models (LLMs) have shown remarkable capabilities in interpreting complex patterns across various domains, yet their application to genomic data remains limited. We see great potential in leveraging LLMs for vital biological tasks, such as predicting transcription factor binding sites and identifying antibiotic-resistant genes. This emergent behavior positions LLMs as powerful tools for enhancing our understanding of intricate biological language. LLMs trained specifically on genomic data, such as DNA sequences, operate distinctly compared to those trained on natural language. This difference is evident not only in the architectural landscape of the models but also in the methodologies employed by …

Quality Improvement Project Implementing Test Anxiety-Reducing Methods In Senior-Level Nursing Students, Ashley Brooke Gray

Doctor of Nursing Practice Projects

Test anxiety is a common occurrence among university students, particularly nursing students. The purpose of this Doctor of Nursing Practice (DNP) quality improvement project was to address the problem of test anxiety among senior-level nursing students and the lack of faculty intervention in a Bachelor of Science in Nursing (BSN) program. This DNP project aimed to increase awareness of test anxiety among nursing students and provide faculty development training on identifying symptoms, utilizing the Westside Test Anxiety Scale (WTAS), and implementing test anxiety-reducing measures in the classroom. The DNP student provided training to senior-level nursing faculty in integrating relaxation methods, …

Characterizing And Modeling The Nonlinear Behavior Of Additively Manufactured Trapped-Powder Dampers, Jonathan Knight Black

Theses and Dissertations

Laser Powder Bed Fusion (LPBF) can be used to create metal parts with pockets of retained, unfused powder that serve as mechanical dampers. These trapped-powder dampers show promise for reducing the amplitude of vibrations at resonance by orders of magnitude. However, little is currently understood about the nonlinearity and repeatability of trapped-powder dampers, meaning that the design process currently consists of expensive trial-and-error prototyping and iteration. The present work contributes a corpus of experimental measurements for rectangular beams with trapped-powder dampers of various dimensions and locations. Preliminary testing revealed the presence of a memory effect which we hypothesize to be …

Investigating Radiation Induced Rowhammer And Retention Failures In Dram, Tyler Ricks

Theses and Dissertations

It is desirable for DRAM devices to be used in harsh radiation environments. Exposure to radiation causes DRAM cells to lose their retention time as their ability to store charge effectively declines. Exposure also worsens the effect of disturbance that causes neighboring cells to flip when a row is opened multiple times: an effect known as the Row Hammer Effect. This thesis evaluates the impact of radiation-induced memory cell degradation by comparing memory cell's retention time and their resilience to the row hammer vulnerability. Three generations of DRAM were placed under a neutron radiation beam. Sections of the irradiated devices …

Remote Running Gait Analysis Using Smartphone Video And Monocular Pose Estimation: A Feasibility Study, Luke Vankeersbilck

Theses and Dissertations

Introduction: Running is a common form of exercise that comes with many health benefits; however, many people stop exercising because of the high injury risk. Running injury is connected with biomechanical risk factors. Yet, these risk factors often show inconsistent and conflicting results across studies, largely due to small sample sizes limiting statistical power. Low subject numbers may be partly due to the time requirements of traditional motion capture. Monocular pose estimation offers a promising alternative by using machine learning to track body landmarks from a single camera. This study evaluated the feasibility of remotely collecting running biomechanics data using …

Controlled-Airflow Sensor Enclosure (Case) Design Document, Catryn N. Cattoor

Mechanical Engineering and Materials Science Independent Study

The purpose of this document is to organize the theory, industry practices, and research related to designing a device that pulls air through a pipe, containing an environmental sensor, at a rate controlled by a computer fan. Using such a device to regulate the airflow over a sensor can improve the accuracy of field readings, as sensors are often unintentionally sensitive to multiple external conditions. Changes in wind direction and speed or heating due to solar radiation, for example, can cause errors in gas concentration and temperature readings, warranting the need to correct for these factors without decoupling these sensors …

Work Extracting And Second Law-Like Inequalities From Non-Extensive Small Systems With Feedback, Mehdi Mirzaee, Saman Amiri

Turkish Journal of Physics

The Gibbs-Boltzmann entropy effectively characterizes systems with a significant reliance on initial conditions. Nonetheless, the majority of materials generally exhibit behavior that is independent of their initial conditions. Conversely, Tsallis entropy—a nonextensive entropy that underpins nonextensive statistical mechanics—provides a comprehensive framework for modeling systems that engage with their environment. In this study, we derive the Tsallis formulation of the Clausius inequality in a quantum context and establish an upper limit for the work that can be extracted from a small system within the framework of nonextensive quantum statistical mechanics. Furthermore, by utilizing a principle from quantum information theory—which posits that …

