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Articles 38191 - 38220 of 1439298
Full-Text Articles in Entire DC Network
High School Teachers’ Experiences Using Data-Driven Decision Making To Implement Supplemental Accelerated Instruction, Stephen Courtney Smith, Sr.
High School Teachers’ Experiences Using Data-Driven Decision Making To Implement Supplemental Accelerated Instruction, Stephen Courtney Smith, Sr.
Walden Dissertations and Doctoral Studies
The problem that was addressed in this study was that high school teachers in a Texas school district struggle to use data-driven decision making (DDDM) to meet the requirements of Texas HB 1416, which mandates specific interventions to address instructional loss. Grounded in the theory of DDDM, by Mandinach et al., the purpose of this basic qualitative study was to explore high school teachers’ experiences using DDDM to implement supplemental accelerated instruction (SAI) for students who failed to demonstrate proficiency on state exams. Data were collected using semistructured interviews with 12 high school teachers from a Texas school district. Using …
Educators’ Perceptions Of Multitiered Systems Of Support For Improving Reading And Math Achievement In An Urban School District, Denice Yvonne Garrett
Educators’ Perceptions Of Multitiered Systems Of Support For Improving Reading And Math Achievement In An Urban School District, Denice Yvonne Garrett
Walden Dissertations and Doctoral Studies
Multitiered systems of support (MTSS) has been shown to benefit students’ academic and behavioral performance in schools. However, despite 4 years of MTSS implementation in one local urban school district, English language arts (ELA) and math underachievement among students remained evident. Guided by Hall and Hord’s concerns-based adoption model, the purpose of this basic qualitative study was to explore educators’ perceptions of MTSS for improving ELA and math achievement in the local urban school district. Ten educators purposively sampled from the local district participated in semistructured interviews. Thematic analysis using inductive, open coding of the interview data was conducted. Themes …
The Association Of Anxiety, Familial Dysfunction, And Child Emotion Regulation Between Family Therapy Sessions 1 And 4, Kaelie Noel Lemmon
The Association Of Anxiety, Familial Dysfunction, And Child Emotion Regulation Between Family Therapy Sessions 1 And 4, Kaelie Noel Lemmon
Theses and Dissertations
Few studies address how relational factors may be interdependent and impact child-focused problems that could be collectively addressed in systemic family therapy. The current study utilized a cross-lagged panel model to explore the associations of parental anxiety, familial dysfunction, and child emotion regulation between four family therapy sessions. The study included 224 parents who sought family therapy and participated in the Marriage and Family Therapy Practice Research Network (MFT-PRN). Data were collected at two time points across four family therapy sessions. The findings indicated that higher levels of parental anxiety at intake were associated with higher familial dysfunction at session …
A Dendrite Equivalence Relation On Loop Spaces, Spencer Arnesen
A Dendrite Equivalence Relation On Loop Spaces, Spencer Arnesen
Theses and Dissertations
In Definition 2.0.3 we define an equivalence relation on paths such that two paths into a space X are related if doing the first, then the second backwards factors as a loop through a dendrite. This equivalence relation induces a group structure L(X) on a large subset of the loop space of X, namely all loops that have a unique reduced representative. We show that certain continuous maps induce a homomorphism between dentropy groups and that projection from three-dimensional real space to two-dimensional real space does not induce a homomorphism on dentropy groups.. We show that dentropy groups are locally …
Illinois Model Programs Of Study Guide: Agriculture, Food, And Natural Resources, Education Systems Center
Illinois Model Programs Of Study Guide: Agriculture, Food, And Natural Resources, Education Systems Center
Reports, Analyses, and other Publications
First published in August 2021. Significantly revised in September 2024 to incorporate updated labor market information. An update in April 2025 included minor corrections. In August 2025, two new sections were added: key terminology and the relationship between concepts.
Illinois Model Programs Of Study Guide: Finance And Business Services, Education Systems Center
Illinois Model Programs Of Study Guide: Finance And Business Services, Education Systems Center
Reports, Analyses, and other Publications
First published in August 2021. Significantly revised in September 2024 to incorporate updated labor market information. An update in April 2025 included minor corrections. In August 2025, two new sections were added: key terminology and the relationship between concepts.
Illinois Model Programs Of Study Guide: Human And Public Services, Education Systems Center
Illinois Model Programs Of Study Guide: Human And Public Services, Education Systems Center
Reports, Analyses, and other Publications
First published in October 2022. Significantly revised in April 2025 to incorporate updated labor market information. Key terminology and relationship between concepts sections added in August 2025.
