Digital Commons Network^™

Csf-Exosomal Mirnas And Delayed Cerebral Ischemia: Insights Into Pathophysiology But No Definitive Biomarkers, Chathathayil M Shafeeque, Devin W Mcbride, Yuanqing Yan, Hussein A Zeineddine, John P Hagen, H Alex Choi, Jude P Savarraj, Ari Dienel, Spiros L Blackburn, Peeyush Kumar Thankamani

Faculty, Staff and Student Publications

Background: Aneurysmal subarachnoid hemorrhage (aSAH) is notoriously known for its high mortality and morbidity. Approximately one-third of the patients who survive aneurysm rupture are reported to develop delayed cerebral ischemia (DCI), which contributes to a poor clinical outcome. Currently, there are no biomarkers for identifying which aSAH patients are at risk of developing DCI. We aimed to determine the feasibility of cerebrospinal fluid (CSF) exosomal microRNAs (miRNAs) for predicting DCI post-aSAH.

Methods: aSAH patients were prospectively enrolled, and CSF samples were collected at two time points (< 24 h and 72 h post-aSAH) from individuals undergoing external ventricular drainage. Exosomal miRNAs were isolated from the CSF for analysis. In the initial group of patients (discovery cohort), an exploratory analysis was conducted using a CSF panel containing 84 miRNAs, assessed by quantitative real-time PCR (RT-qPCR). Based on this analysis, 27 miRNAs were selected for further evaluation in a second group of patients (validation cohort). Among these, 10 miRNAs had previously been reported in SAH-related CSF studies, supporting their relevance for continued investigation.

Results: In this study, RT-qPCR analysis of 84 miRNAs in CSF samples from …

Dalbavancin For Treatment Of Staphylococcus Aureus Bacteremia: The Dots Randomized Clinical Trial, Nicholas A Turner, Toshimitsu Hamasaki, Sarah B Doernberg, Thomas P Lodise, Heather A King, Varduhi Ghazaryan, Sara E Cosgrove, Timothy C Jenkins, Catherine Liu, Shrabani Sharma, Smitha Zaharoff, Lana Wahid, Valerie J Renard, Paul Cook, Issam Raad, Ray Hachem, Anne-Marie Chaftari, Matthew Sims, Carmen Demarco, Loren G Miller, Matthew W Mccarthy, Caryn G Morse, Chris Lucasti, Graeme N Forrest, Kartikeya Cherabuddi, Christopher Polk, Tasaduq Fazili, Mark E Rupp, George R Thompson, Kami Kim, Luke Strnad, Amanda E Schnee, James A Mckinnell, Mayur Ramesh, Fernanda P Silveira, Todd P Mccarty, Todd C Lee, Emily G Mcdonald, Kristopher Paolino, Katie Wiegand, Alison Wall, Todd Riccobene, Rinal Patel, Urania Rappo, Scott Evans, Henry F Chambers, Vance G Fowler, Thomas L Holland

Faculty, Staff and Student Publications

Importance: Dalbavancin is a long-acting intravenous lipoglycopeptide that may be effective for treatment of complicated Staphylococcus aureus bacteremia without requiring long-term intravenous access.

Objective: To evaluate the efficacy and safety of dalbavancin vs standard therapy for completion of treatment of complicated S aureus bacteremia.

Design, setting, and participants: Open-label, assessor-masked, randomized clinical trial conducted from April 2021 to December 2023 at 23 medical centers in the US (n = 22) and Canada (n = 1). Participant follow-up lasted 70 days (180 days for participants with osteomyelitis); date of final follow-up was December 1, 2023. Hospitalized adults with complicated S aureus …

The Effects Of Moderate-Intensity Physical Exercise And Yoga Interventions On Stress In Hispanic College Students: A Pilot Study, Hongxing Lu, Florentino Saenz, Preethi Raju, Ednia Gutierrez, Sue Anne Chew, Saraswathy Nair