Foster Kinship Program Evaluation, Eduardo Cabral-Terrazas, Jamilah Mcgrue, Andrea Rangelova, Jeffrey Vanderlaan

Public Policy and Leadership Theses & Dissertations

Foster Kinship, a Nevada-based nonprofit, operates under the belief that “When children cannot be with their parents, they should be with their family” (Foster Kinship, 2022). It supports kinship caregivers, who often take in children during a crisis, in navigating the foster care system. The organization’s Kinship Navigator Program offers training, case management, and licensing support to kinship caregivers, enabling them to access financial assistance and other benefits. However, many caregivers who complete the training do not finish the licensing process, limiting placement stability and access to resources for the children. Understanding why kinship caregivers trained through the Foster Kinship …

Ai-Enabled Innovations In Automated Essay Scoring And Feedback Systems, Michael J. Murff

Theses and Dissertations

This dissertation examines the evolution and educational implementation of Automated Essay Scoring (AES) systems, with particular focus on generative artificial intelligence integration in educational assessment. Through a two-article format, this research addresses the persistent gap between technical capability and educational adoption that has characterized AES development over seven decades. The first article presents a comprehensive methodological review analyzing 122 studies spanning AES evolution from foundational computational linguistics through contemporary hybrid systems. Despite achieving strong correlations with human scoring, modern AES systems face resistance due to validity concerns and misalignment with pedagogical values, revealing an "adoption paradox" where technical sophistication often …

Under The Sea And Into The Future With Darwin, Verne, & Wells: Evolutionary Ideas In Early Science Fiction Literature And Atomic Age Adaptations, Suzette K. Forston

Theses and Dissertations

In the latter half of the nineteenth century, Charles Darwin's theories challenged traditional ways of thinking about the world so dramatically that his writings inspired the formation of a new genre: science fiction. Two pioneering authors, Jules Verne and H. G. Wells drew from Darwin's writings in their classic novels, 20,000 Leagues Under the Seas (1870) and The Time Machine (1895). Though the two authors are often compared because they were both early science fiction authors, they approached Darwinian theory in different ways. Verne uses a more extrapolative approach and focusing on specific details of Darwin's texts to tell a …

Tracing Sars-Cov-2 Clusters Across Local Scales Using Genomic Data, Leke Lyu, Mandev Gill, Guppy Stott, Sachin Subedi, Cody Dailey, Gabriella Veytsel, Magdy Alabady, Kayo Fujimoto, Ryker Penn, Pamela Brown, Roger Sealy, Justin Bahl

Faculty, Staff and Student Publications

A quantitative understanding of local transmission dynamics is essential for designing effective prevention strategies. In this study, we developed a computational workflow to identify viral introductions and trace locally circulating clusters. We analyzed over 26,000 SARS-CoV-2 genomes and their associated metadata, collected between January and October 2021, to explore introduction and local dispersal patterns in Greater Houston, a major metropolitan area known for its demographic diversity. Our analysis identified more than 1,000 independent introduction events, resulting in clusters of varying sizes. The majority of introductions originated from domestic sources, while international introductions occurred earlier and were associated with larger cluster …

Molecular Inflammatory Expression Profiles Associated With The Frequency Of Pain In Individuals With Sickle Cell Disease, Lana Mucalo Katunaric, Shuang Jia, Ashima Singh, Mark F. Roethle, Julie A. Panepinto, David C. Brousseau, Martin J. Hessner, Amanda M. Brandow

Department of Pediatrics Faculty Papers

Pain is the most common complication of sickle cell disease (SCD). The underlying biology of SCD pain is not well understood, which is a barrier to novel, effective analgesic and preventive therapies. A wide variability in the phenotypic expression of pain exists among individuals with SCD, despite the inheritance of a similar defective hemoglobin gene. This interindividual pain variability further complicates the ability to understand the biology and effectively treat pain. We sought to discover a biological signature comprising differentially expressed genes unique to SCD that could differentiate between individuals with varied pain frequency. We conducted plasma-induced transcription analysis from …

South Carolina Alternative Route Teacher Pipeline Report For 2023–24, Svetlana Dmitrieva, Brian Cartiff, Angela Starrett

Reports

This report presents a detailed analysis of South Carolina’s alternative route teacher workforce for the 2023–24 academic year, with a focus on preparation and retention. As part of SC TEACHER’s ongoing commitment to providing statewide educator workforce profiles, this publication, along with SC TEACHER’s broader research, offers timely, actionable data to inform educators, policymakers, and other stakeholders.