Anthropology Lab - Archaeology Catalog, Naomi Cleghorn, Sydney Lowenthal, Cameron Ditore, Daniel Bright, Kaylean Salazar, Ellie Hong, Jay Williams, Emily Vento, Nawaf Albalawi, Amber Lewis, Alex Helm, Robert Holman, Gareth Nutt, Jazmine Reyna, Lisa Zealey, Amanda Rios, Nichole Clemmons, Kat Frazee, Xandy Clement, Olivia Franklin, Prabhashi Jayawardhana, Sangho Shin, Anna Gonzalez, Irene Flores, Angele Phillips, Citlali Concha, Mickey Lopez, Bianca Martinez, Tapiwaso Chitaya, Alyssa Tomancik, Cain Camarillo, Juan Gonzalez
Anthropology Lab - Archaeology Catalog, Naomi Cleghorn, Sydney Lowenthal, Cameron Ditore, Daniel Bright, Kaylean Salazar, Ellie Hong, Jay Williams, Emily Vento, Nawaf Albalawi, Amber Lewis, Alex Helm, Robert Holman, Gareth Nutt, Jazmine Reyna, Lisa Zealey, Amanda Rios, Nichole Clemmons, Kat Frazee, Xandy Clement, Olivia Franklin, Prabhashi Jayawardhana, Sangho Shin, Anna Gonzalez, Irene Flores, Angele Phillips, Citlali Concha, Mickey Lopez, Bianca Martinez, Tapiwaso Chitaya, Alyssa Tomancik, Cain Camarillo, Juan Gonzalez
Anthropology Laboratory - Archive
The Anthropology Laboratory of the Department of Sociology and Anthropology at UTA houses the archaeological collections of many sites from Texas and around the world. These objects reflect the technology, culture, and values of past people. Studying them can tell us about the decisions those people made and reminds us of the breadth of human achievements.
In 2024, Anthropology students at UTA developed a database for these objects and began recording basic attributes of the collections to make them more accessible to the public. Many volunteers contributed to this database (and are listed as authors here). Data are provided here …
Expanding Functionalities Of Immune Receptors Through Simultaneous Transfer Of Sensor And Helper Nlrs, Dongjiao Wang, Qibin Wu, Daowen Wang, Youxiong Que, Zheng Qing Fu
Expanding Functionalities Of Immune Receptors Through Simultaneous Transfer Of Sensor And Helper Nlrs, Dongjiao Wang, Qibin Wu, Daowen Wang, Youxiong Que, Zheng Qing Fu
Faculty Publications
No abstract provided.
Illinois Model Programs Of Study Guide: Education, Education Systems Center
Illinois Model Programs Of Study Guide: Education, Education Systems Center
Reports, Analyses, and other Publications
First published in October 2020. Significantly revised in October 2022 to reflect credentialing changes, and in September 2024 to incorporate updated labor market information. An update in April 2025 included minor corrections. In August 2025, two new sections were added: key terminology and the relationship between concepts.
Illinois Model Programs Of Study Guide: Architecture, Construction, And Energy, Education Systems Center
Illinois Model Programs Of Study Guide: Architecture, Construction, And Energy, Education Systems Center
Reports, Analyses, and other Publications
First published in August 2021. Significantly revised in September 2024 to incorporate updated labor market information. An update in April 2025 included minor corrections. In August 2025, significant revisions were made to incorporate clean energy career pathways and two new sections were added: key terminology and the relationship between concepts.
Illinois Model Programs Of Study Guide: Arts And Communications, Education Systems Center
Illinois Model Programs Of Study Guide: Arts And Communications, Education Systems Center
Reports, Analyses, and other Publications
First published in August 2021. Significantly revised in September 2024 to incorporate updated labor market information. An update in April 2025 included minor corrections. In August 2025, two new sections were added: key terminology and the relationship between concepts.
Illinois Model Programs Of Study Guide: Culinary And Hospitality, Education Systems Center
Illinois Model Programs Of Study Guide: Culinary And Hospitality, Education Systems Center
Reports, Analyses, and other Publications
First published in October 2022. Significantly revised in April 2025 to incorporate updated labor market information. In August 2025, two new sections were added: key terminology and the relationship between concepts.
Illinois Model Programs Of Study Guide: Manufacturing And Engineering, Education Systems Center
Illinois Model Programs Of Study Guide: Manufacturing And Engineering, Education Systems Center
Reports, Analyses, and other Publications
First published in October 2020. Significantly revised in September 2024 to incorporate updated labor market information. An update in April 2025 included minor corrections. In August 2025, significant revisions were made to incorporate clean energy career pathways and two new sections were added: key terminology and the relationship between concepts.