Health & Biomedical Sciences Faculty Publications

Background: Hispanic college students face high stress, which may increase their risk for chronic stress-related health issues. Effective and accessible stress management strategies for this population remain limited. Objective: This pilot study filled a gap by studying the effects of psychological stress on diet and physical activity habits and evaluating the impact of moderate-intensity physical exercise (MIPE) and yoga interventions on chronic psychological stress and acute stress responses among Hispanic college students. Methods: A total of 18 Hispanic college students participated in a 6-week intervention consisting of either MIPE or yoga, conducted twice weekly. Anthropometric measurements and lifestyle data were …

Advanced Specificity And Sensitivity Studies Relative To A Research Use Only Transcription-Mediated Amplification-Based Assay For Treponema Pallidum Rna Detection, Trinity Krueger, Grace Kadonsky, Elizabeth Thelen, Amanda Zapp, Josephine Moore, Ahmet Muslu, Allan Pillay, Irene A Stafford, Erik Munson

Faculty, Staff and Student Publications

Preliminary experimentation has suggested that a research-use-only real-time transcription-mediated amplification assay for Treponema pallidum (RUO T. pallidum TMA) yields instances of T. pallidum nucleic acid detection that coincide with non-treponemal serology in men who have sex with men (MSM) at increased risk for sexually transmitted infection. To further characterize the specificity of RUO T. pallidum TMA testing, 3,586 rectal swab specimens reported as “not detected” by the assay generated a mean endpoint FAM fluorescence of 637.5 units. Introduction of Treponema denticola, Treponema phagedenis, and Treponema refringens nucleic acid into matrices generated mean endpoint FAM fluorescence ranging from 620.7 …

Rational Tactical Nuclear First Use In Asymmetric Dyads And The States' Calculus Of Costs In An Era Of Interdependence : A Game-Theoretical Approach, Chi Cheong Chiu

Lingnan Theses (MPhil & PhD)

Classical nuclear deterrence theory suggests that nuclear powers could be tempted to strike first in asymmetric dyads (dyads in which only one side is a nuclear power). However, in the Ukraine war, a nuclear-armed Russia has not deployed tactical nuclear weapons on the battlefield, even at times when its military struggles on the ground with unfavorable balance. Why has Russia not used its nuclear weapons, especially after repeated threats of using them? What conditions make it rational for states to cross the nuclear threshold in asymmetric dyads? What discourages them from using nuclear weapons while possessing nuclear monopoly?

Expected utility …

Cybersecurity: Digital Stewardship In A Violent World, Rocky K. C. Chang

University Faculty Publications and Creative Works

This paper defines cybersecurity based on the principle of biblical stewardship. The focus of this principle is God, not the technologies, who is the creator and owner of cyberspace and everything in it. Humankind is called by God to steward them by protecting the digital property of our neighbors in cyberspace from malicious attacks. In the context of cybersecurity, a neighbor can be any individual cyber user, practitioner, educator, organization, tech company, or even hacker. However, as argued from the perspectives of human sin and human finitude, the defending stewards can never win over evil in this spiritual battle. Instead, …

An Exciting Future For Microbial Molecular Biology And Physiology, Andrew A Bridges, Leah Guthrie, Mckenzie Lehman, Elizabeth H Kellogg, Samantha Wellington Miranda, Andrew Pountain, Anthony L Shiver, Andrew Varble, Molecular Biology And Physiology Community Of The Council On Microbial Sciences, Heidi B Kaplan, Elizabeth A Shank, Gisela Storz

Faculty, Staff and Student Publications

Continuous advances in technologies ranging from deep sequencing and genetic manipulation to mass spectrometry, single cell imaging, and structural biology have led to previously unimaginable advances in our understanding of microbial physiology and the molecular mechanisms underlying microbial responses in a multitude of environments. Simultaneously, these advances are revealing how much more there is to learn. At the 2024 virtual retreat of the Molecular Biology and Physiology (MBP) Community of the Council on Microbial Sciences (COMS) of the American Society for Microbiology (ASM), eight early-career investigators, along with retreat attendees, discussed some of these astounding advances, as well as the …