The findings presented here are based on educator-level data provided by the South Carolina Department of Education (SCDE) for 2023–24, along with longitudinal data from the 2019–20 through 2022–23 academic years. The 2023–24 analyses reflect a sample of 5,079 educators affiliated with state-approved …

Evidence-Based Intervention Proposal For Reducing Intimate Partner Violence Against Jamaican Women, Kimisha K. Campbell

Walden Dissertations and Doctoral Studies

Domestic violence (DV) is a significant public health concern that negatively impacts women’s health, yet gaps in trauma-informed screening and referral processes persist within nursing practice. In Jamaica, DV remains underreported, highlighting the need for enhanced provider competency in identifying and supporting survivors. The doctoral project was used to examine how implementing the trauma-informed care (TIC) model and the Identification and Referral to Improve Safety (IRIS) program could improve healthcare staff’s ability to recognize, assess, and support DV survivors. Guided by the TIC framework and the IRIS program, a mixed-methods approach was used, incorporating pre- and posttraining assessments, staff surveys, …

Charting New Territory: Ai Applications In Dental Caries Detection From Panoramic Imaging., Man Hung, Daniel Yevseyevich, Milan Khazana, Connor Schwartz, Martin S. Lipsky

Institute on Aging Publications

Dental caries remains a public health concern, and early detection prevents its progression and complications. Panoramic radiographs are essential diagnostic tools, yet the interpretation of panoramic X-rays varies among practitioners. Artificial intelligence (AI) presents a promising approach to enhance diagnostic accuracy in detecting dental caries. This scoping review examines the current literature on the use of AI programs to analyze panoramic radiographs for the diagnosis of dental caries. This scoping review searched PubMed, Scopus, Web of Science, and Dentistry and Oral Sciences Source, adhering to PRISMA guidelines. The review included peer-reviewed, original research published in English that investigated the use …

Assessing The Muc5b Promoter Variant In A Large Cohort Of Systemic Sclerosis-Associated Interstitial Lung Disease, Carlos Rosa-Baez, Carlos Rangel-Pelaez, Inmaculada Rodriguez-Martin, Martin Kerick, Alfredo Guillen-Del-Castillo, Carmen P Simeon-Aznar, José Luis Callejas, Alexandre E Voskuyl, Alexander Kreuter, Oliver Distler, Susanna M Proudman, Mandana Nikpour, Nicolas Hunzelmann, Jeska K De Vries-Bouwstra, Ariane L Herrick, Yannick Allanore, Lorenzo Beretta, Maureen D Mayes, Christopher P Denton, Shervin Assassi, Javier Martin, Marialbert Acosta-Herrera

Faculty, Staff and Student Publications

Objective: The common gain-of-function variant rs35705950, located in the promoter of MUC5B gene, has been strongly associated with interstitial lung diseases (ILDs) of different aetiology, such as idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis-associated ILD (RA-ILD). In this study, we aimed to investigate the association of this variant and its nearby single nucleotide polymorphisms (SNPs) in the largest cohort of systemic sclerosis-associated ILD (SSc-ILD) to date.

Methods: Samples were collected from blood/saliva, followed by DNA extraction and genotyping using SNP arrays. Data for rs35705950 and additional 903 variants within 100 Kb were obtained using genomic imputation. Subsequently, we tested their …

Computational And Mathematical Modeling Of Microbial Community And Host Responses To Microbiota-Directed Complementary Foods Administered To Children With Acute Malnutrition., Steven J. Hartman

Arts & Sciences Graduate Student Theses and Dissertations

Globally, millions of children suffer from undernutrition, with stunting affecting 150 million and wasting nearly 50 million under five years old. Current interventions have shown limited effectiveness in mitigating long-term consequences such as stunted growth, cognitive deficits, and immune dysfunction. Through this body of work, I investigated the efficacy of a microbiota- directed complementary food (MDCF-2) as a next generation therapeutic food to combat childhood stunting. Across two randomized controlled trials involving Bangladeshi children with either moderate acute malnutrition or post-severe acute malnutrition, MDCF-2 significantly outperformed standard ready-to-use supplementary foods (RUSF), leading to significantly improved ponderal and sustained linear growth …

First-Year Writing Student Perceptions Of Graduate Student Instructor Authority, Lacey Madison Hamilton

Theses and Dissertations

Graduate student instructors (GSIs) are trusted to teach first-year writing (FYW) courses across U.S. campuses, yet many still wonder how their undergraduate students actually perceive their authority, especially when they're new to teaching or sharing a classroom with full-time faculty. While previous research has explored how GSIs view their own authority and how institutional structures shape their roles, we know far less about what students of these GSIs think. This study aims to fill that gap. Building on Reed and Ostenson's work in Big Comp, I conducted a mixed-methods study in Fall 2024 to hear directly from FYW students about …