The Role Of The Poly-N Repeat In The Plasmodium Falciparum Histone Acetyltransferase Protein, Pfgcn5, Kely Johana Rubiano Cardona
The Role Of The Poly-N Repeat In The Plasmodium Falciparum Histone Acetyltransferase Protein, Pfgcn5, Kely Johana Rubiano Cardona
Arts & Sciences Graduate Student Theses and Dissertations
P. falciparum possesses the most AT-rich genome sequenced to date, with long AAT repeats coding for asparagines (N) in intragenic regions. As a result, nearly a quarter of its proteome is composed of proteins with poly-N repeats. Since the discovery of its genome, the function of these repeats has remained as one of the biggest mysteries in the biology of this parasite. Furthermore, it has long been known that proteins with N-rich domains aggregate easily, particularly during heat stress (HS). Given that the hallmark of this disease is recurrent febrile episodes, it is not well understood how the parasite survives …
Role Of Perceived Social Support And Knowledge Of Postpartum Depression Among Women In Anambra State, Eastern Nigeria, Raphael Oluwasina Babatola Folorunsho
Role Of Perceived Social Support And Knowledge Of Postpartum Depression Among Women In Anambra State, Eastern Nigeria, Raphael Oluwasina Babatola Folorunsho
Walden Dissertations and Doctoral Studies
Postpartum depression (PPD) is an increasingly pressing public health issue, particularly in low-resource settings like Nigeria, where maternal mental health tends to receive limited attention. This study explored the relationship between maternal awareness of PPD, perceived social support, and prevalence of depressive symptoms among postpartum women in the Nnewi North Local Government Area (LGA) of Anambra State. Grounded in the social support theory, health belief model, and socioecological model, the study used a descriptive cross-sectional research design. A total of 406 postpartum women attending primary healthcare centers were surveyed using validated instruments, including the PHQ-9 and MSPSS. Statistical analyses included …
The Effects Of Electoral Outcomes And Cross-Party Relationships On Affective Polarization, Jenna Pedersen
The Effects Of Electoral Outcomes And Cross-Party Relationships On Affective Polarization, Jenna Pedersen
Arts & Sciences Graduate Student Theses and Dissertations
This dissertation explores several under-studied aspects of affective polarization through four chapters. The first chapter discusses the history of polarization research and the measurement challenges facing polarization scholars. The second chapter analyzes how electoral outcomes differentially influence Democrats' and Republicans' inparty, outparty, and general affect. I find that winning elections affects both outparty and inparty attitudes, but the size and direction of these effects varies by party: electoral success reduces Republicans' inparty affect, but for Democrats success reduces outparty affect. The third and fourth chapters contain survey experiment data measuring the effects of cross-partisan relationships. I find that positive relationships …
Bclaf1 Is A Novel Regulator Of Hematopoietic Stem Cells, Stephanie Crowley
Bclaf1 Is A Novel Regulator Of Hematopoietic Stem Cells, Stephanie Crowley
Arts & Sciences Graduate Student Theses and Dissertations
Hematopoietic stem cells (HSC) maintain both a self-renewal capacity to persist throughout life and an ability to differentiate into mature cell lineages. HSC self-renewal programs are often ectopically activated in leukemia cells to sustain developmental arrest and neoplastic proliferation. Recently, the transcriptional regulator Bclaf1 (Bcl2 associated transcription factor 1) was shown to support proliferation and block differentiation of AML blasts. Bclaf1 is ubiquitously expressed in hematopoietic cells but its function in normal hematopoiesis has not been elucidated. Our data demonstrate that BCLAF1 promotes HSC development and function. To study the role of BCLAF1 in normal HSCs, we used murine models …
Immigration And Customs Enforcement (Ice) Arrests In The Mountain West, 2025, Sydney Mitchell, Olivia K. Cheche, Caitlin J. Saladino, William E. Brown Jr.
Immigration And Customs Enforcement (Ice) Arrests In The Mountain West, 2025, Sydney Mitchell, Olivia K. Cheche, Caitlin J. Saladino, William E. Brown Jr.
