Digital Commons Network^™

Eltrombopag In Combination With Immunosuppressive Therapy In Pediatric Severe Aplastic Anemia: Phase 2 Escalate Trial, Akiko Shimamura, Alexey Maschan, Carolyn Bennett, Sujith Samarasinghe, Jason E Farrar, Chi-Kong Li, Nongnuch Sirachainan, Bunchoo Pongtanakul, Patcharee Komvilaisak, Ludmila Zubarovskaya, Jennifer A Rothman, Kelly Walkovich, Taizo A Nakano, Alison A Bertuch, Anabela Ferrao, Rukhmi Bhat, Rabi Hanna, Kathleen Overholt, Jessica Boklan, Tze Fang Wong, Qinxia Wang, Patrick Urban, Brigitte Strahm, Winfred Wang, Adrianna Vlachos, David A Williams

Faculty, Staff and Students Publications

Severe aplastic anemia (SAA) is a rare, life-threatening disease with acquired pancytopenia and hypocellular bone marrow. ESCALATE evaluated eltrombopag in combination with immunosuppressive therapy (IST) in pediatric patients (aged 1 to < 18 years) with relapsed/refractory (R/R) or treatment-naïve SAA. The eltrombopag starting dose was 25 mg/d for patients aged 1 to < 6 years and 50 mg/d for patients aged 6 to < 18 years; dose modifications (maximum dose, 150 mg/d) were allowed to achieve a target platelet count of 50 × 109/L to 200 × 109/L. Eltrombopag was administered with cyclosporine A, with or without horse antithymocyte globulin, for 26 weeks and could be extended if clinically beneficial. Fifty-one patients were treated (R/R SAA, n = 14; treatment-naïve SAA, n = 37). Data were analyzed overall and as 2 cohorts: R/R and treatment-naïve cohorts. The overall response rate (ORR; per North American Pediatric Aplastic Anemia Consortium criteria) at 26 weeks was 54.9% in both cohorts combined and 71.4% and 48.6% in the R/R and treatment-naïve cohorts, respectively; most responders had sustained responses after discontinuing eltrombopag. Among baseline transfusion-dependent patients, 66.7% and 76.7% achieved red blood cell and platelet transfusion independence, respectively, with rates of 70% and 80% for the R/R cohort and 65.6% and 75.8% for the treatment-naïve cohort, respectively. The most common treatment-related adverse events were abnormalities in liver function tests, including increased bilirubin (43.1%), alanine aminotransferase (37.3%), and aspartate aminotransferase (33.3%). Eltrombopag with IST showed a trend toward a favorable ORR in the R/R cohort, with no new safety signals.

Pd-1 Inhibition For Relapse After Allogeneic Transplantation In Acute Myeloid Leukemia And Myelodysplastic Syndrome, John M Magenau, David G Frame, Mary Riwes, John Maciejewski, Sarah Anand, Attaphol Pawarode, Anamarija M Perry, Marcus Geer, Thomas Braun, Monalisa Ghosh, Pavan Reddy

Faculty, Staff and Students Publications

Relapse of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remains the primary source of mortality after allogeneic hematopoietic stem cell transplantation (HCT). Targeting programmed death-1 (PD-1) for reversing T-cell exhaustion and restoring the graft-versus-leukemia (GVL) effect may have logistical advantages over donor lymphocyte infusion. In a prospective phase 1B clinical trial, pembrolizumab was administered every 3 weeks to 16 patients with AML (n = 12) and MDS (n = 4) in relapse after HCT to assess graft-versus-host disease (GVHD), clinical response, and survival. The median time to relapse after HCT was 5.5 months and the median pretreatment bone marrow …

The Effects Of Forest Bathing On Anxiety In Adults: An Integrative Review, Nancyruth Leibold

General Submissions: Non-Traditional Settings and Methods

The aim of this study is to explore the effects of forest bathing on anxiety levels in adults. An abundance of forest bathing research evidence is present in the literature. There are documented physiological and psychological benefits from walking or spending time in forest nature. Yet, there are still many unanswered questions about the health benefits of forest bathing for humans. In this study, an integrated review of forest bathing specific to the effect on anxiety levels in adults is the focus. A thorough search of six electronic databases (CINAHL, Health and Medical Collection, OVID, Pub Med, Public Health Database, …

Developing Cross-Cultural Competence And Media Literacy Through Multi-Modal Instruction And Projects, Michelle Verbitskaya, Alla Kourova, Irina Pidberejna

Journal of Educational Research and Practice

We explore the integration of Media Literacy in the 2-year Russian language STARTALK program, “How Words Shape People: Understanding Business Russian Through Proverbs.” Given the current geopolitical climate, particularly the ongoing war in Ukraine, fostering critical engagement with media has become more essential than ever. By encouraging students to interact with multimedia resources—including animated videos, podcasts, news articles, and the Russian National Corpora—the curriculum aims to enhance both language and media literacy skills. Media Literacy’s Five Key Framework is applied to guide students in analyzing media critically while producing academic projects and cultural responses. We present a curriculum that fosters …