The Face Of Fluent Reading: Using Eye Tracking And Spectrographic Analysis Of Prosody To Predict Comprehension, Hannah Anderson

Electronic Theses and Dissertations Archive

The purpose of the current study was to examine the contributions of oral and silent reading fluency to comprehension in grade four students (N = 192). Participants were administered grade-level CBM probes and i-Ready Diagnostic measures of comprehension. Eye movements, spectrographic measures of prosody, reading rate, and accuracy were extracted from the CBM readings. A two-factor measurement model was proposed, with an oral reading fluency factor and a silent reading fluency factor. Additionally, a mediation model was proposed to consider oral contributions to silent reading (and, subsequently, comprehension). Results instead supported a bifactor model, indicating a general reading fluency factor …

Cross-Cultural Dialogue In Sound: An Analytical Exploration Of Tan Dun’S Elegy: Snow In June, Weipeng Liu

Electronic Theses and Dissertations Archive

This dissertation explores Tan Dun’s cross-cultural synthesis in contemporary music, focusing on his work Elegy: Snow in June (1991) to illuminate his role in redefining global musical dialogues. Situating Tan Dun within the broader trajectory of Chinese-Western musical encounters, the research addresses gaps in existing scholarship by integrating historical, analytical, and performative perspectives. Through meticulous score analysis, cultural-historical contextualization, and insights from performance practice, the study reveals how Tan Dun hybridizes Chinese pentatonic modes with Western harmonic frameworks, subverts orchestral hierarchies through unique timbres (such as stones and paper), and synthesizes Beijing opera’s jinda, manchang (“hasty stroke with slow singing”) …

Digital Trading Platform Selection Under Neutrosophic Numbers And Multi-Criteria Decision-Making Methodology: An Illustrative Example, Eman Sayed, Karam M. Sallam, Ibrahim Alrashdi

Neutrosophic Systems with Applications

Uncertainty, vagueness, and incomplete information are pervasive in real-world decision-making scenarios, particularly in multi-criteria decision-making (MCDM) contexts involving expert judgments. To address these challenges, this study introduces a comprehensive decision-making framework that integrates Triangular Neutrosophic Numbers (TNNs) with the Weighted Aggregated Sum Product Assessment (WASPAS) method. The framework begins by capturing expert evaluations using TNNs, which effectively represent the degrees of truth, indeterminacy, and falsity inherent in subjective assessments. These evaluations are then transformed into crisp values using a novel score function that preserves the embedded uncertainty. The resulting decision matrices are aggregated into a unified structure to ensure consistency …