Criminal Justice
This fact sheet reveals data on the total Immigration and Customs Enforcement (ICE) arrests and daily average of ICE arrests between January 20, 2025 and June 10, 2025 for the five Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah. Originally reported by the New York Times (NYT) in “Immigration Arrests Are Up Sharply in Every State. Here Are the Numbers,” this fact sheet also details each Mountain West state’s national ranking for total ICE arrests between January 20, 2025 and June 10, 2025, as well as the percentage increase in daily average ICE arrests between 2024 and …
Gastrointestinal Fistulas-What Gastroenterologists Need To Know In 2025, Monjur Ahmed
Gastrointestinal Fistulas-What Gastroenterologists Need To Know In 2025, Monjur Ahmed
Division of Gastroenterology and Hepatology Faculty Papers
Gastrointestinal fistulas are increasingly being encountered in our clinical practice because of the increased burden of Crohn's disease, bariatric surgeries, interventional endoscopic procedures, nonsurgical trauma, and war and disaster zones worldwide. Presentation depends on the location and specific type of the fistula. Symptomatic ones can have a tremendous impact on social life and can cause dehydration, electrolyte imbalance, malnutrition, increased morbidity, and mortality. Different imaging studies and endoscopic procedures are done to establish the diagnosis. Treatment modalities to close the fistula depend on the underlying disease and the type of fistula. They include conservative treatment, medical therapy, endoscopic interventions, and …
Operative Trends In Endovascular And Open Procedures Among Vascular Fellows, Jin Park, Nicola Habash, Dawn Salvatore, Michael Nooromid, Paul J. Dimuzio, Babak Abai
Operative Trends In Endovascular And Open Procedures Among Vascular Fellows, Jin Park, Nicola Habash, Dawn Salvatore, Michael Nooromid, Paul J. Dimuzio, Babak Abai
Department of Surgery Faculty Papers
Objective: Over the past decade, there has been a growing adoption of endovascular approaches for treating vascular pathologies. This shift toward minimally invasive techniques has raised concerns about declining open surgical case volumes for vascular surgery fellows, particularly in procedures such as aortic aneurysm repair. This study aimed to analyze trends in both open and endovascular case volumes across major vascular procedure categories, including aortic aneurysm, lower extremity arterial disease, abdominal occlusive disease, and cerebrovascular disease, among graduating vascular surgery fellows. Methods: National case log data from the Accreditation Council for Graduate Medical Education were collected for 5 + 2 …
Clinical Outcomes Following Endoscopic Carpal Tunnel Release With The Arthrex Nanoscopic Release System-A Single Surgeon Experience, Sina Ramtin, Asif M. Ilyas
Clinical Outcomes Following Endoscopic Carpal Tunnel Release With The Arthrex Nanoscopic Release System-A Single Surgeon Experience, Sina Ramtin, Asif M. Ilyas
Department of Orthopaedic Surgery Faculty Papers
PURPOSE: Endoscopic carpal tunnel release (ECTR) is a minimally invasive alternative to open release, offering faster recovery and reduced postoperative discomfort. The Arthrex NanoScopic ECTR system, a novel single-use device using chip-on-tip digital imaging and designed for use under local anesthesia without arthroscopic equipment, may further streamline care and expand surgical access.
METHODS: A retrospective review was conducted of the first 50 consecutive ECTR procedures performed using the Arthrex NanoScopic system by a single hand fellowship-trained hand surgeon. All procedures were completed under wide-awake local anesthesia no tourniquet technique in an outpatient surgical center. Outcomes included operative times, adverse events, …
Implementation Of A Forensic Ancestry Inference Indel Panel, Jacqueline Molina
Implementation Of A Forensic Ancestry Inference Indel Panel, Jacqueline Molina
Student Theses
Ancestry-informative markers (AIMs) are genetic variants that exhibit significant frequency differences between populations, making them valuable tools for inferring biogeographical ancestry in forensic investigations. Insertion/deletion polymorphisms (INDELs) offer particular advantages for degraded forensic samples due to their short amplicon sizes and binary allelic nature. As forensic laboratories adopt newer instrumentation, validation of established assays becomes critical to ensure analytical continuity and reliability. This study evaluated the comparative performance of the SeqStudio™ Genetic Analyzer in detecting a 46 AIMs INDEL multiplex panel, previously established with the ABI 3130 Genetic Analyzer. Four commercial blood samples were analyzed using both platforms to assess …
Computational Modeling Of Magnetic Field Interaction With Superconductors Under High-Field And High-Dissipation Conditions: A Tdgl Approach Applied To Nb And Nb3sn, Aiden Victor Harbick
Computational Modeling Of Magnetic Field Interaction With Superconductors Under High-Field And High-Dissipation Conditions: A Tdgl Approach Applied To Nb And Nb3sn, Aiden Victor Harbick
Theses and Dissertations
Superconducting radiofrequency (SRF) cavities are essential components in modern particle accelerators, enabling the efficient acceleration of charged particles for various applications in physics, medicine, materials science, and beyond. The performance of these cavities is significantly influenced by the properties of superconducting materials, such as niobium (Nb) and triniobium-tin (Nb3Sn), and the defects and surface features present within the material. This dissertation presents a computational study focused on understanding the behavior of SRF cavities, using a sample-specific time-dependent Ginzburg-Landau (TDGL) framework to simulate their performance under realistic material conditions. The research integrates experimental data and density functional theory (DFT) calculations to …
Expanding Functionalities Of Immune Receptors Through Simultaneous Transfer Of Sensor And Helper Nlrs, Dongjiao Wang, Qibin Wu, Daowen Wang, Youxiong Que, Zheng Qing Fu
Expanding Functionalities Of Immune Receptors Through Simultaneous Transfer Of Sensor And Helper Nlrs, Dongjiao Wang, Qibin Wu, Daowen Wang, Youxiong Que, Zheng Qing Fu
Faculty Publications
No abstract provided.