Memorabilia And Oeconomicus, Xenophon

Hannah Arendt Marginalia - All

London : Cambridge, Mass. : Harvard University Press, 1953, c19

Call #: PA3612 .X3 1953

Contains marginalia, underlining, marginal lining and endpaper notes

PDF Information: 87 pages – 46 MB

The Age Of Analysis, Morton Gabriel White

Hannah Arendt Marginalia - All

[New York] New American Library [1955]

Call #: B790 .W3

Contains underlining and marginal lining

PDF Information: 47 pages – 3.7MB

To The Finland Station; A Study In The Writing And Acting Of History, Edmund Wilson

Hannah Arendt Marginalia - All

Garden City, NY: Doubleday, 1953

Call #: HX36 .W5 1953

Contains underlining, marginal lining and notes on the back cover.

PDF Information: 53 pages – 34.5mb

W. H. Auden: A Tribute, Stephen Spender

Hannah Arendt Marginalia - All

New York : Macmillan Pub. Co., 1975

Call #: PR6023 .S63

Contains endpaper notes

PDF Information: 6 pages – 249 KB

Platonic Studies, Gregory Vlastos

Hannah Arendt Marginalia - All

[Princeton, N.J.] Princeton University Press [1973]

Call #: B395 .V58

Contains underlining and marginal lining

PDF Information: 20 pages – 1,766KB

The New Science Of Politics; An Introduction, Eric Voegelin

Hannah Arendt Marginalia - All

Chicago, University of Chicago Press, 1952

Call #: JC251 .V6

Contains marginalia, underlining, marginal lining, and endpaper notes.

PDF Information: 91 pages – 41.6mb

Development Of An Intervention For Optimizing Values Discussions Between Patients With An Lvad, Their Family Caregivers, And The Healthcare Team, Avery C. Bechthold, Rachel D. Wells, Colleen K. Mcilvennan, Martha Abshire Saylor, Daniel D. Matlock, Jesse Lejeune, J. Nicholas Odom

Sigma Foundation for Nursing Research Grant Reports

This project aimed to characterize how adults living with a left ventricular assist device (LVAD) and their family/friend caregivers engage in values-centered discussions, with the goal of informing future interventions that promote values-centered communication with the healthcare team.

The New Science Of Giambattista Vico, Giambattista Vico

Hannah Arendt Marginalia - All

New York: Anchor Books, 1961

Call #: B3317 .S34

Contains marginalia and endpaper notes.

PDF Information: 42 pages – 17.6mb

The Aeneid Of Virgil, Virgil

Hannah Arendt Marginalia - All

London: J.M. Dent; New York: E.P. Dutton, 1907

Contains underlining and marginal lining.

Call #: PA6807.A5 T3

PDF Information: 17 pages – 8.8mb

The Adams-Jefferson Letters: The Complete Correspondence Between Thomas Jefferson And Abigail And John Adams V.2, Thomas Jefferson, Abigail Adams, John Adams

Hannah Arendt Marginalia - All

Chapel Hill : Published for the Institute of Early American History and Culture at Williamsburg, Va., by the University of North Carolina Press, 1959.

Call#: E322 .A516

Contains light underlining and marginal lining in v.2

PDF Information: 20 pages – 1.4 MB

The Making Of The English Working Class, E. P. Thompson

Hannah Arendt Marginalia - All

New York, Pantheon Books [1964, c1963]

Call #: HD8388. .T47 1964

Contains underlining, marginal lining, and endpaper notes

PDF Information: 159 pages – 59.5 MB

Biopolitics, Thomas Landon Thorson

Hannah Arendt Marginalia - All

New York, Holt, Rinehart and Winston [1970]

Call #: JA71 .T53

contains marginal lining, marginalia, underlining, and endnotes

PDF Information: 47 pages – 23 MB

Democracy In America Vol. 1, Alexis De Tocqueville

Hannah Arendt Marginalia - All

New York, A.A. Knopf, 1945

Call #: JK216 .T7 1945

Contains marginalia, underlining, marginal lining, endpaper notes and contained ephemera : matchbook cover found between pp. 418-419. See Arendt ephemera file; folder 076.

PDF Information: 80 pages – 46.3mb

Democracy In America Vol. 2, Alexis De Tocqueville

Hannah Arendt Marginalia - All

New York, A.A. Knopf, 1945

Call #: JK216 .T7 1945

Contains marginalia, underlining and endpaper notes.

PDF Information: 95 pages – 56.7mb

Philosophy And Myth In Karl Marx, Robert C. Tucker

Hannah Arendt Marginalia - All

Cambridge, University Press, 1961

Call #: B3305.M74 T8 1961

Contains marginalia, underlining, marginal lining and notes on pages 264-265

PDF Information: 89 pages – 49.6mb

The Tax Adviser, Volume 9, Number 8, August 1978, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Treatment Of Split Gifts Under The ’76 Act, Alan Mitchell, Ralph Switzer

Tax Adviser

No abstract provided.

After Babel, George Steiner

Hannah Arendt Marginalia - All

New York : Oxford University Press, 1975

Call #: P306 .S66 1975

Contains underlining, marginal lining and endpaper notes.