Shared And Distinct Alterations In Brain Structure Of Youth With Internalizing Or Externalizing Disorders: Findings From The Enigma Antisocial Behavior, Adhd, Mdd, And Anxiety Working Groups, Sophie Townend, Marlene Staginnus, Yidian Gao, Nina Alexander, Volker Arolt, Tobias Banaschewski, Mark A Bellgrove, Vivek Benegal, Robert J Blair, Laura Blanco-Hinojo, Ole Jonas Boeken, Joscha Böhnlein, Sven Bölte, Linda M Bonnekoh, Daniel Brandeis, Rodrigo A Bressan, Fabian Breuer, Willem B Bruin, Jan K Buitelaar, Katie L Burkhouse, Monica E Calkins, Marta Cano, Narcis Cardoner, Hui Chen, Xianliang Chen, David R Coghill, Olivier F Colins, Colm G Connolly, Michael C Craig, Kathryn R Cullen, Udo Dannlowski, Christopher G Davey, Andrea Dietrich, Daifeng Dong, Christine M Freitag, Thomas Frodl, Liesbet Goossens, Dominik Grotegerd, Raquel E Gur, Ruben C Gur, Jan Haavik, Cindy C Hagan, Tim Hahn, Alfons O Hamm, Ben J Harrison, Catharina A Hartman, Martin J Herrmann, Tiffany C Ho, Pieter J Hoekstra, Bharath Holla, Karim Ibrahim, Andrea Jackowski, Hamidreza Jamalabadi, Yali Jiang, Tilo Kircher, Kerstin Konrad, Anna Kraus, Jonna Kuntsi, Till Langhammer, Luisa Lazaro, Elisabeth J Leehr, Ulrike Lueken, Ren Ma, Frank P Macmaster, Gisele G Manfro, Anne Martinelli, Hannah Meinert, Susanne Meinert, Jarosław M Michałowski, Qingsen Ming, Robert Moeck, Lilianne R Mujica-Parodi, Benson Mwangi, Janina Neufeld, Joel T Nigg, Ruth L O'Gorman Tuura, Hyuntaek Oh, Jaap Oosterlaan, Yannis Paloyelis, Pedro M Pan, Luca Passamonti, Wenceslao Peñate, K Luan Phan, Kerstin J Plessen, Jesus Pujol, Karl Lundin Remnélius, Francisco Rivero, Katya Rubia, Ramiro Salas, Giovanni A Salum, Theodore D Satterthwaite, Anne Schienle, Elisabeth Schrammen, Koen R J Schruers, Gunter Schumann, Arjun Sethi, Tim Silk, Norbert Skokauskas, Jordan Smoller, Jair C Soares, Lin Sørensen, Christina Stadler, Michael C Stevens, Benjamin Straube, Thomas Straube, Andreas Ströhle, Gustavo Sudre, Denis G Sukhodolsky, Kate Sully, Xiaoqiang Sun, Chad M Sylvester, Nicola Toschi, Steven J A Van Der Werff, Alasdair Vance, Robert Vermeiren, Albert Wabnegger, Xiaoping Wang, Julia Wendt, Sarah Whittle, Julian Wiemer, Anderson M Winkler, Hans U Wittchen, Mon-Ju Wu, Qiong Wu, Tony T Yang, Yunbo Yang, Shuqiao Yao, Jibiao Zhang, Jiansong Zhou, Andre Zugman, Giovana B Zunta-Soares, Peter M Zwanzger, Sophia I Thomopoulos, Neda Jahanshad, Paul M Thompson, Kevin Hilbert, Arielle Baskin-Sommers, Charlotte A M Cecil, Moji Aghajani, Daniel S Pine, Nic J A Van Der Wee, Dan J Stein, Nynke A Groenewold, Janna Marie Bas-Hoogendam, Laura K M Han, Elena Pozzi, Lianne Schmaal, Barbara Franke, Martine Hoogman, Esther Walton, Stephane A De Brito, Graeme Fairchild, Enigma Antisocial Behavior, Anxiety, Adhd, And Mdd Working Groups

Staff and Researcher Publications

BACKGROUND: Externalizing and internalizing disorders are common in youth but are often studied separately, preventing researchers from identifying shared (i.e., transdiagnostic) alterations in brain structure. Using data from the ENIGMA Consortium, we conducted a mega-analysis to identify shared and distinct cortical and subcortical brain alterations across internalizing (anxiety disorders and depression) and externalizing disorders (attention-deficit/hyperactivity disorder [ADHD] and conduct disorder [CD]) in youth.

METHODS: 3D T1-weighted MRI data from youth (aged 4-21 years) with anxiety disorders (n=1,044), depression (n=504), ADHD (n=1,317), and CD (n=1,172), along with healthy controls (n=4,743) were analyzed. We assessed group differences in regional cortical thickness, surface …

Non-Isolated Tetralogy Of Fallot (Tof+): Exome Sequencing Efficacy And Phenotypic Expansions, Julia Volpi, Xiaonan Zhao, Nichole Owen, Tia Evans, Muriel Holder-Espinasse, Nayana Lahiri, Eleanor Sherlock, Gemma Poke, Jeroen Breckpot, Koen Devriendt, Bjorn Cools, Alfredo Brusco, Giovanni Battista Ferrero, Enrico Grosso, Pradeep Vasudevan, Sara Loddo, Antonio Novelli, Maria Cristina Digilio, Aafke Engwerda, Marrit Hitzert, Alison Male, Lucy Bownass, Ruth Newbury-Ecob, Zosia Miedzybrodzka, Ruth Armstrong, Sally Ann Lynch, Gunnar Houge, Shiyi Xiong, Seema R Lalani, Jill A Rosenfeld, Pamela N Luna, Chad A Shaw, Daryl A Scott

Faculty, Staff and Students Publications

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect (CHD). TOF may present in isolation or in conjunction with one or more non-cardiac congenital anomalies or neurodevelopmental disorders (TOF+). Uncertainty regarding the efficacy of various genetic testing strategies, and an incomplete understanding of the genetic causes of TOF+, may lead to hesitancy in recommending genetic testing, particularly, clinical exome sequencing (cES). Here, we analyzed cES data from 131 individuals with TOF+. A definitive or probable diagnosis was made for 31 individuals, yielding a diagnostic rate of 23.6% (31/131). One individual received three diagnoses. Commercially available CHD panels …