Spatial And Clinical Epidemiology Of Spotted Fever Rickettsioses And Ehrlichiosis, North Carolina, 2010–2019, Amanda Brown Marusiak, Dana A. Giandomenico, Brandon D. Hollingsworth Ph.D., Neha V. Mokashi, Paul L. Delamater, Michael Reiskind, Alexis M. Barbarin, Carl Williams, Ross M. Boyce
Spatial And Clinical Epidemiology Of Spotted Fever Rickettsioses And Ehrlichiosis, North Carolina, 2010–2019, Amanda Brown Marusiak, Dana A. Giandomenico, Brandon D. Hollingsworth Ph.D., Neha V. Mokashi, Paul L. Delamater, Michael Reiskind, Alexis M. Barbarin, Carl Williams, Ross M. Boyce
Faculty Publications
No abstract provided.
Mathematics Student Teachers' Curricular Reasoning During Planning, Erika Breann Miller
Mathematics Student Teachers' Curricular Reasoning During Planning, Erika Breann Miller
Theses and Dissertations
Teaching is a complex practice, in part because of all the decisions teachers make daily. This is especially true for student teachers who have little to no prior teaching experience to inform them about the decisions that need to be made in the classroom and how to reason through all those decisions as they plan and enact the lessons. Secondary mathematics student teachers were introduced to the Instructional Pyramid (Dingman et al., 2021) which organizes and maps teacher’s mathematical reasoning onto four elements of a classroom—teacher, student, mathematics, and curriculum—to examine which curricular reasoning aspects they use while planning mathematics …
Ribosome Deficiency Induces Salmonella Filamentation Within Host Cells, Zhihui Lyu, Cierra Wilson, Kalyn Weiss, Spencer Lewis, Kurt Fredrick, William Margolin, Jiqiang Ling
Ribosome Deficiency Induces Salmonella Filamentation Within Host Cells, Zhihui Lyu, Cierra Wilson, Kalyn Weiss, Spencer Lewis, Kurt Fredrick, William Margolin, Jiqiang Ling
Faculty, Staff and Student Publications
The ribosome is the central hub for protein synthesis and is heavily targeted by antibiotics. Ribosomal mutations, antibiotic treatment, and nutrient starvation can alter translational efficiency and lead to stressed cells. Ribosome deficiency plays a critical role in stress responses and disease progression; yet, how it affects bacteria-host interactions remains poorly understood. In this study, we show that a ribosome-deficient strain exhibits a surprising morphological change from rod shape to filamentous in Salmonella cells growing inside host macrophages. Such filamentation depends on an acidic condition within macrophages and in a defined medium mimicking macrophage conditions. Further genetic analyses revealed that …
Csf-Exosomal Mirnas And Delayed Cerebral Ischemia: Insights Into Pathophysiology But No Definitive Biomarkers, Chathathayil M Shafeeque, Devin W Mcbride, Yuanqing Yan, Hussein A Zeineddine, John P Hagen, H Alex Choi, Jude P Savarraj, Ari Dienel, Spiros L Blackburn, Peeyush Kumar Thankamani
Csf-Exosomal Mirnas And Delayed Cerebral Ischemia: Insights Into Pathophysiology But No Definitive Biomarkers, Chathathayil M Shafeeque, Devin W Mcbride, Yuanqing Yan, Hussein A Zeineddine, John P Hagen, H Alex Choi, Jude P Savarraj, Ari Dienel, Spiros L Blackburn, Peeyush Kumar Thankamani
Faculty, Staff and Student Publications
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is notoriously known for its high mortality and morbidity. Approximately one-third of the patients who survive aneurysm rupture are reported to develop delayed cerebral ischemia (DCI), which contributes to a poor clinical outcome. Currently, there are no biomarkers for identifying which aSAH patients are at risk of developing DCI. We aimed to determine the feasibility of cerebrospinal fluid (CSF) exosomal microRNAs (miRNAs) for predicting DCI post-aSAH.