PDF Information: 67 pages – 25 MB

Natural Right And History, Leo Strauss

Hannah Arendt Marginalia - All

Chicago, University of Chicago Press, 1953

Call #: JC571 .S77

Contains marginalia, underlining and marginal lining

PDF Information: 107 pages – 20.7mb

The Political Philosophy Of Hobbes: Its Basis And Its Genesis, Leo Strauss

Hannah Arendt Marginalia - All

Chicago, University of Chicago Press, 1952

Call #: JC153.H66 S7

Contains marginalia, underlining and marginal lining

PDF Information: 44 pages – 9mb

Friedrich Von Gentz, Defender Of The Old Order, Paul Robinson Sweet

Hannah Arendt Marginalia - All

Madison, Wis., The University of Wisconsin Press, 1941

Call #: D363 .S9

Contains marginal lining.

PDF Information: 90 pages – 51.7mb

The Wealth Of Nations V.1, Adams Smith

Hannah Arendt Marginalia - All

London: Dent; New York: Dutton, 1950, 1910

Contains marginalia, underlining, marginal lining and endpaper notes.

Call #: HB161 .S64 1950

PDF Information: 75 pages – 60.3mb

Ka Mua, Ka Muri—Walking Backwards Into The Future: Revitalizing Indigenous Economies And Economies Of Well-Being, Suzie Greenhalgh, Jason Mika, Christopher Alcantara, Shaun Awatere, Kendon Bell, Kiri Dell, Donn L. Feir, Dustin Frye, Diane Jarvis, Taryn Kong, Kirsten Maclean, Cathy Robinson, Chellie Spiller, Rachel M. Wolfgramm, Emma Woodward

Indigenous Business & Public Administration

The concept of and desire for well-being economies are rising in prevalence as traditional business paradigms are questioned and alternative framings are being sought. Indigenous peoples, their economies, and their approach to business can provide a rich source of learning to enable and help facilitate a transition to economies of well-being. As Indigenous peoples are emerging from their colonial pasts, they are becoming more empowered to make investment choices, use business models, and form partnerships grounded in their worldviews, which are often well aligned with a well-being economy.

In this paper, we note some of the obstacles Indigenous economies have …

Clinical And Demographic Predictors Of The Need For Pharmacotherapy In Neonatal Abstinence Syndrome, Shawana Bibi, Rachana Singh, Janis L. Breeze, Jason Nelson, Walter K. Kraft, Jonathan M. Davis

Department of Pharmacology and Experimental Therapeutics Faculty Papers

OBJECTIVE: Development and validation of a clinical prediction model for receipt of pharmacotherapy for Neonatal Abstinence Syndrome (NAS).

STUDY DESIGN: Data from three cohorts included

RESULTS: Of 698 infants included, 430 received pharmacotherapy. The final model included seven predictors of receipt of pharmacotherapy: gestational age, exposure to maternal breast milk, type of maternal opioid medication, and exposure to heroin, cocaine, benzodiazepines, and/or antipsychotic medications. The model had an AUROC of 0.68 (95% CI: 0.64-0.72; optimism corrected 0.65).

CONCLUSION: Our prediction model was parsimonious and identified seven predictors associated with the need for PT. Larger cohort studies are needed to more …

Circadian Influences On Glycemic Control In 24-Hr Fasts Initiated At Different Mealtimes, Elizabeth Z. Gipson

Theses and Dissertations

This study investigated whether the timing of a 24-hour fast influences indicators of glycemic control throughout the duration of the fast or upon refeeding. Twenty-four adults who have overweight or obesity (13 female, 11 male) completed this randomized crossover study involving three 24-hour fasts initiated at either 8:00 am, 1:00 pm, or 6:00 pm followed by a 75 g oral glucose tolerance test (OGTT) which lasted 2 hours. Continuous glucose monitors (CGMs) were employed to track interstitial glucose throughout each fast and OGTT. Plasma samples for insulin, glucagon, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) were collected at the …

Epitaxial Electrodeposition Of Cu-Btc Metal-Organic Framework Thin Films Onto The (100), (110), And (111) Surfaces Of Single-Crystal Gold And Cuprous Oxide Buffer Layers, Xiaoting Zhang, John Z. Tubbesing, Jay A. Switzer

Chemistry Faculty Research & Creative Works

Metal-organic frameworks (MOFs) have well-defined pore structures. Epitaxial MOFs can produce films with uniform pore sizes and open porosity. However, the growth of epitaxial MOF thin films has remained a challenge. Herein, we demonstrate a cathodic electrodeposition method for the epitaxial growth of a well-known MOF material, copper (II)-benzene-1,3,5-tricarboxylate (Cu-BTC), from solution precursors. The epitaxial electrodeposition of Cu-BTC was achieved in a Cu (NO₃)₂-H₃BTC-H₂O₂ bath using H₂O₂ reduction to deprotonate the H₃BTC molecule. The Cu-BTC films can be grown to micrometer thicknesses with Faradaic efficiencies up …