Military Launching! To Adulthood: A Cultural Adaptation Of A Group Therapy Program For Military-Dependent Young Adults With Autism Spectrum Disorder Transitioning To Adulthood, Antonio F Pagán, Jordan Kenemore, Linda Hernandez, Stephen Armstrong, Katherine A Loveland, Mark Ahlenius, Ron Acierno

Faculty, Staff and Student Publications

Objectives: The transition to adulthood poses distinct challenges for young adults with autism spectrum disorder (ASD) (ages 18-25), particularly in establishing and achieving long-term goals. This is further complicated for those within the military and veteran communities. This study aimed to evaluate the feasibility, acceptability, and cultural fit of "Launching! to Adulthood," a 12-week telehealth intervention, adapted for military-dependent young adults with ASD and their military/veteran parents.

Methods: Building on previous research and incorporating stakeholder feedback, the intervention addressed key transition challenges such as executive functioning, mental health, vocational skills, and social engagement, while also aligning with military cultural values. …

The Relation Between Systems Of Support And Self-Regulated Learning On Academic Achievement In Middle Schoolers, Emma Claire Gunnett

Electronic Theses and Dissertations Archive

The purpose of this study was to examine the closest and most important systems of support available to middle school students, their parents and teachers, and to better understand how specific aspects of parenting (support for autonomy and involvement) and teaching (support for autonomy, and emotional and academic support) may contribute to the student’s self-regulated learning and achievement in mathematics. Previous research has focused primarily on evaluating students as individuals or looking at only one relationship, whereas this study sought to expand on the current literature by evaluating the relationships between students and teachers as well as students and their …

Effects Of Light Wavelength On Broiler Performance, Blood Cell Profiles, Stress Levels, And Tibiotarsi Morphology, Angela Perretti, Victor J. Oyeniran, Jaelen M. Cherry, Rosemarry H. Whittle, Zachary Grider, Alexander H. Nelson, Seong W. Kang, Gisela F. Erf, Shawna L. Wiemer

Poultry Science Faculty Publications and Presentations

Lighting influences broiler production, health, and behavior. The objective of this study was to examine the effects of three light wavelengths (White [350-780 nm], Blue [450 nm], and Green [560 nm]) on broiler production, activity, fear, stress, blood cell profiles, and tibiotarsi (tibia) morphology. Day-of-hatch male broiler chicks (N = 600) were housed in pens (N = 12) with one lighting treatment for 42 days. Body weight and feed consumption were recorded on day (D) 0, 14, 28, and 42, and the feed conversion ratio was calculated. The Tonic Immobility test was used to assess the latency (seconds) to right …

Established And Emerging Asthma Biomarkers With A Focus On Biologic Trials: A Narrative Review, Philip F Lavere, Kaitlin M Phillips, Nicola A Hanania, Muhammad Adrish

Faculty, Staff and Students Publications

Chronic airway inflammation with variable airflow obstruction is clinical asthma, and it arises from distinct molecular and pathological mechanisms called endotypes. Biomarkers allow for precise endotype characterization and have been used in clinical trials to design, monitor, and evaluate outcomes for asthma biologic therapies. This review will highlight the central and evolving role of biomarkers for past, present, and future asthma, with a focus on regulatory-approved biologic therapies and emerging biomarkers. Established biomarkers, including serum immunoglobulin E (IgE), blood eosinophils, the fraction of exhaled nitric oxide (FeNO), and serum periostin, helped elucidate the complex pathophysiology of the eosinophilic type 2 …

Adherence To Inhaled Corticosteroid Medications After An Asthma Exacerbation And The Risk Of Subsequent Exacerbations, Mina Khezrian, Marjan Kerkhof, Tham T Le, Tim Harrison, Tianshi David Wu, Bill Cook, Jonatan Hedberg, Kirsty Rhodes, Nicole Zubizarreta, Joshua Enxing, Trung N Tran

Faculty, Staff and Students Publications

Background: Data on the duration of improved adherence to controller medications after an exacerbation and its impact on asthma outcomes are inconsistent.