Methods: aSAH patients were prospectively enrolled, and CSF samples were collected at two time points (< 24 h and 72 h post-aSAH) from individuals undergoing external ventricular drainage. Exosomal miRNAs were isolated from the CSF for analysis. In the initial group of patients (discovery cohort), an exploratory analysis was conducted using a CSF panel containing 84 miRNAs, assessed by quantitative real-time PCR (RT-qPCR). Based on this analysis, 27 miRNAs were selected for further evaluation in a second group of patients (validation cohort). Among these, 10 miRNAs had previously been reported in SAH-related CSF studies, supporting their relevance for continued investigation.
Results: In this study, RT-qPCR analysis of 84 miRNAs in CSF samples from …
Dalbavancin For Treatment Of Staphylococcus Aureus Bacteremia: The Dots Randomized Clinical Trial, Nicholas A Turner, Toshimitsu Hamasaki, Sarah B Doernberg, Thomas P Lodise, Heather A King, Varduhi Ghazaryan, Sara E Cosgrove, Timothy C Jenkins, Catherine Liu, Shrabani Sharma, Smitha Zaharoff, Lana Wahid, Valerie J Renard, Paul Cook, Issam Raad, Ray Hachem, Anne-Marie Chaftari, Matthew Sims, Carmen Demarco, Loren G Miller, Matthew W Mccarthy, Caryn G Morse, Chris Lucasti, Graeme N Forrest, Kartikeya Cherabuddi, Christopher Polk, Tasaduq Fazili, Mark E Rupp, George R Thompson, Kami Kim, Luke Strnad, Amanda E Schnee, James A Mckinnell, Mayur Ramesh, Fernanda P Silveira, Todd P Mccarty, Todd C Lee, Emily G Mcdonald, Kristopher Paolino, Katie Wiegand, Alison Wall, Todd Riccobene, Rinal Patel, Urania Rappo, Scott Evans, Henry F Chambers, Vance G Fowler, Thomas L Holland
Dalbavancin For Treatment Of Staphylococcus Aureus Bacteremia: The Dots Randomized Clinical Trial, Nicholas A Turner, Toshimitsu Hamasaki, Sarah B Doernberg, Thomas P Lodise, Heather A King, Varduhi Ghazaryan, Sara E Cosgrove, Timothy C Jenkins, Catherine Liu, Shrabani Sharma, Smitha Zaharoff, Lana Wahid, Valerie J Renard, Paul Cook, Issam Raad, Ray Hachem, Anne-Marie Chaftari, Matthew Sims, Carmen Demarco, Loren G Miller, Matthew W Mccarthy, Caryn G Morse, Chris Lucasti, Graeme N Forrest, Kartikeya Cherabuddi, Christopher Polk, Tasaduq Fazili, Mark E Rupp, George R Thompson, Kami Kim, Luke Strnad, Amanda E Schnee, James A Mckinnell, Mayur Ramesh, Fernanda P Silveira, Todd P Mccarty, Todd C Lee, Emily G Mcdonald, Kristopher Paolino, Katie Wiegand, Alison Wall, Todd Riccobene, Rinal Patel, Urania Rappo, Scott Evans, Henry F Chambers, Vance G Fowler, Thomas L Holland
Faculty, Staff and Student Publications
Importance: Dalbavancin is a long-acting intravenous lipoglycopeptide that may be effective for treatment of complicated Staphylococcus aureus bacteremia without requiring long-term intravenous access.
Objective: To evaluate the efficacy and safety of dalbavancin vs standard therapy for completion of treatment of complicated S aureus bacteremia.
Design, setting, and participants: Open-label, assessor-masked, randomized clinical trial conducted from April 2021 to December 2023 at 23 medical centers in the US (n = 22) and Canada (n = 1). Participant follow-up lasted 70 days (180 days for participants with osteomyelitis); date of final follow-up was December 1, 2023. Hospitalized adults with complicated S aureus …