Objective: To describe levels and changes in adherence to inhaled corticosteroid (ICS)-containing medication after a severe exacerbation and the association with future exacerbation risk.

Methods: This retrospective cohort study used data from Optum's deidentified Clinformatics Data Mart Database (October 2015-December 2023). Patients with asthma, 1 or more severe exacerbations, and adherence to ICS-containing therapy (proportion of days covered [PDC]) of less than 80% in the 3 months before an exacerbation were included. Primary and secondary end points were …

Macrophage Phagocytosis Of Human Norovirus-Infected Cells In An Ex Vivo Human Enteroid-Macrophage Coculture Model, Ngan Fung Li, Sue E Crawford, Sydney R Mittiga, Cristian Coarfa, Hoa Nguyen-Phuc, Budi Utama, Sarah E Blutt, Sasirekha Ramani, Mary K Estes

Faculty, Staff and Students Publications

Human norovirus (HuNoV) causes acute gastroenteritis in immunocompetent hosts and chronic infection in immunocompromised individuals. Many recent studies of replication and innate immune responses following HuNoV infection have utilized epithelium-only human intestinal enteroids (HIEs), which lack immune cells. Here, we utilized an ex vivo enteroid-macrophage coculture model consisting of HIEs and different subtypes of human peripheral blood mononuclear cell-derived macrophages to better recapitulate in vivo gut biology and explore the role of macrophages in HuNoV replication and pathogenesis. We show that HuNoV infection in HIEs polarized on Transwells leads to bilateral release of the viral genome, with predominant apical virus …

The Shorthorn: May 15, 1956

The Shorthorn Newspaper Collection: 1950s

No abstract provided.

Does Teach Lead To More Teachers? Evaluating The Effects Of The Federal Teach Program, Daniel Sparks

Journal of Student Financial Aid

Teachers are critical to education production. Yet, recruiting and retaining teachers has remained challenging, particularly in high need fields, at schools serving a high proportion of students from low-income backgrounds, and from racially diverse backgrounds. To incentivize enrollment in teacher preparation programs and to support teacher candidates through degree completion, the federal government implemented the Teacher Education Assistance for College and Higher Education (TEACH) Grant in 2008. The TEACH Grant offers undergraduate and graduate students up to $16,000 and $8,000 in grant aid, respectively, to pursue degrees in high need teaching fields. I use difference-in-differences analyses to estimate the effects …

Snake Spirits, Fishermen And Water Birds On Lake Victoria: A Case Study Of Cultural Conservation In The Musambwa Islands, Uganda, And Prospects For Tourism To Improve Local Livelihoods, Joel T. Heinen, Henry Batenda

Journal of Ecological Anthropology

Abstract.

Using a combination of site visits, document reviews, focus group and key informant surveys of fishermen, we explore the cultural beliefs, taboos and norms that protect Musambwa Islands, Uganda. The islands form part of a large protected wetland with nesting habitat for thousands of water birds and a large population of highly-venomous forest cobras that coexist in and around fishermen dwellings. There are strong taboos against cutting trees, allowing women on the island, and harming cobras. We present some of our ideas on how to improve the economic situation of fishermen through the promotion of nature-based and cultural tourism …

A Place For Ancient Philosophy In Axial Age Historiography, John R. Shook

Comparative Philosophy

Long-standing debates over historiographical approaches to the Axial Age have distracted the history of philosophy from its own disciplined inquiry into the breadth and depth of ancient thought beyond the Greeks. The philosopher Karl Jaspers offered a vista for seeing commonalities among ancient innovations and discerning continuities along history to modern times. That dual agenda divided Axial historiography with the question of whether axiality reflects creativities of ancient systems or have modern reflections created images of axiality. A singular chronology for humanity encourages a mode of philosophical history open to providential designs, epochal turns, spiritual evolutions, psychological leaps, or cognitive …

Moral And Ethical Nature In Confucian Liang-Zhi And Islamic Fitra: Comparative Perspectives On Innate Morality, Yanrong Shi

Comparative Philosophy

This article offers a comparative philosophical analysis of Confucian liang-zhi (innate moral knowledge) and Islamic fitra(primordial nature), focusing on their accounts of innate morality and moral epistemology. Drawing on classical Confucian sources—especially the praxis-oriented interpretation of Wang Yangming—and foundational Islamic texts and commentary, the study demonstrates that both traditions posit an inborn moral faculty grounding ethical universality and responsibility. Wang Yangming’s liang-zhi is conceived as an innate moral principle that, under the imperative of zhi (to actualize or extend), is continually activated through moral practice. In parallel, fitra is understood as a God-given orientation to truth, cultivated and safeguarded through …

A Constructive Engagement Between Oxford Ordinary Language Philosophy And Latin American & Latine Liberatory Philosophy, Alessandro R. Moscaritolo Palacio

Comparative Philosophy

In this paper, I bring into dialogue a movement in Latin American social and political philosophy – which I have named Latin American and Latine Liberatory Philosophy – and a Western, or more precisely global North, philosophical movement sometimes called Ordinary Language Philosophy. By ‘Latin American and Latine Liberatory Philosophy’, I refer to a movement, adumbrated at the dawn of the 19^th century and developed during the 20^th century, whose guiding theme is the political, social, and cultural liberation of Latin America (and global South peoples more generally). By ‘Ordinary Language Philosophy’, on the other hand, I refer …

How Theravāda Buddhism Enriches The Language Of Thought Hypothesis: Beyond Syntax, Juanjuan Cheng, Sumanasara Sandamadulle

Comparative Philosophy

The Language of Thought Hypothesis (LOTH) posits that mental states operate through a language-like representational system physically implemented in the brain. However, this purely symbolic approach faces a significant limitation: certain mental phenomena—such as intuitions, emotions, and intentions—lack the syntactically compositional structure required by LOTH and therefore cannot be adequately explained within its symbolic framework. To address this theoretical challenge, we turn to Theravāda Buddhism (TB), an early Buddhist tradition that integrates rigorous philosophical inquiry with meditative practice. Remarkably, TB began to prefigure a solution to LOTH’s limitations over 2,300 years ago. Although LOTH and TB differ …

Vol 16 No 2 Information Page

Comparative Philosophy

No abstract provided.

Romanticism In Tolkien’S The Hobbit: Nature And Domestic Life As A Force For Good, James J. Schultz

Journal of Tolkien Research

J.R.R. Tolkien’s works tend to be viewed by both the public and by scholars through the lens of religious moralism, or else in the context of medievalism, such as with Tom Shippey’s arguments in The Road to Middle Earth. While these take much into consideration in their arguments, these and other works tend to ignore the influences of the Romantic literary movement on Tolkien’s work. This movement, lasting from the late 1700s to the early 1800s, held ideals like beauty and nature in the highest regard. This is seen in some of the most famous works of its time, such …

Unlocking Reading Success: Addressing The Literacy Crisis In The United States, Jennifer Kaczrowski-Taylor

The Interactive Journal of Global Leadership and Learning

This white paper addresses the literacy crisis in the United States. Currently, in the educational system, millions of children lack access to research-based reading instruction and, as a result, struggle to become proficient readers. Despite decades of academic and reform efforts, national reading achievement has been declining. This literacy crisis can be traced back to outdated or inconsistent instructional practices, socioeconomic background, lack of research-based instructional curricula, as well as inconsistent and ineffective implementation of these approaches. Based on recent research and national data, this white paper advocates for aligning teacher education and professional development with the Science of Reading. …

An Exploratory Study Of Soft Skills Development Expectations In Two-Year Generation Z College Students, Kelli Hallsten Erickson

The Interactive Journal of Global Leadership and Learning

Workplace demands around competent demonstration of soft skills have been steadily increasing; therefore, institutions of higher education have started focusing attention on instilling these skills within their student populations. The latest generational cohort to enter college and the workforce, Generation Z, has only recently begun to be studied for the impact of its members’ attitudes towards work and how those might change employer expectations around soft skills. A research gap exists, however, regarding students in Generation Z attending two-year schools and which soft skills they feel are most valuable to their future careers. This study sought to explore those attitudes …

Counter-Cartographies [Book Review], Jessica Schomberg

Disability in LIS (DisLIS)

An examination of the work of performance artists as that art relates to pre-DSM 5 diagnostic concepts of autism. French anti-institutionalization activist and experimental filmmaker Fernand Deligny is the artist under primary discussion. Some attention is also paid to the art of Pope.L and Mel Baggs.

Quarcs Light: Validation Of An Abbreviated Assessment Of Undergraduate Numeracy And Mathematics Affect, Isaac S. Rosenthal, Kate Follette, Vonna L. Hemmler, Catherine Sarosi, Sanlyn Buxner, Erin Galyen, Margaret Shea, Soon-Young Shimizu, Brendan Seto

Numeracy

In this study, we present evidence for the validity of a shortened form of the Quantitative Reasoning for College Science (QuaRCS) Assessment, a validated instrument assessing the numeracy and math-related affect of undergraduate students in general education/introductory science courses. Previously published analyses of QuaRCS data revealed that 1) roughly 30% of students found the assessment boring, leading to lower self-reported effort and 2) affective factors (e.g. numerical self-efficacy) were significant predictors of QuaRCS score. As a result, we reduced the length of the assessment from 25 to 15 quantitative items, and expanded the affective variable selection from three to eight …

Effect Of Whole-Food Plant-Based Diet On Ldl Cholesterol: A Scoping Literature Review, Joel Gregory Mueller

Nursing Capstones

Background: The whole-food, plant-based (WFPB) diet includes whole grains, whole plants, unrefined sugars, beans, and legumes. The diet excludes meat, dairy, and added fats. The diet has been popularized by documentaries .The diet claims to lower total and LDL cholesterol to a safe level as both a primary and secondary mode of prevention.

Purpose: Review existing studies to see whether the WFPB diet will lower LDL cholesterol in adult males over a 14 day or more duration.

Methods: A scoping literature review was completed of the University of North Dakota’s library system for keyword combinations. The returned 102 studies were …

Assessing The Impact Of Structural And Interpersonal Gendered Racism On Sexual And Reproductive Healthcare Among U.S. Women Of Color, Kimberly Muellers

ETD Collection

No abstract provided.

For Researchers In Literature, This Database Offers A Vast Array Of Resources, Janice Schuster

Library Faculty and Staff papers

Despite some gaps in coverage and shortcomings in the user experience, EBSCO’s LitBase impresses with the size and diversity of its collection.

The Experiences Of Middle School Students In A Career And Character-Focused Curriculum: A Phenomenological Study, Don J. Hoover

ATU Theses and Dissertations 2021 - Present

THE EXPERIENCES OF MIDDLE SCHOOL STUDENTS IN A CAREER

AND CHARACTER-FOCUSED CURRICULUM:

A PHENOMENOLOGICAL STUDY

Don Jason Hoover

The purpose of this qualitative phenomenological study was to explore the lived experiences of former middle school students who participated in a two-year character development, career readiness, and leadership program implemented in a public junior high school. Guided by Bandura’s social learning theory, the study focused on how students experienced and internalized the program’s components, which included leadership training, social learning activities, and college and career readiness preparation. The research was conducted using semistructured interviews with 10 participants who had completed the …